Amino acid dipepetide frequency for Pseudidiomarina taiwanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.692AlaAla: 11.692 ± 0.204
0.901AlaCys: 0.901 ± 0.037
5.987AlaAsp: 5.987 ± 0.093
8.182AlaGlu: 8.182 ± 0.135
3.366AlaPhe: 3.366 ± 0.069
7.373AlaGly: 7.373 ± 0.124
2.008AlaHis: 2.008 ± 0.059
5.982AlaIle: 5.982 ± 0.098
4.346AlaLys: 4.346 ± 0.089
11.287AlaLeu: 11.287 ± 0.157
2.684AlaMet: 2.684 ± 0.07
3.409AlaAsn: 3.409 ± 0.081
3.691AlaPro: 3.691 ± 0.081
5.763AlaGln: 5.763 ± 0.114
5.208AlaArg: 5.208 ± 0.089
5.307AlaSer: 5.307 ± 0.091
5.254AlaThr: 5.254 ± 0.099
7.276AlaVal: 7.276 ± 0.116
1.218AlaTrp: 1.218 ± 0.048
2.646AlaTyr: 2.646 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.839CysAla: 0.839 ± 0.033
0.117CysCys: 0.117 ± 0.014
0.493CysAsp: 0.493 ± 0.027
0.511CysGlu: 0.511 ± 0.027
0.347CysPhe: 0.347 ± 0.025
0.773CysGly: 0.773 ± 0.037
0.28CysHis: 0.28 ± 0.021
0.419CysIle: 0.419 ± 0.028
0.274CysLys: 0.274 ± 0.02
0.805CysLeu: 0.805 ± 0.039
0.151CysMet: 0.151 ± 0.013
0.264CysAsn: 0.264 ± 0.022
0.45CysPro: 0.45 ± 0.027
0.47CysGln: 0.47 ± 0.028
0.482CysArg: 0.482 ± 0.027
0.584CysSer: 0.584 ± 0.03
0.403CysThr: 0.403 ± 0.022
0.542CysVal: 0.542 ± 0.026
0.117CysTrp: 0.117 ± 0.012
0.264CysTyr: 0.264 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.228AspAla: 5.228 ± 0.09
0.505AspCys: 0.505 ± 0.028
3.096AspAsp: 3.096 ± 0.078
3.727AspGlu: 3.727 ± 0.073
2.517AspPhe: 2.517 ± 0.052
3.836AspGly: 3.836 ± 0.082
1.182AspHis: 1.182 ± 0.042
3.444AspIle: 3.444 ± 0.076
2.202AspLys: 2.202 ± 0.057
5.324AspLeu: 5.324 ± 0.099
1.357AspMet: 1.357 ± 0.041
1.846AspAsn: 1.846 ± 0.054
2.413AspPro: 2.413 ± 0.062
2.29AspGln: 2.29 ± 0.055
2.62AspArg: 2.62 ± 0.059
2.924AspSer: 2.924 ± 0.064
2.42AspThr: 2.42 ± 0.061
3.785AspVal: 3.785 ± 0.087
0.981AspTrp: 0.981 ± 0.041
2.23AspTyr: 2.23 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
6.002GluAla: 6.002 ± 0.1
0.409GluCys: 0.409 ± 0.027
2.524GluAsp: 2.524 ± 0.07
3.062GluGlu: 3.062 ± 0.091
2.488GluPhe: 2.488 ± 0.062
3.346GluGly: 3.346 ± 0.086
1.867GluHis: 1.867 ± 0.061
3.554GluIle: 3.554 ± 0.069
2.415GluLys: 2.415 ± 0.069
8.017GluLeu: 8.017 ± 0.14
1.527GluMet: 1.527 ± 0.047
2.053GluAsn: 2.053 ± 0.055
2.631GluPro: 2.631 ± 0.065
5.658GluGln: 5.658 ± 0.096
4.746GluArg: 4.746 ± 0.083
3.012GluSer: 3.012 ± 0.072
3.063GluThr: 3.063 ± 0.07
4.74GluVal: 4.74 ± 0.096
0.744GluTrp: 0.744 ± 0.034
1.68GluTyr: 1.68 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
4.386PheAla: 4.386 ± 0.083
0.392PheCys: 0.392 ± 0.025
2.397PheAsp: 2.397 ± 0.062
2.445PheGlu: 2.445 ± 0.064
1.457PhePhe: 1.457 ± 0.055
3.172PheGly: 3.172 ± 0.075
0.75PheHis: 0.75 ± 0.032
2.539PheIle: 2.539 ± 0.072
1.527PheLys: 1.527 ± 0.053
3.109PheLeu: 3.109 ± 0.072
0.928PheMet: 0.928 ± 0.037
1.65PheAsn: 1.65 ± 0.045
1.4PhePro: 1.4 ± 0.05
1.255PheGln: 1.255 ± 0.044
1.77PheArg: 1.77 ± 0.047
2.792PheSer: 2.792 ± 0.067
2.248PheThr: 2.248 ± 0.057
2.684PheVal: 2.684 ± 0.066
0.556PheTrp: 0.556 ± 0.029
1.312PheTyr: 1.312 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
6.283GlyAla: 6.283 ± 0.103
0.776GlyCys: 0.776 ± 0.03
3.734GlyAsp: 3.734 ± 0.079
4.435GlyGlu: 4.435 ± 0.085
3.186GlyPhe: 3.186 ± 0.068
5.047GlyGly: 5.047 ± 0.104
1.641GlyHis: 1.641 ± 0.05
4.241GlyIle: 4.241 ± 0.086
3.261GlyLys: 3.261 ± 0.082
7.519GlyLeu: 7.519 ± 0.131
2.019GlyMet: 2.019 ± 0.06
2.114GlyAsn: 2.114 ± 0.063
2.002GlyPro: 2.002 ± 0.059
3.375GlyGln: 3.375 ± 0.07
3.876GlyArg: 3.876 ± 0.085
3.936GlySer: 3.936 ± 0.085
3.377GlyThr: 3.377 ± 0.074
5.39GlyVal: 5.39 ± 0.102
1.032GlyTrp: 1.032 ± 0.041
2.533GlyTyr: 2.533 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
2.071HisAla: 2.071 ± 0.062
0.312HisCys: 0.312 ± 0.024
1.262HisAsp: 1.262 ± 0.049
1.283HisGlu: 1.283 ± 0.045
0.965HisPhe: 0.965 ± 0.042
1.795HisGly: 1.795 ± 0.058
0.655HisHis: 0.655 ± 0.034
1.322HisIle: 1.322 ± 0.045
0.877HisLys: 0.877 ± 0.036
2.251HisLeu: 2.251 ± 0.068
0.447HisMet: 0.447 ± 0.027
0.759HisAsn: 0.759 ± 0.033
1.357HisPro: 1.357 ± 0.049
1.294HisGln: 1.294 ± 0.052
1.243HisArg: 1.243 ± 0.05
1.231HisSer: 1.231 ± 0.041
0.984HisThr: 0.984 ± 0.045
1.3HisVal: 1.3 ± 0.04
0.379HisTrp: 0.379 ± 0.025
0.943HisTyr: 0.943 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.658IleAla: 6.658 ± 0.1
0.567IleCys: 0.567 ± 0.028
3.848IleAsp: 3.848 ± 0.087
4.339IleGlu: 4.339 ± 0.09
1.905IlePhe: 1.905 ± 0.059
4.513IleGly: 4.513 ± 0.091
1.171IleHis: 1.171 ± 0.044
3.131IleIle: 3.131 ± 0.074
2.295IleLys: 2.295 ± 0.059
4.948IleLeu: 4.948 ± 0.097
1.154IleMet: 1.154 ± 0.04
2.106IleAsn: 2.106 ± 0.062
2.538IlePro: 2.538 ± 0.061
2.104IleGln: 2.104 ± 0.055
2.997IleArg: 2.997 ± 0.066
3.29IleSer: 3.29 ± 0.073
2.936IleThr: 2.936 ± 0.072
3.923IleVal: 3.923 ± 0.092
0.672IleTrp: 0.672 ± 0.034
1.555IleTyr: 1.555 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
4.131LysAla: 4.131 ± 0.088
0.215LysCys: 0.215 ± 0.022
1.839LysAsp: 1.839 ± 0.053
1.978LysGlu: 1.978 ± 0.06
1.363LysPhe: 1.363 ± 0.046
2.416LysGly: 2.416 ± 0.066
0.93LysHis: 0.93 ± 0.038
2.049LysIle: 2.049 ± 0.063
1.696LysLys: 1.696 ± 0.063
4.314LysLeu: 4.314 ± 0.092
0.969LysMet: 0.969 ± 0.041
1.234LysAsn: 1.234 ± 0.045
2.097LysPro: 2.097 ± 0.063
2.464LysGln: 2.464 ± 0.064
2.746LysArg: 2.746 ± 0.057
1.986LysSer: 1.986 ± 0.057
2.053LysThr: 2.053 ± 0.057
3.098LysVal: 3.098 ± 0.069
0.439LysTrp: 0.439 ± 0.026
1.024LysTyr: 1.024 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
12.476LeuAla: 12.476 ± 0.15
0.854LeuCys: 0.854 ± 0.039
5.733LeuAsp: 5.733 ± 0.107
6.859LeuGlu: 6.859 ± 0.111
3.877LeuPhe: 3.877 ± 0.084
7.354LeuGly: 7.354 ± 0.117
2.246LeuHis: 2.246 ± 0.068
5.759LeuIle: 5.759 ± 0.111
4.263LeuLys: 4.263 ± 0.084
11.508LeuLeu: 11.508 ± 0.212
2.319LeuMet: 2.319 ± 0.064
3.996LeuAsn: 3.996 ± 0.093
5.065LeuPro: 5.065 ± 0.097
5.592LeuGln: 5.592 ± 0.118
6.128LeuArg: 6.128 ± 0.116
6.723LeuSer: 6.723 ± 0.131
6.238LeuThr: 6.238 ± 0.1
7.421LeuVal: 7.421 ± 0.111
1.347LeuTrp: 1.347 ± 0.049
2.609LeuTyr: 2.609 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.587MetAla: 2.587 ± 0.076
0.136MetCys: 0.136 ± 0.015
1.012MetAsp: 1.012 ± 0.044
1.073MetGlu: 1.073 ± 0.042
0.763MetPhe: 0.763 ± 0.034
1.583MetGly: 1.583 ± 0.053
0.432MetHis: 0.432 ± 0.027
1.221MetIle: 1.221 ± 0.039
1.05MetLys: 1.05 ± 0.043
2.779MetLeu: 2.779 ± 0.07
0.618MetMet: 0.618 ± 0.037
0.852MetAsn: 0.852 ± 0.032
1.205MetPro: 1.205 ± 0.045
1.286MetGln: 1.286 ± 0.049
1.42MetArg: 1.42 ± 0.043
1.661MetSer: 1.661 ± 0.053
1.476MetThr: 1.476 ± 0.043
1.781MetVal: 1.781 ± 0.051
0.226MetTrp: 0.226 ± 0.017
0.492MetTyr: 0.492 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.1AsnAla: 3.1 ± 0.07
0.34AsnCys: 0.34 ± 0.021
1.867AsnAsp: 1.867 ± 0.051
1.937AsnGlu: 1.937 ± 0.056
1.4AsnPhe: 1.4 ± 0.049
2.627AsnGly: 2.627 ± 0.072
0.734AsnHis: 0.734 ± 0.035
1.868AsnIle: 1.868 ± 0.058
1.333AsnLys: 1.333 ± 0.044
3.363AsnLeu: 3.363 ± 0.074
0.816AsnMet: 0.816 ± 0.033
1.173AsnAsn: 1.173 ± 0.042
2.008AsnPro: 2.008 ± 0.053
1.798AsnGln: 1.798 ± 0.057
1.876AsnArg: 1.876 ± 0.053
1.858AsnSer: 1.858 ± 0.052
1.754AsnThr: 1.754 ± 0.054
2.128AsnVal: 2.128 ± 0.067
0.575AsnTrp: 0.575 ± 0.03
1.133AsnTyr: 1.133 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.135ProAla: 4.135 ± 0.088
0.288ProCys: 0.288 ± 0.022
2.457ProAsp: 2.457 ± 0.058
3.617ProGlu: 3.617 ± 0.088
1.693ProPhe: 1.693 ± 0.053
2.787ProGly: 2.787 ± 0.069
0.975ProHis: 0.975 ± 0.037
2.324ProIle: 2.324 ± 0.056
1.7ProLys: 1.7 ± 0.065
4.838ProLeu: 4.838 ± 0.101
1.01ProMet: 1.01 ± 0.038
1.669ProAsn: 1.669 ± 0.048
1.369ProPro: 1.369 ± 0.045
2.34ProGln: 2.34 ± 0.066
1.933ProArg: 1.933 ± 0.053
2.434ProSer: 2.434 ± 0.063
2.306ProThr: 2.306 ± 0.057
3.21ProVal: 3.21 ± 0.075
0.573ProTrp: 0.573 ± 0.034
1.264ProTyr: 1.264 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
6.115GlnAla: 6.115 ± 0.121
0.321GlnCys: 0.321 ± 0.02
1.994GlnAsp: 1.994 ± 0.049
2.508GlnGlu: 2.508 ± 0.064
2.041GlnPhe: 2.041 ± 0.06
3.299GlnGly: 3.299 ± 0.072
1.608GlnHis: 1.608 ± 0.054
2.627GlnIle: 2.627 ± 0.06
1.687GlnLys: 1.687 ± 0.049
7.386GlnLeu: 7.386 ± 0.158
1.111GlnMet: 1.111 ± 0.038
1.458GlnAsn: 1.458 ± 0.048
2.466GlnPro: 2.466 ± 0.067
5.664GlnGln: 5.664 ± 0.159
4.052GlnArg: 4.052 ± 0.098
2.577GlnSer: 2.577 ± 0.06
2.627GlnThr: 2.627 ± 0.062
4.122GlnVal: 4.122 ± 0.078
0.804GlnTrp: 0.804 ± 0.04
1.313GlnTyr: 1.313 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
5.367ArgAla: 5.367 ± 0.094
0.441ArgCys: 0.441 ± 0.028
3.223ArgAsp: 3.223 ± 0.063
3.867ArgGlu: 3.867 ± 0.09
2.516ArgPhe: 2.516 ± 0.062
3.542ArgGly: 3.542 ± 0.071
1.302ArgHis: 1.302 ± 0.048
3.318ArgIle: 3.318 ± 0.064
2.185ArgLys: 2.185 ± 0.064
6.34ArgLeu: 6.34 ± 0.113
1.428ArgMet: 1.428 ± 0.046
1.923ArgAsn: 1.923 ± 0.048
2.167ArgPro: 2.167 ± 0.055
3.153ArgGln: 3.153 ± 0.079
3.383ArgArg: 3.383 ± 0.084
3.139ArgSer: 3.139 ± 0.068
2.445ArgThr: 2.445 ± 0.054
3.968ArgVal: 3.968 ± 0.079
0.855ArgTrp: 0.855 ± 0.033
2.126ArgTyr: 2.126 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
5.911SerAla: 5.911 ± 0.084
0.536SerCys: 0.536 ± 0.024
3.18SerAsp: 3.18 ± 0.062
3.428SerGlu: 3.428 ± 0.075
2.428SerPhe: 2.428 ± 0.062
4.488SerGly: 4.488 ± 0.088
1.299SerHis: 1.299 ± 0.049
3.216SerIle: 3.216 ± 0.082
2.185SerLys: 2.185 ± 0.059
6.064SerLeu: 6.064 ± 0.103
1.412SerMet: 1.412 ± 0.044
1.814SerAsn: 1.814 ± 0.057
2.302SerPro: 2.302 ± 0.058
2.688SerGln: 2.688 ± 0.079
2.924SerArg: 2.924 ± 0.062
3.361SerSer: 3.361 ± 0.083
2.63SerThr: 2.63 ± 0.067
3.787SerVal: 3.787 ± 0.076
0.918SerTrp: 0.918 ± 0.034
1.8SerTyr: 1.8 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
5.305ThrAla: 5.305 ± 0.096
0.403ThrCys: 0.403 ± 0.025
3.012ThrAsp: 3.012 ± 0.069
3.566ThrGlu: 3.566 ± 0.075
1.851ThrPhe: 1.851 ± 0.051
4.112ThrGly: 4.112 ± 0.086
1.066ThrHis: 1.066 ± 0.039
2.977ThrIle: 2.977 ± 0.063
1.529ThrLys: 1.529 ± 0.046
5.821ThrLeu: 5.821 ± 0.105
0.985ThrMet: 0.985 ± 0.037
1.482ThrAsn: 1.482 ± 0.048
2.754ThrPro: 2.754 ± 0.068
2.333ThrGln: 2.333 ± 0.057
2.522ThrArg: 2.522 ± 0.06
2.729ThrSer: 2.729 ± 0.064
2.724ThrThr: 2.724 ± 0.073
4.006ThrVal: 4.006 ± 0.087
0.643ThrTrp: 0.643 ± 0.032
1.391ThrTyr: 1.391 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
7.702ValAla: 7.702 ± 0.127
0.606ValCys: 0.606 ± 0.031
4.049ValAsp: 4.049 ± 0.077
4.632ValGlu: 4.632 ± 0.093
2.615ValPhe: 2.615 ± 0.071
4.772ValGly: 4.772 ± 0.095
1.419ValHis: 1.419 ± 0.044
4.636ValIle: 4.636 ± 0.082
2.952ValLys: 2.952 ± 0.07
7.152ValLeu: 7.152 ± 0.103
1.868ValMet: 1.868 ± 0.056
2.605ValAsn: 2.605 ± 0.063
2.94ValPro: 2.94 ± 0.067
2.75ValGln: 2.75 ± 0.067
3.725ValArg: 3.725 ± 0.08
4.331ValSer: 4.331 ± 0.102
4.374ValThr: 4.374 ± 0.087
5.51ValVal: 5.51 ± 0.092
0.851ValTrp: 0.851 ± 0.04
1.95ValTyr: 1.95 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.886TrpAla: 0.886 ± 0.04
0.149TrpCys: 0.149 ± 0.016
0.571TrpAsp: 0.571 ± 0.029
0.533TrpGlu: 0.533 ± 0.033
0.679TrpPhe: 0.679 ± 0.036
0.776TrpGly: 0.776 ± 0.035
0.404TrpHis: 0.404 ± 0.027
0.619TrpIle: 0.619 ± 0.034
0.272TrpLys: 0.272 ± 0.019
2.158TrpLeu: 2.158 ± 0.072
0.31TrpMet: 0.31 ± 0.021
0.359TrpAsn: 0.359 ± 0.022
0.596TrpPro: 0.596 ± 0.031
1.432TrpGln: 1.432 ± 0.058
1.038TrpArg: 1.038 ± 0.045
0.715TrpSer: 0.715 ± 0.03
0.505TrpThr: 0.505 ± 0.031
0.958TrpVal: 0.958 ± 0.036
0.274TrpTrp: 0.274 ± 0.021
0.432TrpTyr: 0.432 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.707TyrAla: 2.707 ± 0.067
0.316TyrCys: 0.316 ± 0.023
1.649TyrAsp: 1.649 ± 0.06
1.555TyrGlu: 1.555 ± 0.055
1.312TyrPhe: 1.312 ± 0.044
2.169TyrGly: 2.169 ± 0.065
0.763TyrHis: 0.763 ± 0.034
1.404TyrIle: 1.404 ± 0.047
0.994TyrLys: 0.994 ± 0.04
3.384TyrLeu: 3.384 ± 0.074
0.536TyrMet: 0.536 ± 0.03
0.921TyrAsn: 0.921 ± 0.045
1.47TyrPro: 1.47 ± 0.053
2.072TyrGln: 2.072 ± 0.067
1.999TyrArg: 1.999 ± 0.063
1.779TyrSer: 1.779 ± 0.057
1.393TyrThr: 1.393 ± 0.052
1.811TyrVal: 1.811 ± 0.043
0.463TyrTrp: 0.463 ± 0.028
0.921TyrTyr: 0.921 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2021 proteins (682925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski