Amino acid dipepetide frequency for Armadillidium vulgare iridescent virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.87AlaAla: 2.87 ± 0.554
0.624AlaCys: 0.624 ± 0.102
2.168AlaAsp: 2.168 ± 0.192
2.215AlaGlu: 2.215 ± 0.251
2.293AlaPhe: 2.293 ± 0.211
3.525AlaGly: 3.525 ± 0.607
0.593AlaHis: 0.593 ± 0.098
3.697AlaIle: 3.697 ± 0.288
2.886AlaLys: 2.886 ± 0.193
4.133AlaLeu: 4.133 ± 0.258
0.936AlaMet: 0.936 ± 0.107
3.166AlaAsn: 3.166 ± 0.554
2.433AlaPro: 2.433 ± 0.412
1.653AlaGln: 1.653 ± 0.203
1.575AlaArg: 1.575 ± 0.146
3.353AlaSer: 3.353 ± 0.471
3.026AlaThr: 3.026 ± 0.711
3.275AlaVal: 3.275 ± 0.341
0.421AlaTrp: 0.421 ± 0.08
1.7AlaTyr: 1.7 ± 0.187
0.0AlaXaa: 0.0 ± 0.0
Cys
0.359CysAla: 0.359 ± 0.073
0.437CysCys: 0.437 ± 0.085
1.17CysAsp: 1.17 ± 0.132
1.076CysGlu: 1.076 ± 0.116
0.967CysPhe: 0.967 ± 0.138
1.123CysGly: 1.123 ± 0.133
0.374CysHis: 0.374 ± 0.082
1.295CysIle: 1.295 ± 0.151
1.622CysLys: 1.622 ± 0.189
1.841CysLeu: 1.841 ± 0.181
0.328CysMet: 0.328 ± 0.073
0.936CysAsn: 0.936 ± 0.158
0.749CysPro: 0.749 ± 0.123
0.655CysGln: 0.655 ± 0.1
0.686CysArg: 0.686 ± 0.122
1.17CysSer: 1.17 ± 0.146
0.702CysThr: 0.702 ± 0.117
1.17CysVal: 1.17 ± 0.155
0.125CysTrp: 0.125 ± 0.045
0.515CysTyr: 0.515 ± 0.078
0.0CysXaa: 0.0 ± 0.0
Asp
3.057AspAla: 3.057 ± 0.339
1.154AspCys: 1.154 ± 0.137
3.478AspAsp: 3.478 ± 0.253
4.071AspGlu: 4.071 ± 0.342
2.995AspPhe: 2.995 ± 0.219
2.714AspGly: 2.714 ± 0.255
0.795AspHis: 0.795 ± 0.132
4.336AspIle: 4.336 ± 0.302
4.523AspLys: 4.523 ± 0.269
5.49AspLeu: 5.49 ± 0.279
1.123AspMet: 1.123 ± 0.135
2.636AspAsn: 2.636 ± 0.192
2.308AspPro: 2.308 ± 0.182
1.591AspGln: 1.591 ± 0.15
2.168AspArg: 2.168 ± 0.194
3.338AspSer: 3.338 ± 0.296
2.979AspThr: 2.979 ± 0.227
3.291AspVal: 3.291 ± 0.245
0.562AspTrp: 0.562 ± 0.105
2.152AspTyr: 2.152 ± 0.171
0.0AspXaa: 0.0 ± 0.0
Glu
2.87GluAla: 2.87 ± 0.248
1.061GluCys: 1.061 ± 0.133
4.804GluAsp: 4.804 ± 0.334
7.393GluGlu: 7.393 ± 0.603
2.839GluPhe: 2.839 ± 0.236
3.4GluGly: 3.4 ± 0.293
1.31GluHis: 1.31 ± 0.15
5.475GluIle: 5.475 ± 0.338
7.424GluLys: 7.424 ± 0.508
5.272GluLeu: 5.272 ± 0.368
1.825GluMet: 1.825 ± 0.253
4.757GluAsn: 4.757 ± 0.337
2.152GluPro: 2.152 ± 0.194
2.542GluGln: 2.542 ± 0.242
3.65GluArg: 3.65 ± 0.353
3.603GluSer: 3.603 ± 0.295
4.539GluThr: 4.539 ± 0.32
3.197GluVal: 3.197 ± 0.232
0.936GluTrp: 0.936 ± 0.123
2.449GluTyr: 2.449 ± 0.194
0.0GluXaa: 0.0 ± 0.0
Phe
1.95PheAla: 1.95 ± 0.185
0.889PheCys: 0.889 ± 0.123
3.119PheAsp: 3.119 ± 0.249
3.509PheGlu: 3.509 ± 0.318
2.34PhePhe: 2.34 ± 0.244
2.808PheGly: 2.808 ± 0.206
0.78PheHis: 0.78 ± 0.114
3.431PheIle: 3.431 ± 0.302
4.944PheLys: 4.944 ± 0.312
5.038PheLeu: 5.038 ± 0.37
1.341PheMet: 1.341 ± 0.134
3.01PheAsn: 3.01 ± 0.22
2.215PhePro: 2.215 ± 0.178
1.918PheGln: 1.918 ± 0.179
1.575PheArg: 1.575 ± 0.177
3.743PheSer: 3.743 ± 0.281
2.496PheThr: 2.496 ± 0.193
3.151PheVal: 3.151 ± 0.244
0.343PheTrp: 0.343 ± 0.075
1.451PheTyr: 1.451 ± 0.171
0.0PheXaa: 0.0 ± 0.0
Gly
2.605GlyAla: 2.605 ± 0.429
0.842GlyCys: 0.842 ± 0.125
3.338GlyAsp: 3.338 ± 0.31
3.291GlyGlu: 3.291 ± 0.243
2.433GlyPhe: 2.433 ± 0.195
4.18GlyGly: 4.18 ± 0.464
0.842GlyHis: 0.842 ± 0.148
3.338GlyIle: 3.338 ± 0.262
4.601GlyLys: 4.601 ± 0.326
4.367GlyLeu: 4.367 ± 0.361
0.967GlyMet: 0.967 ± 0.126
2.823GlyAsn: 2.823 ± 0.32
2.215GlyPro: 2.215 ± 0.286
1.763GlyGln: 1.763 ± 0.16
2.262GlyArg: 2.262 ± 0.195
4.554GlySer: 4.554 ± 0.545
4.913GlyThr: 4.913 ± 0.773
3.977GlyVal: 3.977 ± 0.31
0.546GlyTrp: 0.546 ± 0.107
1.965GlyTyr: 1.965 ± 0.224
0.0GlyXaa: 0.0 ± 0.0
His
0.452HisAla: 0.452 ± 0.108
0.452HisCys: 0.452 ± 0.085
0.764HisAsp: 0.764 ± 0.109
1.045HisGlu: 1.045 ± 0.141
1.014HisPhe: 1.014 ± 0.118
0.655HisGly: 0.655 ± 0.122
0.421HisHis: 0.421 ± 0.081
1.451HisIle: 1.451 ± 0.172
1.435HisLys: 1.435 ± 0.149
1.529HisLeu: 1.529 ± 0.164
0.374HisMet: 0.374 ± 0.074
1.061HisAsn: 1.061 ± 0.138
0.811HisPro: 0.811 ± 0.113
0.593HisGln: 0.593 ± 0.104
0.795HisArg: 0.795 ± 0.146
1.123HisSer: 1.123 ± 0.126
0.795HisThr: 0.795 ± 0.113
0.967HisVal: 0.967 ± 0.118
0.172HisTrp: 0.172 ± 0.053
0.889HisTyr: 0.889 ± 0.116
0.0HisXaa: 0.0 ± 0.0
Ile
3.65IleAla: 3.65 ± 0.289
1.341IleCys: 1.341 ± 0.179
4.383IleAsp: 4.383 ± 0.273
5.319IleGlu: 5.319 ± 0.403
3.79IlePhe: 3.79 ± 0.267
3.587IleGly: 3.587 ± 0.237
1.497IleHis: 1.497 ± 0.166
5.366IleIle: 5.366 ± 0.362
6.816IleLys: 6.816 ± 0.38
6.473IleLeu: 6.473 ± 0.327
1.747IleMet: 1.747 ± 0.178
4.367IleAsn: 4.367 ± 0.314
3.26IlePro: 3.26 ± 0.251
2.839IleGln: 2.839 ± 0.255
3.026IleArg: 3.026 ± 0.234
5.709IleSer: 5.709 ± 0.426
4.445IleThr: 4.445 ± 0.423
4.352IleVal: 4.352 ± 0.275
0.468IleTrp: 0.468 ± 0.081
2.714IleTyr: 2.714 ± 0.219
0.0IleXaa: 0.0 ± 0.0
Lys
3.385LysAla: 3.385 ± 0.199
1.56LysCys: 1.56 ± 0.173
5.085LysAsp: 5.085 ± 0.382
7.362LysGlu: 7.362 ± 0.485
3.962LysPhe: 3.962 ± 0.324
3.712LysGly: 3.712 ± 0.296
1.887LysHis: 1.887 ± 0.153
8.391LysIle: 8.391 ± 0.328
8.001LysLys: 8.001 ± 0.522
7.081LysLeu: 7.081 ± 0.415
2.152LysMet: 2.152 ± 0.177
5.911LysAsn: 5.911 ± 0.392
2.558LysPro: 2.558 ± 0.24
3.213LysGln: 3.213 ± 0.222
3.931LysArg: 3.931 ± 0.301
4.43LysSer: 4.43 ± 0.288
5.522LysThr: 5.522 ± 0.344
4.336LysVal: 4.336 ± 0.316
0.92LysTrp: 0.92 ± 0.114
3.088LysTyr: 3.088 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
4.258LeuAla: 4.258 ± 0.607
1.56LeuCys: 1.56 ± 0.174
4.243LeuAsp: 4.243 ± 0.293
6.629LeuGlu: 6.629 ± 0.388
4.367LeuPhe: 4.367 ± 0.35
4.882LeuGly: 4.882 ± 0.534
1.248LeuHis: 1.248 ± 0.154
6.411LeuIle: 6.411 ± 0.312
8.828LeuLys: 8.828 ± 0.494
7.799LeuLeu: 7.799 ± 0.367
1.638LeuMet: 1.638 ± 0.156
5.693LeuAsn: 5.693 ± 0.292
3.993LeuPro: 3.993 ± 0.285
3.478LeuGln: 3.478 ± 0.253
3.01LeuArg: 3.01 ± 0.269
7.284LeuSer: 7.284 ± 0.439
5.334LeuThr: 5.334 ± 0.315
4.414LeuVal: 4.414 ± 0.261
0.905LeuTrp: 0.905 ± 0.112
2.901LeuTyr: 2.901 ± 0.205
0.0LeuXaa: 0.0 ± 0.0
Met
1.326MetAla: 1.326 ± 0.183
0.452MetCys: 0.452 ± 0.083
1.529MetAsp: 1.529 ± 0.158
1.653MetGlu: 1.653 ± 0.199
0.951MetPhe: 0.951 ± 0.112
1.123MetGly: 1.123 ± 0.13
0.312MetHis: 0.312 ± 0.075
1.669MetIle: 1.669 ± 0.21
2.106MetLys: 2.106 ± 0.226
1.731MetLeu: 1.731 ± 0.186
0.484MetMet: 0.484 ± 0.085
1.653MetAsn: 1.653 ± 0.149
0.562MetPro: 0.562 ± 0.094
0.515MetGln: 0.515 ± 0.09
0.858MetArg: 0.858 ± 0.103
1.638MetSer: 1.638 ± 0.158
1.404MetThr: 1.404 ± 0.154
1.341MetVal: 1.341 ± 0.146
0.25MetTrp: 0.25 ± 0.063
0.795MetTyr: 0.795 ± 0.117
0.0MetXaa: 0.0 ± 0.0
Asn
3.073AsnAla: 3.073 ± 0.31
1.17AsnCys: 1.17 ± 0.15
3.291AsnAsp: 3.291 ± 0.243
4.149AsnGlu: 4.149 ± 0.289
3.104AsnPhe: 3.104 ± 0.208
4.133AsnGly: 4.133 ± 0.275
0.967AsnHis: 0.967 ± 0.151
4.929AsnIle: 4.929 ± 0.336
4.757AsnLys: 4.757 ± 0.241
5.537AsnLeu: 5.537 ± 0.379
1.185AsnMet: 1.185 ± 0.123
3.884AsnAsn: 3.884 ± 0.224
2.558AsnPro: 2.558 ± 0.24
2.23AsnGln: 2.23 ± 0.185
2.012AsnArg: 2.012 ± 0.2
3.619AsnSer: 3.619 ± 0.287
3.119AsnThr: 3.119 ± 0.217
3.915AsnVal: 3.915 ± 0.282
0.484AsnTrp: 0.484 ± 0.086
1.996AsnTyr: 1.996 ± 0.197
0.0AsnXaa: 0.0 ± 0.0
Pro
2.074ProAla: 2.074 ± 0.355
0.437ProCys: 0.437 ± 0.087
2.028ProAsp: 2.028 ± 0.187
2.73ProGlu: 2.73 ± 0.273
2.542ProPhe: 2.542 ± 0.207
2.121ProGly: 2.121 ± 0.37
0.686ProHis: 0.686 ± 0.105
3.135ProIle: 3.135 ± 0.225
2.667ProLys: 2.667 ± 0.247
3.743ProLeu: 3.743 ± 0.233
0.78ProMet: 0.78 ± 0.144
2.527ProAsn: 2.527 ± 0.254
2.106ProPro: 2.106 ± 0.294
1.404ProGln: 1.404 ± 0.123
1.996ProArg: 1.996 ± 0.291
3.821ProSer: 3.821 ± 0.346
2.792ProThr: 2.792 ± 0.444
3.01ProVal: 3.01 ± 0.297
0.343ProTrp: 0.343 ± 0.075
1.295ProTyr: 1.295 ± 0.143
0.0ProXaa: 0.0 ± 0.0
Gln
1.482GlnAla: 1.482 ± 0.174
0.655GlnCys: 0.655 ± 0.115
1.685GlnAsp: 1.685 ± 0.166
2.371GlnGlu: 2.371 ± 0.21
1.685GlnPhe: 1.685 ± 0.173
1.326GlnGly: 1.326 ± 0.145
0.655GlnHis: 0.655 ± 0.107
2.948GlnIle: 2.948 ± 0.228
3.104GlnLys: 3.104 ± 0.235
3.743GlnLeu: 3.743 ± 0.336
0.92GlnMet: 0.92 ± 0.106
2.496GlnAsn: 2.496 ± 0.185
1.326GlnPro: 1.326 ± 0.149
1.638GlnGln: 1.638 ± 0.188
1.887GlnArg: 1.887 ± 0.208
1.965GlnSer: 1.965 ± 0.192
1.981GlnThr: 1.981 ± 0.177
1.747GlnVal: 1.747 ± 0.17
0.39GlnTrp: 0.39 ± 0.097
1.404GlnTyr: 1.404 ± 0.157
0.0GlnXaa: 0.0 ± 0.0
Arg
1.996ArgAla: 1.996 ± 0.188
0.764ArgCys: 0.764 ± 0.145
2.137ArgAsp: 2.137 ± 0.195
3.431ArgGlu: 3.431 ± 0.328
2.371ArgPhe: 2.371 ± 0.224
1.794ArgGly: 1.794 ± 0.202
0.858ArgHis: 0.858 ± 0.117
2.496ArgIle: 2.496 ± 0.207
3.884ArgLys: 3.884 ± 0.333
3.073ArgLeu: 3.073 ± 0.237
0.764ArgMet: 0.764 ± 0.093
2.355ArgAsn: 2.355 ± 0.205
1.466ArgPro: 1.466 ± 0.187
1.809ArgGln: 1.809 ± 0.199
2.776ArgArg: 2.776 ± 0.45
3.119ArgSer: 3.119 ± 0.345
2.23ArgThr: 2.23 ± 0.211
1.716ArgVal: 1.716 ± 0.196
0.312ArgTrp: 0.312 ± 0.06
1.419ArgTyr: 1.419 ± 0.153
0.0ArgXaa: 0.0 ± 0.0
Ser
3.931SerAla: 3.931 ± 0.905
1.061SerCys: 1.061 ± 0.132
3.307SerAsp: 3.307 ± 0.268
4.32SerGlu: 4.32 ± 0.318
3.868SerPhe: 3.868 ± 0.256
5.007SerGly: 5.007 ± 0.614
1.014SerHis: 1.014 ± 0.118
4.757SerIle: 4.757 ± 0.346
5.428SerLys: 5.428 ± 0.349
7.487SerLeu: 7.487 ± 0.395
1.794SerMet: 1.794 ± 0.18
3.681SerAsn: 3.681 ± 0.25
3.541SerPro: 3.541 ± 0.415
2.527SerGln: 2.527 ± 0.212
2.246SerArg: 2.246 ± 0.192
7.206SerSer: 7.206 ± 0.496
4.149SerThr: 4.149 ± 0.439
4.258SerVal: 4.258 ± 0.33
0.577SerTrp: 0.577 ± 0.106
2.355SerTyr: 2.355 ± 0.205
0.0SerXaa: 0.0 ± 0.0
Thr
2.636ThrAla: 2.636 ± 0.417
0.951ThrCys: 0.951 ± 0.14
2.667ThrAsp: 2.667 ± 0.2
4.211ThrGlu: 4.211 ± 0.324
2.932ThrPhe: 2.932 ± 0.237
3.993ThrGly: 3.993 ± 0.55
0.905ThrHis: 0.905 ± 0.114
4.788ThrIle: 4.788 ± 0.313
4.944ThrLys: 4.944 ± 0.336
5.724ThrLeu: 5.724 ± 0.406
1.373ThrMet: 1.373 ± 0.176
3.369ThrAsn: 3.369 ± 0.268
3.385ThrPro: 3.385 ± 0.323
1.794ThrGln: 1.794 ± 0.163
2.184ThrArg: 2.184 ± 0.209
4.851ThrSer: 4.851 ± 0.702
4.57ThrThr: 4.57 ± 0.507
3.509ThrVal: 3.509 ± 0.354
0.562ThrTrp: 0.562 ± 0.106
1.825ThrTyr: 1.825 ± 0.184
0.0ThrXaa: 0.0 ± 0.0
Val
2.73ValAla: 2.73 ± 0.274
1.076ValCys: 1.076 ± 0.139
3.275ValAsp: 3.275 ± 0.239
3.821ValGlu: 3.821 ± 0.26
2.901ValPhe: 2.901 ± 0.23
3.057ValGly: 3.057 ± 0.249
0.92ValHis: 0.92 ± 0.133
3.977ValIle: 3.977 ± 0.274
4.508ValLys: 4.508 ± 0.3
4.82ValLeu: 4.82 ± 0.302
1.607ValMet: 1.607 ± 0.18
3.057ValAsn: 3.057 ± 0.272
3.229ValPro: 3.229 ± 0.393
1.918ValGln: 1.918 ± 0.165
2.09ValArg: 2.09 ± 0.205
4.788ValSer: 4.788 ± 0.251
3.509ValThr: 3.509 ± 0.376
3.868ValVal: 3.868 ± 0.29
0.437ValTrp: 0.437 ± 0.078
2.371ValTyr: 2.371 ± 0.199
0.0ValXaa: 0.0 ± 0.0
Trp
0.53TrpAla: 0.53 ± 0.107
0.172TrpCys: 0.172 ± 0.062
0.452TrpAsp: 0.452 ± 0.076
0.577TrpGlu: 0.577 ± 0.085
0.593TrpPhe: 0.593 ± 0.109
0.359TrpGly: 0.359 ± 0.077
0.156TrpHis: 0.156 ± 0.044
0.499TrpIle: 0.499 ± 0.088
0.858TrpLys: 0.858 ± 0.127
0.717TrpLeu: 0.717 ± 0.101
0.25TrpMet: 0.25 ± 0.061
0.686TrpAsn: 0.686 ± 0.103
0.187TrpPro: 0.187 ± 0.057
0.203TrpGln: 0.203 ± 0.05
0.499TrpArg: 0.499 ± 0.09
0.827TrpSer: 0.827 ± 0.123
0.577TrpThr: 0.577 ± 0.11
0.452TrpVal: 0.452 ± 0.09
0.125TrpTrp: 0.125 ± 0.043
0.406TrpTyr: 0.406 ± 0.077
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.31TyrAla: 1.31 ± 0.141
0.639TyrCys: 0.639 ± 0.104
1.841TyrAsp: 1.841 ± 0.215
2.324TyrGlu: 2.324 ± 0.228
2.106TyrPhe: 2.106 ± 0.197
2.324TyrGly: 2.324 ± 0.225
0.577TyrHis: 0.577 ± 0.101
2.761TyrIle: 2.761 ± 0.214
3.151TyrLys: 3.151 ± 0.238
3.275TyrLeu: 3.275 ± 0.238
0.749TyrMet: 0.749 ± 0.095
2.059TyrAsn: 2.059 ± 0.163
1.185TyrPro: 1.185 ± 0.147
1.123TyrGln: 1.123 ± 0.132
1.544TyrArg: 1.544 ± 0.155
2.371TyrSer: 2.371 ± 0.184
2.09TyrThr: 2.09 ± 0.176
2.012TyrVal: 2.012 ± 0.238
0.25TyrTrp: 0.25 ± 0.061
1.373TyrTyr: 1.373 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 203 proteins (64114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski