Amino acid dipepetide frequency for Porcine reproductive and respiratory syndrome virus (PRRSV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.242AlaAla: 8.242 ± 0.886
3.45AlaCys: 3.45 ± 0.827
2.875AlaAsp: 2.875 ± 0.908
3.259AlaGlu: 3.259 ± 0.803
4.984AlaPhe: 4.984 ± 1.338
5.75AlaGly: 5.75 ± 1.056
1.725AlaHis: 1.725 ± 0.873
5.75AlaIle: 5.75 ± 1.788
3.259AlaLys: 3.259 ± 0.558
7.859AlaLeu: 7.859 ± 1.3
1.15AlaMet: 1.15 ± 0.661
3.067AlaAsn: 3.067 ± 0.958
4.792AlaPro: 4.792 ± 1.623
3.067AlaGln: 3.067 ± 0.64
3.067AlaArg: 3.067 ± 1.267
5.559AlaSer: 5.559 ± 2.365
5.75AlaThr: 5.75 ± 0.62
7.859AlaVal: 7.859 ± 0.872
0.958AlaTrp: 0.958 ± 0.527
1.917AlaTyr: 1.917 ± 0.904
0.0AlaXaa: 0.0 ± 0.0
Cys
2.875CysAla: 2.875 ± 0.952
1.342CysCys: 1.342 ± 0.773
0.958CysAsp: 0.958 ± 0.452
0.958CysGlu: 0.958 ± 0.443
1.342CysPhe: 1.342 ± 0.821
2.875CysGly: 2.875 ± 1.022
0.575CysHis: 0.575 ± 0.523
1.917CysIle: 1.917 ± 0.503
1.342CysLys: 1.342 ± 0.712
4.217CysLeu: 4.217 ± 1.457
0.575CysMet: 0.575 ± 0.269
0.575CysAsn: 0.575 ± 0.312
1.725CysPro: 1.725 ± 0.506
0.575CysGln: 0.575 ± 0.569
1.917CysArg: 1.917 ± 0.466
1.533CysSer: 1.533 ± 0.627
2.684CysThr: 2.684 ± 0.395
1.15CysVal: 1.15 ± 0.633
1.342CysTrp: 1.342 ± 0.689
0.383CysTyr: 0.383 ± 0.15
0.0CysXaa: 0.0 ± 0.0
Asp
2.3AspAla: 2.3 ± 0.986
1.342AspCys: 1.342 ± 0.522
1.917AspAsp: 1.917 ± 0.617
2.684AspGlu: 2.684 ± 0.719
2.3AspPhe: 2.3 ± 0.503
3.642AspGly: 3.642 ± 0.734
0.383AspHis: 0.383 ± 0.585
2.492AspIle: 2.492 ± 0.872
2.108AspLys: 2.108 ± 0.537
5.75AspLeu: 5.75 ± 1.54
1.342AspMet: 1.342 ± 0.522
0.575AspAsn: 0.575 ± 0.538
4.025AspPro: 4.025 ± 1.472
0.958AspGln: 0.958 ± 0.437
2.684AspArg: 2.684 ± 0.79
2.875AspSer: 2.875 ± 1.047
1.533AspThr: 1.533 ± 0.474
3.067AspVal: 3.067 ± 0.972
1.342AspTrp: 1.342 ± 0.599
0.958AspTyr: 0.958 ± 0.933
0.0AspXaa: 0.0 ± 0.0
Glu
3.834GluAla: 3.834 ± 0.997
1.533GluCys: 1.533 ± 0.634
3.259GluAsp: 3.259 ± 0.696
2.3GluGlu: 2.3 ± 0.694
1.533GluPhe: 1.533 ± 0.617
2.875GluGly: 2.875 ± 0.637
1.725GluHis: 1.725 ± 0.537
1.533GluIle: 1.533 ± 0.705
3.067GluLys: 3.067 ± 0.672
4.217GluLeu: 4.217 ± 0.915
0.958GluMet: 0.958 ± 0.441
1.15GluAsn: 1.15 ± 0.423
1.917GluPro: 1.917 ± 0.843
1.533GluGln: 1.533 ± 0.411
1.917GluArg: 1.917 ± 0.664
1.917GluSer: 1.917 ± 0.562
2.108GluThr: 2.108 ± 0.395
3.834GluVal: 3.834 ± 1.121
0.767GluTrp: 0.767 ± 0.325
0.958GluTyr: 0.958 ± 0.452
0.0GluXaa: 0.0 ± 0.0
Phe
4.984PheAla: 4.984 ± 1.438
2.108PheCys: 2.108 ± 0.99
3.067PheAsp: 3.067 ± 0.757
2.108PheGlu: 2.108 ± 0.657
2.492PhePhe: 2.492 ± 1.215
2.492PheGly: 2.492 ± 0.658
1.15PheHis: 1.15 ± 1.036
1.15PheIle: 1.15 ± 0.496
1.725PheLys: 1.725 ± 0.756
5.559PheLeu: 5.559 ± 2.688
0.958PheMet: 0.958 ± 0.546
0.958PheAsn: 0.958 ± 0.338
2.875PhePro: 2.875 ± 0.306
1.533PheGln: 1.533 ± 0.797
1.533PheArg: 1.533 ± 0.459
3.642PheSer: 3.642 ± 0.997
3.259PheThr: 3.259 ± 1.166
2.684PheVal: 2.684 ± 1.114
0.575PheTrp: 0.575 ± 0.519
0.767PheTyr: 0.767 ± 0.314
0.0PheXaa: 0.0 ± 0.0
Gly
5.559GlyAla: 5.559 ± 1.08
1.917GlyCys: 1.917 ± 0.489
4.409GlyAsp: 4.409 ± 1.337
1.725GlyGlu: 1.725 ± 0.631
4.217GlyPhe: 4.217 ± 0.794
5.367GlyGly: 5.367 ± 1.952
2.3GlyHis: 2.3 ± 0.657
3.067GlyIle: 3.067 ± 0.712
4.217GlyLys: 4.217 ± 1.402
4.984GlyLeu: 4.984 ± 0.868
1.15GlyMet: 1.15 ± 0.786
3.067GlyAsn: 3.067 ± 1.086
4.025GlyPro: 4.025 ± 0.978
2.108GlyGln: 2.108 ± 0.589
4.6GlyArg: 4.6 ± 1.429
5.75GlySer: 5.75 ± 1.188
4.025GlyThr: 4.025 ± 1.009
5.367GlyVal: 5.367 ± 1.838
1.15GlyTrp: 1.15 ± 0.48
2.108GlyTyr: 2.108 ± 0.673
0.0GlyXaa: 0.0 ± 0.0
His
1.15HisAla: 1.15 ± 0.496
0.575HisCys: 0.575 ± 0.312
1.342HisAsp: 1.342 ± 1.306
0.575HisGlu: 0.575 ± 0.393
1.725HisPhe: 1.725 ± 1.321
1.533HisGly: 1.533 ± 0.53
1.725HisHis: 1.725 ± 0.853
0.767HisIle: 0.767 ± 0.505
0.767HisLys: 0.767 ± 0.304
3.259HisLeu: 3.259 ± 0.849
0.575HisMet: 0.575 ± 0.312
1.15HisAsn: 1.15 ± 0.416
2.108HisPro: 2.108 ± 0.701
0.767HisGln: 0.767 ± 0.846
1.533HisArg: 1.533 ± 0.793
0.958HisSer: 0.958 ± 0.714
1.533HisThr: 1.533 ± 0.455
2.492HisVal: 2.492 ± 0.627
0.767HisTrp: 0.767 ± 0.492
0.575HisTyr: 0.575 ± 0.393
0.0HisXaa: 0.0 ± 0.0
Ile
2.875IleAla: 2.875 ± 0.554
0.767IleCys: 0.767 ± 0.429
2.492IleAsp: 2.492 ± 0.493
2.108IleGlu: 2.108 ± 0.505
2.684IlePhe: 2.684 ± 1.569
2.492IleGly: 2.492 ± 0.793
0.575IleHis: 0.575 ± 0.324
2.492IleIle: 2.492 ± 0.75
1.15IleLys: 1.15 ± 0.564
4.792IleLeu: 4.792 ± 0.89
0.767IleMet: 0.767 ± 0.557
0.575IleAsn: 0.575 ± 0.56
1.725IlePro: 1.725 ± 0.443
1.15IleGln: 1.15 ± 0.451
2.684IleArg: 2.684 ± 0.564
2.875IleSer: 2.875 ± 1.074
2.492IleThr: 2.492 ± 0.932
3.067IleVal: 3.067 ± 0.603
0.575IleTrp: 0.575 ± 0.312
2.108IleTyr: 2.108 ± 1.086
0.0IleXaa: 0.0 ± 0.0
Lys
3.067LysAla: 3.067 ± 0.649
1.533LysCys: 1.533 ± 0.32
1.533LysAsp: 1.533 ± 0.983
2.684LysGlu: 2.684 ± 0.808
2.875LysPhe: 2.875 ± 0.727
2.684LysGly: 2.684 ± 0.844
1.15LysHis: 1.15 ± 0.41
2.875LysIle: 2.875 ± 0.712
3.067LysLys: 3.067 ± 1.283
3.642LysLeu: 3.642 ± 1.072
0.767LysMet: 0.767 ± 0.28
1.533LysAsn: 1.533 ± 0.748
3.067LysPro: 3.067 ± 1.217
1.342LysGln: 1.342 ± 0.738
1.917LysArg: 1.917 ± 0.545
1.533LysSer: 1.533 ± 0.591
2.492LysThr: 2.492 ± 0.981
4.025LysVal: 4.025 ± 1.117
0.767LysTrp: 0.767 ± 0.304
2.3LysTyr: 2.3 ± 0.666
0.0LysXaa: 0.0 ± 0.0
Leu
10.542LeuAla: 10.542 ± 0.97
3.642LeuCys: 3.642 ± 0.796
5.559LeuAsp: 5.559 ± 1.499
4.025LeuGlu: 4.025 ± 1.0
3.45LeuPhe: 3.45 ± 1.43
7.476LeuGly: 7.476 ± 0.861
2.875LeuHis: 2.875 ± 0.852
3.067LeuIle: 3.067 ± 1.38
4.6LeuLys: 4.6 ± 1.083
8.626LeuLeu: 8.626 ± 2.242
1.725LeuMet: 1.725 ± 0.504
3.259LeuAsn: 3.259 ± 0.42
7.667LeuPro: 7.667 ± 1.67
3.642LeuGln: 3.642 ± 0.515
5.75LeuArg: 5.75 ± 1.323
8.434LeuSer: 8.434 ± 1.754
7.284LeuThr: 7.284 ± 1.364
7.476LeuVal: 7.476 ± 1.426
1.917LeuTrp: 1.917 ± 1.242
2.108LeuTyr: 2.108 ± 0.672
0.0LeuXaa: 0.0 ± 0.0
Met
1.917MetAla: 1.917 ± 0.866
0.0MetCys: 0.0 ± 0.0
0.383MetAsp: 0.383 ± 0.15
0.575MetGlu: 0.575 ± 0.395
0.192MetPhe: 0.192 ± 0.131
1.533MetGly: 1.533 ± 0.743
0.383MetHis: 0.383 ± 0.15
0.767MetIle: 0.767 ± 0.32
0.767MetLys: 0.767 ± 0.359
2.684MetLeu: 2.684 ± 0.787
1.15MetMet: 1.15 ± 0.562
0.575MetAsn: 0.575 ± 0.393
1.533MetPro: 1.533 ± 0.548
0.192MetGln: 0.192 ± 0.38
0.958MetArg: 0.958 ± 0.529
1.725MetSer: 1.725 ± 0.361
0.958MetThr: 0.958 ± 0.647
2.492MetVal: 2.492 ± 0.7
0.383MetTrp: 0.383 ± 0.15
0.383MetTyr: 0.383 ± 0.358
0.0MetXaa: 0.0 ± 0.0
Asn
1.342AsnAla: 1.342 ± 0.476
1.15AsnCys: 1.15 ± 0.462
1.15AsnAsp: 1.15 ± 0.462
0.958AsnGlu: 0.958 ± 0.341
1.15AsnPhe: 1.15 ± 0.77
2.492AsnGly: 2.492 ± 0.499
1.15AsnHis: 1.15 ± 0.426
0.767AsnIle: 0.767 ± 0.325
2.108AsnLys: 2.108 ± 0.539
2.875AsnLeu: 2.875 ± 0.502
0.767AsnMet: 0.767 ± 0.273
1.342AsnAsn: 1.342 ± 0.689
0.767AsnPro: 0.767 ± 0.307
1.917AsnGln: 1.917 ± 1.123
1.917AsnArg: 1.917 ± 0.748
2.492AsnSer: 2.492 ± 0.545
2.108AsnThr: 2.108 ± 0.751
2.684AsnVal: 2.684 ± 0.83
0.575AsnTrp: 0.575 ± 0.354
1.15AsnTyr: 1.15 ± 0.633
0.0AsnXaa: 0.0 ± 0.0
Pro
6.134ProAla: 6.134 ± 1.606
1.533ProCys: 1.533 ± 0.473
2.492ProAsp: 2.492 ± 0.922
3.834ProGlu: 3.834 ± 0.711
2.492ProPhe: 2.492 ± 0.901
5.942ProGly: 5.942 ± 0.855
1.533ProHis: 1.533 ± 0.548
3.259ProIle: 3.259 ± 0.643
2.875ProLys: 2.875 ± 0.809
5.367ProLeu: 5.367 ± 1.574
0.383ProMet: 0.383 ± 0.493
2.108ProAsn: 2.108 ± 0.618
5.367ProPro: 5.367 ± 1.694
1.725ProGln: 1.725 ± 0.516
3.45ProArg: 3.45 ± 1.406
4.792ProSer: 4.792 ± 1.198
3.45ProThr: 3.45 ± 0.698
8.434ProVal: 8.434 ± 1.777
0.767ProTrp: 0.767 ± 0.317
1.917ProTyr: 1.917 ± 0.904
0.0ProXaa: 0.0 ± 0.0
Gln
2.875GlnAla: 2.875 ± 0.644
1.15GlnCys: 1.15 ± 0.441
0.575GlnAsp: 0.575 ± 0.493
0.767GlnGlu: 0.767 ± 0.317
1.533GlnPhe: 1.533 ± 0.44
2.875GlnGly: 2.875 ± 0.628
1.533GlnHis: 1.533 ± 0.58
0.767GlnIle: 0.767 ± 0.325
0.958GlnLys: 0.958 ± 0.697
4.984GlnLeu: 4.984 ± 1.23
0.767GlnMet: 0.767 ± 0.54
1.533GlnAsn: 1.533 ± 0.402
1.15GlnPro: 1.15 ± 0.333
1.15GlnGln: 1.15 ± 0.803
1.15GlnArg: 1.15 ± 0.431
1.533GlnSer: 1.533 ± 0.666
2.3GlnThr: 2.3 ± 0.763
3.642GlnVal: 3.642 ± 1.19
0.575GlnTrp: 0.575 ± 0.483
0.383GlnTyr: 0.383 ± 0.15
0.0GlnXaa: 0.0 ± 0.0
Arg
3.834ArgAla: 3.834 ± 1.122
1.725ArgCys: 1.725 ± 0.402
0.958ArgAsp: 0.958 ± 0.792
1.917ArgGlu: 1.917 ± 0.748
1.725ArgPhe: 1.725 ± 0.812
3.834ArgGly: 3.834 ± 0.587
1.533ArgHis: 1.533 ± 0.589
2.492ArgIle: 2.492 ± 0.619
2.684ArgLys: 2.684 ± 0.842
5.75ArgLeu: 5.75 ± 1.302
1.917ArgMet: 1.917 ± 1.098
1.15ArgAsn: 1.15 ± 0.562
4.025ArgPro: 4.025 ± 1.072
2.108ArgGln: 2.108 ± 0.678
3.45ArgArg: 3.45 ± 0.969
3.642ArgSer: 3.642 ± 0.662
2.492ArgThr: 2.492 ± 0.452
5.75ArgVal: 5.75 ± 0.839
1.533ArgTrp: 1.533 ± 0.492
1.725ArgTyr: 1.725 ± 0.9
0.0ArgXaa: 0.0 ± 0.0
Ser
5.367SerAla: 5.367 ± 1.093
2.3SerCys: 2.3 ± 0.652
3.067SerAsp: 3.067 ± 0.687
4.025SerGlu: 4.025 ± 1.131
2.684SerPhe: 2.684 ± 1.557
6.134SerGly: 6.134 ± 1.916
1.15SerHis: 1.15 ± 0.501
1.15SerIle: 1.15 ± 1.128
1.533SerLys: 1.533 ± 0.423
7.667SerLeu: 7.667 ± 1.014
1.342SerMet: 1.342 ± 0.401
2.3SerAsn: 2.3 ± 1.023
6.134SerPro: 6.134 ± 0.906
2.3SerGln: 2.3 ± 0.86
4.025SerArg: 4.025 ± 1.709
7.476SerSer: 7.476 ± 2.353
3.45SerThr: 3.45 ± 1.367
4.984SerVal: 4.984 ± 0.877
1.533SerTrp: 1.533 ± 0.913
2.492SerTyr: 2.492 ± 0.862
0.0SerXaa: 0.0 ± 0.0
Thr
5.75ThrAla: 5.75 ± 1.137
1.533ThrCys: 1.533 ± 0.579
2.492ThrAsp: 2.492 ± 0.535
1.725ThrGlu: 1.725 ± 0.478
1.342ThrPhe: 1.342 ± 0.791
3.067ThrGly: 3.067 ± 0.899
1.15ThrHis: 1.15 ± 0.579
2.684ThrIle: 2.684 ± 0.68
2.492ThrLys: 2.492 ± 0.624
5.175ThrLeu: 5.175 ± 1.43
1.15ThrMet: 1.15 ± 0.646
1.917ThrAsn: 1.917 ± 0.59
7.284ThrPro: 7.284 ± 0.905
2.492ThrGln: 2.492 ± 0.975
3.642ThrArg: 3.642 ± 0.905
4.025ThrSer: 4.025 ± 0.742
2.875ThrThr: 2.875 ± 1.07
5.942ThrVal: 5.942 ± 0.808
1.342ThrTrp: 1.342 ± 0.383
1.533ThrTyr: 1.533 ± 0.845
0.0ThrXaa: 0.0 ± 0.0
Val
7.859ValAla: 7.859 ± 0.593
1.15ValCys: 1.15 ± 0.985
3.259ValAsp: 3.259 ± 1.114
4.217ValGlu: 4.217 ± 0.868
4.409ValPhe: 4.409 ± 1.263
5.175ValGly: 5.175 ± 1.437
1.533ValHis: 1.533 ± 0.361
2.875ValIle: 2.875 ± 0.757
4.217ValLys: 4.217 ± 0.963
9.584ValLeu: 9.584 ± 1.683
1.342ValMet: 1.342 ± 0.718
3.45ValAsn: 3.45 ± 0.812
5.75ValPro: 5.75 ± 1.107
1.917ValGln: 1.917 ± 0.66
5.367ValArg: 5.367 ± 0.812
7.284ValSer: 7.284 ± 1.661
5.75ValThr: 5.75 ± 1.067
6.517ValVal: 6.517 ± 1.324
0.575ValTrp: 0.575 ± 0.21
2.684ValTyr: 2.684 ± 0.713
0.0ValXaa: 0.0 ± 0.0
Trp
1.15TrpAla: 1.15 ± 0.52
1.15TrpCys: 1.15 ± 0.621
0.958TrpAsp: 0.958 ± 0.437
0.958TrpGlu: 0.958 ± 0.341
1.15TrpPhe: 1.15 ± 1.267
1.725TrpGly: 1.725 ± 0.775
0.575TrpHis: 0.575 ± 0.395
0.192TrpIle: 0.192 ± 0.131
0.767TrpLys: 0.767 ± 0.605
3.45TrpLeu: 3.45 ± 1.661
0.192TrpMet: 0.192 ± 0.366
0.0TrpAsn: 0.0 ± 0.0
0.575TrpPro: 0.575 ± 0.441
0.383TrpGln: 0.383 ± 0.15
1.15TrpArg: 1.15 ± 0.501
0.767TrpSer: 0.767 ± 0.468
1.342TrpThr: 1.342 ± 0.917
0.767TrpVal: 0.767 ± 0.299
0.575TrpTrp: 0.575 ± 0.306
0.575TrpTyr: 0.575 ± 0.21
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.684TyrAla: 2.684 ± 1.48
0.958TyrCys: 0.958 ± 0.559
1.533TyrAsp: 1.533 ± 0.573
1.533TyrGlu: 1.533 ± 0.396
1.342TyrPhe: 1.342 ± 0.564
1.15TyrGly: 1.15 ± 0.276
1.15TyrHis: 1.15 ± 0.86
0.383TyrIle: 0.383 ± 0.421
1.15TyrLys: 1.15 ± 1.12
2.875TyrLeu: 2.875 ± 1.27
0.383TyrMet: 0.383 ± 0.421
0.575TyrAsn: 0.575 ± 0.5
1.342TyrPro: 1.342 ± 0.522
1.342TyrGln: 1.342 ± 0.374
1.533TyrArg: 1.533 ± 0.7
2.3TyrSer: 2.3 ± 0.393
1.725TyrThr: 1.725 ± 0.986
2.684TyrVal: 2.684 ± 0.611
0.383TyrTrp: 0.383 ± 0.15
0.767TyrTyr: 0.767 ± 0.429
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (5218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski