Amino acid dipepetide frequency for Seal anellovirus TFFN/USA/2006

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.277AlaAla: 1.277 ± 0.729
0.0AlaCys: 0.0 ± 0.0
3.831AlaAsp: 3.831 ± 0.968
0.0AlaGlu: 0.0 ± 0.0
1.277AlaPhe: 1.277 ± 1.503
3.831AlaGly: 3.831 ± 5.804
0.0AlaHis: 0.0 ± 0.0
0.0AlaIle: 0.0 ± 0.0
5.109AlaLys: 5.109 ± 2.066
2.554AlaLeu: 2.554 ± 2.233
0.0AlaMet: 0.0 ± 0.0
2.554AlaAsn: 2.554 ± 3.007
6.386AlaPro: 6.386 ± 3.482
0.0AlaGln: 0.0 ± 0.0
2.554AlaArg: 2.554 ± 1.457
3.831AlaSer: 3.831 ± 0.968
3.831AlaThr: 3.831 ± 2.186
3.831AlaVal: 3.831 ± 3.585
1.277AlaTrp: 1.277 ± 0.729
3.831AlaTyr: 3.831 ± 1.793
0.0AlaXaa: 0.0 ± 0.0
Cys
1.277CysAla: 1.277 ± 0.729
1.277CysCys: 1.277 ± 0.729
0.0CysAsp: 0.0 ± 0.0
2.554CysGlu: 2.554 ± 1.457
3.831CysPhe: 3.831 ± 1.793
1.277CysGly: 1.277 ± 1.503
1.277CysHis: 1.277 ± 0.729
0.0CysIle: 0.0 ± 0.0
2.554CysLys: 2.554 ± 1.457
2.554CysLeu: 2.554 ± 2.233
0.0CysMet: 0.0 ± 0.0
2.554CysAsn: 2.554 ± 1.457
0.0CysPro: 0.0 ± 0.0
1.277CysGln: 1.277 ± 1.503
1.277CysArg: 1.277 ± 0.729
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
1.277CysTrp: 1.277 ± 1.503
1.277CysTyr: 1.277 ± 0.729
0.0CysXaa: 0.0 ± 0.0
Asp
3.831AspAla: 3.831 ± 1.57
1.277AspCys: 1.277 ± 0.729
1.277AspAsp: 1.277 ± 0.729
3.831AspGlu: 3.831 ± 0.968
0.0AspPhe: 0.0 ± 0.0
1.277AspGly: 1.277 ± 1.935
0.0AspHis: 0.0 ± 0.0
5.109AspIle: 5.109 ± 1.367
0.0AspLys: 0.0 ± 0.0
8.94AspLeu: 8.94 ± 1.736
2.554AspMet: 2.554 ± 1.217
1.277AspAsn: 1.277 ± 0.729
3.831AspPro: 3.831 ± 0.968
3.831AspGln: 3.831 ± 1.793
0.0AspArg: 0.0 ± 0.0
10.217AspSer: 10.217 ± 2.785
0.0AspThr: 0.0 ± 0.0
0.0AspVal: 0.0 ± 0.0
3.831AspTrp: 3.831 ± 1.793
5.109AspTyr: 5.109 ± 2.915
0.0AspXaa: 0.0 ± 0.0
Glu
6.386GluAla: 6.386 ± 3.643
0.0GluCys: 0.0 ± 0.0
0.0GluAsp: 0.0 ± 0.0
6.386GluGlu: 6.386 ± 5.459
1.277GluPhe: 1.277 ± 1.935
5.109GluGly: 5.109 ± 3.962
0.0GluHis: 0.0 ± 0.0
1.277GluIle: 1.277 ± 0.729
3.831GluLys: 3.831 ± 3.278
2.554GluLeu: 2.554 ± 3.007
0.0GluMet: 0.0 ± 0.0
3.831GluAsn: 3.831 ± 1.57
1.277GluPro: 1.277 ± 0.729
5.109GluGln: 5.109 ± 2.066
3.831GluArg: 3.831 ± 2.186
2.554GluSer: 2.554 ± 1.033
7.663GluThr: 7.663 ± 1.099
1.277GluVal: 1.277 ± 1.935
0.0GluTrp: 0.0 ± 0.0
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.277PheAla: 1.277 ± 1.935
1.277PheCys: 1.277 ± 0.729
5.109PheAsp: 5.109 ± 2.132
1.277PheGlu: 1.277 ± 1.935
3.831PhePhe: 3.831 ± 1.793
0.0PheGly: 0.0 ± 0.0
1.277PheHis: 1.277 ± 0.729
1.277PheIle: 1.277 ± 0.729
5.109PheLys: 5.109 ± 2.915
6.386PheLeu: 6.386 ± 1.823
1.277PheMet: 1.277 ± 2.131
2.554PheAsn: 2.554 ± 1.457
2.554PhePro: 2.554 ± 1.033
1.277PheGln: 1.277 ± 0.729
5.109PheArg: 5.109 ± 2.915
1.277PheSer: 1.277 ± 0.729
2.554PheThr: 2.554 ± 1.457
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
1.277PheTyr: 1.277 ± 0.729
0.0PheXaa: 0.0 ± 0.0
Gly
11.494GlyAla: 11.494 ± 8.251
0.0GlyCys: 0.0 ± 0.0
6.386GlyAsp: 6.386 ± 2.634
5.109GlyGlu: 5.109 ± 2.066
1.277GlyPhe: 1.277 ± 0.729
7.663GlyGly: 7.663 ± 3.187
1.277GlyHis: 1.277 ± 0.729
8.94GlyIle: 8.94 ± 2.513
3.831GlyLys: 3.831 ± 1.793
6.386GlyLeu: 6.386 ± 1.823
2.554GlyMet: 2.554 ± 1.717
1.277GlyAsn: 1.277 ± 0.729
2.554GlyPro: 2.554 ± 1.717
1.277GlyGln: 1.277 ± 1.935
6.386GlyArg: 6.386 ± 0.785
2.554GlySer: 2.554 ± 1.033
1.277GlyThr: 1.277 ± 0.729
1.277GlyVal: 1.277 ± 0.729
3.831GlyTrp: 3.831 ± 1.793
1.277GlyTyr: 1.277 ± 0.729
0.0GlyXaa: 0.0 ± 0.0
His
1.277HisAla: 1.277 ± 1.503
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
2.554HisHis: 2.554 ± 1.457
1.277HisIle: 1.277 ± 1.935
1.277HisLys: 1.277 ± 0.729
2.554HisLeu: 2.554 ± 1.717
1.277HisMet: 1.277 ± 0.729
1.277HisAsn: 1.277 ± 0.729
2.554HisPro: 2.554 ± 1.457
0.0HisGln: 0.0 ± 0.0
2.554HisArg: 2.554 ± 1.457
0.0HisSer: 0.0 ± 0.0
1.277HisThr: 1.277 ± 1.935
0.0HisVal: 0.0 ± 0.0
3.831HisTrp: 3.831 ± 2.186
1.277HisTyr: 1.277 ± 0.729
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
1.277IleCys: 1.277 ± 1.935
0.0IleAsp: 0.0 ± 0.0
2.554IleGlu: 2.554 ± 1.033
1.277IlePhe: 1.277 ± 0.729
0.0IleGly: 0.0 ± 0.0
1.277IleHis: 1.277 ± 0.729
2.554IleIle: 2.554 ± 3.869
2.554IleLys: 2.554 ± 1.033
8.94IleLeu: 8.94 ± 3.96
0.0IleMet: 0.0 ± 0.0
3.831IleAsn: 3.831 ± 2.475
2.554IlePro: 2.554 ± 1.457
0.0IleGln: 0.0 ± 0.0
1.277IleArg: 1.277 ± 0.729
2.554IleSer: 2.554 ± 1.033
2.554IleThr: 2.554 ± 1.457
2.554IleVal: 2.554 ± 2.233
0.0IleTrp: 0.0 ± 0.0
6.386IleTyr: 6.386 ± 5.278
0.0IleXaa: 0.0 ± 0.0
Lys
1.277LysAla: 1.277 ± 0.729
1.277LysCys: 1.277 ± 1.503
7.663LysAsp: 7.663 ± 3.224
5.109LysGlu: 5.109 ± 2.066
2.554LysPhe: 2.554 ± 1.717
3.831LysGly: 3.831 ± 2.186
2.554LysHis: 2.554 ± 1.717
1.277LysIle: 1.277 ± 0.729
2.554LysLys: 2.554 ± 2.233
3.831LysLeu: 3.831 ± 1.57
1.277LysMet: 1.277 ± 0.729
0.0LysAsn: 0.0 ± 0.0
6.386LysPro: 6.386 ± 1.965
1.277LysGln: 1.277 ± 1.503
3.831LysArg: 3.831 ± 2.186
3.831LysSer: 3.831 ± 0.968
3.831LysThr: 3.831 ± 4.51
2.554LysVal: 2.554 ± 1.457
0.0LysTrp: 0.0 ± 0.0
5.109LysTyr: 5.109 ± 1.367
0.0LysXaa: 0.0 ± 0.0
Leu
2.554LeuAla: 2.554 ± 1.033
0.0LeuCys: 0.0 ± 0.0
7.663LeuAsp: 7.663 ± 1.935
3.831LeuGlu: 3.831 ± 2.475
5.109LeuPhe: 5.109 ± 1.005
6.386LeuGly: 6.386 ± 2.927
2.554LeuHis: 2.554 ± 2.233
5.109LeuIle: 5.109 ± 3.369
7.663LeuLys: 7.663 ± 1.099
2.554LeuLeu: 2.554 ± 1.033
3.831LeuMet: 3.831 ± 0.968
6.386LeuAsn: 6.386 ± 6.051
1.277LeuPro: 1.277 ± 0.729
3.831LeuGln: 3.831 ± 2.475
3.831LeuArg: 3.831 ± 0.968
6.386LeuSer: 6.386 ± 3.881
3.831LeuThr: 3.831 ± 2.475
6.386LeuVal: 6.386 ± 1.823
1.277LeuTrp: 1.277 ± 0.729
2.554LeuTyr: 2.554 ± 1.457
0.0LeuXaa: 0.0 ± 0.0
Met
1.277MetAla: 1.277 ± 0.729
2.554MetCys: 2.554 ± 1.457
1.277MetAsp: 1.277 ± 0.729
2.554MetGlu: 2.554 ± 1.717
0.0MetPhe: 0.0 ± 0.0
1.277MetGly: 1.277 ± 1.935
0.0MetHis: 0.0 ± 0.0
2.554MetIle: 2.554 ± 1.717
1.277MetLys: 1.277 ± 0.729
1.277MetLeu: 1.277 ± 0.729
1.277MetMet: 1.277 ± 1.503
2.554MetAsn: 2.554 ± 1.457
3.831MetPro: 3.831 ± 0.968
0.0MetGln: 0.0 ± 0.0
1.277MetArg: 1.277 ± 1.503
1.277MetSer: 1.277 ± 0.729
2.554MetThr: 2.554 ± 3.007
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.277AsnAla: 1.277 ± 1.503
1.277AsnCys: 1.277 ± 0.729
1.277AsnAsp: 1.277 ± 0.729
1.277AsnGlu: 1.277 ± 0.729
3.831AsnPhe: 3.831 ± 1.793
1.277AsnGly: 1.277 ± 1.935
0.0AsnHis: 0.0 ± 0.0
2.554AsnIle: 2.554 ± 3.007
0.0AsnLys: 0.0 ± 0.0
3.831AsnLeu: 3.831 ± 3.585
1.277AsnMet: 1.277 ± 0.729
0.0AsnAsn: 0.0 ± 0.0
2.554AsnPro: 2.554 ± 3.007
1.277AsnGln: 1.277 ± 1.935
2.554AsnArg: 2.554 ± 1.457
2.554AsnSer: 2.554 ± 1.033
5.109AsnThr: 5.109 ± 1.367
1.277AsnVal: 1.277 ± 0.729
1.277AsnTrp: 1.277 ± 0.729
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
1.277ProAla: 1.277 ± 0.729
2.554ProCys: 2.554 ± 3.007
1.277ProAsp: 1.277 ± 1.935
3.831ProGlu: 3.831 ± 0.968
3.831ProPhe: 3.831 ± 2.186
5.109ProGly: 5.109 ± 2.066
1.277ProHis: 1.277 ± 0.729
2.554ProIle: 2.554 ± 1.033
6.386ProLys: 6.386 ± 1.965
7.663ProLeu: 7.663 ± 1.099
2.554ProMet: 2.554 ± 1.033
1.277ProAsn: 1.277 ± 0.729
5.109ProPro: 5.109 ± 2.066
3.831ProGln: 3.831 ± 2.475
5.109ProArg: 5.109 ± 1.367
5.109ProSer: 5.109 ± 1.367
2.554ProThr: 2.554 ± 1.457
1.277ProVal: 1.277 ± 1.935
1.277ProTrp: 1.277 ± 0.729
2.554ProTyr: 2.554 ± 1.033
0.0ProXaa: 0.0 ± 0.0
Gln
1.277GlnAla: 1.277 ± 1.503
2.554GlnCys: 2.554 ± 1.457
3.831GlnAsp: 3.831 ± 3.585
1.277GlnGlu: 1.277 ± 0.729
3.831GlnPhe: 3.831 ± 0.968
8.94GlnGly: 8.94 ± 3.96
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
3.831GlnLys: 3.831 ± 4.51
1.277GlnLeu: 1.277 ± 0.729
1.277GlnMet: 1.277 ± 0.729
0.0GlnAsn: 0.0 ± 0.0
5.109GlnPro: 5.109 ± 2.55
1.277GlnGln: 1.277 ± 1.935
1.277GlnArg: 1.277 ± 0.729
1.277GlnSer: 1.277 ± 1.503
0.0GlnThr: 0.0 ± 0.0
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
1.277GlnTyr: 1.277 ± 0.729
0.0GlnXaa: 0.0 ± 0.0
Arg
5.109ArgAla: 5.109 ± 1.005
0.0ArgCys: 0.0 ± 0.0
1.277ArgAsp: 1.277 ± 0.729
2.554ArgGlu: 2.554 ± 2.233
3.831ArgPhe: 3.831 ± 2.186
10.217ArgGly: 10.217 ± 5.829
5.109ArgHis: 5.109 ± 2.915
1.277ArgIle: 1.277 ± 0.729
2.554ArgLys: 2.554 ± 1.457
5.109ArgLeu: 5.109 ± 1.367
1.277ArgMet: 1.277 ± 0.656
2.554ArgAsn: 2.554 ± 1.717
7.663ArgPro: 7.663 ± 3.224
1.277ArgGln: 1.277 ± 0.729
22.989ArgArg: 22.989 ± 5.844
2.554ArgSer: 2.554 ± 1.033
5.109ArgThr: 5.109 ± 1.367
1.277ArgVal: 1.277 ± 0.729
2.554ArgTrp: 2.554 ± 1.457
6.386ArgTyr: 6.386 ± 1.965
0.0ArgXaa: 0.0 ± 0.0
Ser
1.277SerAla: 1.277 ± 1.503
2.554SerCys: 2.554 ± 1.457
7.663SerAsp: 7.663 ± 6.958
1.277SerGlu: 1.277 ± 1.503
1.277SerPhe: 1.277 ± 1.503
8.94SerGly: 8.94 ± 2.489
1.277SerHis: 1.277 ± 0.729
0.0SerIle: 0.0 ± 0.0
3.831SerLys: 3.831 ± 2.186
2.554SerLeu: 2.554 ± 3.007
1.277SerMet: 1.277 ± 1.503
1.277SerAsn: 1.277 ± 0.729
2.554SerPro: 2.554 ± 1.457
5.109SerGln: 5.109 ± 2.066
3.831SerArg: 3.831 ± 0.968
11.494SerSer: 11.494 ± 5.525
2.554SerThr: 2.554 ± 1.033
2.554SerVal: 2.554 ± 1.457
6.386SerTrp: 6.386 ± 1.965
3.831SerTyr: 3.831 ± 2.475
0.0SerXaa: 0.0 ± 0.0
Thr
2.554ThrAla: 2.554 ± 1.457
0.0ThrCys: 0.0 ± 0.0
1.277ThrAsp: 1.277 ± 0.729
2.554ThrGlu: 2.554 ± 1.033
1.277ThrPhe: 1.277 ± 0.729
5.109ThrGly: 5.109 ± 1.005
1.277ThrHis: 1.277 ± 1.935
0.0ThrIle: 0.0 ± 0.0
1.277ThrLys: 1.277 ± 0.729
7.663ThrLeu: 7.663 ± 3.099
1.277ThrMet: 1.277 ± 0.729
0.0ThrAsn: 0.0 ± 0.0
5.109ThrPro: 5.109 ± 2.066
1.277ThrGln: 1.277 ± 1.503
1.277ThrArg: 1.277 ± 0.729
7.663ThrSer: 7.663 ± 3.099
5.109ThrThr: 5.109 ± 1.005
3.831ThrVal: 3.831 ± 0.968
2.554ThrTrp: 2.554 ± 1.457
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
3.831ValCys: 3.831 ± 1.793
0.0ValAsp: 0.0 ± 0.0
1.277ValGlu: 1.277 ± 1.503
2.554ValPhe: 2.554 ± 1.457
0.0ValGly: 0.0 ± 0.0
0.0ValHis: 0.0 ± 0.0
3.831ValIle: 3.831 ± 3.898
2.554ValLys: 2.554 ± 1.717
1.277ValLeu: 1.277 ± 1.503
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
2.554ValPro: 2.554 ± 1.033
2.554ValGln: 2.554 ± 3.869
6.386ValArg: 6.386 ± 2.634
2.554ValSer: 2.554 ± 1.717
0.0ValThr: 0.0 ± 0.0
2.554ValVal: 2.554 ± 1.457
1.277ValTrp: 1.277 ± 0.729
1.277ValTyr: 1.277 ± 0.729
0.0ValXaa: 0.0 ± 0.0
Trp
1.277TrpAla: 1.277 ± 0.729
1.277TrpCys: 1.277 ± 1.503
2.554TrpAsp: 2.554 ± 1.457
3.831TrpGlu: 3.831 ± 1.793
1.277TrpPhe: 1.277 ± 0.729
3.831TrpGly: 3.831 ± 2.186
0.0TrpHis: 0.0 ± 0.0
1.277TrpIle: 1.277 ± 0.729
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.277TrpAsn: 1.277 ± 0.729
0.0TrpPro: 0.0 ± 0.0
1.277TrpGln: 1.277 ± 0.729
7.663TrpArg: 7.663 ± 3.224
2.554TrpSer: 2.554 ± 1.033
1.277TrpThr: 1.277 ± 0.729
1.277TrpVal: 1.277 ± 0.729
2.554TrpTrp: 2.554 ± 1.717
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.277TyrCys: 1.277 ± 0.729
3.831TyrAsp: 3.831 ± 2.186
1.277TyrGlu: 1.277 ± 1.935
3.831TyrPhe: 3.831 ± 2.186
2.554TyrGly: 2.554 ± 1.033
1.277TyrHis: 1.277 ± 0.729
1.277TyrIle: 1.277 ± 0.729
3.831TyrLys: 3.831 ± 2.186
5.109TyrLeu: 5.109 ± 2.066
2.554TyrMet: 2.554 ± 1.457
0.0TyrAsn: 0.0 ± 0.0
2.554TyrPro: 2.554 ± 1.033
2.554TyrGln: 2.554 ± 1.457
7.663TyrArg: 7.663 ± 1.134
1.277TyrSer: 1.277 ± 0.729
0.0TyrThr: 0.0 ± 0.0
2.554TyrVal: 2.554 ± 3.869
0.0TyrTrp: 0.0 ± 0.0
1.277TyrTyr: 1.277 ± 0.729
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski