Amino acid dipepetide frequency for Niastella populi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.565AlaAla: 7.565 ± 0.085	0.811AlaCys: 0.811 ± 0.022	4.125AlaAsp: 4.125 ± 0.049	4.02AlaGlu: 4.02 ± 0.052	3.534AlaPhe: 3.534 ± 0.042	6.923AlaGly: 6.923 ± 0.069	1.36AlaHis: 1.36 ± 0.024	5.358AlaIle: 5.358 ± 0.046	4.043AlaLys: 4.043 ± 0.048	6.811AlaLeu: 6.811 ± 0.067	1.786AlaMet: 1.786 ± 0.029	3.89AlaAsn: 3.89 ± 0.049	2.773AlaPro: 2.773 ± 0.045	2.925AlaGln: 2.925 ± 0.038	3.152AlaArg: 3.152 ± 0.04	4.647AlaSer: 4.647 ± 0.052	4.651AlaThr: 4.651 ± 0.064	5.193AlaVal: 5.193 ± 0.053	1.027AlaTrp: 1.027 ± 0.023	2.904AlaTyr: 2.904 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.562CysAla: 0.562 ± 0.018	0.144CysCys: 0.144 ± 0.009	0.413CysAsp: 0.413 ± 0.012	0.434CysGlu: 0.434 ± 0.013	0.456CysPhe: 0.456 ± 0.012	0.645CysGly: 0.645 ± 0.019	0.199CysHis: 0.199 ± 0.01	0.699CysIle: 0.699 ± 0.02	0.558CysLys: 0.558 ± 0.017	0.82CysLeu: 0.82 ± 0.021	0.241CysMet: 0.241 ± 0.009	0.49CysAsn: 0.49 ± 0.015	0.352CysPro: 0.352 ± 0.013	0.246CysGln: 0.246 ± 0.01	0.43CysArg: 0.43 ± 0.012	0.622CysSer: 0.622 ± 0.017	0.559CysThr: 0.559 ± 0.019	0.508CysVal: 0.508 ± 0.012	0.118CysTrp: 0.118 ± 0.007	0.384CysTyr: 0.384 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.058AspAla: 4.058 ± 0.041	0.413AspCys: 0.413 ± 0.016	2.459AspAsp: 2.459 ± 0.04	3.052AspGlu: 3.052 ± 0.043	2.538AspPhe: 2.538 ± 0.038	3.839AspGly: 3.839 ± 0.05	1.033AspHis: 1.033 ± 0.024	3.505AspIle: 3.505 ± 0.044	3.426AspLys: 3.426 ± 0.045	4.463AspLeu: 4.463 ± 0.054	1.111AspMet: 1.111 ± 0.024	2.874AspAsn: 2.874 ± 0.038	2.176AspPro: 2.176 ± 0.031	1.565AspGln: 1.565 ± 0.028	2.216AspArg: 2.216 ± 0.031	2.983AspSer: 2.983 ± 0.044	2.632AspThr: 2.632 ± 0.037	3.348AspVal: 3.348 ± 0.037	0.762AspTrp: 0.762 ± 0.018	2.337AspTyr: 2.337 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	4.179GluAla: 4.179 ± 0.052	0.373GluCys: 0.373 ± 0.013	2.31GluAsp: 2.31 ± 0.036	3.549GluGlu: 3.549 ± 0.06	2.203GluPhe: 2.203 ± 0.037	3.248GluGly: 3.248 ± 0.041	1.036GluHis: 1.036 ± 0.02	3.682GluIle: 3.682 ± 0.041	4.748GluLys: 4.748 ± 0.058	5.414GluLeu: 5.414 ± 0.061	1.475GluMet: 1.475 ± 0.029	3.003GluAsn: 3.003 ± 0.035	1.776GluPro: 1.776 ± 0.029	2.449GluGln: 2.449 ± 0.031	2.508GluArg: 2.508 ± 0.043	2.55GluSer: 2.55 ± 0.032	2.869GluThr: 2.869 ± 0.038	3.553GluVal: 3.553 ± 0.051	0.776GluTrp: 0.776 ± 0.019	2.049GluTyr: 2.049 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.189PheAla: 3.189 ± 0.039	0.48PheCys: 0.48 ± 0.015	2.741PheAsp: 2.741 ± 0.034	2.531PheGlu: 2.531 ± 0.032	2.347PhePhe: 2.347 ± 0.039	3.168PheGly: 3.168 ± 0.043	0.858PheHis: 0.858 ± 0.019	3.32PheIle: 3.32 ± 0.039	2.649PheLys: 2.649 ± 0.035	4.003PheLeu: 4.003 ± 0.046	1.092PheMet: 1.092 ± 0.023	2.945PheAsn: 2.945 ± 0.046	1.778PhePro: 1.778 ± 0.031	1.421PheGln: 1.421 ± 0.025	2.179PheArg: 2.179 ± 0.035	3.591PheSer: 3.591 ± 0.043	3.499PheThr: 3.499 ± 0.046	2.796PheVal: 2.796 ± 0.036	0.585PheTrp: 0.585 ± 0.015	2.054PheTyr: 2.054 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	5.095GlyAla: 5.095 ± 0.06	0.786GlyCys: 0.786 ± 0.026	3.478GlyAsp: 3.478 ± 0.045	3.339GlyGlu: 3.339 ± 0.036	3.512GlyPhe: 3.512 ± 0.041	5.286GlyGly: 5.286 ± 0.071	1.268GlyHis: 1.268 ± 0.022	5.345GlyIle: 5.345 ± 0.051	5.202GlyLys: 5.202 ± 0.057	5.955GlyLeu: 5.955 ± 0.049	1.802GlyMet: 1.802 ± 0.025	4.414GlyAsn: 4.414 ± 0.064	1.728GlyPro: 1.728 ± 0.031	2.279GlyGln: 2.279 ± 0.034	3.107GlyArg: 3.107 ± 0.043	4.708GlySer: 4.708 ± 0.062	4.641GlyThr: 4.641 ± 0.08	4.525GlyVal: 4.525 ± 0.051	1.144GlyTrp: 1.144 ± 0.026	3.257GlyTyr: 3.257 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.271HisAla: 1.271 ± 0.027	0.222HisCys: 0.222 ± 0.01	0.93HisAsp: 0.93 ± 0.02	1.005HisGlu: 1.005 ± 0.023	1.166HisPhe: 1.166 ± 0.022	1.22HisGly: 1.22 ± 0.028	0.549HisHis: 0.549 ± 0.015	1.44HisIle: 1.44 ± 0.028	1.035HisLys: 1.035 ± 0.023	1.876HisLeu: 1.876 ± 0.034	0.416HisMet: 0.416 ± 0.013	1.013HisAsn: 1.013 ± 0.021	1.036HisPro: 1.036 ± 0.022	0.739HisGln: 0.739 ± 0.017	0.877HisArg: 0.877 ± 0.019	1.122HisSer: 1.122 ± 0.022	1.135HisThr: 1.135 ± 0.024	1.063HisVal: 1.063 ± 0.022	0.274HisTrp: 0.274 ± 0.011	0.929HisTyr: 0.929 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.451IleAla: 5.451 ± 0.054	0.687IleCys: 0.687 ± 0.02	4.069IleAsp: 4.069 ± 0.042	3.807IleGlu: 3.807 ± 0.047	2.747IlePhe: 2.747 ± 0.04	4.506IleGly: 4.506 ± 0.054	1.296IleHis: 1.296 ± 0.024	4.478IleIle: 4.478 ± 0.052	4.33IleLys: 4.33 ± 0.046	5.297IleLeu: 5.297 ± 0.059	1.333IleMet: 1.333 ± 0.023	3.864IleAsn: 3.864 ± 0.042	2.98IlePro: 2.98 ± 0.035	2.346IleGln: 2.346 ± 0.033	3.183IleArg: 3.183 ± 0.04	4.566IleSer: 4.566 ± 0.049	4.971IleThr: 4.971 ± 0.051	4.213IleVal: 4.213 ± 0.045	0.75IleTrp: 0.75 ± 0.021	2.455IleTyr: 2.455 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.83LysAla: 4.83 ± 0.055	0.39LysCys: 0.39 ± 0.014	3.636LysAsp: 3.636 ± 0.047	4.524LysGlu: 4.524 ± 0.061	2.173LysPhe: 2.173 ± 0.029	4.34LysGly: 4.34 ± 0.044	1.215LysHis: 1.215 ± 0.022	4.072LysIle: 4.072 ± 0.05	5.426LysLys: 5.426 ± 0.065	5.57LysLeu: 5.57 ± 0.053	1.796LysMet: 1.796 ± 0.029	3.752LysAsn: 3.752 ± 0.043	2.68LysPro: 2.68 ± 0.036	2.891LysGln: 2.891 ± 0.041	2.817LysArg: 2.817 ± 0.041	3.223LysSer: 3.223 ± 0.038	3.915LysThr: 3.915 ± 0.041	4.076LysVal: 4.076 ± 0.046	0.888LysTrp: 0.888 ± 0.019	2.652LysTyr: 2.652 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	6.644LeuAla: 6.644 ± 0.065	0.825LeuCys: 0.825 ± 0.021	4.035LeuAsp: 4.035 ± 0.039	4.376LeuGlu: 4.376 ± 0.052	4.608LeuPhe: 4.608 ± 0.052	5.321LeuGly: 5.321 ± 0.051	1.976LeuHis: 1.976 ± 0.035	5.641LeuIle: 5.641 ± 0.059	6.198LeuLys: 6.198 ± 0.067	9.452LeuLeu: 9.452 ± 0.093	2.074LeuMet: 2.074 ± 0.03	5.165LeuAsn: 5.165 ± 0.056	4.372LeuPro: 4.372 ± 0.042	4.66LeuGln: 4.66 ± 0.058	3.887LeuArg: 3.887 ± 0.048	6.158LeuSer: 6.158 ± 0.054	5.526LeuThr: 5.526 ± 0.046	5.577LeuVal: 5.577 ± 0.052	1.023LeuTrp: 1.023 ± 0.022	3.533LeuTyr: 3.533 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.966MetAla: 1.966 ± 0.028	0.145MetCys: 0.145 ± 0.008	1.064MetAsp: 1.064 ± 0.021	1.346MetGlu: 1.346 ± 0.029	0.821MetPhe: 0.821 ± 0.017	1.515MetGly: 1.515 ± 0.026	0.502MetHis: 0.502 ± 0.013	1.384MetIle: 1.384 ± 0.026	1.902MetLys: 1.902 ± 0.031	2.182MetLeu: 2.182 ± 0.033	0.596MetMet: 0.596 ± 0.015	1.39MetAsn: 1.39 ± 0.026	1.16MetPro: 1.16 ± 0.023	1.154MetGln: 1.154 ± 0.023	1.121MetArg: 1.121 ± 0.02	1.266MetSer: 1.266 ± 0.023	1.124MetThr: 1.124 ± 0.021	1.531MetVal: 1.531 ± 0.029	0.233MetTrp: 0.233 ± 0.011	0.807MetTyr: 0.807 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	4.305AsnAla: 4.305 ± 0.051	0.496AsnCys: 0.496 ± 0.015	3.051AsnAsp: 3.051 ± 0.041	3.053AsnGlu: 3.053 ± 0.032	2.408AsnPhe: 2.408 ± 0.035	4.723AsnGly: 4.723 ± 0.071	0.908AsnHis: 0.908 ± 0.019	4.035AsnIle: 4.035 ± 0.049	3.489AsnLys: 3.489 ± 0.035	4.494AsnLeu: 4.494 ± 0.049	1.248AsnMet: 1.248 ± 0.022	3.777AsnAsn: 3.777 ± 0.064	2.688AsnPro: 2.688 ± 0.034	1.902AsnGln: 1.902 ± 0.031	2.808AsnArg: 2.808 ± 0.039	3.387AsnSer: 3.387 ± 0.043	3.68AsnThr: 3.68 ± 0.059	3.401AsnVal: 3.401 ± 0.04	0.9AsnTrp: 0.9 ± 0.02	2.603AsnTyr: 2.603 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.197ProAla: 4.197 ± 0.048	0.263ProCys: 0.263 ± 0.01	2.612ProAsp: 2.612 ± 0.034	2.559ProGlu: 2.559 ± 0.035	2.098ProPhe: 2.098 ± 0.032	3.468ProGly: 3.468 ± 0.04	0.739ProHis: 0.739 ± 0.019	2.016ProIle: 2.016 ± 0.033	1.867ProLys: 1.867 ± 0.028	3.534ProLeu: 3.534 ± 0.038	0.802ProMet: 0.802 ± 0.02	1.991ProAsn: 1.991 ± 0.034	1.38ProPro: 1.38 ± 0.031	1.454ProGln: 1.454 ± 0.022	1.319ProArg: 1.319 ± 0.024	2.106ProSer: 2.106 ± 0.034	1.93ProThr: 1.93 ± 0.034	4.177ProVal: 4.177 ± 0.044	0.507ProTrp: 0.507 ± 0.017	1.595ProTyr: 1.595 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.84GlnAla: 2.84 ± 0.04	0.275GlnCys: 0.275 ± 0.012	1.432GlnAsp: 1.432 ± 0.025	2.071GlnGlu: 2.071 ± 0.035	1.854GlnPhe: 1.854 ± 0.028	2.16GlnGly: 2.16 ± 0.032	0.941GlnHis: 0.941 ± 0.022	2.141GlnIle: 2.141 ± 0.032	2.6GlnLys: 2.6 ± 0.035	4.361GlnLeu: 4.361 ± 0.052	0.951GlnMet: 0.951 ± 0.018	1.96GlnAsn: 1.96 ± 0.028	1.918GlnPro: 1.918 ± 0.029	2.608GlnGln: 2.608 ± 0.048	1.761GlnArg: 1.761 ± 0.028	2.126GlnSer: 2.126 ± 0.028	2.284GlnThr: 2.284 ± 0.033	2.62GlnVal: 2.62 ± 0.033	0.593GlnTrp: 0.593 ± 0.017	1.751GlnTyr: 1.751 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.603ArgAla: 2.603 ± 0.037	0.305ArgCys: 0.305 ± 0.013	2.056ArgAsp: 2.056 ± 0.032	2.478ArgGlu: 2.478 ± 0.041	2.445ArgPhe: 2.445 ± 0.035	2.338ArgGly: 2.338 ± 0.036	0.904ArgHis: 0.904 ± 0.023	3.257ArgIle: 3.257 ± 0.038	3.105ArgLys: 3.105 ± 0.04	4.443ArgLeu: 4.443 ± 0.048	1.209ArgMet: 1.209 ± 0.02	2.762ArgAsn: 2.762 ± 0.035	1.543ArgPro: 1.543 ± 0.023	1.863ArgGln: 1.863 ± 0.037	1.996ArgArg: 1.996 ± 0.035	2.715ArgSer: 2.715 ± 0.035	2.405ArgThr: 2.405 ± 0.033	2.639ArgVal: 2.639 ± 0.033	0.708ArgTrp: 0.708 ± 0.018	2.15ArgTyr: 2.15 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.737SerAla: 4.737 ± 0.054	0.622SerCys: 0.622 ± 0.018	2.852SerAsp: 2.852 ± 0.036	2.692SerGlu: 2.692 ± 0.038	3.535SerPhe: 3.535 ± 0.036	5.057SerGly: 5.057 ± 0.072	1.107SerHis: 1.107 ± 0.026	4.358SerIle: 4.358 ± 0.047	3.399SerLys: 3.399 ± 0.04	5.87SerLeu: 5.87 ± 0.049	1.406SerMet: 1.406 ± 0.023	3.33SerAsn: 3.33 ± 0.044	2.405SerPro: 2.405 ± 0.034	1.965SerGln: 1.965 ± 0.028	2.638SerArg: 2.638 ± 0.032	3.79SerSer: 3.79 ± 0.051	3.709SerThr: 3.709 ± 0.052	4.174SerVal: 4.174 ± 0.041	0.878SerTrp: 0.878 ± 0.02	2.684SerTyr: 2.684 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.396ThrAla: 5.396 ± 0.065	0.468ThrCys: 0.468 ± 0.016	3.353ThrAsp: 3.353 ± 0.047	2.853ThrGlu: 2.853 ± 0.037	2.724ThrPhe: 2.724 ± 0.039	5.893ThrGly: 5.893 ± 0.073	1.054ThrHis: 1.054 ± 0.023	4.58ThrIle: 4.58 ± 0.051	2.901ThrLys: 2.901 ± 0.036	5.26ThrLeu: 5.26 ± 0.047	1.085ThrMet: 1.085 ± 0.02	3.157ThrAsn: 3.157 ± 0.045	2.949ThrPro: 2.949 ± 0.041	1.921ThrGln: 1.921 ± 0.026	2.435ThrArg: 2.435 ± 0.039	3.777ThrSer: 3.777 ± 0.056	4.102ThrThr: 4.102 ± 0.068	4.507ThrVal: 4.507 ± 0.059	0.898ThrTrp: 0.898 ± 0.024	2.385ThrTyr: 2.385 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.903ValAla: 4.903 ± 0.05	0.629ValCys: 0.629 ± 0.017	3.129ValAsp: 3.129 ± 0.037	3.255ValGlu: 3.255 ± 0.043	3.196ValPhe: 3.196 ± 0.038	3.505ValGly: 3.505 ± 0.044	1.209ValHis: 1.209 ± 0.025	4.724ValIle: 4.724 ± 0.048	4.372ValLys: 4.372 ± 0.049	6.042ValLeu: 6.042 ± 0.064	1.575ValMet: 1.575 ± 0.028	3.966ValAsn: 3.966 ± 0.046	2.769ValPro: 2.769 ± 0.031	2.597ValGln: 2.597 ± 0.036	2.716ValArg: 2.716 ± 0.037	4.328ValSer: 4.328 ± 0.049	4.557ValThr: 4.557 ± 0.061	4.486ValVal: 4.486 ± 0.048	0.803ValTrp: 0.803 ± 0.018	2.752ValTyr: 2.752 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.87TrpAla: 0.87 ± 0.019	0.136TrpCys: 0.136 ± 0.007	0.704TrpAsp: 0.704 ± 0.019	0.725TrpGlu: 0.725 ± 0.017	0.664TrpPhe: 0.664 ± 0.02	0.904TrpGly: 0.904 ± 0.022	0.319TrpHis: 0.319 ± 0.011	0.779TrpIle: 0.779 ± 0.022	0.981TrpLys: 0.981 ± 0.022	1.417TrpLeu: 1.417 ± 0.026	0.398TrpMet: 0.398 ± 0.013	0.854TrpAsn: 0.854 ± 0.022	0.443TrpPro: 0.443 ± 0.014	0.729TrpGln: 0.729 ± 0.019	0.63TrpArg: 0.63 ± 0.015	0.756TrpSer: 0.756 ± 0.018	0.721TrpThr: 0.721 ± 0.021	0.838TrpVal: 0.838 ± 0.017	0.257TrpTrp: 0.257 ± 0.011	0.601TrpTyr: 0.601 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.836TyrAla: 2.836 ± 0.035	0.408TyrCys: 0.408 ± 0.014	2.34TyrAsp: 2.34 ± 0.04	2.083TyrGlu: 2.083 ± 0.03	2.197TyrPhe: 2.197 ± 0.031	2.813TyrGly: 2.813 ± 0.038	0.845TyrHis: 0.845 ± 0.02	2.516TyrIle: 2.516 ± 0.035	2.637TyrLys: 2.637 ± 0.032	3.788TyrLeu: 3.788 ± 0.043	0.814TyrMet: 0.814 ± 0.019	2.758TyrAsn: 2.758 ± 0.037	1.708TyrPro: 1.708 ± 0.03	1.531TyrGln: 1.531 ± 0.03	2.143TyrArg: 2.143 ± 0.031	2.785TyrSer: 2.785 ± 0.041	2.789TyrThr: 2.789 ± 0.044	2.288TyrVal: 2.288 ± 0.034	0.602TyrTrp: 0.602 ± 0.018	2.043TyrTyr: 2.043 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6536 proteins (2361176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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