Amino acid dipepetide frequency for Leuconostocaceae bacterium R-53105

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.136AlaAla: 8.136 ± 0.257
0.239AlaCys: 0.239 ± 0.029
5.929AlaAsp: 5.929 ± 0.166
4.305AlaGlu: 4.305 ± 0.106
3.353AlaPhe: 3.353 ± 0.098
6.662AlaGly: 6.662 ± 0.141
1.645AlaHis: 1.645 ± 0.061
6.45AlaIle: 6.45 ± 0.178
5.29AlaLys: 5.29 ± 0.171
9.061AlaLeu: 9.061 ± 0.18
2.258AlaMet: 2.258 ± 0.077
4.17AlaAsn: 4.17 ± 0.1
2.492AlaPro: 2.492 ± 0.083
5.672AlaGln: 5.672 ± 0.18
3.061AlaArg: 3.061 ± 0.1
5.158AlaSer: 5.158 ± 0.209
5.237AlaThr: 5.237 ± 0.187
6.191AlaVal: 6.191 ± 0.142
0.771AlaTrp: 0.771 ± 0.044
2.534AlaTyr: 2.534 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.176CysAla: 0.176 ± 0.021
0.019CysCys: 0.019 ± 0.006
0.128CysAsp: 0.128 ± 0.017
0.086CysGlu: 0.086 ± 0.015
0.181CysPhe: 0.181 ± 0.026
0.252CysGly: 0.252 ± 0.028
0.095CysHis: 0.095 ± 0.015
0.139CysIle: 0.139 ± 0.018
0.084CysLys: 0.084 ± 0.014
0.368CysLeu: 0.368 ± 0.032
0.05CysMet: 0.05 ± 0.011
0.082CysAsn: 0.082 ± 0.012
0.116CysPro: 0.116 ± 0.015
0.197CysGln: 0.197 ± 0.025
0.103CysArg: 0.103 ± 0.016
0.17CysSer: 0.17 ± 0.022
0.105CysThr: 0.105 ± 0.019
0.166CysVal: 0.166 ± 0.021
0.032CysTrp: 0.032 ± 0.008
0.101CysTyr: 0.101 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.433AspAla: 4.433 ± 0.19
0.212AspCys: 0.212 ± 0.024
3.38AspAsp: 3.38 ± 0.101
3.75AspGlu: 3.75 ± 0.105
3.162AspPhe: 3.162 ± 0.092
3.723AspGly: 3.723 ± 0.088
1.273AspHis: 1.273 ± 0.052
3.71AspIle: 3.71 ± 0.107
2.918AspLys: 2.918 ± 0.093
6.397AspLeu: 6.397 ± 0.151
1.345AspMet: 1.345 ± 0.059
2.893AspAsn: 2.893 ± 0.1
2.137AspPro: 2.137 ± 0.057
3.973AspGln: 3.973 ± 0.104
2.281AspArg: 2.281 ± 0.075
3.376AspSer: 3.376 ± 0.136
2.708AspThr: 2.708 ± 0.079
3.798AspVal: 3.798 ± 0.113
0.887AspTrp: 0.887 ± 0.049
2.51AspTyr: 2.51 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
4.788GluAla: 4.788 ± 0.156
0.097GluCys: 0.097 ± 0.016
2.651GluAsp: 2.651 ± 0.081
2.935GluGlu: 2.935 ± 0.094
2.095GluPhe: 2.095 ± 0.079
2.479GluGly: 2.479 ± 0.08
1.065GluHis: 1.065 ± 0.051
4.021GluIle: 4.021 ± 0.109
3.393GluLys: 3.393 ± 0.095
5.582GluLeu: 5.582 ± 0.127
1.534GluMet: 1.534 ± 0.064
2.853GluAsn: 2.853 ± 0.081
1.641GluPro: 1.641 ± 0.065
2.939GluGln: 2.939 ± 0.084
2.426GluArg: 2.426 ± 0.079
3.179GluSer: 3.179 ± 0.138
2.485GluThr: 2.485 ± 0.077
3.973GluVal: 3.973 ± 0.157
0.502GluTrp: 0.502 ± 0.034
1.647GluTyr: 1.647 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.288PheAla: 3.288 ± 0.097
0.145PheCys: 0.145 ± 0.018
2.823PheAsp: 2.823 ± 0.08
2.445PheGlu: 2.445 ± 0.098
1.874PhePhe: 1.874 ± 0.074
3.174PheGly: 3.174 ± 0.091
0.771PheHis: 0.771 ± 0.038
2.899PheIle: 2.899 ± 0.089
2.359PheLys: 2.359 ± 0.083
3.866PheLeu: 3.866 ± 0.112
1.095PheMet: 1.095 ± 0.051
2.229PheAsn: 2.229 ± 0.072
1.326PhePro: 1.326 ± 0.059
1.685PheGln: 1.685 ± 0.063
1.225PheArg: 1.225 ± 0.059
2.786PheSer: 2.786 ± 0.078
2.447PheThr: 2.447 ± 0.075
2.828PheVal: 2.828 ± 0.081
0.544PheTrp: 0.544 ± 0.038
1.504PheTyr: 1.504 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.971GlyAla: 4.971 ± 0.124
0.183GlyCys: 0.183 ± 0.022
3.584GlyAsp: 3.584 ± 0.108
3.107GlyGlu: 3.107 ± 0.08
3.025GlyPhe: 3.025 ± 0.093
4.277GlyGly: 4.277 ± 0.137
1.565GlyHis: 1.565 ± 0.054
5.137GlyIle: 5.137 ± 0.123
3.88GlyLys: 3.88 ± 0.092
7.084GlyLeu: 7.084 ± 0.151
1.87GlyMet: 1.87 ± 0.066
2.697GlyAsn: 2.697 ± 0.079
1.798GlyPro: 1.798 ± 0.071
4.26GlyGln: 4.26 ± 0.122
2.798GlyArg: 2.798 ± 0.083
4.347GlySer: 4.347 ± 0.109
3.71GlyThr: 3.71 ± 0.097
4.92GlyVal: 4.92 ± 0.109
0.788GlyTrp: 0.788 ± 0.048
2.504GlyTyr: 2.504 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.321HisAla: 1.321 ± 0.061
0.074HisCys: 0.074 ± 0.013
1.185HisAsp: 1.185 ± 0.051
0.981HisGlu: 0.981 ± 0.05
1.13HisPhe: 1.13 ± 0.049
1.458HisGly: 1.458 ± 0.065
0.567HisHis: 0.567 ± 0.033
1.189HisIle: 1.189 ± 0.05
0.798HisLys: 0.798 ± 0.041
2.214HisLeu: 2.214 ± 0.07
0.466HisMet: 0.466 ± 0.028
0.861HisAsn: 0.861 ± 0.04
1.059HisPro: 1.059 ± 0.041
1.426HisGln: 1.426 ± 0.059
0.926HisArg: 0.926 ± 0.048
1.126HisSer: 1.126 ± 0.048
0.979HisThr: 0.979 ± 0.047
1.202HisVal: 1.202 ± 0.056
0.256HisTrp: 0.256 ± 0.026
0.859HisTyr: 0.859 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.2IleAla: 6.2 ± 0.121
0.235IleCys: 0.235 ± 0.023
4.51IleAsp: 4.51 ± 0.185
3.8IleGlu: 3.8 ± 0.1
3.073IlePhe: 3.073 ± 0.108
5.029IleGly: 5.029 ± 0.126
1.223IleHis: 1.223 ± 0.048
4.996IleIle: 4.996 ± 0.141
4.017IleLys: 4.017 ± 0.089
6.868IleLeu: 6.868 ± 0.163
1.618IleMet: 1.618 ± 0.061
3.58IleAsn: 3.58 ± 0.091
2.639IlePro: 2.639 ± 0.078
3.069IleGln: 3.069 ± 0.083
2.479IleArg: 2.479 ± 0.085
4.584IleSer: 4.584 ± 0.137
4.155IleThr: 4.155 ± 0.114
5.057IleVal: 5.057 ± 0.124
0.71IleTrp: 0.71 ± 0.04
2.092IleTyr: 2.092 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
4.899LysAla: 4.899 ± 0.213
0.061LysCys: 0.061 ± 0.011
3.097LysAsp: 3.097 ± 0.118
3.269LysGlu: 3.269 ± 0.092
1.83LysPhe: 1.83 ± 0.067
3.008LysGly: 3.008 ± 0.084
1.032LysHis: 1.032 ± 0.043
4.342LysIle: 4.342 ± 0.088
3.836LysLys: 3.836 ± 0.097
5.021LysLeu: 5.021 ± 0.112
1.788LysMet: 1.788 ± 0.061
3.155LysAsn: 3.155 ± 0.091
2.095LysPro: 2.095 ± 0.073
3.162LysGln: 3.162 ± 0.109
2.485LysArg: 2.485 ± 0.073
3.376LysSer: 3.376 ± 0.123
3.422LysThr: 3.422 ± 0.114
3.821LysVal: 3.821 ± 0.096
0.492LysTrp: 0.492 ± 0.032
1.891LysTyr: 1.891 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
10.735LeuAla: 10.735 ± 0.223
0.242LeuCys: 0.242 ± 0.023
6.01LeuAsp: 6.01 ± 0.13
4.618LeuGlu: 4.618 ± 0.124
3.723LeuPhe: 3.723 ± 0.124
6.832LeuGly: 6.832 ± 0.147
1.685LeuHis: 1.685 ± 0.064
7.069LeuIle: 7.069 ± 0.157
5.813LeuLys: 5.813 ± 0.124
9.914LeuLeu: 9.914 ± 0.213
2.546LeuMet: 2.546 ± 0.082
5.027LeuAsn: 5.027 ± 0.093
4.513LeuPro: 4.513 ± 0.1
4.296LeuGln: 4.296 ± 0.094
3.485LeuArg: 3.485 ± 0.115
6.926LeuSer: 6.926 ± 0.149
6.657LeuThr: 6.657 ± 0.12
7.544LeuVal: 7.544 ± 0.149
0.939LeuTrp: 0.939 ± 0.045
2.723LeuTyr: 2.723 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
2.679MetAla: 2.679 ± 0.077
0.048MetCys: 0.048 ± 0.01
1.363MetAsp: 1.363 ± 0.055
0.989MetGlu: 0.989 ± 0.041
0.842MetPhe: 0.842 ± 0.045
1.756MetGly: 1.756 ± 0.069
0.395MetHis: 0.395 ± 0.031
1.876MetIle: 1.876 ± 0.071
1.456MetLys: 1.456 ± 0.057
2.233MetLeu: 2.233 ± 0.087
0.71MetMet: 0.71 ± 0.038
1.223MetAsn: 1.223 ± 0.063
1.09MetPro: 1.09 ± 0.05
1.107MetGln: 1.107 ± 0.048
0.994MetArg: 0.994 ± 0.048
1.641MetSer: 1.641 ± 0.066
1.935MetThr: 1.935 ± 0.055
2.04MetVal: 2.04 ± 0.064
0.176MetTrp: 0.176 ± 0.022
0.595MetTyr: 0.595 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.586AsnAla: 3.586 ± 0.114
0.12AsnCys: 0.12 ± 0.017
2.84AsnAsp: 2.84 ± 0.093
2.166AsnGlu: 2.166 ± 0.075
2.166AsnPhe: 2.166 ± 0.075
3.397AsnGly: 3.397 ± 0.097
1.252AsnHis: 1.252 ± 0.045
3.223AsnIle: 3.223 ± 0.104
2.387AsnLys: 2.387 ± 0.084
4.708AsnLeu: 4.708 ± 0.107
1.095AsnMet: 1.095 ± 0.041
2.397AsnAsn: 2.397 ± 0.093
2.254AsnPro: 2.254 ± 0.074
3.691AsnGln: 3.691 ± 0.11
2.048AsnArg: 2.048 ± 0.062
2.834AsnSer: 2.834 ± 0.11
2.382AsnThr: 2.382 ± 0.078
2.926AsnVal: 2.926 ± 0.092
0.695AsnTrp: 0.695 ± 0.039
1.851AsnTyr: 1.851 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
3.494ProAla: 3.494 ± 0.096
0.069ProCys: 0.069 ± 0.014
2.454ProAsp: 2.454 ± 0.09
2.529ProGlu: 2.529 ± 0.087
1.51ProPhe: 1.51 ± 0.056
2.21ProGly: 2.21 ± 0.082
0.685ProHis: 0.685 ± 0.037
2.58ProIle: 2.58 ± 0.074
2.12ProLys: 2.12 ± 0.064
3.389ProLeu: 3.389 ± 0.095
0.779ProMet: 0.779 ± 0.042
1.952ProAsn: 1.952 ± 0.06
0.588ProPro: 0.588 ± 0.045
1.851ProGln: 1.851 ± 0.064
1.158ProArg: 1.158 ± 0.053
2.235ProSer: 2.235 ± 0.074
2.284ProThr: 2.284 ± 0.075
3.025ProVal: 3.025 ± 0.079
0.387ProTrp: 0.387 ± 0.029
1.233ProTyr: 1.233 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
6.609GlnAla: 6.609 ± 0.184
0.113GlnCys: 0.113 ± 0.02
2.769GlnAsp: 2.769 ± 0.08
3.426GlnGlu: 3.426 ± 0.087
1.756GlnPhe: 1.756 ± 0.059
3.164GlnGly: 3.164 ± 0.088
1.212GlnHis: 1.212 ± 0.062
3.763GlnIle: 3.763 ± 0.096
3.485GlnLys: 3.485 ± 0.138
6.048GlnLeu: 6.048 ± 0.16
1.332GlnMet: 1.332 ± 0.055
2.534GlnAsn: 2.534 ± 0.085
2.147GlnPro: 2.147 ± 0.075
3.586GlnGln: 3.586 ± 0.139
2.609GlnArg: 2.609 ± 0.083
3.307GlnSer: 3.307 ± 0.129
3.206GlnThr: 3.206 ± 0.091
4.103GlnVal: 4.103 ± 0.103
0.567GlnTrp: 0.567 ± 0.034
1.752GlnTyr: 1.752 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
2.834ArgAla: 2.834 ± 0.091
0.103ArgCys: 0.103 ± 0.014
2.09ArgAsp: 2.09 ± 0.075
2.183ArgGlu: 2.183 ± 0.075
1.702ArgPhe: 1.702 ± 0.059
2.418ArgGly: 2.418 ± 0.081
0.916ArgHis: 0.916 ± 0.05
2.597ArgIle: 2.597 ± 0.081
2.027ArgLys: 2.027 ± 0.074
4.267ArgLeu: 4.267 ± 0.113
1.084ArgMet: 1.084 ± 0.048
1.62ArgAsn: 1.62 ± 0.064
1.607ArgPro: 1.607 ± 0.066
2.809ArgGln: 2.809 ± 0.098
1.933ArgArg: 1.933 ± 0.066
2.162ArgSer: 2.162 ± 0.073
1.788ArgThr: 1.788 ± 0.063
2.723ArgVal: 2.723 ± 0.079
0.431ArgTrp: 0.431 ± 0.034
1.735ArgTyr: 1.735 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.307SerAla: 5.307 ± 0.205
0.132SerCys: 0.132 ± 0.019
3.561SerAsp: 3.561 ± 0.103
3.263SerGlu: 3.263 ± 0.143
2.718SerPhe: 2.718 ± 0.078
4.439SerGly: 4.439 ± 0.105
1.229SerHis: 1.229 ± 0.053
3.966SerIle: 3.966 ± 0.117
3.38SerLys: 3.38 ± 0.113
6.263SerLeu: 6.263 ± 0.136
1.576SerMet: 1.576 ± 0.066
2.916SerAsn: 2.916 ± 0.106
1.979SerPro: 1.979 ± 0.068
4.258SerGln: 4.258 ± 0.189
2.403SerArg: 2.403 ± 0.084
4.076SerSer: 4.076 ± 0.208
4.525SerThr: 4.525 ± 0.432
3.924SerVal: 3.924 ± 0.099
0.697SerTrp: 0.697 ± 0.045
2.048SerTyr: 2.048 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.208ThrAla: 5.208 ± 0.114
0.147ThrCys: 0.147 ± 0.02
3.359ThrAsp: 3.359 ± 0.091
2.555ThrGlu: 2.555 ± 0.071
2.431ThrPhe: 2.431 ± 0.071
4.521ThrGly: 4.521 ± 0.099
1.027ThrHis: 1.027 ± 0.048
4.181ThrIle: 4.181 ± 0.096
3.323ThrLys: 3.323 ± 0.11
5.683ThrLeu: 5.683 ± 0.12
1.286ThrMet: 1.286 ± 0.056
2.742ThrAsn: 2.742 ± 0.098
2.534ThrPro: 2.534 ± 0.09
2.464ThrGln: 2.464 ± 0.071
1.815ThrArg: 1.815 ± 0.057
4.437ThrSer: 4.437 ± 0.392
3.754ThrThr: 3.754 ± 0.102
4.51ThrVal: 4.51 ± 0.104
0.567ThrTrp: 0.567 ± 0.035
1.88ThrTyr: 1.88 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
6.811ValAla: 6.811 ± 0.138
0.214ValCys: 0.214 ± 0.022
4.702ValAsp: 4.702 ± 0.135
3.895ValGlu: 3.895 ± 0.167
2.597ValPhe: 2.597 ± 0.085
4.83ValGly: 4.83 ± 0.109
1.223ValHis: 1.223 ± 0.056
5.252ValIle: 5.252 ± 0.116
3.973ValLys: 3.973 ± 0.107
6.87ValLeu: 6.87 ± 0.139
1.794ValMet: 1.794 ± 0.062
3.334ValAsn: 3.334 ± 0.08
2.721ValPro: 2.721 ± 0.076
3.103ValGln: 3.103 ± 0.091
2.504ValArg: 2.504 ± 0.078
4.456ValSer: 4.456 ± 0.109
4.5ValThr: 4.5 ± 0.1
5.695ValVal: 5.695 ± 0.113
0.63ValTrp: 0.63 ± 0.04
2.088ValTyr: 2.088 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.75TrpAla: 0.75 ± 0.041
0.029TrpCys: 0.029 ± 0.008
0.496TrpAsp: 0.496 ± 0.034
0.395TrpGlu: 0.395 ± 0.031
0.504TrpPhe: 0.504 ± 0.033
0.599TrpGly: 0.599 ± 0.038
0.334TrpHis: 0.334 ± 0.027
0.672TrpIle: 0.672 ± 0.036
0.34TrpLys: 0.34 ± 0.031
1.548TrpLeu: 1.548 ± 0.066
0.235TrpMet: 0.235 ± 0.021
0.408TrpAsn: 0.408 ± 0.033
0.384TrpPro: 0.384 ± 0.029
1.065TrpGln: 1.065 ± 0.054
0.492TrpArg: 0.492 ± 0.035
0.672TrpSer: 0.672 ± 0.038
0.506TrpThr: 0.506 ± 0.035
0.752TrpVal: 0.752 ± 0.046
0.185TrpTrp: 0.185 ± 0.021
0.345TrpTyr: 0.345 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.389TyrAla: 2.389 ± 0.076
0.166TyrCys: 0.166 ± 0.021
1.933TyrAsp: 1.933 ± 0.085
1.586TyrGlu: 1.586 ± 0.067
1.641TyrPhe: 1.641 ± 0.056
2.279TyrGly: 2.279 ± 0.073
0.887TyrHis: 0.887 ± 0.043
1.874TyrIle: 1.874 ± 0.068
1.202TyrLys: 1.202 ± 0.062
3.916TyrLeu: 3.916 ± 0.108
0.687TyrMet: 0.687 ± 0.041
1.347TyrAsn: 1.347 ± 0.059
1.414TyrPro: 1.414 ± 0.06
2.874TyrGln: 2.874 ± 0.088
1.8TyrArg: 1.8 ± 0.066
1.815TyrSer: 1.815 ± 0.064
1.637TyrThr: 1.637 ± 0.061
1.992TyrVal: 1.992 ± 0.061
0.456TyrTrp: 0.456 ± 0.03
1.286TyrTyr: 1.286 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1574 proteins (476006 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski