Amino acid dipepetide frequency for Bacteroidales bacterium Barb7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.169AlaAla: 7.169 ± 0.148
1.151AlaCys: 1.151 ± 0.049
4.818AlaAsp: 4.818 ± 0.082
5.179AlaGlu: 5.179 ± 0.092
3.925AlaPhe: 3.925 ± 0.08
6.557AlaGly: 6.557 ± 0.128
1.291AlaHis: 1.291 ± 0.046
4.036AlaIle: 4.036 ± 0.094
4.218AlaLys: 4.218 ± 0.083
6.971AlaLeu: 6.971 ± 0.118
1.541AlaMet: 1.541 ± 0.058
3.03AlaAsn: 3.03 ± 0.084
2.18AlaPro: 2.18 ± 0.064
2.376AlaGln: 2.376 ± 0.062
3.342AlaArg: 3.342 ± 0.085
4.634AlaSer: 4.634 ± 0.097
3.582AlaThr: 3.582 ± 0.078
6.768AlaVal: 6.768 ± 0.127
0.694AlaTrp: 0.694 ± 0.039
2.913AlaTyr: 2.913 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.875CysAla: 0.875 ± 0.039
0.287CysCys: 0.287 ± 0.02
0.522CysAsp: 0.522 ± 0.028
0.596CysGlu: 0.596 ± 0.031
0.766CysPhe: 0.766 ± 0.036
1.065CysGly: 1.065 ± 0.042
0.41CysHis: 0.41 ± 0.025
0.893CysIle: 0.893 ± 0.039
0.678CysLys: 0.678 ± 0.036
1.36CysLeu: 1.36 ± 0.04
0.277CysMet: 0.277 ± 0.02
0.582CysAsn: 0.582 ± 0.03
0.69CysPro: 0.69 ± 0.036
0.44CysGln: 0.44 ± 0.025
0.939CysArg: 0.939 ± 0.04
0.776CysSer: 0.776 ± 0.039
0.726CysThr: 0.726 ± 0.037
0.76CysVal: 0.76 ± 0.032
0.138CysTrp: 0.138 ± 0.014
0.463CysTyr: 0.463 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.882AspAla: 3.882 ± 0.089
0.655AspCys: 0.655 ± 0.031
2.681AspAsp: 2.681 ± 0.067
3.379AspGlu: 3.379 ± 0.077
2.934AspPhe: 2.934 ± 0.063
4.124AspGly: 4.124 ± 0.097
0.697AspHis: 0.697 ± 0.031
4.141AspIle: 4.141 ± 0.069
3.636AspLys: 3.636 ± 0.08
4.471AspLeu: 4.471 ± 0.072
1.398AspMet: 1.398 ± 0.051
2.856AspAsn: 2.856 ± 0.084
1.725AspPro: 1.725 ± 0.048
0.884AspGln: 0.884 ± 0.033
2.692AspArg: 2.692 ± 0.059
3.044AspSer: 3.044 ± 0.074
3.094AspThr: 3.094 ± 0.068
3.484AspVal: 3.484 ± 0.068
0.609AspTrp: 0.609 ± 0.031
2.624AspTyr: 2.624 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
5.19GluAla: 5.19 ± 0.108
0.563GluCys: 0.563 ± 0.03
2.912GluAsp: 2.912 ± 0.071
4.556GluGlu: 4.556 ± 0.107
2.176GluPhe: 2.176 ± 0.057
4.029GluGly: 4.029 ± 0.087
1.236GluHis: 1.236 ± 0.045
4.423GluIle: 4.423 ± 0.088
4.829GluLys: 4.829 ± 0.113
5.621GluLeu: 5.621 ± 0.109
1.588GluMet: 1.588 ± 0.056
3.266GluAsn: 3.266 ± 0.082
1.696GluPro: 1.696 ± 0.057
2.415GluGln: 2.415 ± 0.061
3.217GluArg: 3.217 ± 0.067
3.273GluSer: 3.273 ± 0.075
3.715GluThr: 3.715 ± 0.072
3.93GluVal: 3.93 ± 0.085
0.765GluTrp: 0.765 ± 0.032
2.442GluTyr: 2.442 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.927PheAla: 3.927 ± 0.083
0.733PheCys: 0.733 ± 0.034
2.817PheAsp: 2.817 ± 0.066
2.64PheGlu: 2.64 ± 0.059
2.612PhePhe: 2.612 ± 0.069
3.783PheGly: 3.783 ± 0.103
1.125PheHis: 1.125 ± 0.048
3.337PheIle: 3.337 ± 0.075
2.396PheLys: 2.396 ± 0.057
4.628PheLeu: 4.628 ± 0.103
1.051PheMet: 1.051 ± 0.042
2.363PheAsn: 2.363 ± 0.058
2.063PhePro: 2.063 ± 0.057
1.557PheGln: 1.557 ± 0.05
2.683PheArg: 2.683 ± 0.066
3.391PheSer: 3.391 ± 0.071
2.898PheThr: 2.898 ± 0.067
3.191PheVal: 3.191 ± 0.078
0.438PheTrp: 0.438 ± 0.027
1.794PheTyr: 1.794 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.28GlyAla: 4.28 ± 0.101
1.104GlyCys: 1.104 ± 0.047
3.654GlyAsp: 3.654 ± 0.095
4.394GlyGlu: 4.394 ± 0.084
3.633GlyPhe: 3.633 ± 0.084
5.815GlyGly: 5.815 ± 0.16
1.334GlyHis: 1.334 ± 0.047
5.899GlyIle: 5.899 ± 0.111
5.309GlyLys: 5.309 ± 0.088
5.884GlyLeu: 5.884 ± 0.108
1.969GlyMet: 1.969 ± 0.057
3.914GlyAsn: 3.914 ± 0.106
0.789GlyPro: 0.789 ± 0.035
2.001GlyGln: 2.001 ± 0.053
3.646GlyArg: 3.646 ± 0.074
4.312GlySer: 4.312 ± 0.095
4.241GlyThr: 4.241 ± 0.096
4.655GlyVal: 4.655 ± 0.085
0.778GlyTrp: 0.778 ± 0.036
3.369GlyTyr: 3.369 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
1.4HisAla: 1.4 ± 0.05
0.331HisCys: 0.331 ± 0.023
0.865HisAsp: 0.865 ± 0.038
0.9HisGlu: 0.9 ± 0.037
1.295HisPhe: 1.295 ± 0.064
1.299HisGly: 1.299 ± 0.044
0.582HisHis: 0.582 ± 0.033
1.851HisIle: 1.851 ± 0.066
1.0HisLys: 1.0 ± 0.039
2.078HisLeu: 2.078 ± 0.061
0.309HisMet: 0.309 ± 0.021
0.941HisAsn: 0.941 ± 0.035
1.194HisPro: 1.194 ± 0.041
0.648HisGln: 0.648 ± 0.033
1.184HisArg: 1.184 ± 0.045
1.269HisSer: 1.269 ± 0.047
1.269HisThr: 1.269 ± 0.04
1.189HisVal: 1.189 ± 0.045
0.207HisTrp: 0.207 ± 0.014
0.86HisTyr: 0.86 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.42IleAla: 5.42 ± 0.096
0.916IleCys: 0.916 ± 0.04
4.145IleAsp: 4.145 ± 0.081
4.204IleGlu: 4.204 ± 0.088
2.722IlePhe: 2.722 ± 0.067
4.737IleGly: 4.737 ± 0.099
1.463IleHis: 1.463 ± 0.042
4.759IleIle: 4.759 ± 0.12
4.047IleLys: 4.047 ± 0.088
5.981IleLeu: 5.981 ± 0.11
1.245IleMet: 1.245 ± 0.047
3.428IleAsn: 3.428 ± 0.076
3.366IlePro: 3.366 ± 0.077
2.213IleGln: 2.213 ± 0.057
3.894IleArg: 3.894 ± 0.078
4.481IleSer: 4.481 ± 0.085
4.06IleThr: 4.06 ± 0.111
4.586IleVal: 4.586 ± 0.094
0.522IleTrp: 0.522 ± 0.032
2.556IleTyr: 2.556 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
4.918LysAla: 4.918 ± 0.105
0.529LysCys: 0.529 ± 0.031
3.612LysAsp: 3.612 ± 0.073
5.127LysGlu: 5.127 ± 0.117
1.95LysPhe: 1.95 ± 0.055
4.464LysGly: 4.464 ± 0.08
1.261LysHis: 1.261 ± 0.054
3.914LysIle: 3.914 ± 0.093
4.423LysLys: 4.423 ± 0.115
4.87LysLeu: 4.87 ± 0.095
1.712LysMet: 1.712 ± 0.056
3.082LysAsn: 3.082 ± 0.08
2.156LysPro: 2.156 ± 0.065
2.543LysGln: 2.543 ± 0.063
3.243LysArg: 3.243 ± 0.078
3.656LysSer: 3.656 ± 0.09
3.514LysThr: 3.514 ± 0.081
3.848LysVal: 3.848 ± 0.073
0.752LysTrp: 0.752 ± 0.041
2.535LysTyr: 2.535 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
6.334LeuAla: 6.334 ± 0.11
1.407LeuCys: 1.407 ± 0.045
4.303LeuAsp: 4.303 ± 0.077
4.782LeuGlu: 4.782 ± 0.09
5.223LeuPhe: 5.223 ± 0.106
5.041LeuGly: 5.041 ± 0.095
2.36LeuHis: 2.36 ± 0.068
5.753LeuIle: 5.753 ± 0.115
6.124LeuLys: 6.124 ± 0.109
9.329LeuLeu: 9.329 ± 0.169
2.012LeuMet: 2.012 ± 0.055
4.385LeuAsn: 4.385 ± 0.087
4.634LeuPro: 4.634 ± 0.083
3.5LeuGln: 3.5 ± 0.078
4.678LeuArg: 4.678 ± 0.094
7.422LeuSer: 7.422 ± 0.11
5.498LeuThr: 5.498 ± 0.101
5.112LeuVal: 5.112 ± 0.114
0.776LeuTrp: 0.776 ± 0.035
3.575LeuTyr: 3.575 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
1.729MetAla: 1.729 ± 0.064
0.217MetCys: 0.217 ± 0.017
1.18MetAsp: 1.18 ± 0.038
1.616MetGlu: 1.616 ± 0.061
0.923MetPhe: 0.923 ± 0.04
1.419MetGly: 1.419 ± 0.049
0.401MetHis: 0.401 ± 0.026
1.561MetIle: 1.561 ± 0.051
1.843MetLys: 1.843 ± 0.055
2.183MetLeu: 2.183 ± 0.065
0.548MetMet: 0.548 ± 0.031
1.216MetAsn: 1.216 ± 0.039
1.121MetPro: 1.121 ± 0.049
0.931MetGln: 0.931 ± 0.039
1.268MetArg: 1.268 ± 0.043
1.249MetSer: 1.249 ± 0.046
1.319MetThr: 1.319 ± 0.051
1.294MetVal: 1.294 ± 0.041
0.148MetTrp: 0.148 ± 0.016
0.733MetTyr: 0.733 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.57AsnAla: 3.57 ± 0.083
0.542AsnCys: 0.542 ± 0.046
2.39AsnAsp: 2.39 ± 0.067
2.768AsnGlu: 2.768 ± 0.068
2.038AsnPhe: 2.038 ± 0.057
3.761AsnGly: 3.761 ± 0.092
1.028AsnHis: 1.028 ± 0.036
3.694AsnIle: 3.694 ± 0.079
2.833AsnLys: 2.833 ± 0.079
4.099AsnLeu: 4.099 ± 0.078
1.102AsnMet: 1.102 ± 0.045
2.472AsnAsn: 2.472 ± 0.074
2.484AsnPro: 2.484 ± 0.073
1.398AsnGln: 1.398 ± 0.047
2.649AsnArg: 2.649 ± 0.069
2.883AsnSer: 2.883 ± 0.081
2.869AsnThr: 2.869 ± 0.085
2.985AsnVal: 2.985 ± 0.072
0.515AsnTrp: 0.515 ± 0.028
1.989AsnTyr: 1.989 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
3.504ProAla: 3.504 ± 0.089
0.502ProCys: 0.502 ± 0.028
2.757ProAsp: 2.757 ± 0.069
3.041ProGlu: 3.041 ± 0.071
2.186ProPhe: 2.186 ± 0.058
1.907ProGly: 1.907 ± 0.056
0.86ProHis: 0.86 ± 0.038
1.914ProIle: 1.914 ± 0.061
1.907ProLys: 1.907 ± 0.059
3.537ProLeu: 3.537 ± 0.072
0.713ProMet: 0.713 ± 0.036
1.489ProAsn: 1.489 ± 0.053
1.406ProPro: 1.406 ± 0.056
1.36ProGln: 1.36 ± 0.047
1.414ProArg: 1.414 ± 0.052
2.558ProSer: 2.558 ± 0.07
1.712ProThr: 1.712 ± 0.053
3.678ProVal: 3.678 ± 0.078
0.31ProTrp: 0.31 ± 0.024
1.687ProTyr: 1.687 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.599GlnAla: 2.599 ± 0.066
0.351GlnCys: 0.351 ± 0.025
1.348GlnAsp: 1.348 ± 0.043
2.075GlnGlu: 2.075 ± 0.056
1.45GlnPhe: 1.45 ± 0.047
2.018GlnGly: 2.018 ± 0.055
0.711GlnHis: 0.711 ± 0.029
2.314GlnIle: 2.314 ± 0.069
2.183GlnLys: 2.183 ± 0.06
3.215GlnLeu: 3.215 ± 0.072
0.895GlnMet: 0.895 ± 0.043
1.433GlnAsn: 1.433 ± 0.046
1.318GlnPro: 1.318 ± 0.052
1.568GlnGln: 1.568 ± 0.061
1.854GlnArg: 1.854 ± 0.054
2.113GlnSer: 2.113 ± 0.054
2.18GlnThr: 2.18 ± 0.065
1.9GlnVal: 1.9 ± 0.047
0.368GlnTrp: 0.368 ± 0.025
1.337GlnTyr: 1.337 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.093ArgAla: 3.093 ± 0.078
0.632ArgCys: 0.632 ± 0.025
2.19ArgAsp: 2.19 ± 0.061
3.224ArgGlu: 3.224 ± 0.074
2.688ArgPhe: 2.688 ± 0.064
2.656ArgGly: 2.656 ± 0.068
1.332ArgHis: 1.332 ± 0.052
4.244ArgIle: 4.244 ± 0.096
3.547ArgLys: 3.547 ± 0.077
5.456ArgLeu: 5.456 ± 0.109
1.538ArgMet: 1.538 ± 0.043
2.558ArgAsn: 2.558 ± 0.07
1.848ArgPro: 1.848 ± 0.058
2.324ArgGln: 2.324 ± 0.065
2.886ArgArg: 2.886 ± 0.082
2.673ArgSer: 2.673 ± 0.069
2.87ArgThr: 2.87 ± 0.064
2.913ArgVal: 2.913 ± 0.059
0.529ArgTrp: 0.529 ± 0.03
2.106ArgTyr: 2.106 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.864SerAla: 4.864 ± 0.087
0.934SerCys: 0.934 ± 0.035
3.477SerAsp: 3.477 ± 0.073
3.313SerGlu: 3.313 ± 0.069
3.474SerPhe: 3.474 ± 0.084
5.289SerGly: 5.289 ± 0.107
1.143SerHis: 1.143 ± 0.041
4.144SerIle: 4.144 ± 0.103
3.263SerLys: 3.263 ± 0.074
6.441SerLeu: 6.441 ± 0.114
1.299SerMet: 1.299 ± 0.048
2.79SerAsn: 2.79 ± 0.071
2.623SerPro: 2.623 ± 0.068
1.751SerGln: 1.751 ± 0.058
3.235SerArg: 3.235 ± 0.079
4.236SerSer: 4.236 ± 0.105
2.99SerThr: 2.99 ± 0.076
4.87SerVal: 4.87 ± 0.098
0.615SerTrp: 0.615 ± 0.033
2.479SerTyr: 2.479 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
5.304ThrAla: 5.304 ± 0.106
0.663ThrCys: 0.663 ± 0.032
3.744ThrAsp: 3.744 ± 0.088
3.405ThrGlu: 3.405 ± 0.076
2.98ThrPhe: 2.98 ± 0.069
4.95ThrGly: 4.95 ± 0.105
0.937ThrHis: 0.937 ± 0.037
3.685ThrIle: 3.685 ± 0.091
2.537ThrLys: 2.537 ± 0.078
5.291ThrLeu: 5.291 ± 0.097
0.921ThrMet: 0.921 ± 0.036
2.176ThrAsn: 2.176 ± 0.07
2.602ThrPro: 2.602 ± 0.067
1.489ThrGln: 1.489 ± 0.05
2.109ThrArg: 2.109 ± 0.055
3.176ThrSer: 3.176 ± 0.09
2.889ThrThr: 2.889 ± 0.083
5.045ThrVal: 5.045 ± 0.114
0.463ThrTrp: 0.463 ± 0.029
2.081ThrTyr: 2.081 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
4.776ValAla: 4.776 ± 0.108
1.125ValCys: 1.125 ± 0.039
2.834ValAsp: 2.834 ± 0.063
3.861ValGlu: 3.861 ± 0.098
3.836ValPhe: 3.836 ± 0.076
4.346ValGly: 4.346 ± 0.109
1.357ValHis: 1.357 ± 0.048
4.765ValIle: 4.765 ± 0.086
4.223ValLys: 4.223 ± 0.081
6.208ValLeu: 6.208 ± 0.102
1.58ValMet: 1.58 ± 0.071
3.31ValAsn: 3.31 ± 0.07
2.653ValPro: 2.653 ± 0.074
2.129ValGln: 2.129 ± 0.057
3.668ValArg: 3.668 ± 0.08
5.052ValSer: 5.052 ± 0.094
3.963ValThr: 3.963 ± 0.099
4.834ValVal: 4.834 ± 0.106
0.663ValTrp: 0.663 ± 0.035
2.56ValTyr: 2.56 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.608TrpAla: 0.608 ± 0.03
0.111TrpCys: 0.111 ± 0.013
0.515TrpAsp: 0.515 ± 0.027
0.648TrpGlu: 0.648 ± 0.031
0.473TrpPhe: 0.473 ± 0.029
0.743TrpGly: 0.743 ± 0.034
0.239TrpHis: 0.239 ± 0.018
0.618TrpIle: 0.618 ± 0.033
0.674TrpLys: 0.674 ± 0.033
0.946TrpLeu: 0.946 ± 0.039
0.275TrpMet: 0.275 ± 0.021
0.556TrpAsn: 0.556 ± 0.032
0.131TrpPro: 0.131 ± 0.015
0.497TrpGln: 0.497 ± 0.031
0.507TrpArg: 0.507 ± 0.029
0.496TrpSer: 0.496 ± 0.027
0.677TrpThr: 0.677 ± 0.042
0.571TrpVal: 0.571 ± 0.03
0.088TrpTrp: 0.088 ± 0.012
0.398TrpTyr: 0.398 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.932TyrAla: 2.932 ± 0.07
0.49TyrCys: 0.49 ± 0.026
2.248TyrAsp: 2.248 ± 0.081
2.133TyrGlu: 2.133 ± 0.063
2.142TyrPhe: 2.142 ± 0.059
2.977TyrGly: 2.977 ± 0.065
0.907TyrHis: 0.907 ± 0.047
2.801TyrIle: 2.801 ± 0.072
2.435TyrLys: 2.435 ± 0.063
3.681TyrLeu: 3.681 ± 0.066
0.923TyrMet: 0.923 ± 0.04
2.223TyrAsn: 2.223 ± 0.068
1.765TyrPro: 1.765 ± 0.055
1.209TyrGln: 1.209 ± 0.046
2.202TyrArg: 2.202 ± 0.055
2.534TyrSer: 2.534 ± 0.084
2.379TyrThr: 2.379 ± 0.07
2.129TyrVal: 2.129 ± 0.055
0.392TyrTrp: 0.392 ± 0.023
1.71TyrTyr: 1.71 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2857 proteins (695753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski