Amino acid dipepetide frequency for Jannaschia helgolandensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.335AlaAla: 16.335 ± 0.191	1.156AlaCys: 1.156 ± 0.036	7.526AlaAsp: 7.526 ± 0.094	7.435AlaGlu: 7.435 ± 0.11	4.277AlaPhe: 4.277 ± 0.066	10.515AlaGly: 10.515 ± 0.117	2.167AlaHis: 2.167 ± 0.054	6.309AlaIle: 6.309 ± 0.093	3.362AlaLys: 3.362 ± 0.065	13.565AlaLeu: 13.565 ± 0.152	3.989AlaMet: 3.989 ± 0.067	2.788AlaAsn: 2.788 ± 0.058	5.715AlaPro: 5.715 ± 0.091	4.315AlaGln: 4.315 ± 0.07	9.331AlaArg: 9.331 ± 0.116	5.847AlaSer: 5.847 ± 0.081	6.932AlaThr: 6.932 ± 0.086	8.57AlaVal: 8.57 ± 0.105	1.468AlaTrp: 1.468 ± 0.04	2.339AlaTyr: 2.339 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.078CysAla: 1.078 ± 0.034	0.099CysCys: 0.099 ± 0.012	0.661CysAsp: 0.661 ± 0.022	0.429CysGlu: 0.429 ± 0.019	0.301CysPhe: 0.301 ± 0.019	0.884CysGly: 0.884 ± 0.033	0.274CysHis: 0.274 ± 0.016	0.438CysIle: 0.438 ± 0.022	0.195CysLys: 0.195 ± 0.013	0.776CysLeu: 0.776 ± 0.028	0.146CysMet: 0.146 ± 0.012	0.211CysAsn: 0.211 ± 0.015	0.495CysPro: 0.495 ± 0.024	0.206CysGln: 0.206 ± 0.013	0.54CysArg: 0.54 ± 0.022	0.405CysSer: 0.405 ± 0.022	0.444CysThr: 0.444 ± 0.022	0.566CysVal: 0.566 ± 0.023	0.094CysTrp: 0.094 ± 0.011	0.193CysTyr: 0.193 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.513AspAla: 8.513 ± 0.1	0.547AspCys: 0.547 ± 0.024	4.124AspAsp: 4.124 ± 0.083	3.309AspGlu: 3.309 ± 0.065	2.242AspPhe: 2.242 ± 0.05	6.318AspGly: 6.318 ± 0.105	1.42AspHis: 1.42 ± 0.045	3.35AspIle: 3.35 ± 0.053	1.546AspLys: 1.546 ± 0.036	7.01AspLeu: 7.01 ± 0.085	1.891AspMet: 1.891 ± 0.046	1.29AspAsn: 1.29 ± 0.036	3.892AspPro: 3.892 ± 0.063	1.86AspGln: 1.86 ± 0.045	5.151AspArg: 5.151 ± 0.073	2.086AspSer: 2.086 ± 0.053	3.457AspThr: 3.457 ± 0.071	4.701AspVal: 4.701 ± 0.062	1.372AspTrp: 1.372 ± 0.038	1.508AspTyr: 1.508 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.376GluAla: 7.376 ± 0.1	0.321GluCys: 0.321 ± 0.017	3.222GluAsp: 3.222 ± 0.071	2.938GluGlu: 2.938 ± 0.069	1.548GluPhe: 1.548 ± 0.04	4.546GluGly: 4.546 ± 0.065	0.973GluHis: 0.973 ± 0.037	3.365GluIle: 3.365 ± 0.062	1.735GluLys: 1.735 ± 0.051	4.487GluLeu: 4.487 ± 0.073	1.811GluMet: 1.811 ± 0.046	1.585GluAsn: 1.585 ± 0.04	2.283GluPro: 2.283 ± 0.046	1.689GluGln: 1.689 ± 0.043	4.172GluArg: 4.172 ± 0.064	2.057GluSer: 2.057 ± 0.041	3.783GluThr: 3.783 ± 0.067	4.226GluVal: 4.226 ± 0.06	0.711GluTrp: 0.711 ± 0.026	0.972GluTyr: 0.972 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.487PheAla: 4.487 ± 0.054	0.379PheCys: 0.379 ± 0.022	2.895PheAsp: 2.895 ± 0.056	2.034PheGlu: 2.034 ± 0.045	1.288PhePhe: 1.288 ± 0.04	3.659PheGly: 3.659 ± 0.06	0.735PheHis: 0.735 ± 0.022	1.578PheIle: 1.578 ± 0.038	0.816PheLys: 0.816 ± 0.032	3.43PheLeu: 3.43 ± 0.057	0.83PheMet: 0.83 ± 0.027	0.889PheAsn: 0.889 ± 0.028	1.557PhePro: 1.557 ± 0.04	0.954PheGln: 0.954 ± 0.031	2.243PheArg: 2.243 ± 0.047	1.923PheSer: 1.923 ± 0.047	1.991PheThr: 1.991 ± 0.045	2.659PheVal: 2.659 ± 0.052	0.553PheTrp: 0.553 ± 0.024	0.792PheTyr: 0.792 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.766GlyAla: 9.766 ± 0.127	0.827GlyCys: 0.827 ± 0.03	5.246GlyAsp: 5.246 ± 0.093	4.42GlyGlu: 4.42 ± 0.078	3.739GlyPhe: 3.739 ± 0.065	7.751GlyGly: 7.751 ± 0.147	1.934GlyHis: 1.934 ± 0.044	4.628GlyIle: 4.628 ± 0.07	2.961GlyLys: 2.961 ± 0.065	9.489GlyLeu: 9.489 ± 0.099	2.538GlyMet: 2.538 ± 0.047	2.163GlyAsn: 2.163 ± 0.059	3.89GlyPro: 3.89 ± 0.059	3.064GlyGln: 3.064 ± 0.058	6.057GlyArg: 6.057 ± 0.077	4.354GlySer: 4.354 ± 0.077	5.289GlyThr: 5.289 ± 0.091	6.61GlyVal: 6.61 ± 0.09	1.575GlyTrp: 1.575 ± 0.04	2.205GlyTyr: 2.205 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.277HisAla: 2.277 ± 0.049	0.22HisCys: 0.22 ± 0.016	1.364HisAsp: 1.364 ± 0.036	0.945HisGlu: 0.945 ± 0.031	0.741HisPhe: 0.741 ± 0.031	1.825HisGly: 1.825 ± 0.049	0.572HisHis: 0.572 ± 0.028	0.963HisIle: 0.963 ± 0.029	0.415HisLys: 0.415 ± 0.021	2.062HisLeu: 2.062 ± 0.052	0.542HisMet: 0.542 ± 0.023	0.402HisAsn: 0.402 ± 0.02	1.306HisPro: 1.306 ± 0.043	0.512HisGln: 0.512 ± 0.02	1.408HisArg: 1.408 ± 0.041	0.866HisSer: 0.866 ± 0.033	0.806HisThr: 0.806 ± 0.029	1.57HisVal: 1.57 ± 0.046	0.358HisTrp: 0.358 ± 0.019	0.464HisTyr: 0.464 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.364IleAla: 7.364 ± 0.085	0.565IleCys: 0.565 ± 0.024	3.765IleAsp: 3.765 ± 0.06	3.452IleGlu: 3.452 ± 0.067	1.797IlePhe: 1.797 ± 0.045	5.086IleGly: 5.086 ± 0.071	0.919IleHis: 0.919 ± 0.034	2.221IleIle: 2.221 ± 0.059	1.227IleLys: 1.227 ± 0.034	5.205IleLeu: 5.205 ± 0.08	1.113IleMet: 1.113 ± 0.032	1.269IleAsn: 1.269 ± 0.039	2.455IlePro: 2.455 ± 0.051	1.138IleGln: 1.138 ± 0.036	3.325IleArg: 3.325 ± 0.057	2.751IleSer: 2.751 ± 0.057	2.86IleThr: 2.86 ± 0.049	4.17IleVal: 4.17 ± 0.067	0.753IleTrp: 0.753 ± 0.025	1.085IleTyr: 1.085 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.367LysAla: 3.367 ± 0.069	0.165LysCys: 0.165 ± 0.013	1.601LysAsp: 1.601 ± 0.045	1.136LysGlu: 1.136 ± 0.032	0.805LysPhe: 0.805 ± 0.032	2.39LysGly: 2.39 ± 0.052	0.563LysHis: 0.563 ± 0.023	1.495LysIle: 1.495 ± 0.039	0.955LysLys: 0.955 ± 0.043	2.687LysLeu: 2.687 ± 0.057	0.786LysMet: 0.786 ± 0.028	0.698LysAsn: 0.698 ± 0.032	1.629LysPro: 1.629 ± 0.05	0.735LysGln: 0.735 ± 0.028	2.134LysArg: 2.134 ± 0.047	1.718LysSer: 1.718 ± 0.05	1.786LysThr: 1.786 ± 0.045	2.085LysVal: 2.085 ± 0.056	0.348LysTrp: 0.348 ± 0.017	0.57LysTyr: 0.57 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.707LeuAla: 12.707 ± 0.125	0.846LeuCys: 0.846 ± 0.029	6.416LeuAsp: 6.416 ± 0.085	4.882LeuGlu: 4.882 ± 0.074	3.449LeuPhe: 3.449 ± 0.068	8.309LeuGly: 8.309 ± 0.099	1.859LeuHis: 1.859 ± 0.04	5.459LeuIle: 5.459 ± 0.076	2.816LeuLys: 2.816 ± 0.057	8.943LeuLeu: 8.943 ± 0.11	2.797LeuMet: 2.797 ± 0.059	2.721LeuAsn: 2.721 ± 0.059	5.695LeuPro: 5.695 ± 0.088	2.613LeuGln: 2.613 ± 0.052	7.532LeuArg: 7.532 ± 0.101	6.83LeuSer: 6.83 ± 0.084	6.866LeuThr: 6.866 ± 0.101	6.704LeuVal: 6.704 ± 0.094	1.319LeuTrp: 1.319 ± 0.038	1.847LeuTyr: 1.847 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.644MetAla: 3.644 ± 0.058	0.176MetCys: 0.176 ± 0.015	1.577MetAsp: 1.577 ± 0.041	1.346MetGlu: 1.346 ± 0.036	0.834MetPhe: 0.834 ± 0.031	2.381MetGly: 2.381 ± 0.051	0.467MetHis: 0.467 ± 0.021	1.645MetIle: 1.645 ± 0.044	1.022MetLys: 1.022 ± 0.032	2.679MetLeu: 2.679 ± 0.055	0.812MetMet: 0.812 ± 0.032	0.833MetAsn: 0.833 ± 0.026	1.642MetPro: 1.642 ± 0.038	1.002MetGln: 1.002 ± 0.028	1.889MetArg: 1.889 ± 0.047	1.644MetSer: 1.644 ± 0.036	2.312MetThr: 2.312 ± 0.051	1.881MetVal: 1.881 ± 0.04	0.251MetTrp: 0.251 ± 0.016	0.329MetTyr: 0.329 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.136AsnAla: 3.136 ± 0.06	0.237AsnCys: 0.237 ± 0.014	1.543AsnAsp: 1.543 ± 0.057	1.015AsnGlu: 1.015 ± 0.032	0.87AsnPhe: 0.87 ± 0.032	2.355AsnGly: 2.355 ± 0.058	0.474AsnHis: 0.474 ± 0.02	1.36AsnIle: 1.36 ± 0.041	0.576AsnLys: 0.576 ± 0.025	2.456AsnLeu: 2.456 ± 0.051	0.678AsnMet: 0.678 ± 0.028	0.608AsnAsn: 0.608 ± 0.03	1.825AsnPro: 1.825 ± 0.032	0.668AsnGln: 0.668 ± 0.028	1.825AsnArg: 1.825 ± 0.044	1.064AsnSer: 1.064 ± 0.037	1.328AsnThr: 1.328 ± 0.038	1.884AsnVal: 1.884 ± 0.045	0.409AsnTrp: 0.409 ± 0.02	0.579AsnTyr: 0.579 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.715ProAla: 5.715 ± 0.083	0.363ProCys: 0.363 ± 0.018	4.545ProAsp: 4.545 ± 0.067	3.72ProGlu: 3.72 ± 0.058	1.944ProPhe: 1.944 ± 0.043	4.688ProGly: 4.688 ± 0.077	0.999ProHis: 0.999 ± 0.033	2.306ProIle: 2.306 ± 0.049	1.482ProLys: 1.482 ± 0.048	4.653ProLeu: 4.653 ± 0.064	1.388ProMet: 1.388 ± 0.04	1.288ProAsn: 1.288 ± 0.032	2.338ProPro: 2.338 ± 0.049	1.518ProGln: 1.518 ± 0.038	2.959ProArg: 2.959 ± 0.057	2.616ProSer: 2.616 ± 0.054	2.664ProThr: 2.664 ± 0.045	4.464ProVal: 4.464 ± 0.065	0.693ProTrp: 0.693 ± 0.025	1.014ProTyr: 1.014 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.077GlnAla: 4.077 ± 0.077	0.183GlnCys: 0.183 ± 0.014	1.764GlnAsp: 1.764 ± 0.037	1.363GlnGlu: 1.363 ± 0.037	0.976GlnPhe: 0.976 ± 0.03	2.521GlnGly: 2.521 ± 0.052	0.48GlnHis: 0.48 ± 0.021	1.908GlnIle: 1.908 ± 0.036	0.902GlnLys: 0.902 ± 0.029	2.597GlnLeu: 2.597 ± 0.055	1.037GlnMet: 1.037 ± 0.034	0.769GlnAsn: 0.769 ± 0.029	1.463GlnPro: 1.463 ± 0.036	0.975GlnGln: 0.975 ± 0.033	1.987GlnArg: 1.987 ± 0.049	1.677GlnSer: 1.677 ± 0.039	1.989GlnThr: 1.989 ± 0.046	2.415GlnVal: 2.415 ± 0.048	0.373GlnTrp: 0.373 ± 0.02	0.507GlnTyr: 0.507 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.578ArgAla: 8.578 ± 0.11	0.475ArgCys: 0.475 ± 0.023	5.136ArgAsp: 5.136 ± 0.072	3.543ArgGlu: 3.543 ± 0.064	2.6ArgPhe: 2.6 ± 0.053	4.934ArgGly: 4.934 ± 0.072	1.611ArgHis: 1.611 ± 0.043	4.17ArgIle: 4.17 ± 0.068	2.068ArgLys: 2.068 ± 0.049	7.686ArgLeu: 7.686 ± 0.111	2.152ArgMet: 2.152 ± 0.049	1.846ArgAsn: 1.846 ± 0.042	3.439ArgPro: 3.439 ± 0.069	2.282ArgGln: 2.282 ± 0.045	5.346ArgArg: 5.346 ± 0.09	3.413ArgSer: 3.413 ± 0.062	3.741ArgThr: 3.741 ± 0.059	4.957ArgVal: 4.957 ± 0.069	0.951ArgTrp: 0.951 ± 0.032	1.505ArgTyr: 1.505 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.764SerAla: 5.764 ± 0.08	0.388SerCys: 0.388 ± 0.023	3.669SerAsp: 3.669 ± 0.064	2.835SerGlu: 2.835 ± 0.056	1.967SerPhe: 1.967 ± 0.047	5.542SerGly: 5.542 ± 0.08	0.946SerHis: 0.946 ± 0.03	2.527SerIle: 2.527 ± 0.057	1.366SerLys: 1.366 ± 0.037	4.912SerLeu: 4.912 ± 0.062	1.368SerMet: 1.368 ± 0.036	1.335SerAsn: 1.335 ± 0.037	2.486SerPro: 2.486 ± 0.046	1.504SerGln: 1.504 ± 0.041	3.421SerArg: 3.421 ± 0.068	2.522SerSer: 2.522 ± 0.052	2.524SerThr: 2.524 ± 0.054	3.907SerVal: 3.907 ± 0.062	0.687SerTrp: 0.687 ± 0.025	1.163SerTyr: 1.163 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.74ThrAla: 6.74 ± 0.093	0.519ThrCys: 0.519 ± 0.022	3.757ThrAsp: 3.757 ± 0.065	2.986ThrGlu: 2.986 ± 0.058	2.216ThrPhe: 2.216 ± 0.046	6.03ThrGly: 6.03 ± 0.09	1.143ThrHis: 1.143 ± 0.031	2.963ThrIle: 2.963 ± 0.066	1.323ThrLys: 1.323 ± 0.033	6.475ThrLeu: 6.475 ± 0.09	1.5ThrMet: 1.5 ± 0.037	1.309ThrAsn: 1.309 ± 0.036	3.667ThrPro: 3.667 ± 0.056	1.689ThrGln: 1.689 ± 0.042	3.975ThrArg: 3.975 ± 0.066	2.932ThrSer: 2.932 ± 0.056	3.153ThrThr: 3.153 ± 0.066	4.666ThrVal: 4.666 ± 0.061	0.716ThrTrp: 0.716 ± 0.028	1.273ThrTyr: 1.273 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.249ValAla: 9.249 ± 0.1	0.637ValCys: 0.637 ± 0.024	4.378ValAsp: 4.378 ± 0.06	4.34ValGlu: 4.34 ± 0.075	2.705ValPhe: 2.705 ± 0.05	5.687ValGly: 5.687 ± 0.085	1.3ValHis: 1.3 ± 0.04	4.189ValIle: 4.189 ± 0.067	1.968ValLys: 1.968 ± 0.042	7.626ValLeu: 7.626 ± 0.096	2.113ValMet: 2.113 ± 0.047	1.96ValAsn: 1.96 ± 0.056	3.859ValPro: 3.859 ± 0.068	2.098ValGln: 2.098 ± 0.039	4.509ValArg: 4.509 ± 0.067	4.242ValSer: 4.242 ± 0.062	5.121ValThr: 5.121 ± 0.066	5.623ValVal: 5.623 ± 0.081	1.038ValTrp: 1.038 ± 0.035	1.36ValTyr: 1.36 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.375TrpAla: 1.375 ± 0.038	0.13TrpCys: 0.13 ± 0.013	0.834TrpAsp: 0.834 ± 0.028	0.562TrpGlu: 0.562 ± 0.021	0.57TrpPhe: 0.57 ± 0.024	1.017TrpGly: 1.017 ± 0.035	0.314TrpHis: 0.314 ± 0.017	0.755TrpIle: 0.755 ± 0.026	0.45TrpLys: 0.45 ± 0.023	1.721TrpLeu: 1.721 ± 0.046	0.436TrpMet: 0.436 ± 0.022	0.426TrpAsn: 0.426 ± 0.021	0.723TrpPro: 0.723 ± 0.027	0.596TrpGln: 0.596 ± 0.024	1.115TrpArg: 1.115 ± 0.034	0.835TrpSer: 0.835 ± 0.031	0.941TrpThr: 0.941 ± 0.032	0.945TrpVal: 0.945 ± 0.029	0.257TrpTrp: 0.257 ± 0.017	0.264TrpTyr: 0.264 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.395TyrAla: 2.395 ± 0.053	0.203TyrCys: 0.203 ± 0.014	1.565TyrAsp: 1.565 ± 0.042	1.112TyrGlu: 1.112 ± 0.031	0.822TyrPhe: 0.822 ± 0.025	2.069TyrGly: 2.069 ± 0.049	0.467TyrHis: 0.467 ± 0.021	0.891TyrIle: 0.891 ± 0.028	0.47TyrLys: 0.47 ± 0.021	2.151TyrLeu: 2.151 ± 0.044	0.437TyrMet: 0.437 ± 0.019	0.498TyrAsn: 0.498 ± 0.024	0.996TyrPro: 0.996 ± 0.033	0.547TyrGln: 0.547 ± 0.024	1.512TyrArg: 1.512 ± 0.044	1.052TyrSer: 1.052 ± 0.039	1.045TyrThr: 1.045 ± 0.032	1.402TyrVal: 1.402 ± 0.037	0.337TyrTrp: 0.337 ± 0.021	0.522TyrTyr: 0.522 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3471 proteins (1060539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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