Amino acid dipepetide frequency for Candidatus Nitrosocosmicus sp. SS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.328AlaAla: 3.328 ± 0.083	0.546AlaCys: 0.546 ± 0.033	2.534AlaAsp: 2.534 ± 0.067	2.798AlaGlu: 2.798 ± 0.057	2.376AlaPhe: 2.376 ± 0.063	3.43AlaGly: 3.43 ± 0.083	0.86AlaHis: 0.86 ± 0.036	5.165AlaIle: 5.165 ± 0.096	3.603AlaLys: 3.603 ± 0.079	5.032AlaLeu: 5.032 ± 0.092	1.193AlaMet: 1.193 ± 0.041	2.741AlaAsn: 2.741 ± 0.076	1.465AlaPro: 1.465 ± 0.052	1.667AlaGln: 1.667 ± 0.059	1.947AlaArg: 1.947 ± 0.049	3.853AlaSer: 3.853 ± 0.065	2.779AlaThr: 2.779 ± 0.07	3.161AlaVal: 3.161 ± 0.067	0.421AlaTrp: 0.421 ± 0.026	1.697AlaTyr: 1.697 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	0.433CysAla: 0.433 ± 0.026	0.203CysCys: 0.203 ± 0.015	0.562CysAsp: 0.562 ± 0.028	0.591CysGlu: 0.591 ± 0.035	0.411CysPhe: 0.411 ± 0.026	0.849CysGly: 0.849 ± 0.041	0.219CysHis: 0.219 ± 0.019	0.913CysIle: 0.913 ± 0.037	0.812CysLys: 0.812 ± 0.042	0.807CysLeu: 0.807 ± 0.038	0.206CysMet: 0.206 ± 0.015	0.741CysAsn: 0.741 ± 0.036	0.538CysPro: 0.538 ± 0.03	0.28CysGln: 0.28 ± 0.02	0.421CysArg: 0.421 ± 0.029	0.767CysSer: 0.767 ± 0.038	0.507CysThr: 0.507 ± 0.026	0.571CysVal: 0.571 ± 0.032	0.068CysTrp: 0.068 ± 0.01	0.396CysTyr: 0.396 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	2.614AspAla: 2.614 ± 0.064	0.56AspCys: 0.56 ± 0.034	3.272AspAsp: 3.272 ± 0.112	3.721AspGlu: 3.721 ± 0.07	2.62AspPhe: 2.62 ± 0.061	3.449AspGly: 3.449 ± 0.078	1.114AspHis: 1.114 ± 0.034	5.229AspIle: 5.229 ± 0.077	4.508AspLys: 4.508 ± 0.093	5.605AspLeu: 5.605 ± 0.082	1.264AspMet: 1.264 ± 0.047	3.866AspAsn: 3.866 ± 0.092	2.365AspPro: 2.365 ± 0.076	1.702AspGln: 1.702 ± 0.05	2.088AspArg: 2.088 ± 0.052	4.507AspSer: 4.507 ± 0.081	2.967AspThr: 2.967 ± 0.07	3.264AspVal: 3.264 ± 0.066	0.537AspTrp: 0.537 ± 0.027	2.227AspTyr: 2.227 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	2.75GluAla: 2.75 ± 0.07	0.545GluCys: 0.545 ± 0.029	3.086GluAsp: 3.086 ± 0.064	3.736GluGlu: 3.736 ± 0.072	2.868GluPhe: 2.868 ± 0.067	3.137GluGly: 3.137 ± 0.063	1.013GluHis: 1.013 ± 0.041	6.397GluIle: 6.397 ± 0.097	5.509GluLys: 5.509 ± 0.103	5.37GluLeu: 5.37 ± 0.083	1.566GluMet: 1.566 ± 0.046	4.369GluAsn: 4.369 ± 0.08	1.763GluPro: 1.763 ± 0.055	1.845GluGln: 1.845 ± 0.062	2.61GluArg: 2.61 ± 0.067	4.599GluSer: 4.599 ± 0.079	2.856GluThr: 2.856 ± 0.064	3.399GluVal: 3.399 ± 0.072	0.594GluTrp: 0.594 ± 0.032	2.311GluTyr: 2.311 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	2.594PheAla: 2.594 ± 0.058	0.486PheCys: 0.486 ± 0.026	3.211PheAsp: 3.211 ± 0.069	2.805PheGlu: 2.805 ± 0.064	1.919PhePhe: 1.919 ± 0.062	3.095PheGly: 3.095 ± 0.073	0.875PheHis: 0.875 ± 0.039	3.657PheIle: 3.657 ± 0.08	2.75PheLys: 2.75 ± 0.058	4.177PheLeu: 4.177 ± 0.088	0.913PheMet: 0.913 ± 0.042	2.627PheAsn: 2.627 ± 0.063	1.632PhePro: 1.632 ± 0.047	1.246PheGln: 1.246 ± 0.041	1.667PheArg: 1.667 ± 0.044	3.735PheSer: 3.735 ± 0.077	2.333PheThr: 2.333 ± 0.056	3.251PheVal: 3.251 ± 0.07	0.44PheTrp: 0.44 ± 0.022	1.596PheTyr: 1.596 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	3.197GlyAla: 3.197 ± 0.083	0.675GlyCys: 0.675 ± 0.037	3.23GlyAsp: 3.23 ± 0.071	3.065GlyGlu: 3.065 ± 0.067	3.021GlyPhe: 3.021 ± 0.071	4.223GlyGly: 4.223 ± 0.111	1.222GlyHis: 1.222 ± 0.042	6.358GlyIle: 6.358 ± 0.106	4.69GlyLys: 4.69 ± 0.084	5.563GlyLeu: 5.563 ± 0.106	1.573GlyMet: 1.573 ± 0.053	3.89GlyAsn: 3.89 ± 0.1	1.934GlyPro: 1.934 ± 0.06	1.958GlyGln: 1.958 ± 0.057	2.17GlyArg: 2.17 ± 0.066	4.672GlySer: 4.672 ± 0.092	3.441GlyThr: 3.441 ± 0.071	3.543GlyVal: 3.543 ± 0.076	0.637GlyTrp: 0.637 ± 0.031	2.364GlyTyr: 2.364 ± 0.059	0.001GlyXaa: 0.001 ± 0.002
His	0.857HisAla: 0.857 ± 0.036	0.262HisCys: 0.262 ± 0.02	1.055HisAsp: 1.055 ± 0.033	1.081HisGlu: 1.081 ± 0.039	0.86HisPhe: 0.86 ± 0.034	1.243HisGly: 1.243 ± 0.041	0.567HisHis: 0.567 ± 0.031	1.572HisIle: 1.572 ± 0.05	1.141HisLys: 1.141 ± 0.039	1.601HisLeu: 1.601 ± 0.046	0.443HisMet: 0.443 ± 0.025	1.164HisAsn: 1.164 ± 0.036	0.981HisPro: 0.981 ± 0.038	0.55HisGln: 0.55 ± 0.027	0.73HisArg: 0.73 ± 0.03	1.402HisSer: 1.402 ± 0.045	0.998HisThr: 0.998 ± 0.04	1.104HisVal: 1.104 ± 0.037	0.185HisTrp: 0.185 ± 0.016	0.694HisTyr: 0.694 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.194IleAla: 5.194 ± 0.104	0.973IleCys: 0.973 ± 0.044	5.687IleAsp: 5.687 ± 0.104	5.798IleGlu: 5.798 ± 0.095	3.962IlePhe: 3.962 ± 0.083	5.793IleGly: 5.793 ± 0.1	1.753IleHis: 1.753 ± 0.052	8.299IleIle: 8.299 ± 0.135	6.726IleLys: 6.726 ± 0.111	8.728IleLeu: 8.728 ± 0.126	1.929IleMet: 1.929 ± 0.048	5.504IleAsn: 5.504 ± 0.095	4.149IlePro: 4.149 ± 0.077	2.948IleGln: 2.948 ± 0.055	3.568IleArg: 3.568 ± 0.069	7.831IleSer: 7.831 ± 0.11	5.173IleThr: 5.173 ± 0.099	5.973IleVal: 5.973 ± 0.097	0.726IleTrp: 0.726 ± 0.03	2.899IleTyr: 2.899 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	3.207LysAla: 3.207 ± 0.075	0.719LysCys: 0.719 ± 0.037	4.522LysAsp: 4.522 ± 0.078	5.621LysGlu: 5.621 ± 0.094	3.034LysPhe: 3.034 ± 0.062	3.888LysGly: 3.888 ± 0.082	1.25LysHis: 1.25 ± 0.046	7.901LysIle: 7.901 ± 0.115	6.423LysLys: 6.423 ± 0.119	6.298LysLeu: 6.298 ± 0.095	2.054LysMet: 2.054 ± 0.054	5.405LysAsn: 5.405 ± 0.091	2.412LysPro: 2.412 ± 0.068	2.164LysGln: 2.164 ± 0.056	3.012LysArg: 3.012 ± 0.073	5.573LysSer: 5.573 ± 0.091	3.911LysThr: 3.911 ± 0.08	4.442LysVal: 4.442 ± 0.084	0.693LysTrp: 0.693 ± 0.03	3.04LysTyr: 3.04 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	5.087LeuAla: 5.087 ± 0.092	0.779LeuCys: 0.779 ± 0.034	5.42LeuAsp: 5.42 ± 0.095	5.754LeuGlu: 5.754 ± 0.094	3.99LeuPhe: 3.99 ± 0.081	5.623LeuGly: 5.623 ± 0.093	1.54LeuHis: 1.54 ± 0.046	8.058LeuIle: 8.058 ± 0.111	7.078LeuLys: 7.078 ± 0.108	8.531LeuLeu: 8.531 ± 0.142	1.964LeuMet: 1.964 ± 0.054	5.483LeuAsn: 5.483 ± 0.088	3.421LeuPro: 3.421 ± 0.08	2.687LeuGln: 2.687 ± 0.065	3.629LeuArg: 3.629 ± 0.077	7.965LeuSer: 7.965 ± 0.129	4.639LeuThr: 4.639 ± 0.073	5.754LeuVal: 5.754 ± 0.092	0.688LeuTrp: 0.688 ± 0.032	3.01LeuTyr: 3.01 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	1.323MetAla: 1.323 ± 0.043	0.17MetCys: 0.17 ± 0.017	1.394MetAsp: 1.394 ± 0.051	1.271MetGlu: 1.271 ± 0.043	0.906MetPhe: 0.906 ± 0.036	1.516MetGly: 1.516 ± 0.05	0.447MetHis: 0.447 ± 0.027	2.219MetIle: 2.219 ± 0.058	1.794MetLys: 1.794 ± 0.052	1.964MetLeu: 1.964 ± 0.057	0.663MetMet: 0.663 ± 0.034	1.561MetAsn: 1.561 ± 0.047	0.9MetPro: 0.9 ± 0.037	0.716MetGln: 0.716 ± 0.031	0.875MetArg: 0.875 ± 0.036	1.92MetSer: 1.92 ± 0.049	1.532MetThr: 1.532 ± 0.042	1.572MetVal: 1.572 ± 0.046	0.166MetTrp: 0.166 ± 0.014	0.665MetTyr: 0.665 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.037AsnAla: 3.037 ± 0.069	0.675AsnCys: 0.675 ± 0.03	3.739AsnAsp: 3.739 ± 0.102	3.908AsnGlu: 3.908 ± 0.076	2.705AsnPhe: 2.705 ± 0.064	3.81AsnGly: 3.81 ± 0.086	1.235AsnHis: 1.235 ± 0.047	5.562AsnIle: 5.562 ± 0.098	4.966AsnLys: 4.966 ± 0.086	5.931AsnLeu: 5.931 ± 0.09	1.568AsnMet: 1.568 ± 0.048	5.646AsnAsn: 5.646 ± 0.152	2.928AsnPro: 2.928 ± 0.077	2.516AsnGln: 2.516 ± 0.078	2.291AsnArg: 2.291 ± 0.055	5.807AsnSer: 5.807 ± 0.106	3.612AsnThr: 3.612 ± 0.082	3.513AsnVal: 3.513 ± 0.078	0.58AsnTrp: 0.58 ± 0.029	2.276AsnTyr: 2.276 ± 0.061	0.001AsnXaa: 0.001 ± 0.001
Pro	1.75ProAla: 1.75 ± 0.054	0.358ProCys: 0.358 ± 0.022	2.302ProAsp: 2.302 ± 0.061	2.315ProGlu: 2.315 ± 0.053	1.776ProPhe: 1.776 ± 0.05	2.104ProGly: 2.104 ± 0.069	0.762ProHis: 0.762 ± 0.031	3.403ProIle: 3.403 ± 0.064	2.429ProLys: 2.429 ± 0.064	3.331ProLeu: 3.331 ± 0.072	0.765ProMet: 0.765 ± 0.035	2.205ProAsn: 2.205 ± 0.064	1.394ProPro: 1.394 ± 0.054	1.281ProGln: 1.281 ± 0.05	1.263ProArg: 1.263 ± 0.047	3.129ProSer: 3.129 ± 0.078	2.116ProThr: 2.116 ± 0.057	2.454ProVal: 2.454 ± 0.066	0.353ProTrp: 0.353 ± 0.025	1.406ProTyr: 1.406 ± 0.052	0.001ProXaa: 0.001 ± 0.002
Gln	1.487GlnAla: 1.487 ± 0.05	0.304GlnCys: 0.304 ± 0.022	1.559GlnAsp: 1.559 ± 0.056	1.75GlnGlu: 1.75 ± 0.051	1.349GlnPhe: 1.349 ± 0.044	1.653GlnGly: 1.653 ± 0.062	0.5GlnHis: 0.5 ± 0.028	3.058GlnIle: 3.058 ± 0.064	2.517GlnLys: 2.517 ± 0.07	2.58GlnLeu: 2.58 ± 0.064	0.825GlnMet: 0.825 ± 0.035	2.509GlnAsn: 2.509 ± 0.072	0.98GlnPro: 0.98 ± 0.043	1.242GlnGln: 1.242 ± 0.059	1.24GlnArg: 1.24 ± 0.041	2.842GlnSer: 2.842 ± 0.091	1.844GlnThr: 1.844 ± 0.066	1.771GlnVal: 1.771 ± 0.049	0.265GlnTrp: 0.265 ± 0.019	1.073GlnTyr: 1.073 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	1.594ArgAla: 1.594 ± 0.046	0.426ArgCys: 0.426 ± 0.027	2.011ArgAsp: 2.011 ± 0.056	2.472ArgGlu: 2.472 ± 0.064	1.773ArgPhe: 1.773 ± 0.055	2.09ArgGly: 2.09 ± 0.059	0.68ArgHis: 0.68 ± 0.032	3.986ArgIle: 3.986 ± 0.08	3.088ArgLys: 3.088 ± 0.066	3.467ArgLeu: 3.467 ± 0.074	1.062ArgMet: 1.062 ± 0.04	2.536ArgAsn: 2.536 ± 0.063	1.185ArgPro: 1.185 ± 0.043	1.12ArgGln: 1.12 ± 0.043	1.589ArgArg: 1.589 ± 0.058	2.503ArgSer: 2.503 ± 0.063	1.962ArgThr: 1.962 ± 0.051	2.244ArgVal: 2.244 ± 0.063	0.382ArgTrp: 0.382 ± 0.022	1.426ArgTyr: 1.426 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.569SerAla: 3.569 ± 0.081	0.801SerCys: 0.801 ± 0.04	4.454SerAsp: 4.454 ± 0.095	4.648SerGlu: 4.648 ± 0.089	3.725SerPhe: 3.725 ± 0.067	5.159SerGly: 5.159 ± 0.113	1.547SerHis: 1.547 ± 0.056	7.779SerIle: 7.779 ± 0.122	6.461SerLys: 6.461 ± 0.108	7.311SerLeu: 7.311 ± 0.104	1.915SerMet: 1.915 ± 0.055	6.057SerAsn: 6.057 ± 0.12	2.74SerPro: 2.74 ± 0.062	2.779SerGln: 2.779 ± 0.079	2.766SerArg: 2.766 ± 0.063	7.469SerSer: 7.469 ± 0.15	4.66SerThr: 4.66 ± 0.113	4.373SerVal: 4.373 ± 0.09	0.627SerTrp: 0.627 ± 0.03	2.656SerTyr: 2.656 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	2.896ThrAla: 2.896 ± 0.072	0.544ThrCys: 0.544 ± 0.028	2.878ThrAsp: 2.878 ± 0.065	3.038ThrGlu: 3.038 ± 0.069	2.511ThrPhe: 2.511 ± 0.062	3.766ThrGly: 3.766 ± 0.078	0.963ThrHis: 0.963 ± 0.038	5.264ThrIle: 5.264 ± 0.095	3.848ThrLys: 3.848 ± 0.073	4.893ThrLeu: 4.893 ± 0.092	1.348ThrMet: 1.348 ± 0.043	3.671ThrAsn: 3.671 ± 0.086	2.155ThrPro: 2.155 ± 0.068	1.621ThrGln: 1.621 ± 0.052	1.795ThrArg: 1.795 ± 0.048	4.609ThrSer: 4.609 ± 0.093	3.318ThrThr: 3.318 ± 0.112	3.203ThrVal: 3.203 ± 0.068	0.495ThrTrp: 0.495 ± 0.029	1.672ThrTyr: 1.672 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	3.54ValAla: 3.54 ± 0.07	0.659ValCys: 0.659 ± 0.027	3.692ValAsp: 3.692 ± 0.086	3.412ValGlu: 3.412 ± 0.077	2.883ValPhe: 2.883 ± 0.059	3.745ValGly: 3.745 ± 0.088	0.944ValHis: 0.944 ± 0.037	5.469ValIle: 5.469 ± 0.1	4.333ValLys: 4.333 ± 0.084	5.508ValLeu: 5.508 ± 0.089	1.367ValMet: 1.367 ± 0.042	3.519ValAsn: 3.519 ± 0.07	2.132ValPro: 2.132 ± 0.06	1.604ValGln: 1.604 ± 0.045	2.184ValArg: 2.184 ± 0.059	4.768ValSer: 4.768 ± 0.087	3.668ValThr: 3.668 ± 0.068	3.899ValVal: 3.899 ± 0.088	0.523ValTrp: 0.523 ± 0.03	2.149ValTyr: 2.149 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.387TrpAla: 0.387 ± 0.022	0.102TrpCys: 0.102 ± 0.011	0.449TrpAsp: 0.449 ± 0.023	0.442TrpGlu: 0.442 ± 0.024	0.45TrpPhe: 0.45 ± 0.028	0.556TrpGly: 0.556 ± 0.031	0.183TrpHis: 0.183 ± 0.016	0.949TrpIle: 0.949 ± 0.036	0.743TrpLys: 0.743 ± 0.032	0.867TrpLeu: 0.867 ± 0.037	0.266TrpMet: 0.266 ± 0.019	0.633TrpAsn: 0.633 ± 0.031	0.259TrpPro: 0.259 ± 0.018	0.249TrpGln: 0.249 ± 0.02	0.34TrpArg: 0.34 ± 0.022	0.556TrpSer: 0.556 ± 0.028	0.514TrpThr: 0.514 ± 0.028	0.449TrpVal: 0.449 ± 0.022	0.113TrpTrp: 0.113 ± 0.013	0.353TrpTyr: 0.353 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.752TyrAla: 1.752 ± 0.057	0.509TyrCys: 0.509 ± 0.028	2.422TyrAsp: 2.422 ± 0.06	2.096TyrGlu: 2.096 ± 0.05	1.869TyrPhe: 1.869 ± 0.054	2.295TyrGly: 2.295 ± 0.063	0.818TyrHis: 0.818 ± 0.038	2.376TyrIle: 2.376 ± 0.063	2.149TyrLys: 2.149 ± 0.055	3.537TyrLeu: 3.537 ± 0.076	0.687TyrMet: 0.687 ± 0.032	2.18TyrAsn: 2.18 ± 0.059	1.564TyrPro: 1.564 ± 0.047	1.172TyrGln: 1.172 ± 0.039	1.413TyrArg: 1.413 ± 0.048	2.992TyrSer: 2.992 ± 0.055	1.656TyrThr: 1.656 ± 0.054	2.054TyrVal: 2.054 ± 0.05	0.368TyrTrp: 0.368 ± 0.022	1.618TyrTyr: 1.618 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2921 proteins (717542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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