Amino acid dipepetide frequency for Acinetobacter phage fLi-Aba02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.228AlaAla: 7.228 ± 1.032
1.372AlaCys: 1.372 ± 0.403
3.019AlaAsp: 3.019 ± 0.483
6.222AlaGlu: 6.222 ± 0.899
2.745AlaPhe: 2.745 ± 0.407
5.215AlaGly: 5.215 ± 0.866
1.189AlaHis: 1.189 ± 0.321
5.124AlaIle: 5.124 ± 0.905
6.496AlaLys: 6.496 ± 0.795
7.228AlaLeu: 7.228 ± 0.862
2.653AlaMet: 2.653 ± 0.613
3.477AlaAsn: 3.477 ± 0.927
2.379AlaPro: 2.379 ± 0.447
4.209AlaGln: 4.209 ± 0.689
3.019AlaArg: 3.019 ± 0.607
5.49AlaSer: 5.49 ± 1.418
7.411AlaThr: 7.411 ± 1.175
4.483AlaVal: 4.483 ± 0.653
1.098AlaTrp: 1.098 ± 0.301
2.653AlaTyr: 2.653 ± 0.539
0.0AlaXaa: 0.0 ± 0.0
Cys
0.732CysAla: 0.732 ± 0.26
0.366CysCys: 0.366 ± 0.19
0.549CysAsp: 0.549 ± 0.246
0.823CysGlu: 0.823 ± 0.327
0.549CysPhe: 0.549 ± 0.218
1.006CysGly: 1.006 ± 0.391
0.274CysHis: 0.274 ± 0.193
0.732CysIle: 0.732 ± 0.264
0.64CysLys: 0.64 ± 0.254
0.732CysLeu: 0.732 ± 0.26
0.183CysMet: 0.183 ± 0.154
0.64CysAsn: 0.64 ± 0.278
0.457CysPro: 0.457 ± 0.182
0.274CysGln: 0.274 ± 0.173
0.549CysArg: 0.549 ± 0.228
0.732CysSer: 0.732 ± 0.341
0.091CysThr: 0.091 ± 0.096
0.915CysVal: 0.915 ± 0.308
0.0CysTrp: 0.0 ± 0.0
0.457CysTyr: 0.457 ± 0.222
0.0CysXaa: 0.0 ± 0.0
Asp
4.392AspAla: 4.392 ± 0.746
0.64AspCys: 0.64 ± 0.248
4.666AspAsp: 4.666 ± 0.709
4.3AspGlu: 4.3 ± 0.704
2.379AspPhe: 2.379 ± 0.39
5.581AspGly: 5.581 ± 0.718
1.372AspHis: 1.372 ± 0.327
3.294AspIle: 3.294 ± 0.53
4.209AspLys: 4.209 ± 0.56
5.032AspLeu: 5.032 ± 0.66
1.372AspMet: 1.372 ± 0.325
3.294AspAsn: 3.294 ± 0.805
2.379AspPro: 2.379 ± 0.49
1.83AspGln: 1.83 ± 0.318
1.83AspArg: 1.83 ± 0.397
4.3AspSer: 4.3 ± 0.707
2.836AspThr: 2.836 ± 0.535
4.117AspVal: 4.117 ± 0.608
0.915AspTrp: 0.915 ± 0.257
1.83AspTyr: 1.83 ± 0.422
0.0AspXaa: 0.0 ± 0.0
Glu
4.758GluAla: 4.758 ± 0.561
0.64GluCys: 0.64 ± 0.245
3.019GluAsp: 3.019 ± 0.61
3.751GluGlu: 3.751 ± 0.698
3.111GluPhe: 3.111 ± 0.484
4.209GluGly: 4.209 ± 0.551
0.915GluHis: 0.915 ± 0.283
4.392GluIle: 4.392 ± 0.803
5.215GluLys: 5.215 ± 0.712
6.588GluLeu: 6.588 ± 0.887
1.738GluMet: 1.738 ± 0.407
3.568GluAsn: 3.568 ± 0.479
1.83GluPro: 1.83 ± 0.435
4.392GluGln: 4.392 ± 0.638
3.111GluArg: 3.111 ± 0.522
4.3GluSer: 4.3 ± 0.748
3.934GluThr: 3.934 ± 0.548
3.843GluVal: 3.843 ± 0.596
1.006GluTrp: 1.006 ± 0.239
3.111GluTyr: 3.111 ± 0.491
0.0GluXaa: 0.0 ± 0.0
Phe
2.47PheAla: 2.47 ± 0.42
0.183PheCys: 0.183 ± 0.099
2.379PheAsp: 2.379 ± 0.419
2.836PheGlu: 2.836 ± 0.448
2.104PhePhe: 2.104 ± 0.411
2.47PheGly: 2.47 ± 0.342
0.64PheHis: 0.64 ± 0.207
2.196PheIle: 2.196 ± 0.595
2.836PheLys: 2.836 ± 0.506
3.568PheLeu: 3.568 ± 0.652
1.098PheMet: 1.098 ± 0.315
2.196PheAsn: 2.196 ± 0.495
1.189PhePro: 1.189 ± 0.297
1.189PheGln: 1.189 ± 0.247
1.098PheArg: 1.098 ± 0.218
1.555PheSer: 1.555 ± 0.456
2.653PheThr: 2.653 ± 0.442
1.372PheVal: 1.372 ± 0.309
0.549PheTrp: 0.549 ± 0.285
1.83PheTyr: 1.83 ± 0.46
0.0PheXaa: 0.0 ± 0.0
Gly
5.673GlyAla: 5.673 ± 0.908
0.549GlyCys: 0.549 ± 0.231
4.026GlyAsp: 4.026 ± 0.945
3.751GlyGlu: 3.751 ± 0.597
2.47GlyPhe: 2.47 ± 0.468
4.3GlyGly: 4.3 ± 0.573
0.915GlyHis: 0.915 ± 0.36
4.117GlyIle: 4.117 ± 0.5
5.307GlyLys: 5.307 ± 0.643
5.124GlyLeu: 5.124 ± 0.755
2.287GlyMet: 2.287 ± 0.423
3.477GlyAsn: 3.477 ± 0.59
1.647GlyPro: 1.647 ± 0.5
2.196GlyGln: 2.196 ± 0.518
3.751GlyArg: 3.751 ± 0.529
3.751GlySer: 3.751 ± 0.47
2.836GlyThr: 2.836 ± 0.466
4.117GlyVal: 4.117 ± 0.564
0.549GlyTrp: 0.549 ± 0.344
3.568GlyTyr: 3.568 ± 0.7
0.0GlyXaa: 0.0 ± 0.0
His
0.732HisAla: 0.732 ± 0.277
0.183HisCys: 0.183 ± 0.13
0.915HisAsp: 0.915 ± 0.271
0.823HisGlu: 0.823 ± 0.272
0.732HisPhe: 0.732 ± 0.24
1.83HisGly: 1.83 ± 0.44
0.366HisHis: 0.366 ± 0.182
1.098HisIle: 1.098 ± 0.366
0.549HisLys: 0.549 ± 0.213
2.47HisLeu: 2.47 ± 0.554
0.183HisMet: 0.183 ± 0.132
0.549HisAsn: 0.549 ± 0.177
0.549HisPro: 0.549 ± 0.239
0.457HisGln: 0.457 ± 0.229
0.732HisArg: 0.732 ± 0.23
0.823HisSer: 0.823 ± 0.307
0.64HisThr: 0.64 ± 0.227
1.281HisVal: 1.281 ± 0.408
0.274HisTrp: 0.274 ± 0.141
1.006HisTyr: 1.006 ± 0.34
0.0HisXaa: 0.0 ± 0.0
Ile
5.215IleAla: 5.215 ± 0.667
0.823IleCys: 0.823 ± 0.298
5.124IleAsp: 5.124 ± 0.842
4.758IleGlu: 4.758 ± 0.786
1.647IlePhe: 1.647 ± 0.433
4.026IleGly: 4.026 ± 0.498
0.823IleHis: 0.823 ± 0.349
2.928IleIle: 2.928 ± 0.488
4.575IleLys: 4.575 ± 0.491
4.209IleLeu: 4.209 ± 0.514
1.098IleMet: 1.098 ± 0.267
3.294IleAsn: 3.294 ± 0.749
2.47IlePro: 2.47 ± 0.407
2.836IleGln: 2.836 ± 0.752
2.562IleArg: 2.562 ± 0.459
4.483IleSer: 4.483 ± 0.54
3.843IleThr: 3.843 ± 0.554
3.934IleVal: 3.934 ± 0.719
0.366IleTrp: 0.366 ± 0.166
2.47IleTyr: 2.47 ± 0.611
0.0IleXaa: 0.0 ± 0.0
Lys
7.137LysAla: 7.137 ± 1.047
0.549LysCys: 0.549 ± 0.323
5.124LysAsp: 5.124 ± 0.649
5.032LysGlu: 5.032 ± 0.774
2.47LysPhe: 2.47 ± 0.468
3.477LysGly: 3.477 ± 0.511
1.281LysHis: 1.281 ± 0.328
4.117LysIle: 4.117 ± 0.654
4.392LysLys: 4.392 ± 0.698
7.503LysLeu: 7.503 ± 0.614
1.738LysMet: 1.738 ± 0.351
4.666LysAsn: 4.666 ± 0.835
2.836LysPro: 2.836 ± 0.495
2.745LysGln: 2.745 ± 0.508
3.751LysArg: 3.751 ± 0.607
4.575LysSer: 4.575 ± 0.532
4.026LysThr: 4.026 ± 0.426
6.13LysVal: 6.13 ± 0.697
1.006LysTrp: 1.006 ± 0.308
2.104LysTyr: 2.104 ± 0.497
0.0LysXaa: 0.0 ± 0.0
Leu
7.686LeuAla: 7.686 ± 1.092
0.64LeuCys: 0.64 ± 0.238
6.679LeuAsp: 6.679 ± 0.561
7.594LeuGlu: 7.594 ± 0.868
3.111LeuPhe: 3.111 ± 0.62
4.3LeuGly: 4.3 ± 0.768
1.189LeuHis: 1.189 ± 0.374
6.679LeuIle: 6.679 ± 1.027
6.496LeuLys: 6.496 ± 0.732
6.588LeuLeu: 6.588 ± 0.727
2.196LeuMet: 2.196 ± 0.555
3.66LeuAsn: 3.66 ± 0.686
2.928LeuPro: 2.928 ± 0.534
4.483LeuGln: 4.483 ± 0.691
4.483LeuArg: 4.483 ± 0.631
6.862LeuSer: 6.862 ± 0.866
6.405LeuThr: 6.405 ± 0.622
4.483LeuVal: 4.483 ± 0.571
0.457LeuTrp: 0.457 ± 0.143
2.745LeuTyr: 2.745 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
1.921MetAla: 1.921 ± 0.423
0.457MetCys: 0.457 ± 0.175
1.464MetAsp: 1.464 ± 0.403
1.098MetGlu: 1.098 ± 0.297
0.915MetPhe: 0.915 ± 0.251
1.189MetGly: 1.189 ± 0.331
0.274MetHis: 0.274 ± 0.186
1.006MetIle: 1.006 ± 0.21
1.372MetLys: 1.372 ± 0.328
2.104MetLeu: 2.104 ± 0.542
0.366MetMet: 0.366 ± 0.172
1.555MetAsn: 1.555 ± 0.402
0.915MetPro: 0.915 ± 0.297
1.372MetGln: 1.372 ± 0.382
1.921MetArg: 1.921 ± 0.446
2.104MetSer: 2.104 ± 0.357
2.013MetThr: 2.013 ± 0.376
1.555MetVal: 1.555 ± 0.416
0.274MetTrp: 0.274 ± 0.135
0.366MetTyr: 0.366 ± 0.188
0.0MetXaa: 0.0 ± 0.0
Asn
4.941AsnAla: 4.941 ± 0.869
0.183AsnCys: 0.183 ± 0.117
3.111AsnAsp: 3.111 ± 0.66
2.928AsnGlu: 2.928 ± 0.546
0.915AsnPhe: 0.915 ± 0.293
4.483AsnGly: 4.483 ± 0.597
1.372AsnHis: 1.372 ± 0.349
2.653AsnIle: 2.653 ± 0.54
4.483AsnLys: 4.483 ± 0.528
4.483AsnLeu: 4.483 ± 0.47
1.006AsnMet: 1.006 ± 0.331
2.745AsnAsn: 2.745 ± 0.505
3.568AsnPro: 3.568 ± 0.557
2.379AsnGln: 2.379 ± 0.543
2.379AsnArg: 2.379 ± 0.505
3.294AsnSer: 3.294 ± 0.954
2.287AsnThr: 2.287 ± 0.482
2.013AsnVal: 2.013 ± 0.414
0.823AsnTrp: 0.823 ± 0.286
1.372AsnTyr: 1.372 ± 0.451
0.0AsnXaa: 0.0 ± 0.0
Pro
3.202ProAla: 3.202 ± 0.65
1.098ProCys: 1.098 ± 0.398
1.83ProAsp: 1.83 ± 0.453
2.562ProGlu: 2.562 ± 0.566
1.098ProPhe: 1.098 ± 0.291
0.915ProGly: 0.915 ± 0.322
0.915ProHis: 0.915 ± 0.32
2.287ProIle: 2.287 ± 0.448
3.568ProLys: 3.568 ± 0.644
3.202ProLeu: 3.202 ± 0.578
0.732ProMet: 0.732 ± 0.275
2.013ProAsn: 2.013 ± 0.409
1.006ProPro: 1.006 ± 0.303
1.647ProGln: 1.647 ± 0.291
0.823ProArg: 0.823 ± 0.199
2.928ProSer: 2.928 ± 0.495
1.83ProThr: 1.83 ± 0.409
2.104ProVal: 2.104 ± 0.477
0.091ProTrp: 0.091 ± 0.095
1.372ProTyr: 1.372 ± 0.454
0.0ProXaa: 0.0 ± 0.0
Gln
4.758GlnAla: 4.758 ± 1.046
0.64GlnCys: 0.64 ± 0.264
2.104GlnAsp: 2.104 ± 0.464
2.928GlnGlu: 2.928 ± 0.561
1.921GlnPhe: 1.921 ± 0.414
1.555GlnGly: 1.555 ± 0.621
0.549GlnHis: 0.549 ± 0.191
2.653GlnIle: 2.653 ± 0.569
3.477GlnLys: 3.477 ± 0.913
5.764GlnLeu: 5.764 ± 0.836
1.372GlnMet: 1.372 ± 0.404
2.836GlnAsn: 2.836 ± 0.579
1.738GlnPro: 1.738 ± 0.442
1.738GlnGln: 1.738 ± 0.589
1.738GlnArg: 1.738 ± 0.568
2.836GlnSer: 2.836 ± 0.432
3.111GlnThr: 3.111 ± 0.625
2.287GlnVal: 2.287 ± 0.389
0.457GlnTrp: 0.457 ± 0.183
1.372GlnTyr: 1.372 ± 0.337
0.0GlnXaa: 0.0 ± 0.0
Arg
3.019ArgAla: 3.019 ± 0.473
0.549ArgCys: 0.549 ± 0.25
3.751ArgAsp: 3.751 ± 0.539
3.385ArgGlu: 3.385 ± 0.761
2.196ArgPhe: 2.196 ± 0.522
2.745ArgGly: 2.745 ± 0.493
0.823ArgHis: 0.823 ± 0.314
2.745ArgIle: 2.745 ± 0.515
3.294ArgLys: 3.294 ± 0.585
4.666ArgLeu: 4.666 ± 0.7
1.098ArgMet: 1.098 ± 0.27
2.013ArgAsn: 2.013 ± 0.457
1.738ArgPro: 1.738 ± 0.405
1.464ArgGln: 1.464 ± 0.547
2.287ArgArg: 2.287 ± 0.422
2.745ArgSer: 2.745 ± 0.528
2.47ArgThr: 2.47 ± 0.524
2.379ArgVal: 2.379 ± 0.502
0.64ArgTrp: 0.64 ± 0.175
1.83ArgTyr: 1.83 ± 0.401
0.0ArgXaa: 0.0 ± 0.0
Ser
6.496SerAla: 6.496 ± 2.211
0.183SerCys: 0.183 ± 0.163
3.385SerAsp: 3.385 ± 0.507
4.758SerGlu: 4.758 ± 0.702
2.379SerPhe: 2.379 ± 0.44
5.673SerGly: 5.673 ± 0.738
0.915SerHis: 0.915 ± 0.293
3.934SerIle: 3.934 ± 0.594
4.666SerLys: 4.666 ± 0.757
5.764SerLeu: 5.764 ± 0.566
1.921SerMet: 1.921 ± 0.44
4.026SerAsn: 4.026 ± 0.68
1.83SerPro: 1.83 ± 0.457
2.836SerGln: 2.836 ± 0.533
3.111SerArg: 3.111 ± 0.552
5.947SerSer: 5.947 ± 1.074
2.836SerThr: 2.836 ± 0.483
2.745SerVal: 2.745 ± 0.533
0.549SerTrp: 0.549 ± 0.232
2.379SerTyr: 2.379 ± 0.372
0.0SerXaa: 0.0 ± 0.0
Thr
4.3ThrAla: 4.3 ± 0.65
0.732ThrCys: 0.732 ± 0.271
2.836ThrAsp: 2.836 ± 0.568
3.019ThrGlu: 3.019 ± 0.557
2.013ThrPhe: 2.013 ± 0.482
5.764ThrGly: 5.764 ± 1.286
0.732ThrHis: 0.732 ± 0.291
4.849ThrIle: 4.849 ± 0.61
3.934ThrLys: 3.934 ± 0.444
5.947ThrLeu: 5.947 ± 0.601
1.189ThrMet: 1.189 ± 0.25
2.836ThrAsn: 2.836 ± 0.441
2.287ThrPro: 2.287 ± 0.515
3.568ThrGln: 3.568 ± 0.54
2.379ThrArg: 2.379 ± 0.41
3.385ThrSer: 3.385 ± 0.546
3.477ThrThr: 3.477 ± 0.807
3.477ThrVal: 3.477 ± 0.588
0.915ThrTrp: 0.915 ± 0.204
1.83ThrTyr: 1.83 ± 0.42
0.0ThrXaa: 0.0 ± 0.0
Val
3.934ValAla: 3.934 ± 0.681
0.366ValCys: 0.366 ± 0.197
3.66ValAsp: 3.66 ± 0.658
3.843ValGlu: 3.843 ± 0.471
2.104ValPhe: 2.104 ± 0.339
3.568ValGly: 3.568 ± 0.493
0.457ValHis: 0.457 ± 0.199
4.209ValIle: 4.209 ± 0.757
4.849ValLys: 4.849 ± 0.649
4.117ValLeu: 4.117 ± 0.604
1.189ValMet: 1.189 ± 0.272
2.836ValAsn: 2.836 ± 0.657
2.47ValPro: 2.47 ± 0.519
3.568ValGln: 3.568 ± 0.596
3.111ValArg: 3.111 ± 0.556
2.928ValSer: 2.928 ± 0.57
3.477ValThr: 3.477 ± 0.584
4.209ValVal: 4.209 ± 0.522
1.189ValTrp: 1.189 ± 0.294
2.287ValTyr: 2.287 ± 0.375
0.0ValXaa: 0.0 ± 0.0
Trp
1.281TrpAla: 1.281 ± 0.399
0.274TrpCys: 0.274 ± 0.157
0.732TrpAsp: 0.732 ± 0.304
0.732TrpGlu: 0.732 ± 0.238
0.274TrpPhe: 0.274 ± 0.153
0.64TrpGly: 0.64 ± 0.249
0.274TrpHis: 0.274 ± 0.152
0.915TrpIle: 0.915 ± 0.291
0.915TrpLys: 0.915 ± 0.329
1.281TrpLeu: 1.281 ± 0.332
0.183TrpMet: 0.183 ± 0.106
0.549TrpAsn: 0.549 ± 0.24
0.183TrpPro: 0.183 ± 0.136
0.64TrpGln: 0.64 ± 0.247
0.915TrpArg: 0.915 ± 0.289
0.915TrpSer: 0.915 ± 0.337
0.457TrpThr: 0.457 ± 0.214
0.457TrpVal: 0.457 ± 0.203
0.183TrpTrp: 0.183 ± 0.12
0.457TrpTyr: 0.457 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.836TyrAla: 2.836 ± 0.656
0.274TyrCys: 0.274 ± 0.196
2.196TyrAsp: 2.196 ± 0.441
2.287TyrGlu: 2.287 ± 0.483
1.281TyrPhe: 1.281 ± 0.355
1.464TyrGly: 1.464 ± 0.456
0.915TyrHis: 0.915 ± 0.389
1.555TyrIle: 1.555 ± 0.343
3.385TyrLys: 3.385 ± 0.437
3.294TyrLeu: 3.294 ± 0.506
0.549TyrMet: 0.549 ± 0.197
1.189TyrAsn: 1.189 ± 0.239
0.915TyrPro: 0.915 ± 0.274
2.013TyrGln: 2.013 ± 0.461
2.287TyrArg: 2.287 ± 0.381
2.379TyrSer: 2.379 ± 0.487
2.836TyrThr: 2.836 ± 0.599
2.47TyrVal: 2.47 ± 0.453
0.915TyrTrp: 0.915 ± 0.29
1.647TyrTyr: 1.647 ± 0.517
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (10930 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski