Amino acid dipepetide frequency for Ancrocorticia populi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.268AlaAla: 14.268 ± 0.18	0.938AlaCys: 0.938 ± 0.04	6.725AlaAsp: 6.725 ± 0.107	7.216AlaGlu: 7.216 ± 0.115	3.435AlaPhe: 3.435 ± 0.074	10.431AlaGly: 10.431 ± 0.129	2.095AlaHis: 2.095 ± 0.058	6.097AlaIle: 6.097 ± 0.094	3.444AlaLys: 3.444 ± 0.078	11.151AlaLeu: 11.151 ± 0.14	2.844AlaMet: 2.844 ± 0.058	2.933AlaAsn: 2.933 ± 0.066	4.668AlaPro: 4.668 ± 0.096	4.026AlaGln: 4.026 ± 0.086	6.868AlaArg: 6.868 ± 0.105	6.993AlaSer: 6.993 ± 0.11	6.406AlaThr: 6.406 ± 0.094	8.853AlaVal: 8.853 ± 0.133	1.42AlaTrp: 1.42 ± 0.044	2.398AlaTyr: 2.398 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.816CysAla: 0.816 ± 0.035	0.08CysCys: 0.08 ± 0.012	0.399CysAsp: 0.399 ± 0.023	0.529CysGlu: 0.529 ± 0.026	0.244CysPhe: 0.244 ± 0.017	0.878CysGly: 0.878 ± 0.04	0.199CysHis: 0.199 ± 0.019	0.374CysIle: 0.374 ± 0.021	0.17CysLys: 0.17 ± 0.014	0.694CysLeu: 0.694 ± 0.03	0.145CysMet: 0.145 ± 0.015	0.183CysAsn: 0.183 ± 0.016	0.421CysPro: 0.421 ± 0.026	0.216CysGln: 0.216 ± 0.018	0.39CysArg: 0.39 ± 0.02	0.507CysSer: 0.507 ± 0.029	0.419CysThr: 0.419 ± 0.024	0.558CysVal: 0.558 ± 0.029	0.109CysTrp: 0.109 ± 0.014	0.189CysTyr: 0.189 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.257AspAla: 6.257 ± 0.102	0.38AspCys: 0.38 ± 0.022	3.544AspAsp: 3.544 ± 0.077	4.263AspGlu: 4.263 ± 0.085	1.951AspPhe: 1.951 ± 0.047	5.457AspGly: 5.457 ± 0.096	1.292AspHis: 1.292 ± 0.042	3.025AspIle: 3.025 ± 0.065	1.461AspLys: 1.461 ± 0.05	6.085AspLeu: 6.085 ± 0.082	1.233AspMet: 1.233 ± 0.039	1.459AspAsn: 1.459 ± 0.051	3.805AspPro: 3.805 ± 0.08	2.219AspGln: 2.219 ± 0.054	3.516AspArg: 3.516 ± 0.067	3.927AspSer: 3.927 ± 0.08	2.948AspThr: 2.948 ± 0.071	5.156AspVal: 5.156 ± 0.079	0.917AspTrp: 0.917 ± 0.034	1.54AspTyr: 1.54 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.606GluAla: 7.606 ± 0.114	0.395GluCys: 0.395 ± 0.023	4.07GluAsp: 4.07 ± 0.08	4.6GluGlu: 4.6 ± 0.098	2.044GluPhe: 2.044 ± 0.052	4.881GluGly: 4.881 ± 0.091	1.36GluHis: 1.36 ± 0.043	3.477GluIle: 3.477 ± 0.067	2.163GluLys: 2.163 ± 0.054	6.905GluLeu: 6.905 ± 0.107	1.434GluMet: 1.434 ± 0.044	1.966GluAsn: 1.966 ± 0.054	3.034GluPro: 3.034 ± 0.072	2.61GluGln: 2.61 ± 0.062	4.274GluArg: 4.274 ± 0.088	3.838GluSer: 3.838 ± 0.074	3.319GluThr: 3.319 ± 0.067	4.806GluVal: 4.806 ± 0.089	0.935GluTrp: 0.935 ± 0.031	1.595GluTyr: 1.595 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.61PheAla: 3.61 ± 0.077	0.252PheCys: 0.252 ± 0.016	2.237PheAsp: 2.237 ± 0.057	2.047PheGlu: 2.047 ± 0.056	1.169PhePhe: 1.169 ± 0.042	3.244PheGly: 3.244 ± 0.074	0.628PheHis: 0.628 ± 0.029	1.55PheIle: 1.55 ± 0.052	0.849PheLys: 0.849 ± 0.035	2.808PheLeu: 2.808 ± 0.07	0.687PheMet: 0.687 ± 0.032	0.935PheAsn: 0.935 ± 0.04	1.415PhePro: 1.415 ± 0.047	0.915PheGln: 0.915 ± 0.03	1.493PheArg: 1.493 ± 0.049	2.307PheSer: 2.307 ± 0.06	2.08PheThr: 2.08 ± 0.056	2.699PheVal: 2.699 ± 0.062	0.459PheTrp: 0.459 ± 0.028	0.76PheTyr: 0.76 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.009GlyAla: 9.009 ± 0.142	0.731GlyCys: 0.731 ± 0.036	4.553GlyAsp: 4.553 ± 0.094	5.381GlyGlu: 5.381 ± 0.087	3.157GlyPhe: 3.157 ± 0.064	7.114GlyGly: 7.114 ± 0.123	1.754GlyHis: 1.754 ± 0.058	5.13GlyIle: 5.13 ± 0.087	3.157GlyLys: 3.157 ± 0.07	8.382GlyLeu: 8.382 ± 0.112	2.273GlyMet: 2.273 ± 0.055	2.433GlyAsn: 2.433 ± 0.062	3.502GlyPro: 3.502 ± 0.082	3.041GlyGln: 3.041 ± 0.078	5.089GlyArg: 5.089 ± 0.083	5.768GlySer: 5.768 ± 0.082	5.623GlyThr: 5.623 ± 0.095	7.008GlyVal: 7.008 ± 0.1	1.389GlyTrp: 1.389 ± 0.047	2.47GlyTyr: 2.47 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.956HisAla: 1.956 ± 0.059	0.156HisCys: 0.156 ± 0.013	1.164HisAsp: 1.164 ± 0.043	1.281HisGlu: 1.281 ± 0.048	0.611HisPhe: 0.611 ± 0.028	1.803HisGly: 1.803 ± 0.053	0.564HisHis: 0.564 ± 0.024	0.963HisIle: 0.963 ± 0.033	0.472HisLys: 0.472 ± 0.023	1.957HisLeu: 1.957 ± 0.052	0.425HisMet: 0.425 ± 0.025	0.511HisAsn: 0.511 ± 0.025	1.312HisPro: 1.312 ± 0.045	0.634HisGln: 0.634 ± 0.031	1.317HisArg: 1.317 ± 0.038	1.181HisSer: 1.181 ± 0.043	1.112HisThr: 1.112 ± 0.037	1.591HisVal: 1.591 ± 0.043	0.256HisTrp: 0.256 ± 0.018	0.539HisTyr: 0.539 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.547IleAla: 6.547 ± 0.098	0.449IleCys: 0.449 ± 0.028	3.65IleAsp: 3.65 ± 0.082	3.585IleGlu: 3.585 ± 0.07	1.546IlePhe: 1.546 ± 0.046	5.095IleGly: 5.095 ± 0.092	0.994IleHis: 0.994 ± 0.037	2.597IleIle: 2.597 ± 0.065	1.304IleLys: 1.304 ± 0.045	4.629IleLeu: 4.629 ± 0.084	1.094IleMet: 1.094 ± 0.042	1.458IleAsn: 1.458 ± 0.037	2.856IlePro: 2.856 ± 0.063	1.354IleGln: 1.354 ± 0.04	2.817IleArg: 2.817 ± 0.075	3.3IleSer: 3.3 ± 0.071	3.393IleThr: 3.393 ± 0.075	4.716IleVal: 4.716 ± 0.085	0.581IleTrp: 0.581 ± 0.032	1.047IleTyr: 1.047 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.334LysAla: 3.334 ± 0.075	0.16LysCys: 0.16 ± 0.015	1.866LysAsp: 1.866 ± 0.055	1.832LysGlu: 1.832 ± 0.051	0.741LysPhe: 0.741 ± 0.028	2.054LysGly: 2.054 ± 0.054	0.589LysHis: 0.589 ± 0.026	1.666LysIle: 1.666 ± 0.051	1.354LysLys: 1.354 ± 0.051	2.832LysLeu: 2.832 ± 0.062	0.806LysMet: 0.806 ± 0.032	0.965LysAsn: 0.965 ± 0.037	1.561LysPro: 1.561 ± 0.05	0.965LysGln: 0.965 ± 0.036	2.019LysArg: 2.019 ± 0.057	1.723LysSer: 1.723 ± 0.054	1.712LysThr: 1.712 ± 0.05	2.313LysVal: 2.313 ± 0.062	0.37LysTrp: 0.37 ± 0.023	0.719LysTyr: 0.719 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	12.154LeuAla: 12.154 ± 0.164	0.753LeuCys: 0.753 ± 0.037	6.224LeuAsp: 6.224 ± 0.108	5.694LeuGlu: 5.694 ± 0.082	2.725LeuPhe: 2.725 ± 0.066	8.598LeuGly: 8.598 ± 0.103	1.705LeuHis: 1.705 ± 0.049	5.089LeuIle: 5.089 ± 0.095	2.582LeuLys: 2.582 ± 0.069	9.029LeuLeu: 9.029 ± 0.142	2.062LeuMet: 2.062 ± 0.055	2.477LeuAsn: 2.477 ± 0.063	5.021LeuPro: 5.021 ± 0.087	2.55LeuGln: 2.55 ± 0.058	5.955LeuArg: 5.955 ± 0.104	6.201LeuSer: 6.201 ± 0.103	6.425LeuThr: 6.425 ± 0.102	7.79LeuVal: 7.79 ± 0.106	1.195LeuTrp: 1.195 ± 0.042	1.897LeuTyr: 1.897 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.76MetAla: 2.76 ± 0.06	0.178MetCys: 0.178 ± 0.014	1.205MetAsp: 1.205 ± 0.041	1.172MetGlu: 1.172 ± 0.042	0.708MetPhe: 0.708 ± 0.03	1.892MetGly: 1.892 ± 0.056	0.367MetHis: 0.367 ± 0.022	1.198MetIle: 1.198 ± 0.036	0.774MetLys: 0.774 ± 0.031	2.087MetLeu: 2.087 ± 0.047	0.56MetMet: 0.56 ± 0.027	0.748MetAsn: 0.748 ± 0.032	1.218MetPro: 1.218 ± 0.037	0.61MetGln: 0.61 ± 0.031	1.531MetArg: 1.531 ± 0.042	1.795MetSer: 1.795 ± 0.045	1.518MetThr: 1.518 ± 0.043	1.813MetVal: 1.813 ± 0.049	0.279MetTrp: 0.279 ± 0.018	0.451MetTyr: 0.451 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.953AsnAla: 2.953 ± 0.069	0.222AsnCys: 0.222 ± 0.018	1.545AsnAsp: 1.545 ± 0.049	1.618AsnGlu: 1.618 ± 0.043	0.856AsnPhe: 0.856 ± 0.035	2.33AsnGly: 2.33 ± 0.064	0.583AsnHis: 0.583 ± 0.028	1.388AsnIle: 1.388 ± 0.045	0.738AsnLys: 0.738 ± 0.034	2.689AsnLeu: 2.689 ± 0.058	0.598AsnMet: 0.598 ± 0.023	0.876AsnAsn: 0.876 ± 0.038	1.849AsnPro: 1.849 ± 0.05	0.992AsnGln: 0.992 ± 0.038	1.615AsnArg: 1.615 ± 0.049	1.681AsnSer: 1.681 ± 0.049	1.604AsnThr: 1.604 ± 0.052	2.285AsnVal: 2.285 ± 0.056	0.434AsnTrp: 0.434 ± 0.024	0.74AsnTyr: 0.74 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.342ProAla: 5.342 ± 0.086	0.268ProCys: 0.268 ± 0.017	3.479ProAsp: 3.479 ± 0.074	4.706ProGlu: 4.706 ± 0.084	1.565ProPhe: 1.565 ± 0.043	4.317ProGly: 4.317 ± 0.083	1.047ProHis: 1.047 ± 0.037	2.35ProIle: 2.35 ± 0.059	1.4ProLys: 1.4 ± 0.047	4.127ProLeu: 4.127 ± 0.077	0.993ProMet: 0.993 ± 0.036	1.4ProAsn: 1.4 ± 0.044	1.665ProPro: 1.665 ± 0.051	1.55ProGln: 1.55 ± 0.046	2.497ProArg: 2.497 ± 0.065	3.256ProSer: 3.256 ± 0.069	3.097ProThr: 3.097 ± 0.066	4.089ProVal: 4.089 ± 0.079	0.766ProTrp: 0.766 ± 0.032	1.218ProTyr: 1.218 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.937GlnAla: 3.937 ± 0.086	0.216GlnCys: 0.216 ± 0.02	1.702GlnAsp: 1.702 ± 0.05	1.952GlnGlu: 1.952 ± 0.049	1.042GlnPhe: 1.042 ± 0.038	2.396GlnGly: 2.396 ± 0.058	0.635GlnHis: 0.635 ± 0.029	2.077GlnIle: 2.077 ± 0.055	0.992GlnLys: 0.992 ± 0.037	3.39GlnLeu: 3.39 ± 0.08	0.9GlnMet: 0.9 ± 0.035	0.939GlnAsn: 0.939 ± 0.042	1.531GlnPro: 1.531 ± 0.057	1.314GlnGln: 1.314 ± 0.056	2.293GlnArg: 2.293 ± 0.06	1.856GlnSer: 1.856 ± 0.055	1.844GlnThr: 1.844 ± 0.046	2.634GlnVal: 2.634 ± 0.066	0.558GlnTrp: 0.558 ± 0.025	0.827GlnTyr: 0.827 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	6.298ArgAla: 6.298 ± 0.109	0.408ArgCys: 0.408 ± 0.026	3.586ArgAsp: 3.586 ± 0.074	4.422ArgGlu: 4.422 ± 0.086	1.989ArgPhe: 1.989 ± 0.054	4.559ArgGly: 4.559 ± 0.084	1.294ArgHis: 1.294 ± 0.042	3.296ArgIle: 3.296 ± 0.073	2.036ArgLys: 2.036 ± 0.058	5.715ArgLeu: 5.715 ± 0.096	1.512ArgMet: 1.512 ± 0.046	1.632ArgAsn: 1.632 ± 0.043	2.831ArgPro: 2.831 ± 0.07	2.184ArgGln: 2.184 ± 0.06	4.698ArgArg: 4.698 ± 0.093	3.663ArgSer: 3.663 ± 0.072	3.496ArgThr: 3.496 ± 0.067	4.566ArgVal: 4.566 ± 0.069	0.936ArgTrp: 0.936 ± 0.034	1.572ArgTyr: 1.572 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.893SerAla: 6.893 ± 0.108	0.421SerCys: 0.421 ± 0.026	3.809SerAsp: 3.809 ± 0.08	4.134SerGlu: 4.134 ± 0.068	2.244SerPhe: 2.244 ± 0.056	6.548SerGly: 6.548 ± 0.086	1.304SerHis: 1.304 ± 0.046	3.202SerIle: 3.202 ± 0.066	1.787SerLys: 1.787 ± 0.055	5.999SerLeu: 5.999 ± 0.104	1.456SerMet: 1.456 ± 0.041	1.673SerAsn: 1.673 ± 0.046	3.087SerPro: 3.087 ± 0.067	2.217SerGln: 2.217 ± 0.056	3.701SerArg: 3.701 ± 0.07	4.34SerSer: 4.34 ± 0.095	3.613SerThr: 3.613 ± 0.066	5.083SerVal: 5.083 ± 0.089	0.974SerTrp: 0.974 ± 0.035	1.523SerTyr: 1.523 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.49ThrAla: 6.49 ± 0.097	0.467ThrCys: 0.467 ± 0.023	3.501ThrAsp: 3.501 ± 0.083	3.67ThrGlu: 3.67 ± 0.074	2.085ThrPhe: 2.085 ± 0.06	5.487ThrGly: 5.487 ± 0.091	1.141ThrHis: 1.141 ± 0.037	3.234ThrIle: 3.234 ± 0.067	1.72ThrLys: 1.72 ± 0.047	5.618ThrLeu: 5.618 ± 0.086	1.277ThrMet: 1.277 ± 0.04	1.627ThrAsn: 1.627 ± 0.05	3.286ThrPro: 3.286 ± 0.07	1.834ThrGln: 1.834 ± 0.056	3.034ThrArg: 3.034 ± 0.059	3.873ThrSer: 3.873 ± 0.064	3.464ThrThr: 3.464 ± 0.079	5.375ThrVal: 5.375 ± 0.097	0.842ThrTrp: 0.842 ± 0.04	1.439ThrTyr: 1.439 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.398ValAla: 9.398 ± 0.116	0.741ValCys: 0.741 ± 0.032	4.989ValAsp: 4.989 ± 0.095	4.855ValGlu: 4.855 ± 0.081	2.661ValPhe: 2.661 ± 0.062	6.647ValGly: 6.647 ± 0.102	1.461ValHis: 1.461 ± 0.043	4.456ValIle: 4.456 ± 0.08	2.162ValLys: 2.162 ± 0.057	8.117ValLeu: 8.117 ± 0.12	1.69ValMet: 1.69 ± 0.052	2.191ValAsn: 2.191 ± 0.055	4.205ValPro: 4.205 ± 0.082	2.396ValGln: 2.396 ± 0.047	4.985ValArg: 4.985 ± 0.086	5.501ValSer: 5.501 ± 0.088	5.165ValThr: 5.165 ± 0.092	7.188ValVal: 7.188 ± 0.12	1.07ValTrp: 1.07 ± 0.032	1.615ValTyr: 1.615 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.312TrpAla: 1.312 ± 0.047	0.129TrpCys: 0.129 ± 0.014	0.863TrpAsp: 0.863 ± 0.032	0.816TrpGlu: 0.816 ± 0.029	0.515TrpPhe: 0.515 ± 0.029	0.992TrpGly: 0.992 ± 0.035	0.346TrpHis: 0.346 ± 0.02	0.846TrpIle: 0.846 ± 0.031	0.447TrpLys: 0.447 ± 0.021	1.499TrpLeu: 1.499 ± 0.046	0.389TrpMet: 0.389 ± 0.022	0.525TrpAsn: 0.525 ± 0.027	0.603TrpPro: 0.603 ± 0.026	0.57TrpGln: 0.57 ± 0.026	0.958TrpArg: 0.958 ± 0.035	0.782TrpSer: 0.782 ± 0.031	0.799TrpThr: 0.799 ± 0.035	1.121TrpVal: 1.121 ± 0.036	0.308TrpTrp: 0.308 ± 0.022	0.328TrpTyr: 0.328 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.052	0.177TyrCys: 0.177 ± 0.015	1.324TyrAsp: 1.324 ± 0.036	1.538TyrGlu: 1.538 ± 0.05	0.858TyrPhe: 0.858 ± 0.03	2.241TyrGly: 2.241 ± 0.064	0.447TyrHis: 0.447 ± 0.023	0.998TyrIle: 0.998 ± 0.034	0.573TyrLys: 0.573 ± 0.029	2.413TyrLeu: 2.413 ± 0.058	0.483TyrMet: 0.483 ± 0.026	0.665TyrAsn: 0.665 ± 0.033	1.261TyrPro: 1.261 ± 0.043	0.838TyrGln: 0.838 ± 0.032	1.643TyrArg: 1.643 ± 0.048	1.518TyrSer: 1.518 ± 0.047	1.426TyrThr: 1.426 ± 0.042	1.849TyrVal: 1.849 ± 0.049	0.35TyrTrp: 0.35 ± 0.023	0.599TyrTyr: 0.599 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2288 proteins (792421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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