Amino acid dipepetide frequency for Sphingomonas laterariae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.252AlaAla: 21.252 ± 0.195	1.082AlaCys: 1.082 ± 0.035	8.727AlaAsp: 8.727 ± 0.096	8.432AlaGlu: 8.432 ± 0.107	4.446AlaPhe: 4.446 ± 0.058	12.534AlaGly: 12.534 ± 0.145	2.399AlaHis: 2.399 ± 0.041	7.577AlaIle: 7.577 ± 0.09	4.172AlaLys: 4.172 ± 0.068	14.128AlaLeu: 14.128 ± 0.145	4.13AlaMet: 4.13 ± 0.062	3.18AlaAsn: 3.18 ± 0.058	6.621AlaPro: 6.621 ± 0.088	4.285AlaGln: 4.285 ± 0.066	10.54AlaArg: 10.54 ± 0.127	6.37AlaSer: 6.37 ± 0.081	7.031AlaThr: 7.031 ± 0.079	8.985AlaVal: 8.985 ± 0.114	1.783AlaTrp: 1.783 ± 0.04	2.657AlaTyr: 2.657 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.984CysAla: 0.984 ± 0.03	0.078CysCys: 0.078 ± 0.008	0.508CysAsp: 0.508 ± 0.022	0.36CysGlu: 0.36 ± 0.018	0.269CysPhe: 0.269 ± 0.015	0.837CysGly: 0.837 ± 0.028	0.232CysHis: 0.232 ± 0.017	0.318CysIle: 0.318 ± 0.015	0.144CysLys: 0.144 ± 0.011	0.666CysLeu: 0.666 ± 0.025	0.124CysMet: 0.124 ± 0.01	0.184CysAsn: 0.184 ± 0.013	0.475CysPro: 0.475 ± 0.021	0.204CysGln: 0.204 ± 0.013	0.603CysArg: 0.603 ± 0.023	0.386CysSer: 0.386 ± 0.015	0.372CysThr: 0.372 ± 0.017	0.49CysVal: 0.49 ± 0.02	0.11CysTrp: 0.11 ± 0.008	0.171CysTyr: 0.171 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.55AspAla: 8.55 ± 0.092	0.464AspCys: 0.464 ± 0.019	3.566AspAsp: 3.566 ± 0.059	3.474AspGlu: 3.474 ± 0.056	2.217AspPhe: 2.217 ± 0.048	6.155AspGly: 6.155 ± 0.087	1.357AspHis: 1.357 ± 0.037	2.993AspIle: 2.993 ± 0.047	1.702AspLys: 1.702 ± 0.04	5.849AspLeu: 5.849 ± 0.07	1.436AspMet: 1.436 ± 0.034	1.365AspAsn: 1.365 ± 0.036	3.847AspPro: 3.847 ± 0.062	1.863AspGln: 1.863 ± 0.041	5.253AspArg: 5.253 ± 0.077	2.206AspSer: 2.206 ± 0.041	2.469AspThr: 2.469 ± 0.041	4.174AspVal: 4.174 ± 0.057	1.111AspTrp: 1.111 ± 0.032	1.656AspTyr: 1.656 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.905GluAla: 7.905 ± 0.105	0.323GluCys: 0.323 ± 0.016	2.661GluAsp: 2.661 ± 0.049	2.706GluGlu: 2.706 ± 0.061	1.521GluPhe: 1.521 ± 0.037	4.454GluGly: 4.454 ± 0.059	1.064GluHis: 1.064 ± 0.029	3.086GluIle: 3.086 ± 0.054	1.824GluLys: 1.824 ± 0.042	4.981GluLeu: 4.981 ± 0.068	1.437GluMet: 1.437 ± 0.033	1.292GluAsn: 1.292 ± 0.036	2.568GluPro: 2.568 ± 0.05	2.04GluGln: 2.04 ± 0.038	5.02GluArg: 5.02 ± 0.08	2.114GluSer: 2.114 ± 0.041	3.108GluThr: 3.108 ± 0.049	3.479GluVal: 3.479 ± 0.06	0.757GluTrp: 0.757 ± 0.025	0.998GluTyr: 0.998 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.835PheAla: 4.835 ± 0.054	0.3PheCys: 0.3 ± 0.016	2.764PheAsp: 2.764 ± 0.048	1.97PheGlu: 1.97 ± 0.039	1.166PhePhe: 1.166 ± 0.038	3.618PheGly: 3.618 ± 0.062	0.739PheHis: 0.739 ± 0.027	1.425PheIle: 1.425 ± 0.035	0.807PheLys: 0.807 ± 0.027	2.956PheLeu: 2.956 ± 0.055	0.73PheMet: 0.73 ± 0.025	1.033PheAsn: 1.033 ± 0.033	1.491PhePro: 1.491 ± 0.035	0.914PheGln: 0.914 ± 0.027	2.284PheArg: 2.284 ± 0.046	1.917PheSer: 1.917 ± 0.043	2.067PheThr: 2.067 ± 0.041	2.569PheVal: 2.569 ± 0.044	0.515PheTrp: 0.515 ± 0.021	0.86PheTyr: 0.86 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.319GlyAla: 10.319 ± 0.142	0.802GlyCys: 0.802 ± 0.024	5.321GlyAsp: 5.321 ± 0.077	4.831GlyGlu: 4.831 ± 0.066	3.684GlyPhe: 3.684 ± 0.061	8.569GlyGly: 8.569 ± 0.19	1.985GlyHis: 1.985 ± 0.046	4.482GlyIle: 4.482 ± 0.06	3.153GlyLys: 3.153 ± 0.056	8.856GlyLeu: 8.856 ± 0.09	2.328GlyMet: 2.328 ± 0.045	2.256GlyAsn: 2.256 ± 0.058	3.732GlyPro: 3.732 ± 0.054	3.132GlyGln: 3.132 ± 0.049	7.056GlyArg: 7.056 ± 0.086	4.646GlySer: 4.646 ± 0.097	4.738GlyThr: 4.738 ± 0.128	6.276GlyVal: 6.276 ± 0.081	1.712GlyTrp: 1.712 ± 0.038	2.311GlyTyr: 2.311 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.5HisAla: 2.5 ± 0.047	0.208HisCys: 0.208 ± 0.013	1.294HisAsp: 1.294 ± 0.035	0.951HisGlu: 0.951 ± 0.025	0.848HisPhe: 0.848 ± 0.026	2.064HisGly: 2.064 ± 0.043	0.609HisHis: 0.609 ± 0.025	0.951HisIle: 0.951 ± 0.026	0.456HisLys: 0.456 ± 0.019	1.888HisLeu: 1.888 ± 0.038	0.474HisMet: 0.474 ± 0.022	0.46HisAsn: 0.46 ± 0.018	1.265HisPro: 1.265 ± 0.031	0.577HisGln: 0.577 ± 0.023	1.466HisArg: 1.466 ± 0.039	0.866HisSer: 0.866 ± 0.03	0.653HisThr: 0.653 ± 0.024	1.515HisVal: 1.515 ± 0.038	0.347HisTrp: 0.347 ± 0.017	0.584HisTyr: 0.584 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	8.641IleAla: 8.641 ± 0.091	0.401IleCys: 0.401 ± 0.019	4.036IleAsp: 4.036 ± 0.056	3.557IleGlu: 3.557 ± 0.063	1.595IlePhe: 1.595 ± 0.038	5.355IleGly: 5.355 ± 0.055	0.988IleHis: 0.988 ± 0.027	2.149IleIle: 2.149 ± 0.042	1.162IleLys: 1.162 ± 0.033	4.017IleLeu: 4.017 ± 0.062	0.798IleMet: 0.798 ± 0.03	1.294IleAsn: 1.294 ± 0.033	2.14IlePro: 2.14 ± 0.043	1.199IleGln: 1.199 ± 0.032	3.452IleArg: 3.452 ± 0.053	2.49IleSer: 2.49 ± 0.051	2.608IleThr: 2.608 ± 0.058	4.172IleVal: 4.172 ± 0.059	0.614IleTrp: 0.614 ± 0.025	1.014IleTyr: 1.014 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.313LysAla: 4.313 ± 0.075	0.126LysCys: 0.126 ± 0.009	1.56LysAsp: 1.56 ± 0.039	1.218LysGlu: 1.218 ± 0.035	0.776LysPhe: 0.776 ± 0.027	2.488LysGly: 2.488 ± 0.046	0.502LysHis: 0.502 ± 0.02	1.405LysIle: 1.405 ± 0.031	0.974LysLys: 0.974 ± 0.033	3.098LysLeu: 3.098 ± 0.058	0.7LysMet: 0.7 ± 0.025	0.644LysAsn: 0.644 ± 0.021	1.889LysPro: 1.889 ± 0.046	0.878LysGln: 0.878 ± 0.028	2.161LysArg: 2.161 ± 0.043	1.539LysSer: 1.539 ± 0.04	1.519LysThr: 1.519 ± 0.037	2.067LysVal: 2.067 ± 0.049	0.376LysTrp: 0.376 ± 0.017	0.544LysTyr: 0.544 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.782LeuAla: 14.782 ± 0.14	0.738LeuCys: 0.738 ± 0.026	6.443LeuAsp: 6.443 ± 0.074	4.475LeuGlu: 4.475 ± 0.061	3.476LeuPhe: 3.476 ± 0.061	8.21LeuGly: 8.21 ± 0.096	1.781LeuHis: 1.781 ± 0.038	5.139LeuIle: 5.139 ± 0.072	3.016LeuLys: 3.016 ± 0.052	9.082LeuLeu: 9.082 ± 0.11	2.121LeuMet: 2.121 ± 0.042	2.355LeuAsn: 2.355 ± 0.047	5.637LeuPro: 5.637 ± 0.067	2.331LeuGln: 2.331 ± 0.045	6.9LeuArg: 6.9 ± 0.084	5.413LeuSer: 5.413 ± 0.065	5.221LeuThr: 5.221 ± 0.074	6.921LeuVal: 6.921 ± 0.08	1.287LeuTrp: 1.287 ± 0.033	1.921LeuTyr: 1.921 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.534MetAla: 3.534 ± 0.053	0.158MetCys: 0.158 ± 0.01	1.084MetAsp: 1.084 ± 0.031	1.033MetGlu: 1.033 ± 0.029	0.696MetPhe: 0.696 ± 0.023	1.854MetGly: 1.854 ± 0.032	0.423MetHis: 0.423 ± 0.018	1.323MetIle: 1.323 ± 0.032	0.863MetLys: 0.863 ± 0.025	2.606MetLeu: 2.606 ± 0.05	0.64MetMet: 0.64 ± 0.026	0.66MetAsn: 0.66 ± 0.024	1.497MetPro: 1.497 ± 0.037	0.652MetGln: 0.652 ± 0.024	1.815MetArg: 1.815 ± 0.037	1.347MetSer: 1.347 ± 0.032	1.727MetThr: 1.727 ± 0.033	1.635MetVal: 1.635 ± 0.034	0.232MetTrp: 0.232 ± 0.014	0.237MetTyr: 0.237 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.228AsnAla: 3.228 ± 0.059	0.226AsnCys: 0.226 ± 0.014	1.374AsnAsp: 1.374 ± 0.04	1.097AsnGlu: 1.097 ± 0.027	0.89AsnPhe: 0.89 ± 0.026	2.449AsnGly: 2.449 ± 0.065	0.49AsnHis: 0.49 ± 0.017	1.327AsnIle: 1.327 ± 0.038	0.58AsnLys: 0.58 ± 0.024	2.416AsnLeu: 2.416 ± 0.047	0.553AsnMet: 0.553 ± 0.021	0.654AsnAsn: 0.654 ± 0.033	1.731AsnPro: 1.731 ± 0.047	0.735AsnGln: 0.735 ± 0.024	1.786AsnArg: 1.786 ± 0.035	1.171AsnSer: 1.171 ± 0.042	1.018AsnThr: 1.018 ± 0.035	1.781AsnVal: 1.781 ± 0.042	0.388AsnTrp: 0.388 ± 0.017	0.644AsnTyr: 0.644 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.843ProAla: 7.843 ± 0.098	0.331ProCys: 0.331 ± 0.017	3.773ProAsp: 3.773 ± 0.058	3.383ProGlu: 3.383 ± 0.044	1.951ProPhe: 1.951 ± 0.037	4.841ProGly: 4.841 ± 0.059	1.058ProHis: 1.058 ± 0.028	2.634ProIle: 2.634 ± 0.046	1.455ProLys: 1.455 ± 0.032	4.785ProLeu: 4.785 ± 0.06	1.256ProMet: 1.256 ± 0.031	1.26ProAsn: 1.26 ± 0.033	3.106ProPro: 3.106 ± 0.065	1.645ProGln: 1.645 ± 0.039	3.127ProArg: 3.127 ± 0.047	2.528ProSer: 2.528 ± 0.042	2.675ProThr: 2.675 ± 0.045	4.278ProVal: 4.278 ± 0.066	0.769ProTrp: 0.769 ± 0.027	1.058ProTyr: 1.058 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.32GlnAla: 4.32 ± 0.059	0.202GlnCys: 0.202 ± 0.011	1.363GlnAsp: 1.363 ± 0.032	1.245GlnGlu: 1.245 ± 0.031	1.091GlnPhe: 1.091 ± 0.031	2.493GlnGly: 2.493 ± 0.044	0.584GlnHis: 0.584 ± 0.021	1.731GlnIle: 1.731 ± 0.043	0.901GlnLys: 0.901 ± 0.027	2.989GlnLeu: 2.989 ± 0.049	0.781GlnMet: 0.781 ± 0.026	0.71GlnAsn: 0.71 ± 0.024	1.877GlnPro: 1.877 ± 0.036	1.066GlnGln: 1.066 ± 0.032	2.51GlnArg: 2.51 ± 0.045	1.554GlnSer: 1.554 ± 0.034	1.493GlnThr: 1.493 ± 0.035	2.116GlnVal: 2.116 ± 0.043	0.45GlnTrp: 0.45 ± 0.019	0.578GlnTyr: 0.578 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.64ArgAla: 9.64 ± 0.124	0.523ArgCys: 0.523 ± 0.02	4.584ArgAsp: 4.584 ± 0.068	3.965ArgGlu: 3.965 ± 0.068	3.155ArgPhe: 3.155 ± 0.051	5.298ArgGly: 5.298 ± 0.066	1.776ArgHis: 1.776 ± 0.039	4.389ArgIle: 4.389 ± 0.061	2.076ArgLys: 2.076 ± 0.045	8.6ArgLeu: 8.6 ± 0.111	1.975ArgMet: 1.975 ± 0.04	1.908ArgAsn: 1.908 ± 0.038	4.075ArgPro: 4.075 ± 0.061	2.51ArgGln: 2.51 ± 0.043	6.171ArgArg: 6.171 ± 0.1	3.646ArgSer: 3.646 ± 0.057	3.58ArgThr: 3.58 ± 0.053	4.743ArgVal: 4.743 ± 0.061	1.24ArgTrp: 1.24 ± 0.029	1.828ArgTyr: 1.828 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.337SerAla: 6.337 ± 0.091	0.388SerCys: 0.388 ± 0.019	2.814SerAsp: 2.814 ± 0.049	2.337SerGlu: 2.337 ± 0.051	2.091SerPhe: 2.091 ± 0.042	5.157SerGly: 5.157 ± 0.095	0.937SerHis: 0.937 ± 0.027	2.541SerIle: 2.541 ± 0.048	1.248SerLys: 1.248 ± 0.031	4.784SerLeu: 4.784 ± 0.062	1.09SerMet: 1.09 ± 0.031	1.196SerAsn: 1.196 ± 0.033	2.692SerPro: 2.692 ± 0.045	1.394SerGln: 1.394 ± 0.03	3.399SerArg: 3.399 ± 0.046	2.47SerSer: 2.47 ± 0.054	2.467SerThr: 2.467 ± 0.049	3.395SerVal: 3.395 ± 0.057	0.777SerTrp: 0.777 ± 0.025	1.294SerTyr: 1.294 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.77ThrAla: 6.77 ± 0.071	0.324ThrCys: 0.324 ± 0.016	2.804ThrAsp: 2.804 ± 0.048	2.217ThrGlu: 2.217 ± 0.044	1.706ThrPhe: 1.706 ± 0.034	5.317ThrGly: 5.317 ± 0.095	0.917ThrHis: 0.917 ± 0.029	3.134ThrIle: 3.134 ± 0.061	1.27ThrLys: 1.27 ± 0.03	5.603ThrLeu: 5.603 ± 0.078	1.111ThrMet: 1.111 ± 0.029	1.251ThrAsn: 1.251 ± 0.033	3.473ThrPro: 3.473 ± 0.058	1.316ThrGln: 1.316 ± 0.029	3.486ThrArg: 3.486 ± 0.044	2.492ThrSer: 2.492 ± 0.054	2.573ThrThr: 2.573 ± 0.059	3.93ThrVal: 3.93 ± 0.065	0.596ThrTrp: 0.596 ± 0.024	1.121ThrTyr: 1.121 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.233ValAla: 10.233 ± 0.108	0.481ValCys: 0.481 ± 0.02	4.751ValAsp: 4.751 ± 0.063	4.391ValGlu: 4.391 ± 0.066	1.976ValPhe: 1.976 ± 0.041	5.395ValGly: 5.395 ± 0.073	1.323ValHis: 1.323 ± 0.035	3.583ValIle: 3.583 ± 0.059	1.964ValLys: 1.964 ± 0.044	6.146ValLeu: 6.146 ± 0.078	1.603ValMet: 1.603 ± 0.037	1.84ValAsn: 1.84 ± 0.042	3.88ValPro: 3.88 ± 0.058	1.964ValGln: 1.964 ± 0.045	5.305ValArg: 5.305 ± 0.074	3.75ValSer: 3.75 ± 0.057	4.314ValThr: 4.314 ± 0.076	4.999ValVal: 4.999 ± 0.068	0.753ValTrp: 0.753 ± 0.028	1.291ValTyr: 1.291 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.538TrpAla: 1.538 ± 0.037	0.13TrpCys: 0.13 ± 0.01	0.729TrpAsp: 0.729 ± 0.026	0.621TrpGlu: 0.621 ± 0.02	0.593TrpPhe: 0.593 ± 0.021	0.96TrpGly: 0.96 ± 0.028	0.338TrpHis: 0.338 ± 0.016	0.722TrpIle: 0.722 ± 0.023	0.456TrpLys: 0.456 ± 0.018	1.776TrpLeu: 1.776 ± 0.04	0.353TrpMet: 0.353 ± 0.016	0.438TrpAsn: 0.438 ± 0.02	0.76TrpPro: 0.76 ± 0.023	0.64TrpGln: 0.64 ± 0.022	1.381TrpArg: 1.381 ± 0.039	0.8TrpSer: 0.8 ± 0.025	0.843TrpThr: 0.843 ± 0.027	0.812TrpVal: 0.812 ± 0.023	0.238TrpTrp: 0.238 ± 0.014	0.274TrpTyr: 0.274 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.806TyrAla: 2.806 ± 0.048	0.229TyrCys: 0.229 ± 0.014	1.545TyrAsp: 1.545 ± 0.035	1.076TyrGlu: 1.076 ± 0.029	0.813TyrPhe: 0.813 ± 0.027	2.143TyrGly: 2.143 ± 0.05	0.475TyrHis: 0.475 ± 0.02	0.772TyrIle: 0.772 ± 0.026	0.557TyrLys: 0.557 ± 0.024	2.026TyrLeu: 2.026 ± 0.046	0.377TyrMet: 0.377 ± 0.016	0.553TyrAsn: 0.553 ± 0.026	0.999TyrPro: 0.999 ± 0.026	0.709TyrGln: 0.709 ± 0.023	1.967TyrArg: 1.967 ± 0.038	1.108TyrSer: 1.108 ± 0.026	0.935TyrThr: 0.935 ± 0.035	1.606TyrVal: 1.606 ± 0.038	0.346TyrTrp: 0.346 ± 0.015	0.614TyrTyr: 0.614 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4276 proteins (1329728 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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