Amino acid dipepetide frequency for Hamiltosporidium tvaerminnensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.114AlaAla: 1.114 ± 0.059	0.55AlaCys: 0.55 ± 0.018	1.37AlaAsp: 1.37 ± 0.03	1.914AlaGlu: 1.914 ± 0.036	1.432AlaPhe: 1.432 ± 0.026	0.892AlaGly: 0.892 ± 0.03	0.442AlaHis: 0.442 ± 0.016	2.481AlaIle: 2.481 ± 0.04	2.26AlaLys: 2.26 ± 0.039	2.608AlaLeu: 2.608 ± 0.038	0.531AlaMet: 0.531 ± 0.017	1.689AlaAsn: 1.689 ± 0.03	0.635AlaPro: 0.635 ± 0.024	0.768AlaGln: 0.768 ± 0.028	1.026AlaArg: 1.026 ± 0.027	1.897AlaSer: 1.897 ± 0.033	1.411AlaThr: 1.411 ± 0.029	1.554AlaVal: 1.554 ± 0.034	0.149AlaTrp: 0.149 ± 0.008	1.246AlaTyr: 1.246 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.449CysAla: 0.449 ± 0.015	0.507CysCys: 0.507 ± 0.018	1.009CysAsp: 1.009 ± 0.023	1.233CysGlu: 1.233 ± 0.024	1.273CysPhe: 1.273 ± 0.024	0.933CysGly: 0.933 ± 0.022	0.309CysHis: 0.309 ± 0.012	1.76CysIle: 1.76 ± 0.035	1.869CysLys: 1.869 ± 0.031	2.089CysLeu: 2.089 ± 0.032	0.426CysMet: 0.426 ± 0.013	1.414CysAsn: 1.414 ± 0.03	0.411CysPro: 0.411 ± 0.03	0.468CysGln: 0.468 ± 0.015	0.663CysArg: 0.663 ± 0.021	1.519CysSer: 1.519 ± 0.027	0.88CysThr: 0.88 ± 0.022	1.096CysVal: 1.096 ± 0.024	0.083CysTrp: 0.083 ± 0.005	1.046CysTyr: 1.046 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	1.3AspAla: 1.3 ± 0.03	0.994AspCys: 0.994 ± 0.023	2.333AspAsp: 2.333 ± 0.04	3.555AspGlu: 3.555 ± 0.052	3.68AspPhe: 3.68 ± 0.055	1.982AspGly: 1.982 ± 0.03	0.626AspHis: 0.626 ± 0.014	5.913AspIle: 5.913 ± 0.06	4.616AspLys: 4.616 ± 0.06	5.375AspLeu: 5.375 ± 0.055	1.039AspMet: 1.039 ± 0.021	3.848AspAsn: 3.848 ± 0.074	1.063AspPro: 1.063 ± 0.024	0.95AspGln: 0.95 ± 0.025	2.007AspArg: 2.007 ± 0.033	4.955AspSer: 4.955 ± 0.063	2.828AspThr: 2.828 ± 0.044	2.426AspVal: 2.426 ± 0.039	0.304AspTrp: 0.304 ± 0.013	2.141AspTyr: 2.141 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	2.157GluAla: 2.157 ± 0.041	1.374GluCys: 1.374 ± 0.027	3.669GluAsp: 3.669 ± 0.052	7.455GluGlu: 7.455 ± 0.11	3.729GluPhe: 3.729 ± 0.053	2.862GluGly: 2.862 ± 0.072	0.992GluHis: 0.992 ± 0.024	9.05GluIle: 9.05 ± 0.086	7.818GluLys: 7.818 ± 0.083	5.215GluLeu: 5.215 ± 0.058	1.882GluMet: 1.882 ± 0.033	7.664GluAsn: 7.664 ± 0.085	1.536GluPro: 1.536 ± 0.029	1.499GluGln: 1.499 ± 0.032	2.825GluArg: 2.825 ± 0.043	5.322GluSer: 5.322 ± 0.058	3.622GluThr: 3.622 ± 0.046	3.394GluVal: 3.394 ± 0.049	0.427GluTrp: 0.427 ± 0.015	3.52GluTyr: 3.52 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	1.267PheAla: 1.267 ± 0.025	1.445PheCys: 1.445 ± 0.026	3.496PheAsp: 3.496 ± 0.046	4.195PheGlu: 4.195 ± 0.055	3.947PhePhe: 3.947 ± 0.06	2.005PheGly: 2.005 ± 0.037	0.985PheHis: 0.985 ± 0.024	5.944PheIle: 5.944 ± 0.059	5.647PheLys: 5.647 ± 0.062	7.021PheLeu: 7.021 ± 0.079	1.123PheMet: 1.123 ± 0.023	3.86PheAsn: 3.86 ± 0.048	1.432PhePro: 1.432 ± 0.031	1.36PheGln: 1.36 ± 0.028	1.904PheArg: 1.904 ± 0.031	4.794PheSer: 4.794 ± 0.059	2.544PheThr: 2.544 ± 0.038	2.786PheVal: 2.786 ± 0.048	0.426PheTrp: 0.426 ± 0.012	3.482PheTyr: 3.482 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	1.113GlyAla: 1.113 ± 0.036	0.893GlyCys: 0.893 ± 0.022	1.769GlyAsp: 1.769 ± 0.052	1.907GlyGlu: 1.907 ± 0.033	2.044GlyPhe: 2.044 ± 0.031	2.014GlyGly: 2.014 ± 0.068	0.568GlyHis: 0.568 ± 0.018	3.8GlyIle: 3.8 ± 0.047	2.9GlyLys: 2.9 ± 0.043	3.436GlyLeu: 3.436 ± 0.051	0.801GlyMet: 0.801 ± 0.023	2.586GlyAsn: 2.586 ± 0.04	0.553GlyPro: 0.553 ± 0.019	0.576GlyGln: 0.576 ± 0.033	1.336GlyArg: 1.336 ± 0.03	2.539GlySer: 2.539 ± 0.055	1.6GlyThr: 1.6 ± 0.033	3.771GlyVal: 3.771 ± 0.133	0.253GlyTrp: 0.253 ± 0.011	1.597GlyTyr: 1.597 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	0.476HisAla: 0.476 ± 0.016	0.392HisCys: 0.392 ± 0.012	0.697HisAsp: 0.697 ± 0.02	1.1HisGlu: 1.1 ± 0.024	1.09HisPhe: 1.09 ± 0.024	0.482HisGly: 0.482 ± 0.017	0.329HisHis: 0.329 ± 0.012	1.601HisIle: 1.601 ± 0.03	1.55HisLys: 1.55 ± 0.029	2.094HisLeu: 2.094 ± 0.034	0.344HisMet: 0.344 ± 0.013	1.122HisAsn: 1.122 ± 0.021	1.087HisPro: 1.087 ± 0.043	0.421HisGln: 0.421 ± 0.015	0.579HisArg: 0.579 ± 0.018	1.469HisSer: 1.469 ± 0.027	0.912HisThr: 0.912 ± 0.028	0.709HisVal: 0.709 ± 0.019	0.065HisTrp: 0.065 ± 0.007	0.583HisTyr: 0.583 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	2.143IleAla: 2.143 ± 0.037	1.988IleCys: 1.988 ± 0.03	4.923IleAsp: 4.923 ± 0.057	7.101IleGlu: 7.101 ± 0.06	7.311IlePhe: 7.311 ± 0.078	3.059IleGly: 3.059 ± 0.04	1.7IleHis: 1.7 ± 0.032	7.82IleIle: 7.82 ± 0.072	9.429IleLys: 9.429 ± 0.079	10.536IleLeu: 10.536 ± 0.095	1.659IleMet: 1.659 ± 0.029	7.394IleAsn: 7.394 ± 0.075	3.213IlePro: 3.213 ± 0.048	2.819IleGln: 2.819 ± 0.039	3.547IleArg: 3.547 ± 0.051	8.883IleSer: 8.883 ± 0.078	4.33IleThr: 4.33 ± 0.06	4.237IleVal: 4.237 ± 0.053	0.428IleTrp: 0.428 ± 0.015	4.734IleTyr: 4.734 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	2.394LysAla: 2.394 ± 0.045	1.807LysCys: 1.807 ± 0.033	5.223LysAsp: 5.223 ± 0.082	8.769LysGlu: 8.769 ± 0.096	4.524LysPhe: 4.524 ± 0.068	3.587LysGly: 3.587 ± 0.079	1.419LysHis: 1.419 ± 0.025	10.618LysIle: 10.618 ± 0.085	10.125LysLys: 10.125 ± 0.086	7.28LysLeu: 7.28 ± 0.067	2.165LysMet: 2.165 ± 0.034	10.302LysAsn: 10.302 ± 0.099	2.018LysPro: 2.018 ± 0.042	2.483LysGln: 2.483 ± 0.041	4.103LysArg: 4.103 ± 0.054	6.608LysSer: 6.608 ± 0.068	4.805LysThr: 4.805 ± 0.055	3.968LysVal: 3.968 ± 0.043	0.416LysTrp: 0.416 ± 0.015	5.499LysTyr: 5.499 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	2.667LeuAla: 2.667 ± 0.043	1.754LeuCys: 1.754 ± 0.031	5.107LeuAsp: 5.107 ± 0.053	8.235LeuGlu: 8.235 ± 0.075	5.622LeuPhe: 5.622 ± 0.068	2.994LeuGly: 2.994 ± 0.046	1.96LeuHis: 1.96 ± 0.032	7.937LeuIle: 7.937 ± 0.067	11.19LeuLys: 11.19 ± 0.094	8.754LeuLeu: 8.754 ± 0.085	1.466LeuMet: 1.466 ± 0.025	8.34LeuAsn: 8.34 ± 0.074	2.627LeuPro: 2.627 ± 0.039	2.899LeuGln: 2.899 ± 0.037	3.76LeuArg: 3.76 ± 0.047	7.3LeuSer: 7.3 ± 0.068	3.922LeuThr: 3.922 ± 0.048	3.806LeuVal: 3.806 ± 0.044	0.386LeuTrp: 0.386 ± 0.013	4.503LeuTyr: 4.503 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	0.694MetAla: 0.694 ± 0.02	0.519MetCys: 0.519 ± 0.016	0.964MetAsp: 0.964 ± 0.022	1.334MetGlu: 1.334 ± 0.028	1.065MetPhe: 1.065 ± 0.023	0.904MetGly: 0.904 ± 0.028	0.504MetHis: 0.504 ± 0.016	1.531MetIle: 1.531 ± 0.032	1.987MetLys: 1.987 ± 0.035	1.742MetLeu: 1.742 ± 0.031	0.394MetMet: 0.394 ± 0.016	1.706MetAsn: 1.706 ± 0.026	0.524MetPro: 0.524 ± 0.015	0.53MetGln: 0.53 ± 0.018	0.775MetArg: 0.775 ± 0.021	1.252MetSer: 1.252 ± 0.023	1.011MetThr: 1.011 ± 0.02	0.954MetVal: 0.954 ± 0.024	0.125MetTrp: 0.125 ± 0.008	0.826MetTyr: 0.826 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	1.886AsnAla: 1.886 ± 0.033	1.268AsnCys: 1.268 ± 0.027	4.059AsnAsp: 4.059 ± 0.047	6.666AsnGlu: 6.666 ± 0.07	4.879AsnPhe: 4.879 ± 0.061	2.308AsnGly: 2.308 ± 0.037	1.326AsnHis: 1.326 ± 0.025	10.345AsnIle: 10.345 ± 0.098	7.89AsnLys: 7.89 ± 0.093	8.127AsnLeu: 8.127 ± 0.083	1.555AsnMet: 1.555 ± 0.029	8.927AsnAsn: 8.927 ± 0.203	2.183AsnPro: 2.183 ± 0.056	2.097AsnGln: 2.097 ± 0.04	2.928AsnArg: 2.928 ± 0.047	6.406AsnSer: 6.406 ± 0.094	6.578AsnThr: 6.578 ± 0.169	3.457AsnVal: 3.457 ± 0.042	0.367AsnTrp: 0.367 ± 0.013	3.459AsnTyr: 3.459 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	0.709ProAla: 0.709 ± 0.027	0.463ProCys: 0.463 ± 0.026	1.161ProAsp: 1.161 ± 0.026	1.728ProGlu: 1.728 ± 0.034	1.643ProPhe: 1.643 ± 0.032	0.849ProGly: 0.849 ± 0.024	0.468ProHis: 0.468 ± 0.017	2.097ProIle: 2.097 ± 0.037	2.11ProLys: 2.11 ± 0.035	2.775ProLeu: 2.775 ± 0.046	0.522ProMet: 0.522 ± 0.018	2.022ProAsn: 2.022 ± 0.044	1.357ProPro: 1.357 ± 0.058	0.669ProGln: 0.669 ± 0.024	1.066ProArg: 1.066 ± 0.025	2.309ProSer: 2.309 ± 0.045	1.692ProThr: 1.692 ± 0.033	1.395ProVal: 1.395 ± 0.037	0.105ProTrp: 0.105 ± 0.009	1.26ProTyr: 1.26 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	0.801GlnAla: 0.801 ± 0.023	0.366GlnCys: 0.366 ± 0.014	1.283GlnAsp: 1.283 ± 0.028	1.901GlnGlu: 1.901 ± 0.034	1.007GlnPhe: 1.007 ± 0.025	1.151GlnGly: 1.151 ± 0.05	0.769GlnHis: 0.769 ± 0.027	2.5GlnIle: 2.5 ± 0.036	2.533GlnLys: 2.533 ± 0.039	1.783GlnLeu: 1.783 ± 0.033	0.502GlnMet: 0.502 ± 0.018	2.426GlnAsn: 2.426 ± 0.041	0.829GlnPro: 0.829 ± 0.038	1.047GlnGln: 1.047 ± 0.048	0.927GlnArg: 0.927 ± 0.023	1.823GlnSer: 1.823 ± 0.036	1.305GlnThr: 1.305 ± 0.028	0.874GlnVal: 0.874 ± 0.019	0.096GlnTrp: 0.096 ± 0.006	0.88GlnTyr: 0.88 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	1.183ArgAla: 1.183 ± 0.028	0.876ArgCys: 0.876 ± 0.024	2.048ArgAsp: 2.048 ± 0.047	2.311ArgGlu: 2.311 ± 0.041	1.928ArgPhe: 1.928 ± 0.029	1.932ArgGly: 1.932 ± 0.049	0.576ArgHis: 0.576 ± 0.016	3.858ArgIle: 3.858 ± 0.047	4.031ArgLys: 4.031 ± 0.055	3.326ArgLeu: 3.326 ± 0.042	0.847ArgMet: 0.847 ± 0.021	3.474ArgAsn: 3.474 ± 0.042	0.968ArgPro: 0.968 ± 0.024	0.813ArgGln: 0.813 ± 0.023	2.199ArgArg: 2.199 ± 0.044	2.408ArgSer: 2.408 ± 0.035	1.46ArgThr: 1.46 ± 0.027	1.777ArgVal: 1.777 ± 0.031	0.264ArgTrp: 0.264 ± 0.01	1.571ArgTyr: 1.571 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	1.947SerAla: 1.947 ± 0.035	1.256SerCys: 1.256 ± 0.024	4.434SerAsp: 4.434 ± 0.058	5.52SerGlu: 5.52 ± 0.063	4.736SerPhe: 4.736 ± 0.049	2.776SerGly: 2.776 ± 0.042	1.377SerHis: 1.377 ± 0.029	6.994SerIle: 6.994 ± 0.076	7.907SerLys: 7.907 ± 0.081	7.596SerLeu: 7.596 ± 0.072	1.429SerMet: 1.429 ± 0.028	7.024SerAsn: 7.024 ± 0.118	1.655SerPro: 1.655 ± 0.043	1.911SerGln: 1.911 ± 0.033	2.695SerArg: 2.695 ± 0.041	6.809SerSer: 6.809 ± 0.093	3.916SerThr: 3.916 ± 0.061	4.408SerVal: 4.408 ± 0.046	0.459SerTrp: 0.459 ± 0.015	3.398SerTyr: 3.398 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	1.352ThrAla: 1.352 ± 0.028	0.917ThrCys: 0.917 ± 0.024	2.881ThrAsp: 2.881 ± 0.039	3.491ThrGlu: 3.491 ± 0.046	2.592ThrPhe: 2.592 ± 0.036	1.6ThrGly: 1.6 ± 0.034	1.046ThrHis: 1.046 ± 0.024	4.09ThrIle: 4.09 ± 0.046	4.427ThrLys: 4.427 ± 0.047	5.027ThrLeu: 5.027 ± 0.061	0.725ThrMet: 0.725 ± 0.019	5.198ThrAsn: 5.198 ± 0.121	2.147ThrPro: 2.147 ± 0.059	1.162ThrGln: 1.162 ± 0.029	1.963ThrArg: 1.963 ± 0.041	3.822ThrSer: 3.822 ± 0.053	3.179ThrThr: 3.179 ± 0.077	2.525ThrVal: 2.525 ± 0.045	0.398ThrTrp: 0.398 ± 0.015	2.078ThrTyr: 2.078 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	1.149ValAla: 1.149 ± 0.029	1.058ValCys: 1.058 ± 0.022	2.488ValAsp: 2.488 ± 0.039	4.162ValGlu: 4.162 ± 0.057	3.267ValPhe: 3.267 ± 0.038	1.981ValGly: 1.981 ± 0.04	0.641ValHis: 0.641 ± 0.017	3.876ValIle: 3.876 ± 0.048	4.32ValLys: 4.32 ± 0.046	5.002ValLeu: 5.002 ± 0.047	0.992ValMet: 0.992 ± 0.017	3.605ValAsn: 3.605 ± 0.081	1.1ValPro: 1.1 ± 0.026	1.28ValGln: 1.28 ± 0.029	1.683ValArg: 1.683 ± 0.033	4.395ValSer: 4.395 ± 0.061	2.19ValThr: 2.19 ± 0.039	2.744ValVal: 2.744 ± 0.042	0.265ValTrp: 0.265 ± 0.011	1.934ValTyr: 1.934 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.121TrpAla: 0.121 ± 0.007	0.13TrpCys: 0.13 ± 0.007	0.398TrpAsp: 0.398 ± 0.014	0.412TrpGlu: 0.412 ± 0.014	0.292TrpPhe: 0.292 ± 0.011	0.238TrpGly: 0.238 ± 0.011	0.074TrpHis: 0.074 ± 0.006	0.497TrpIle: 0.497 ± 0.017	0.536TrpLys: 0.536 ± 0.014	0.505TrpLeu: 0.505 ± 0.016	0.118TrpMet: 0.118 ± 0.007	0.427TrpAsn: 0.427 ± 0.014	0.201TrpPro: 0.201 ± 0.01	0.106TrpGln: 0.106 ± 0.007	0.172TrpArg: 0.172 ± 0.01	0.349TrpSer: 0.349 ± 0.012	0.204TrpThr: 0.204 ± 0.011	0.223TrpVal: 0.223 ± 0.011	0.054TrpTrp: 0.054 ± 0.005	0.222TrpTyr: 0.222 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.047TyrAla: 1.047 ± 0.021	0.88TyrCys: 0.88 ± 0.02	2.625TyrAsp: 2.625 ± 0.035	3.025TyrGlu: 3.025 ± 0.049	3.598TyrPhe: 3.598 ± 0.048	1.508TyrGly: 1.508 ± 0.037	0.99TyrHis: 0.99 ± 0.026	4.541TyrIle: 4.541 ± 0.055	4.97TyrLys: 4.97 ± 0.065	4.938TyrLeu: 4.938 ± 0.045	0.82TyrMet: 0.82 ± 0.02	3.68TyrAsn: 3.68 ± 0.054	0.862TyrPro: 0.862 ± 0.02	0.946TyrGln: 0.946 ± 0.023	1.691TyrArg: 1.691 ± 0.029	3.388TyrSer: 3.388 ± 0.052	2.228TyrThr: 2.228 ± 0.046	2.031TyrVal: 2.031 ± 0.026	0.21TyrTrp: 0.21 ± 0.01	1.858TyrTyr: 1.858 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5820 proteins (2114574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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