Amino acid dipepetide frequency for Domestic cat hepadnavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.321AlaAla: 6.321 ± 1.198
2.528AlaCys: 2.528 ± 0.753
5.689AlaAsp: 5.689 ± 1.87
2.528AlaGlu: 2.528 ± 1.469
3.161AlaPhe: 3.161 ± 1.837
1.264AlaGly: 1.264 ± 0.506
2.528AlaHis: 2.528 ± 1.069
1.896AlaIle: 1.896 ± 0.669
1.264AlaLys: 1.264 ± 0.735
6.321AlaLeu: 6.321 ± 2.113
1.264AlaMet: 1.264 ± 0.919
1.896AlaAsn: 1.896 ± 0.669
6.953AlaPro: 6.953 ± 2.012
1.896AlaGln: 1.896 ± 0.65
8.85AlaArg: 8.85 ± 4.697
3.793AlaSer: 3.793 ± 0.82
4.425AlaThr: 4.425 ± 0.618
2.528AlaVal: 2.528 ± 1.838
1.264AlaTrp: 1.264 ± 0.506
1.896AlaTyr: 1.896 ± 0.773
0.0AlaXaa: 0.0 ± 0.0
Cys
1.896CysAla: 1.896 ± 1.937
1.896CysCys: 1.896 ± 1.047
0.0CysAsp: 0.0 ± 0.0
0.632CysGlu: 0.632 ± 1.049
0.0CysPhe: 0.0 ± 0.0
0.632CysGly: 0.632 ± 0.367
0.0CysHis: 0.0 ± 0.0
1.264CysIle: 1.264 ± 1.199
0.632CysLys: 0.632 ± 0.599
4.425CysLeu: 4.425 ± 1.565
1.896CysMet: 1.896 ± 1.201
0.0CysAsn: 0.0 ± 0.0
1.264CysPro: 1.264 ± 1.199
0.632CysGln: 0.632 ± 0.367
2.528CysArg: 2.528 ± 1.469
3.161CysSer: 3.161 ± 1.472
3.793CysThr: 3.793 ± 1.463
1.896CysVal: 1.896 ± 1.269
1.264CysTrp: 1.264 ± 0.955
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.161AspAla: 3.161 ± 1.222
0.0AspCys: 0.0 ± 0.0
1.264AspAsp: 1.264 ± 0.735
0.0AspGlu: 0.0 ± 0.0
2.528AspPhe: 2.528 ± 0.502
1.896AspGly: 1.896 ± 0.65
0.632AspHis: 0.632 ± 0.599
0.632AspIle: 0.632 ± 0.884
0.632AspLys: 0.632 ± 0.367
5.689AspLeu: 5.689 ± 2.53
0.0AspMet: 0.0 ± 0.0
1.264AspAsn: 1.264 ± 0.735
2.528AspPro: 2.528 ± 1.691
0.0AspGln: 0.0 ± 0.0
0.0AspArg: 0.0 ± 0.0
3.161AspSer: 3.161 ± 1.685
0.632AspThr: 0.632 ± 0.884
3.161AspVal: 3.161 ± 1.837
1.896AspTrp: 1.896 ± 0.65
1.264AspTyr: 1.264 ± 0.735
0.0AspXaa: 0.0 ± 0.0
Glu
0.632GluAla: 0.632 ± 1.049
0.632GluCys: 0.632 ± 0.367
0.632GluAsp: 0.632 ± 0.367
3.161GluGlu: 3.161 ± 3.674
1.264GluPhe: 1.264 ± 1.767
3.793GluGly: 3.793 ± 1.913
4.425GluHis: 4.425 ± 1.697
0.632GluIle: 0.632 ± 0.367
0.0GluLys: 0.0 ± 0.0
3.161GluLeu: 3.161 ± 0.862
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
0.632GluPro: 0.632 ± 0.367
1.264GluGln: 1.264 ± 0.735
0.0GluArg: 0.0 ± 0.0
3.793GluSer: 3.793 ± 1.913
1.264GluThr: 1.264 ± 0.506
0.632GluVal: 0.632 ± 0.367
1.264GluTrp: 1.264 ± 0.919
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
5.057PheAla: 5.057 ± 2.303
0.632PheCys: 0.632 ± 0.884
0.632PheAsp: 0.632 ± 0.599
0.0PheGlu: 0.0 ± 0.0
1.896PhePhe: 1.896 ± 0.669
4.425PheGly: 4.425 ± 2.404
1.896PheHis: 1.896 ± 2.217
1.264PheIle: 1.264 ± 0.506
0.632PheLys: 0.632 ± 0.367
6.321PheLeu: 6.321 ± 1.084
1.264PheMet: 1.264 ± 0.506
1.896PheAsn: 1.896 ± 1.102
8.217PhePro: 8.217 ± 1.935
0.632PheGln: 0.632 ± 0.367
3.793PheArg: 3.793 ± 2.204
3.793PheSer: 3.793 ± 1.301
3.161PheThr: 3.161 ± 1.303
2.528PheVal: 2.528 ± 0.927
0.632PheTrp: 0.632 ± 0.599
1.264PheTyr: 1.264 ± 0.506
0.0PheXaa: 0.0 ± 0.0
Gly
6.321GlyAla: 6.321 ± 1.583
1.264GlyCys: 1.264 ± 1.133
1.896GlyAsp: 1.896 ± 1.047
1.264GlyGlu: 1.264 ± 0.735
5.689GlyPhe: 5.689 ± 1.715
5.057GlyGly: 5.057 ± 1.109
0.632GlyHis: 0.632 ± 0.367
3.793GlyIle: 3.793 ± 0.964
0.632GlyLys: 0.632 ± 0.367
9.482GlyLeu: 9.482 ± 2.022
1.896GlyMet: 1.896 ± 0.773
1.896GlyAsn: 1.896 ± 1.798
6.321GlyPro: 6.321 ± 1.677
3.161GlyGln: 3.161 ± 0.791
4.425GlyArg: 4.425 ± 1.651
5.689GlySer: 5.689 ± 2.089
3.161GlyThr: 3.161 ± 1.851
3.161GlyVal: 3.161 ± 1.252
0.632GlyTrp: 0.632 ± 0.367
2.528GlyTyr: 2.528 ± 0.927
0.0GlyXaa: 0.0 ± 0.0
His
1.264HisAla: 1.264 ± 0.735
1.264HisCys: 1.264 ± 0.744
0.632HisAsp: 0.632 ± 0.367
0.632HisGlu: 0.632 ± 0.367
1.896HisPhe: 1.896 ± 1.102
1.896HisGly: 1.896 ± 0.65
1.264HisHis: 1.264 ± 0.744
0.0HisIle: 0.0 ± 0.0
2.528HisLys: 2.528 ± 1.069
7.585HisLeu: 7.585 ± 2.181
0.0HisMet: 0.0 ± 0.0
1.264HisAsn: 1.264 ± 1.199
1.896HisPro: 1.896 ± 0.65
1.264HisGln: 1.264 ± 0.506
1.264HisArg: 1.264 ± 0.735
3.161HisSer: 3.161 ± 0.784
3.793HisThr: 3.793 ± 2.599
1.896HisVal: 1.896 ± 1.102
0.632HisTrp: 0.632 ± 0.367
1.264HisTyr: 1.264 ± 0.735
0.0HisXaa: 0.0 ± 0.0
Ile
1.264IleAla: 1.264 ± 0.735
0.0IleCys: 0.0 ± 0.0
0.632IleAsp: 0.632 ± 0.884
0.0IleGlu: 0.0 ± 0.0
1.896IlePhe: 1.896 ± 0.65
3.793IleGly: 3.793 ± 2.094
1.896IleHis: 1.896 ± 1.102
0.632IleIle: 0.632 ± 0.599
0.632IleLys: 0.632 ± 0.367
3.161IleLeu: 3.161 ± 0.572
0.632IleMet: 0.632 ± 0.367
0.0IleAsn: 0.0 ± 0.0
4.425IlePro: 4.425 ± 1.364
1.896IleGln: 1.896 ± 0.669
2.528IleArg: 2.528 ± 1.483
2.528IleSer: 2.528 ± 0.502
1.896IleThr: 1.896 ± 1.047
1.896IleVal: 1.896 ± 0.669
0.632IleTrp: 0.632 ± 0.599
0.632IleTyr: 0.632 ± 0.599
0.0IleXaa: 0.0 ± 0.0
Lys
1.264LysAla: 1.264 ± 0.506
0.0LysCys: 0.0 ± 0.0
0.632LysAsp: 0.632 ± 0.599
1.896LysGlu: 1.896 ± 0.773
0.0LysPhe: 0.0 ± 0.0
2.528LysGly: 2.528 ± 1.012
2.528LysHis: 2.528 ± 0.927
1.896LysIle: 1.896 ± 0.65
0.632LysLys: 0.632 ± 0.599
3.793LysLeu: 3.793 ± 1.546
0.0LysMet: 0.0 ± 0.0
0.632LysAsn: 0.632 ± 0.367
1.264LysPro: 1.264 ± 0.735
1.264LysGln: 1.264 ± 0.735
0.632LysArg: 0.632 ± 0.367
1.264LysSer: 1.264 ± 0.735
2.528LysThr: 2.528 ± 0.753
1.264LysVal: 1.264 ± 0.735
0.632LysTrp: 0.632 ± 0.367
1.264LysTyr: 1.264 ± 0.506
0.0LysXaa: 0.0 ± 0.0
Leu
8.217LeuAla: 8.217 ± 2.191
3.793LeuCys: 3.793 ± 1.575
3.161LeuAsp: 3.161 ± 0.998
3.161LeuGlu: 3.161 ± 1.222
4.425LeuPhe: 4.425 ± 1.124
10.114LeuGly: 10.114 ± 2.748
3.793LeuHis: 3.793 ± 1.588
2.528LeuIle: 2.528 ± 1.029
3.793LeuLys: 3.793 ± 0.82
18.963LeuLeu: 18.963 ± 5.716
1.264LeuMet: 1.264 ± 0.735
3.793LeuAsn: 3.793 ± 1.546
6.953LeuPro: 6.953 ± 0.64
5.057LeuGln: 5.057 ± 0.973
10.746LeuArg: 10.746 ± 8.149
10.746LeuSer: 10.746 ± 0.989
7.585LeuThr: 7.585 ± 1.416
9.482LeuVal: 9.482 ± 1.935
3.793LeuTrp: 3.793 ± 0.97
5.689LeuTyr: 5.689 ± 2.554
0.0LeuXaa: 0.0 ± 0.0
Met
1.264MetAla: 1.264 ± 1.492
0.632MetCys: 0.632 ± 0.599
1.264MetAsp: 1.264 ± 0.744
1.264MetGlu: 1.264 ± 0.919
0.0MetPhe: 0.0 ± 0.0
3.793MetGly: 3.793 ± 1.301
1.896MetHis: 1.896 ± 0.773
0.632MetIle: 0.632 ± 0.367
0.0MetLys: 0.0 ± 0.0
0.632MetLeu: 0.632 ± 0.367
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.896MetPro: 1.896 ± 0.65
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.896MetSer: 1.896 ± 0.65
1.264MetThr: 1.264 ± 1.133
1.264MetVal: 1.264 ± 0.735
0.632MetTrp: 0.632 ± 0.884
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.264AsnAla: 1.264 ± 0.744
2.528AsnCys: 2.528 ± 1.483
0.632AsnAsp: 0.632 ± 0.884
0.0AsnGlu: 0.0 ± 0.0
1.264AsnPhe: 1.264 ± 0.735
0.632AsnGly: 0.632 ± 0.367
0.632AsnHis: 0.632 ± 0.367
2.528AsnIle: 2.528 ± 1.629
0.632AsnLys: 0.632 ± 0.367
2.528AsnLeu: 2.528 ± 0.927
0.0AsnMet: 0.0 ± 0.0
1.264AsnAsn: 1.264 ± 0.735
3.793AsnPro: 3.793 ± 1.519
0.632AsnGln: 0.632 ± 0.599
1.264AsnArg: 1.264 ± 0.735
1.264AsnSer: 1.264 ± 0.744
1.264AsnThr: 1.264 ± 0.735
1.264AsnVal: 1.264 ± 0.744
0.632AsnTrp: 0.632 ± 0.367
1.264AsnTyr: 1.264 ± 0.735
0.0AsnXaa: 0.0 ± 0.0
Pro
6.953ProAla: 6.953 ± 2.38
1.896ProCys: 1.896 ± 0.927
2.528ProAsp: 2.528 ± 1.838
2.528ProGlu: 2.528 ± 1.152
4.425ProPhe: 4.425 ± 0.939
5.057ProGly: 5.057 ± 2.574
2.528ProHis: 2.528 ± 0.502
3.793ProIle: 3.793 ± 1.311
0.632ProLys: 0.632 ± 0.599
10.114ProLeu: 10.114 ± 2.678
1.264ProMet: 1.264 ± 0.694
2.528ProAsn: 2.528 ± 0.502
10.746ProPro: 10.746 ± 4.113
3.161ProGln: 3.161 ± 1.532
7.585ProArg: 7.585 ± 1.426
6.321ProSer: 6.321 ± 1.084
6.953ProThr: 6.953 ± 2.081
3.793ProVal: 3.793 ± 1.301
5.057ProTrp: 5.057 ± 1.246
1.896ProTyr: 1.896 ± 1.592
0.0ProXaa: 0.0 ± 0.0
Gln
2.528GlnAla: 2.528 ± 1.489
0.0GlnCys: 0.0 ± 0.0
2.528GlnAsp: 2.528 ± 0.502
0.0GlnGlu: 0.0 ± 0.0
2.528GlnPhe: 2.528 ± 0.927
1.264GlnGly: 1.264 ± 0.506
1.896GlnHis: 1.896 ± 0.773
0.0GlnIle: 0.0 ± 0.0
3.793GlnLys: 3.793 ± 1.595
3.793GlnLeu: 3.793 ± 1.174
1.264GlnMet: 1.264 ± 0.955
0.0GlnAsn: 0.0 ± 0.0
1.896GlnPro: 1.896 ± 0.889
1.264GlnGln: 1.264 ± 0.744
1.896GlnArg: 1.896 ± 1.102
7.585GlnSer: 7.585 ± 1.796
3.161GlnThr: 3.161 ± 2.221
1.264GlnVal: 1.264 ± 0.506
0.632GlnTrp: 0.632 ± 0.599
0.632GlnTyr: 0.632 ± 0.599
0.0GlnXaa: 0.0 ± 0.0
Arg
3.793ArgAla: 3.793 ± 2.537
2.528ArgCys: 2.528 ± 1.878
1.264ArgAsp: 1.264 ± 0.919
2.528ArgGlu: 2.528 ± 1.123
3.793ArgPhe: 3.793 ± 0.896
4.425ArgGly: 4.425 ± 0.623
1.264ArgHis: 1.264 ± 0.506
0.632ArgIle: 0.632 ± 0.367
1.896ArgLys: 1.896 ± 0.65
8.85ArgLeu: 8.85 ± 4.567
2.528ArgMet: 2.528 ± 0.694
1.264ArgAsn: 1.264 ± 0.735
3.793ArgPro: 3.793 ± 1.67
3.161ArgGln: 3.161 ± 0.862
9.482ArgArg: 9.482 ± 7.226
7.585ArgSer: 7.585 ± 2.863
3.161ArgThr: 3.161 ± 1.796
6.953ArgVal: 6.953 ± 0.935
1.264ArgTrp: 1.264 ± 0.744
1.264ArgTyr: 1.264 ± 0.735
0.0ArgXaa: 0.0 ± 0.0
Ser
4.425SerAla: 4.425 ± 1.364
2.528SerCys: 2.528 ± 0.502
1.896SerAsp: 1.896 ± 0.669
1.896SerGlu: 1.896 ± 0.927
6.321SerPhe: 6.321 ± 1.084
3.161SerGly: 3.161 ± 0.784
1.896SerHis: 1.896 ± 0.65
3.793SerIle: 3.793 ± 0.82
1.896SerLys: 1.896 ± 0.669
11.378SerLeu: 11.378 ± 2.313
1.896SerMet: 1.896 ± 1.102
2.528SerAsn: 2.528 ± 0.954
12.642SerPro: 12.642 ± 2.277
8.85SerGln: 8.85 ± 1.566
4.425SerArg: 4.425 ± 1.579
10.746SerSer: 10.746 ± 3.682
4.425SerThr: 4.425 ± 1.342
2.528SerVal: 2.528 ± 1.069
3.161SerTrp: 3.161 ± 2.221
1.264SerTyr: 1.264 ± 0.506
0.0SerXaa: 0.0 ± 0.0
Thr
5.689ThrAla: 5.689 ± 0.303
1.896ThrCys: 1.896 ± 1.479
1.264ThrAsp: 1.264 ± 0.506
0.632ThrGlu: 0.632 ± 0.367
2.528ThrPhe: 2.528 ± 0.954
5.689ThrGly: 5.689 ± 1.356
2.528ThrHis: 2.528 ± 0.927
2.528ThrIle: 2.528 ± 1.029
3.161ThrLys: 3.161 ± 1.252
6.321ThrLeu: 6.321 ± 2.417
0.632ThrMet: 0.632 ± 0.559
2.528ThrAsn: 2.528 ± 0.927
4.425ThrPro: 4.425 ± 2.136
1.264ThrGln: 1.264 ± 0.955
2.528ThrArg: 2.528 ± 1.069
6.321ThrSer: 6.321 ± 3.593
2.528ThrThr: 2.528 ± 1.029
3.793ThrVal: 3.793 ± 3.479
3.793ThrTrp: 3.793 ± 1.575
1.896ThrTyr: 1.896 ± 0.927
0.0ThrXaa: 0.0 ± 0.0
Val
4.425ValAla: 4.425 ± 0.618
1.264ValCys: 1.264 ± 0.506
3.793ValAsp: 3.793 ± 1.532
1.896ValGlu: 1.896 ± 1.269
2.528ValPhe: 2.528 ± 1.469
1.896ValGly: 1.896 ± 0.65
1.264ValHis: 1.264 ± 0.735
1.264ValIle: 1.264 ± 0.744
0.0ValLys: 0.0 ± 0.0
6.321ValLeu: 6.321 ± 2.563
0.0ValMet: 0.0 ± 0.0
1.896ValAsn: 1.896 ± 0.773
5.689ValPro: 5.689 ± 1.359
1.264ValGln: 1.264 ± 0.744
5.689ValArg: 5.689 ± 1.824
6.953ValSer: 6.953 ± 1.693
1.896ValThr: 1.896 ± 0.889
2.528ValVal: 2.528 ± 1.012
1.896ValTrp: 1.896 ± 1.798
1.896ValTyr: 1.896 ± 0.65
0.0ValXaa: 0.0 ± 0.0
Trp
0.632TrpAla: 0.632 ± 0.599
1.264TrpCys: 1.264 ± 0.506
0.0TrpAsp: 0.0 ± 0.0
2.528TrpGlu: 2.528 ± 1.152
1.264TrpPhe: 1.264 ± 0.955
6.321TrpGly: 6.321 ± 0.59
0.0TrpHis: 0.0 ± 0.0
1.264TrpIle: 1.264 ± 0.744
1.896TrpLys: 1.896 ± 0.65
3.793TrpLeu: 3.793 ± 1.311
1.264TrpMet: 1.264 ± 1.199
0.632TrpAsn: 0.632 ± 0.599
2.528TrpPro: 2.528 ± 1.629
0.632TrpGln: 0.632 ± 1.049
1.896TrpArg: 1.896 ± 0.65
0.0TrpSer: 0.0 ± 0.0
3.161TrpThr: 3.161 ± 0.998
1.264TrpVal: 1.264 ± 0.744
0.632TrpTrp: 0.632 ± 0.599
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.896TyrAla: 1.896 ± 1.102
1.264TyrCys: 1.264 ± 0.735
0.0TyrAsp: 0.0 ± 0.0
0.632TyrGlu: 0.632 ± 0.884
2.528TyrPhe: 2.528 ± 1.469
1.264TyrGly: 1.264 ± 0.506
1.896TyrHis: 1.896 ± 0.65
0.0TyrIle: 0.0 ± 0.0
0.632TyrLys: 0.632 ± 0.884
4.425TyrLeu: 4.425 ± 1.308
0.632TyrMet: 0.632 ± 0.367
0.0TyrAsn: 0.0 ± 0.0
1.896TyrPro: 1.896 ± 1.102
0.632TyrGln: 0.632 ± 0.599
2.528TyrArg: 2.528 ± 0.954
1.896TyrSer: 1.896 ± 1.102
1.896TyrThr: 1.896 ± 0.65
1.264TyrVal: 1.264 ± 0.744
0.632TyrTrp: 0.632 ± 0.367
0.632TyrTyr: 0.632 ± 0.367
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski