Amino acid dipepetide frequency for Halomonas sp. BC04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.818AlaAla: 11.818 ± 0.115	1.288AlaCys: 1.288 ± 0.029	5.595AlaAsp: 5.595 ± 0.06	7.417AlaGlu: 7.417 ± 0.087	4.06AlaPhe: 4.06 ± 0.052	8.963AlaGly: 8.963 ± 0.094	2.288AlaHis: 2.288 ± 0.037	5.551AlaIle: 5.551 ± 0.064	2.506AlaLys: 2.506 ± 0.042	13.105AlaLeu: 13.105 ± 0.114	3.598AlaMet: 3.598 ± 0.05	2.52AlaAsn: 2.52 ± 0.04	4.512AlaPro: 4.512 ± 0.065	3.646AlaGln: 3.646 ± 0.051	8.017AlaArg: 8.017 ± 0.076	6.354AlaSer: 6.354 ± 0.078	5.305AlaThr: 5.305 ± 0.054	7.33AlaVal: 7.33 ± 0.075	2.007AlaTrp: 2.007 ± 0.045	2.286AlaTyr: 2.286 ± 0.04	0.003AlaXaa: 0.003 ± 0.001
Cys	0.934CysAla: 0.934 ± 0.025	0.188CysCys: 0.188 ± 0.011	0.564CysAsp: 0.564 ± 0.019	0.547CysGlu: 0.547 ± 0.018	0.35CysPhe: 0.35 ± 0.014	0.902CysGly: 0.902 ± 0.027	0.386CysHis: 0.386 ± 0.015	0.37CysIle: 0.37 ± 0.017	0.217CysLys: 0.217 ± 0.012	1.083CysLeu: 1.083 ± 0.027	0.273CysMet: 0.273 ± 0.013	0.214CysAsn: 0.214 ± 0.011	0.571CysPro: 0.571 ± 0.021	0.375CysGln: 0.375 ± 0.016	0.909CysArg: 0.909 ± 0.026	0.628CysSer: 0.628 ± 0.02	0.405CysThr: 0.405 ± 0.016	0.657CysVal: 0.657 ± 0.02	0.214CysTrp: 0.214 ± 0.014	0.242CysTyr: 0.242 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.14AspAla: 6.14 ± 0.071	0.461AspCys: 0.461 ± 0.017	3.674AspAsp: 3.674 ± 0.058	4.277AspGlu: 4.277 ± 0.057	2.104AspPhe: 2.104 ± 0.031	4.603AspGly: 4.603 ± 0.068	1.439AspHis: 1.439 ± 0.034	2.912AspIle: 2.912 ± 0.042	1.434AspLys: 1.434 ± 0.036	5.536AspLeu: 5.536 ± 0.067	1.382AspMet: 1.382 ± 0.032	1.457AspAsn: 1.457 ± 0.031	3.152AspPro: 3.152 ± 0.043	1.937AspGln: 1.937 ± 0.038	3.845AspArg: 3.845 ± 0.049	2.736AspSer: 2.736 ± 0.047	2.892AspThr: 2.892 ± 0.042	3.746AspVal: 3.746 ± 0.049	0.951AspTrp: 0.951 ± 0.025	1.66AspTyr: 1.66 ± 0.034	0.001AspXaa: 0.001 ± 0.001
Glu	8.239GluAla: 8.239 ± 0.1	0.486GluCys: 0.486 ± 0.017	2.973GluAsp: 2.973 ± 0.044	4.511GluGlu: 4.511 ± 0.068	1.748GluPhe: 1.748 ± 0.031	4.991GluGly: 4.991 ± 0.065	1.764GluHis: 1.764 ± 0.031	3.112GluIle: 3.112 ± 0.049	1.817GluLys: 1.817 ± 0.041	7.376GluLeu: 7.376 ± 0.067	1.567GluMet: 1.567 ± 0.03	1.535GluAsn: 1.535 ± 0.034	2.994GluPro: 2.994 ± 0.051	3.244GluGln: 3.244 ± 0.053	6.205GluArg: 6.205 ± 0.078	3.395GluSer: 3.395 ± 0.047	3.246GluThr: 3.246 ± 0.053	4.744GluVal: 4.744 ± 0.055	0.974GluTrp: 0.974 ± 0.026	1.291GluTyr: 1.291 ± 0.028	0.003GluXaa: 0.003 ± 0.001
Phe	3.502PheAla: 3.502 ± 0.045	0.398PheCys: 0.398 ± 0.016	2.454PheAsp: 2.454 ± 0.042	2.197PheGlu: 2.197 ± 0.039	1.357PhePhe: 1.357 ± 0.035	3.143PheGly: 3.143 ± 0.045	0.909PheHis: 0.909 ± 0.024	1.749PheIle: 1.749 ± 0.039	0.963PheLys: 0.963 ± 0.026	3.325PheLeu: 3.325 ± 0.054	0.9PheMet: 0.9 ± 0.029	1.018PheAsn: 1.018 ± 0.021	1.534PhePro: 1.534 ± 0.03	1.197PheGln: 1.197 ± 0.026	2.105PheArg: 2.105 ± 0.041	2.301PheSer: 2.301 ± 0.042	2.001PheThr: 2.001 ± 0.037	2.414PheVal: 2.414 ± 0.04	0.522PheTrp: 0.522 ± 0.019	0.954PheTyr: 0.954 ± 0.025	0.001PheXaa: 0.001 ± 0.001
Gly	7.081GlyAla: 7.081 ± 0.085	0.986GlyCys: 0.986 ± 0.025	4.558GlyAsp: 4.558 ± 0.063	5.957GlyGlu: 5.957 ± 0.072	3.222GlyPhe: 3.222 ± 0.044	6.449GlyGly: 6.449 ± 0.096	2.264GlyHis: 2.264 ± 0.035	4.595GlyIle: 4.595 ± 0.061	2.601GlyLys: 2.601 ± 0.047	9.235GlyLeu: 9.235 ± 0.091	2.516GlyMet: 2.516 ± 0.047	2.215GlyAsn: 2.215 ± 0.04	2.838GlyPro: 2.838 ± 0.048	3.133GlyGln: 3.133 ± 0.049	5.83GlyArg: 5.83 ± 0.07	4.68GlySer: 4.68 ± 0.06	3.71GlyThr: 3.71 ± 0.056	6.027GlyVal: 6.027 ± 0.072	1.414GlyTrp: 1.414 ± 0.031	2.4GlyTyr: 2.4 ± 0.044	0.003GlyXaa: 0.003 ± 0.001
His	2.476HisAla: 2.476 ± 0.041	0.352HisCys: 0.352 ± 0.018	1.654HisAsp: 1.654 ± 0.036	1.497HisGlu: 1.497 ± 0.032	1.102HisPhe: 1.102 ± 0.026	2.377HisGly: 2.377 ± 0.053	0.887HisHis: 0.887 ± 0.027	0.972HisIle: 0.972 ± 0.024	0.537HisLys: 0.537 ± 0.019	2.68HisLeu: 2.68 ± 0.044	0.508HisMet: 0.508 ± 0.019	0.571HisAsn: 0.571 ± 0.019	1.551HisPro: 1.551 ± 0.038	0.99HisGln: 0.99 ± 0.025	2.028HisArg: 2.028 ± 0.042	1.205HisSer: 1.205 ± 0.03	1.003HisThr: 1.003 ± 0.024	1.523HisVal: 1.523 ± 0.031	0.463HisTrp: 0.463 ± 0.018	0.827HisTyr: 0.827 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.569IleAla: 5.569 ± 0.07	0.482IleCys: 0.482 ± 0.02	3.468IleAsp: 3.468 ± 0.047	3.597IleGlu: 3.597 ± 0.052	1.571IlePhe: 1.571 ± 0.035	4.49IleGly: 4.49 ± 0.062	1.118IleHis: 1.118 ± 0.027	2.144IleIle: 2.144 ± 0.041	1.305IleLys: 1.305 ± 0.032	4.328IleLeu: 4.328 ± 0.068	1.016IleMet: 1.016 ± 0.028	1.515IleAsn: 1.515 ± 0.034	2.308IlePro: 2.308 ± 0.037	1.509IleGln: 1.509 ± 0.033	3.145IleArg: 3.145 ± 0.044	2.825IleSer: 2.825 ± 0.044	2.664IleThr: 2.664 ± 0.042	3.357IleVal: 3.357 ± 0.048	0.551IleTrp: 0.551 ± 0.018	1.081IleTyr: 1.081 ± 0.024	0.001IleXaa: 0.001 ± 0.001
Lys	3.018LysAla: 3.018 ± 0.05	0.169LysCys: 0.169 ± 0.011	1.179LysAsp: 1.179 ± 0.033	1.507LysGlu: 1.507 ± 0.041	0.578LysPhe: 0.578 ± 0.021	2.082LysGly: 2.082 ± 0.041	0.613LysHis: 0.613 ± 0.019	1.099LysIle: 1.099 ± 0.03	0.839LysLys: 0.839 ± 0.03	2.759LysLeu: 2.759 ± 0.049	0.586LysMet: 0.586 ± 0.02	0.633LysAsn: 0.633 ± 0.022	1.505LysPro: 1.505 ± 0.03	1.171LysGln: 1.171 ± 0.03	2.303LysArg: 2.303 ± 0.039	1.391LysSer: 1.391 ± 0.03	1.303LysThr: 1.303 ± 0.031	1.984LysVal: 1.984 ± 0.038	0.31LysTrp: 0.31 ± 0.014	0.483LysTyr: 0.483 ± 0.017	0.001LysXaa: 0.001 ± 0.001
Leu	14.606LeuAla: 14.606 ± 0.114	1.07LeuCys: 1.07 ± 0.027	7.029LeuAsp: 7.029 ± 0.076	7.531LeuGlu: 7.531 ± 0.078	3.927LeuPhe: 3.927 ± 0.061	9.22LeuGly: 9.22 ± 0.1	2.483LeuHis: 2.483 ± 0.044	5.368LeuIle: 5.368 ± 0.065	3.22LeuLys: 3.22 ± 0.051	12.692LeuLeu: 12.692 ± 0.149	2.994LeuMet: 2.994 ± 0.046	2.757LeuAsn: 2.757 ± 0.038	6.225LeuPro: 6.225 ± 0.066	3.513LeuGln: 3.513 ± 0.051	7.118LeuArg: 7.118 ± 0.083	6.737LeuSer: 6.737 ± 0.074	5.812LeuThr: 5.812 ± 0.06	8.255LeuVal: 8.255 ± 0.076	1.48LeuTrp: 1.48 ± 0.036	2.473LeuTyr: 2.473 ± 0.04	0.002LeuXaa: 0.002 ± 0.001
Met	3.409MetAla: 3.409 ± 0.046	0.174MetCys: 0.174 ± 0.01	1.147MetAsp: 1.147 ± 0.029	1.41MetGlu: 1.41 ± 0.029	0.71MetPhe: 0.71 ± 0.021	2.058MetGly: 2.058 ± 0.039	0.563MetHis: 0.563 ± 0.018	1.367MetIle: 1.367 ± 0.029	0.787MetLys: 0.787 ± 0.021	3.069MetLeu: 3.069 ± 0.055	0.701MetMet: 0.701 ± 0.024	0.786MetAsn: 0.786 ± 0.022	1.585MetPro: 1.585 ± 0.032	1.028MetGln: 1.028 ± 0.029	1.744MetArg: 1.744 ± 0.033	1.769MetSer: 1.769 ± 0.032	1.82MetThr: 1.82 ± 0.034	1.924MetVal: 1.924 ± 0.041	0.219MetTrp: 0.219 ± 0.01	0.382MetTyr: 0.382 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.719AsnAla: 2.719 ± 0.038	0.221AsnCys: 0.221 ± 0.011	1.43AsnAsp: 1.43 ± 0.031	1.431AsnGlu: 1.431 ± 0.032	0.814AsnPhe: 0.814 ± 0.023	2.054AsnGly: 2.054 ± 0.042	0.64AsnHis: 0.64 ± 0.02	1.29AsnIle: 1.29 ± 0.032	0.591AsnLys: 0.591 ± 0.022	2.733AsnLeu: 2.733 ± 0.042	0.571AsnMet: 0.571 ± 0.019	0.7AsnAsn: 0.7 ± 0.019	1.642AsnPro: 1.642 ± 0.032	0.915AsnGln: 0.915 ± 0.022	1.983AsnArg: 1.983 ± 0.036	1.103AsnSer: 1.103 ± 0.031	1.277AsnThr: 1.277 ± 0.029	1.713AsnVal: 1.713 ± 0.03	0.377AsnTrp: 0.377 ± 0.017	0.661AsnTyr: 0.661 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.155ProAla: 5.155 ± 0.057	0.464ProCys: 0.464 ± 0.018	3.335ProAsp: 3.335 ± 0.049	3.934ProGlu: 3.934 ± 0.052	1.751ProPhe: 1.751 ± 0.034	4.552ProGly: 4.552 ± 0.055	1.142ProHis: 1.142 ± 0.026	2.135ProIle: 2.135 ± 0.037	1.124ProLys: 1.124 ± 0.028	5.623ProLeu: 5.623 ± 0.07	1.4ProMet: 1.4 ± 0.03	1.143ProAsn: 1.143 ± 0.03	2.571ProPro: 2.571 ± 0.055	1.707ProGln: 1.707 ± 0.035	3.251ProArg: 3.251 ± 0.054	2.909ProSer: 2.909 ± 0.045	2.391ProThr: 2.391 ± 0.039	3.773ProVal: 3.773 ± 0.046	0.975ProTrp: 0.975 ± 0.025	1.054ProTyr: 1.054 ± 0.028	0.003ProXaa: 0.003 ± 0.001
Gln	5.05GlnAla: 5.05 ± 0.06	0.312GlnCys: 0.312 ± 0.014	1.707GlnAsp: 1.707 ± 0.035	2.212GlnGlu: 2.212 ± 0.041	1.015GlnPhe: 1.015 ± 0.026	3.206GlnGly: 3.206 ± 0.046	0.999GlnHis: 0.999 ± 0.03	1.422GlnIle: 1.422 ± 0.033	0.872GlnLys: 0.872 ± 0.029	4.185GlnLeu: 4.185 ± 0.055	0.846GlnMet: 0.846 ± 0.025	0.711GlnAsn: 0.711 ± 0.023	1.907GlnPro: 1.907 ± 0.038	2.094GlnGln: 2.094 ± 0.041	3.546GlnArg: 3.546 ± 0.057	1.778GlnSer: 1.778 ± 0.031	1.566GlnThr: 1.566 ± 0.032	2.993GlnVal: 2.993 ± 0.048	0.56GlnTrp: 0.56 ± 0.02	0.734GlnTyr: 0.734 ± 0.023	0.003GlnXaa: 0.003 ± 0.001
Arg	6.409ArgAla: 6.409 ± 0.066	0.787ArgCys: 0.787 ± 0.026	4.184ArgAsp: 4.184 ± 0.06	5.405ArgGlu: 5.405 ± 0.069	2.969ArgPhe: 2.969 ± 0.043	4.789ArgGly: 4.789 ± 0.063	2.548ArgHis: 2.548 ± 0.041	3.666ArgIle: 3.666 ± 0.051	1.828ArgLys: 1.828 ± 0.039	10.088ArgLeu: 10.088 ± 0.102	2.075ArgMet: 2.075 ± 0.038	1.759ArgAsn: 1.759 ± 0.034	3.442ArgPro: 3.442 ± 0.056	3.516ArgGln: 3.516 ± 0.055	6.146ArgArg: 6.146 ± 0.086	3.682ArgSer: 3.682 ± 0.054	2.971ArgThr: 2.971 ± 0.045	4.907ArgVal: 4.907 ± 0.063	1.259ArgTrp: 1.259 ± 0.035	2.258ArgTyr: 2.258 ± 0.037	0.003ArgXaa: 0.003 ± 0.001
Ser	5.428SerAla: 5.428 ± 0.073	0.549SerCys: 0.549 ± 0.017	2.975SerAsp: 2.975 ± 0.052	3.155SerGlu: 3.155 ± 0.043	1.937SerPhe: 1.937 ± 0.036	5.125SerGly: 5.125 ± 0.068	1.346SerHis: 1.346 ± 0.026	2.603SerIle: 2.603 ± 0.042	1.236SerLys: 1.236 ± 0.033	6.877SerLeu: 6.877 ± 0.067	1.562SerMet: 1.562 ± 0.035	1.301SerAsn: 1.301 ± 0.033	3.282SerPro: 3.282 ± 0.056	2.08SerGln: 2.08 ± 0.035	4.755SerArg: 4.755 ± 0.069	3.291SerSer: 3.291 ± 0.052	2.685SerThr: 2.685 ± 0.039	3.67SerVal: 3.67 ± 0.048	0.866SerTrp: 0.866 ± 0.027	1.159SerTyr: 1.159 ± 0.029	0.001SerXaa: 0.001 ± 0.001
Thr	5.137ThrAla: 5.137 ± 0.059	0.51ThrCys: 0.51 ± 0.02	2.445ThrAsp: 2.445 ± 0.044	2.63ThrGlu: 2.63 ± 0.046	1.779ThrPhe: 1.779 ± 0.036	4.363ThrGly: 4.363 ± 0.053	1.154ThrHis: 1.154 ± 0.025	2.201ThrIle: 2.201 ± 0.043	0.867ThrLys: 0.867 ± 0.028	6.872ThrLeu: 6.872 ± 0.073	1.156ThrMet: 1.156 ± 0.027	1.129ThrAsn: 1.129 ± 0.025	3.22ThrPro: 3.22 ± 0.044	1.627ThrGln: 1.627 ± 0.034	3.68ThrArg: 3.68 ± 0.053	2.727ThrSer: 2.727 ± 0.043	2.603ThrThr: 2.603 ± 0.04	3.494ThrVal: 3.494 ± 0.053	0.728ThrTrp: 0.728 ± 0.025	1.068ThrTyr: 1.068 ± 0.029	0.001ThrXaa: 0.001 ± 0.001
Val	7.924ValAla: 7.924 ± 0.082	0.669ValCys: 0.669 ± 0.019	4.105ValAsp: 4.105 ± 0.05	4.94ValGlu: 4.94 ± 0.06	2.499ValPhe: 2.499 ± 0.046	5.4ValGly: 5.4 ± 0.064	1.489ValHis: 1.489 ± 0.034	3.896ValIle: 3.896 ± 0.059	1.864ValLys: 1.864 ± 0.039	7.656ValLeu: 7.656 ± 0.079	2.128ValMet: 2.128 ± 0.042	1.954ValAsn: 1.954 ± 0.039	3.414ValPro: 3.414 ± 0.047	2.078ValGln: 2.078 ± 0.037	4.43ValArg: 4.43 ± 0.055	4.295ValSer: 4.295 ± 0.06	3.994ValThr: 3.994 ± 0.049	5.706ValVal: 5.706 ± 0.07	0.857ValTrp: 0.857 ± 0.026	1.435ValTyr: 1.435 ± 0.029	0.001ValXaa: 0.001 ± 0.001
Trp	1.291TrpAla: 1.291 ± 0.03	0.192TrpCys: 0.192 ± 0.012	0.602TrpAsp: 0.602 ± 0.02	0.797TrpGlu: 0.797 ± 0.023	0.524TrpPhe: 0.524 ± 0.018	0.933TrpGly: 0.933 ± 0.029	0.501TrpHis: 0.501 ± 0.017	0.716TrpIle: 0.716 ± 0.021	0.42TrpLys: 0.42 ± 0.016	2.397TrpLeu: 2.397 ± 0.054	0.427TrpMet: 0.427 ± 0.017	0.378TrpAsn: 0.378 ± 0.014	0.874TrpPro: 0.874 ± 0.028	0.974TrpGln: 0.974 ± 0.024	1.298TrpArg: 1.298 ± 0.031	0.828TrpSer: 0.828 ± 0.026	0.608TrpThr: 0.608 ± 0.022	1.005TrpVal: 1.005 ± 0.027	0.345TrpTrp: 0.345 ± 0.016	0.363TrpTyr: 0.363 ± 0.016	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.261TyrAla: 2.261 ± 0.037	0.27TyrCys: 0.27 ± 0.014	1.257TyrAsp: 1.257 ± 0.03	1.26TyrGlu: 1.26 ± 0.029	0.927TyrPhe: 0.927 ± 0.023	2.005TyrGly: 2.005 ± 0.036	0.666TyrHis: 0.666 ± 0.021	0.876TyrIle: 0.876 ± 0.025	0.487TyrLys: 0.487 ± 0.019	2.889TyrLeu: 2.889 ± 0.033	0.447TyrMet: 0.447 ± 0.017	0.566TyrAsn: 0.566 ± 0.02	1.264TyrPro: 1.264 ± 0.029	0.982TyrGln: 0.982 ± 0.028	2.353TyrArg: 2.353 ± 0.041	1.248TyrSer: 1.248 ± 0.026	1.134TyrThr: 1.134 ± 0.03	1.511TyrVal: 1.511 ± 0.034	0.406TyrTrp: 0.406 ± 0.016	0.686TyrTyr: 0.686 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.006XaaGly: 0.006 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.004XaaLeu: 0.004 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 6235 proteins (1595998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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