Amino acid dipepetide frequency for Actinomyces sp. oral taxon 175 str. F0384

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.954AlaAla: 18.954 ± 0.236
1.148AlaCys: 1.148 ± 0.039
7.459AlaAsp: 7.459 ± 0.105
7.656AlaGlu: 7.656 ± 0.119
2.965AlaPhe: 2.965 ± 0.068
12.36AlaGly: 12.36 ± 0.152
2.6AlaHis: 2.6 ± 0.061
4.573AlaIle: 4.573 ± 0.082
2.716AlaLys: 2.716 ± 0.065
13.594AlaLeu: 13.594 ± 0.152
2.744AlaMet: 2.744 ± 0.06
1.958AlaAsn: 1.958 ± 0.048
7.289AlaPro: 7.289 ± 0.144
4.822AlaGln: 4.822 ± 0.083
9.128AlaArg: 9.128 ± 0.126
8.239AlaSer: 8.239 ± 0.137
7.421AlaThr: 7.421 ± 0.103
10.885AlaVal: 10.885 ± 0.124
1.984AlaTrp: 1.984 ± 0.05
2.207AlaTyr: 2.207 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.038
0.098CysCys: 0.098 ± 0.011
0.402CysAsp: 0.402 ± 0.021
0.403CysGlu: 0.403 ± 0.023
0.215CysPhe: 0.215 ± 0.016
0.807CysGly: 0.807 ± 0.031
0.19CysHis: 0.19 ± 0.016
0.242CysIle: 0.242 ± 0.016
0.117CysLys: 0.117 ± 0.011
0.889CysLeu: 0.889 ± 0.042
0.137CysMet: 0.137 ± 0.013
0.127CysAsn: 0.127 ± 0.011
0.474CysPro: 0.474 ± 0.026
0.265CysGln: 0.265 ± 0.017
0.496CysArg: 0.496 ± 0.025
0.534CysSer: 0.534 ± 0.025
0.507CysThr: 0.507 ± 0.026
0.595CysVal: 0.595 ± 0.029
0.106CysTrp: 0.106 ± 0.009
0.167CysTyr: 0.167 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.486AspAla: 7.486 ± 0.115
0.393AspCys: 0.393 ± 0.026
3.803AspAsp: 3.803 ± 0.083
3.787AspGlu: 3.787 ± 0.078
1.469AspPhe: 1.469 ± 0.046
5.545AspGly: 5.545 ± 0.072
1.228AspHis: 1.228 ± 0.038
2.114AspIle: 2.114 ± 0.055
1.384AspLys: 1.384 ± 0.049
6.24AspLeu: 6.24 ± 0.088
0.914AspMet: 0.914 ± 0.028
1.085AspAsn: 1.085 ± 0.039
3.906AspPro: 3.906 ± 0.072
1.569AspGln: 1.569 ± 0.05
3.56AspArg: 3.56 ± 0.077
3.378AspSer: 3.378 ± 0.071
2.92AspThr: 2.92 ± 0.061
4.961AspVal: 4.961 ± 0.076
0.805AspTrp: 0.805 ± 0.035
1.335AspTyr: 1.335 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
8.153GluAla: 8.153 ± 0.101
0.339GluCys: 0.339 ± 0.02
3.305GluAsp: 3.305 ± 0.076
3.705GluGlu: 3.705 ± 0.079
1.088GluPhe: 1.088 ± 0.035
4.398GluGly: 4.398 ± 0.073
1.52GluHis: 1.52 ± 0.049
2.478GluIle: 2.478 ± 0.053
1.36GluLys: 1.36 ± 0.038
5.842GluLeu: 5.842 ± 0.09
1.083GluMet: 1.083 ± 0.034
1.112GluAsn: 1.112 ± 0.045
3.302GluPro: 3.302 ± 0.087
2.394GluGln: 2.394 ± 0.061
4.983GluArg: 4.983 ± 0.076
2.832GluSer: 2.832 ± 0.061
2.922GluThr: 2.922 ± 0.062
4.945GluVal: 4.945 ± 0.074
0.557GluTrp: 0.557 ± 0.022
0.933GluTyr: 0.933 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
2.856PheAla: 2.856 ± 0.069
0.221PheCys: 0.221 ± 0.014
1.607PheAsp: 1.607 ± 0.04
1.228PheGlu: 1.228 ± 0.041
0.894PhePhe: 0.894 ± 0.032
2.31PheGly: 2.31 ± 0.063
0.543PheHis: 0.543 ± 0.028
1.158PheIle: 1.158 ± 0.043
0.557PheLys: 0.557 ± 0.022
2.539PheLeu: 2.539 ± 0.063
0.496PheMet: 0.496 ± 0.027
0.621PheAsn: 0.621 ± 0.029
1.236PhePro: 1.236 ± 0.039
0.667PheGln: 0.667 ± 0.024
1.35PheArg: 1.35 ± 0.037
1.714PheSer: 1.714 ± 0.047
1.884PheThr: 1.884 ± 0.042
1.986PheVal: 1.986 ± 0.055
0.374PheTrp: 0.374 ± 0.019
0.607PheTyr: 0.607 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
10.938GlyAla: 10.938 ± 0.137
0.765GlyCys: 0.765 ± 0.03
4.47GlyAsp: 4.47 ± 0.076
4.862GlyGlu: 4.862 ± 0.089
2.475GlyPhe: 2.475 ± 0.054
7.871GlyGly: 7.871 ± 0.131
1.94GlyHis: 1.94 ± 0.05
3.795GlyIle: 3.795 ± 0.073
2.435GlyLys: 2.435 ± 0.066
8.949GlyLeu: 8.949 ± 0.122
2.011GlyMet: 2.011 ± 0.052
1.716GlyAsn: 1.716 ± 0.051
4.181GlyPro: 4.181 ± 0.079
3.194GlyGln: 3.194 ± 0.068
6.824GlyArg: 6.824 ± 0.097
6.066GlySer: 6.066 ± 0.103
5.813GlyThr: 5.813 ± 0.089
7.251GlyVal: 7.251 ± 0.115
1.562GlyTrp: 1.562 ± 0.047
2.082GlyTyr: 2.082 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.355HisAla: 2.355 ± 0.055
0.161HisCys: 0.161 ± 0.014
1.33HisAsp: 1.33 ± 0.042
1.193HisGlu: 1.193 ± 0.033
0.429HisPhe: 0.429 ± 0.018
1.921HisGly: 1.921 ± 0.051
0.639HisHis: 0.639 ± 0.032
0.678HisIle: 0.678 ± 0.026
0.321HisLys: 0.321 ± 0.021
2.39HisLeu: 2.39 ± 0.048
0.409HisMet: 0.409 ± 0.022
0.438HisAsn: 0.438 ± 0.025
1.539HisPro: 1.539 ± 0.05
0.666HisGln: 0.666 ± 0.031
1.862HisArg: 1.862 ± 0.054
1.152HisSer: 1.152 ± 0.037
1.078HisThr: 1.078 ± 0.036
1.677HisVal: 1.677 ± 0.042
0.322HisTrp: 0.322 ± 0.02
0.507HisTyr: 0.507 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.089IleAla: 5.089 ± 0.101
0.326IleCys: 0.326 ± 0.017
2.781IleAsp: 2.781 ± 0.053
2.503IleGlu: 2.503 ± 0.052
0.948IlePhe: 0.948 ± 0.04
3.705IleGly: 3.705 ± 0.079
0.782IleHis: 0.782 ± 0.03
1.778IleIle: 1.778 ± 0.054
0.954IleLys: 0.954 ± 0.036
3.71IleLeu: 3.71 ± 0.069
0.708IleMet: 0.708 ± 0.031
0.997IleAsn: 0.997 ± 0.033
2.148IlePro: 2.148 ± 0.053
1.001IleGln: 1.001 ± 0.032
2.179IleArg: 2.179 ± 0.044
2.41IleSer: 2.41 ± 0.058
2.763IleThr: 2.763 ± 0.06
3.724IleVal: 3.724 ± 0.066
0.445IleTrp: 0.445 ± 0.022
0.683IleTyr: 0.683 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.965LysAla: 2.965 ± 0.07
0.088LysCys: 0.088 ± 0.01
1.549LysAsp: 1.549 ± 0.045
1.34LysGlu: 1.34 ± 0.042
0.383LysPhe: 0.383 ± 0.024
1.835LysGly: 1.835 ± 0.055
0.435LysHis: 0.435 ± 0.021
0.892LysIle: 0.892 ± 0.036
0.937LysLys: 0.937 ± 0.041
1.487LysLeu: 1.487 ± 0.047
0.411LysMet: 0.411 ± 0.022
0.651LysAsn: 0.651 ± 0.03
1.239LysPro: 1.239 ± 0.048
0.793LysGln: 0.793 ± 0.029
1.55LysArg: 1.55 ± 0.047
1.216LysSer: 1.216 ± 0.036
1.423LysThr: 1.423 ± 0.05
1.943LysVal: 1.943 ± 0.055
0.239LysTrp: 0.239 ± 0.014
0.426LysTyr: 0.426 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.97LeuAla: 13.97 ± 0.165
0.716LeuCys: 0.716 ± 0.028
6.054LeuAsp: 6.054 ± 0.092
5.288LeuGlu: 5.288 ± 0.088
2.253LeuPhe: 2.253 ± 0.056
8.984LeuGly: 8.984 ± 0.114
1.913LeuHis: 1.913 ± 0.051
4.017LeuIle: 4.017 ± 0.078
1.917LeuLys: 1.917 ± 0.046
10.273LeuLeu: 10.273 ± 0.127
1.962LeuMet: 1.962 ± 0.046
1.895LeuAsn: 1.895 ± 0.052
5.752LeuPro: 5.752 ± 0.083
2.223LeuGln: 2.223 ± 0.055
7.355LeuArg: 7.355 ± 0.108
6.841LeuSer: 6.841 ± 0.098
7.198LeuThr: 7.198 ± 0.093
8.81LeuVal: 8.81 ± 0.119
1.225LeuTrp: 1.225 ± 0.042
1.608LeuTyr: 1.608 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.512MetAla: 2.512 ± 0.049
0.149MetCys: 0.149 ± 0.012
0.959MetAsp: 0.959 ± 0.03
0.936MetGlu: 0.936 ± 0.033
0.482MetPhe: 0.482 ± 0.026
1.594MetGly: 1.594 ± 0.041
0.369MetHis: 0.369 ± 0.022
0.784MetIle: 0.784 ± 0.033
0.43MetLys: 0.43 ± 0.024
1.91MetLeu: 1.91 ± 0.05
0.413MetMet: 0.413 ± 0.02
0.505MetAsn: 0.505 ± 0.027
1.281MetPro: 1.281 ± 0.039
0.448MetGln: 0.448 ± 0.02
1.512MetArg: 1.512 ± 0.043
1.815MetSer: 1.815 ± 0.043
1.824MetThr: 1.824 ± 0.042
1.624MetVal: 1.624 ± 0.044
0.248MetTrp: 0.248 ± 0.016
0.273MetTyr: 0.273 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.306AsnAla: 2.306 ± 0.054
0.147AsnCys: 0.147 ± 0.012
1.063AsnAsp: 1.063 ± 0.039
1.066AsnGlu: 1.066 ± 0.035
0.443AsnPhe: 0.443 ± 0.024
1.879AsnGly: 1.879 ± 0.055
0.443AsnHis: 0.443 ± 0.02
0.843AsnIle: 0.843 ± 0.031
0.517AsnLys: 0.517 ± 0.025
2.019AsnLeu: 2.019 ± 0.058
0.308AsnMet: 0.308 ± 0.019
0.563AsnAsn: 0.563 ± 0.045
1.469AsnPro: 1.469 ± 0.047
0.697AsnGln: 0.697 ± 0.026
1.426AsnArg: 1.426 ± 0.036
1.104AsnSer: 1.104 ± 0.037
1.139AsnThr: 1.139 ± 0.037
1.428AsnVal: 1.428 ± 0.044
0.269AsnTrp: 0.269 ± 0.02
0.431AsnTyr: 0.431 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
8.091ProAla: 8.091 ± 0.143
0.285ProCys: 0.285 ± 0.017
3.701ProAsp: 3.701 ± 0.077
4.178ProGlu: 4.178 ± 0.074
1.4ProPhe: 1.4 ± 0.04
5.623ProGly: 5.623 ± 0.087
1.213ProHis: 1.213 ± 0.042
1.683ProIle: 1.683 ± 0.046
1.075ProLys: 1.075 ± 0.034
4.685ProLeu: 4.685 ± 0.071
1.046ProMet: 1.046 ± 0.037
0.977ProAsn: 0.977 ± 0.04
2.485ProPro: 2.485 ± 0.078
2.125ProGln: 2.125 ± 0.06
3.433ProArg: 3.433 ± 0.07
4.221ProSer: 4.221 ± 0.097
3.867ProThr: 3.867 ± 0.078
5.028ProVal: 5.028 ± 0.079
0.888ProTrp: 0.888 ± 0.036
1.052ProTyr: 1.052 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.858GlnAla: 4.858 ± 0.086
0.209GlnCys: 0.209 ± 0.016
1.778GlnAsp: 1.778 ± 0.046
1.89GlnGlu: 1.89 ± 0.057
0.647GlnPhe: 0.647 ± 0.027
2.643GlnGly: 2.643 ± 0.058
0.656GlnHis: 0.656 ± 0.033
1.329GlnIle: 1.329 ± 0.04
0.627GlnLys: 0.627 ± 0.028
2.642GlnLeu: 2.642 ± 0.056
0.69GlnMet: 0.69 ± 0.027
0.568GlnAsn: 0.568 ± 0.031
1.894GlnPro: 1.894 ± 0.061
1.272GlnGln: 1.272 ± 0.049
2.553GlnArg: 2.553 ± 0.063
1.639GlnSer: 1.639 ± 0.042
1.696GlnThr: 1.696 ± 0.045
3.089GlnVal: 3.089 ± 0.061
0.575GlnTrp: 0.575 ± 0.027
0.558GlnTyr: 0.558 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.721ArgAla: 8.721 ± 0.112
0.553ArgCys: 0.553 ± 0.03
3.605ArgAsp: 3.605 ± 0.073
4.155ArgGlu: 4.155 ± 0.079
1.949ArgPhe: 1.949 ± 0.051
5.209ArgGly: 5.209 ± 0.093
1.725ArgHis: 1.725 ± 0.045
3.237ArgIle: 3.237 ± 0.065
1.448ArgLys: 1.448 ± 0.044
7.935ArgLeu: 7.935 ± 0.112
1.594ArgMet: 1.594 ± 0.048
1.328ArgAsn: 1.328 ± 0.042
4.168ArgPro: 4.168 ± 0.086
2.453ArgGln: 2.453 ± 0.055
7.477ArgArg: 7.477 ± 0.138
4.781ArgSer: 4.781 ± 0.084
4.506ArgThr: 4.506 ± 0.084
5.254ArgVal: 5.254 ± 0.08
1.125ArgTrp: 1.125 ± 0.034
1.587ArgTyr: 1.587 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
8.492SerAla: 8.492 ± 0.144
0.507SerCys: 0.507 ± 0.026
3.268SerAsp: 3.268 ± 0.067
3.068SerGlu: 3.068 ± 0.063
1.883SerPhe: 1.883 ± 0.044
6.447SerGly: 6.447 ± 0.098
1.325SerHis: 1.325 ± 0.035
2.234SerIle: 2.234 ± 0.051
1.34SerLys: 1.34 ± 0.043
6.133SerLeu: 6.133 ± 0.078
1.463SerMet: 1.463 ± 0.042
1.197SerAsn: 1.197 ± 0.04
4.087SerPro: 4.087 ± 0.077
2.368SerGln: 2.368 ± 0.057
4.563SerArg: 4.563 ± 0.073
5.27SerSer: 5.27 ± 0.116
4.631SerThr: 4.631 ± 0.093
4.756SerVal: 4.756 ± 0.09
1.109SerTrp: 1.109 ± 0.038
1.318SerTyr: 1.318 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
7.818ThrAla: 7.818 ± 0.108
0.588ThrCys: 0.588 ± 0.025
3.702ThrAsp: 3.702 ± 0.07
3.134ThrGlu: 3.134 ± 0.061
1.676ThrPhe: 1.676 ± 0.05
6.177ThrGly: 6.177 ± 0.101
1.278ThrHis: 1.278 ± 0.043
2.832ThrIle: 2.832 ± 0.063
1.262ThrLys: 1.262 ± 0.039
5.885ThrLeu: 5.885 ± 0.095
1.224ThrMet: 1.224 ± 0.039
1.29ThrAsn: 1.29 ± 0.039
4.105ThrPro: 4.105 ± 0.063
1.797ThrGln: 1.797 ± 0.052
3.964ThrArg: 3.964 ± 0.078
4.418ThrSer: 4.418 ± 0.084
4.536ThrThr: 4.536 ± 0.094
5.712ThrVal: 5.712 ± 0.096
1.176ThrTrp: 1.176 ± 0.04
1.416ThrTyr: 1.416 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
10.36ValAla: 10.36 ± 0.133
0.75ValCys: 0.75 ± 0.028
5.063ValAsp: 5.063 ± 0.073
5.007ValGlu: 5.007 ± 0.079
2.183ValPhe: 2.183 ± 0.055
6.97ValGly: 6.97 ± 0.11
1.599ValHis: 1.599 ± 0.049
3.661ValIle: 3.661 ± 0.064
1.651ValLys: 1.651 ± 0.05
9.333ValLeu: 9.333 ± 0.129
1.744ValMet: 1.744 ± 0.046
1.672ValAsn: 1.672 ± 0.048
4.832ValPro: 4.832 ± 0.079
1.904ValGln: 1.904 ± 0.05
5.817ValArg: 5.817 ± 0.081
5.556ValSer: 5.556 ± 0.086
5.805ValThr: 5.805 ± 0.101
8.421ValVal: 8.421 ± 0.124
0.999ValTrp: 0.999 ± 0.036
1.429ValTyr: 1.429 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.592TrpAla: 1.592 ± 0.043
0.156TrpCys: 0.156 ± 0.012
0.8TrpAsp: 0.8 ± 0.034
0.73TrpGlu: 0.73 ± 0.031
0.484TrpPhe: 0.484 ± 0.026
1.157TrpGly: 1.157 ± 0.04
0.303TrpHis: 0.303 ± 0.019
0.622TrpIle: 0.622 ± 0.028
0.371TrpLys: 0.371 ± 0.021
1.617TrpLeu: 1.617 ± 0.044
0.377TrpMet: 0.377 ± 0.022
0.407TrpAsn: 0.407 ± 0.022
0.654TrpPro: 0.654 ± 0.03
0.512TrpGln: 0.512 ± 0.024
1.202TrpArg: 1.202 ± 0.043
1.004TrpSer: 1.004 ± 0.04
0.895TrpThr: 0.895 ± 0.033
1.102TrpVal: 1.102 ± 0.033
0.38TrpTrp: 0.38 ± 0.022
0.313TrpTyr: 0.313 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.2TyrAla: 2.2 ± 0.063
0.158TyrCys: 0.158 ± 0.012
1.181TyrAsp: 1.181 ± 0.043
1.122TyrGlu: 1.122 ± 0.041
0.583TyrPhe: 0.583 ± 0.024
1.766TyrGly: 1.766 ± 0.048
0.367TyrHis: 0.367 ± 0.022
0.682TyrIle: 0.682 ± 0.027
0.384TyrLys: 0.384 ± 0.022
2.18TyrLeu: 2.18 ± 0.052
0.33TyrMet: 0.33 ± 0.021
0.457TyrAsn: 0.457 ± 0.024
1.012TyrPro: 1.012 ± 0.036
0.643TyrGln: 0.643 ± 0.03
1.576TyrArg: 1.576 ± 0.048
1.271TyrSer: 1.271 ± 0.039
1.161TyrThr: 1.161 ± 0.037
1.568TyrVal: 1.568 ± 0.048
0.291TyrTrp: 0.291 ± 0.019
0.469TyrTyr: 0.469 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2638 proteins (910945 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski