Amino acid dipepetide frequency for Taylorella asinigenitalis (strain MCE3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.962AlaAla: 5.962 ± 0.146
0.857AlaCys: 0.857 ± 0.048
3.916AlaAsp: 3.916 ± 0.096
4.398AlaGlu: 4.398 ± 0.111
3.145AlaPhe: 3.145 ± 0.084
5.229AlaGly: 5.229 ± 0.12
1.538AlaHis: 1.538 ± 0.063
5.674AlaIle: 5.674 ± 0.128
5.079AlaLys: 5.079 ± 0.123
8.292AlaLeu: 8.292 ± 0.137
2.036AlaMet: 2.036 ± 0.069
3.131AlaAsn: 3.131 ± 0.091
2.585AlaPro: 2.585 ± 0.086
3.193AlaGln: 3.193 ± 0.081
3.642AlaArg: 3.642 ± 0.092
5.255AlaSer: 5.255 ± 0.103
4.008AlaThr: 4.008 ± 0.093
5.173AlaVal: 5.173 ± 0.135
0.821AlaTrp: 0.821 ± 0.035
2.384AlaTyr: 2.384 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.673CysAla: 0.673 ± 0.037
0.09CysCys: 0.09 ± 0.012
0.517CysAsp: 0.517 ± 0.035
0.603CysGlu: 0.603 ± 0.038
0.378CysPhe: 0.378 ± 0.028
0.769CysGly: 0.769 ± 0.044
0.284CysHis: 0.284 ± 0.027
0.679CysIle: 0.679 ± 0.04
0.452CysLys: 0.452 ± 0.032
0.773CysLeu: 0.773 ± 0.044
0.238CysMet: 0.238 ± 0.023
0.35CysAsn: 0.35 ± 0.03
0.456CysPro: 0.456 ± 0.037
0.206CysGln: 0.206 ± 0.019
0.346CysArg: 0.346 ± 0.027
0.637CysSer: 0.637 ± 0.037
0.472CysThr: 0.472 ± 0.031
0.621CysVal: 0.621 ± 0.034
0.098CysTrp: 0.098 ± 0.014
0.218CysTyr: 0.218 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.12AspAla: 4.12 ± 0.099
0.462AspCys: 0.462 ± 0.035
2.607AspAsp: 2.607 ± 0.091
3.99AspGlu: 3.99 ± 0.112
2.779AspPhe: 2.779 ± 0.075
4.058AspGly: 4.058 ± 0.122
1.009AspHis: 1.009 ± 0.085
4.883AspIle: 4.883 ± 0.114
3.52AspLys: 3.52 ± 0.099
5.714AspLeu: 5.714 ± 0.108
1.473AspMet: 1.473 ± 0.051
1.99AspAsn: 1.99 ± 0.084
2.324AspPro: 2.324 ± 0.078
1.636AspGln: 1.636 ± 0.055
2.432AspArg: 2.432 ± 0.072
3.852AspSer: 3.852 ± 0.084
2.645AspThr: 2.645 ± 0.079
3.536AspVal: 3.536 ± 0.102
0.775AspTrp: 0.775 ± 0.034
2.096AspTyr: 2.096 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.444GluAla: 5.444 ± 0.137
0.484GluCys: 0.484 ± 0.035
3.486GluAsp: 3.486 ± 0.107
4.438GluGlu: 4.438 ± 0.125
3.023GluPhe: 3.023 ± 0.094
4.154GluGly: 4.154 ± 0.104
1.421GluHis: 1.421 ± 0.056
5.448GluIle: 5.448 ± 0.117
4.451GluLys: 4.451 ± 0.095
6.244GluLeu: 6.244 ± 0.137
1.538GluMet: 1.538 ± 0.059
3.425GluAsn: 3.425 ± 0.085
2.515GluPro: 2.515 ± 0.106
2.509GluGln: 2.509 ± 0.07
3.065GluArg: 3.065 ± 0.111
4.236GluSer: 4.236 ± 0.1
3.151GluThr: 3.151 ± 0.087
4.342GluVal: 4.342 ± 0.092
0.767GluTrp: 0.767 ± 0.038
2.1GluTyr: 2.1 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
3.273PheAla: 3.273 ± 0.09
0.426PheCys: 0.426 ± 0.029
2.855PheAsp: 2.855 ± 0.081
2.989PheGlu: 2.989 ± 0.084
1.96PhePhe: 1.96 ± 0.064
3.193PheGly: 3.193 ± 0.088
0.741PheHis: 0.741 ± 0.04
3.139PheIle: 3.139 ± 0.1
2.999PheLys: 2.999 ± 0.083
3.954PheLeu: 3.954 ± 0.103
1.035PheMet: 1.035 ± 0.051
2.264PheAsn: 2.264 ± 0.071
1.62PhePro: 1.62 ± 0.06
1.083PheGln: 1.083 ± 0.046
1.636PheArg: 1.636 ± 0.067
3.163PheSer: 3.163 ± 0.082
2.188PheThr: 2.188 ± 0.063
3.039PheVal: 3.039 ± 0.079
0.492PheTrp: 0.492 ± 0.035
1.367PheTyr: 1.367 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
5.149GlyAla: 5.149 ± 0.13
0.669GlyCys: 0.669 ± 0.038
3.602GlyAsp: 3.602 ± 0.11
3.884GlyGlu: 3.884 ± 0.115
3.546GlyPhe: 3.546 ± 0.085
4.953GlyGly: 4.953 ± 0.153
1.6GlyHis: 1.6 ± 0.061
5.127GlyIle: 5.127 ± 0.1
4.226GlyLys: 4.226 ± 0.116
7.145GlyLeu: 7.145 ± 0.109
1.776GlyMet: 1.776 ± 0.057
2.731GlyAsn: 2.731 ± 0.106
2.088GlyPro: 2.088 ± 0.074
2.284GlyGln: 2.284 ± 0.073
3.353GlyArg: 3.353 ± 0.097
4.619GlySer: 4.619 ± 0.141
3.65GlyThr: 3.65 ± 0.117
5.275GlyVal: 5.275 ± 0.115
0.733GlyTrp: 0.733 ± 0.046
2.38GlyTyr: 2.38 ± 0.081
0.002GlyXaa: 0.002 ± 0.002
His
1.437HisAla: 1.437 ± 0.054
0.234HisCys: 0.234 ± 0.022
1.139HisAsp: 1.139 ± 0.091
1.341HisGlu: 1.341 ± 0.06
0.861HisPhe: 0.861 ± 0.04
1.494HisGly: 1.494 ± 0.071
0.505HisHis: 0.505 ± 0.03
1.604HisIle: 1.604 ± 0.048
1.327HisLys: 1.327 ± 0.055
1.75HisLeu: 1.75 ± 0.053
0.464HisMet: 0.464 ± 0.029
0.961HisAsn: 0.961 ± 0.046
1.099HisPro: 1.099 ± 0.057
0.599HisGln: 0.599 ± 0.036
0.843HisArg: 0.843 ± 0.04
1.269HisSer: 1.269 ± 0.049
0.989HisThr: 0.989 ± 0.046
1.115HisVal: 1.115 ± 0.045
0.198HisTrp: 0.198 ± 0.022
0.703HisTyr: 0.703 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.481IleAla: 6.481 ± 0.135
0.691IleCys: 0.691 ± 0.043
4.577IleAsp: 4.577 ± 0.102
5.419IleGlu: 5.419 ± 0.107
3.125IlePhe: 3.125 ± 0.091
5.093IleGly: 5.093 ± 0.135
1.307IleHis: 1.307 ± 0.052
4.649IleIle: 4.649 ± 0.106
4.929IleLys: 4.929 ± 0.092
6.701IleLeu: 6.701 ± 0.146
1.62IleMet: 1.62 ± 0.061
3.85IleAsn: 3.85 ± 0.098
3.203IlePro: 3.203 ± 0.071
2.2IleGln: 2.2 ± 0.074
3.163IleArg: 3.163 ± 0.083
5.546IleSer: 5.546 ± 0.103
3.616IleThr: 3.616 ± 0.094
4.837IleVal: 4.837 ± 0.109
0.619IleTrp: 0.619 ± 0.038
2.264IleTyr: 2.264 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
5.085LysAla: 5.085 ± 0.139
0.418LysCys: 0.418 ± 0.033
3.948LysAsp: 3.948 ± 0.108
4.765LysGlu: 4.765 ± 0.104
2.823LysPhe: 2.823 ± 0.079
4.032LysGly: 4.032 ± 0.1
1.329LysHis: 1.329 ± 0.056
4.605LysIle: 4.605 ± 0.104
4.713LysLys: 4.713 ± 0.131
6.525LysLeu: 6.525 ± 0.136
1.457LysMet: 1.457 ± 0.055
3.876LysAsn: 3.876 ± 0.093
2.971LysPro: 2.971 ± 0.085
2.23LysGln: 2.23 ± 0.065
2.915LysArg: 2.915 ± 0.086
4.889LysSer: 4.889 ± 0.108
3.53LysThr: 3.53 ± 0.097
4.232LysVal: 4.232 ± 0.114
0.725LysTrp: 0.725 ± 0.037
2.294LysTyr: 2.294 ± 0.069
0.002LysXaa: 0.002 ± 0.002
Leu
7.548LeuAla: 7.548 ± 0.131
0.875LeuCys: 0.875 ± 0.04
5.608LeuAsp: 5.608 ± 0.116
6.392LeuGlu: 6.392 ± 0.138
3.838LeuPhe: 3.838 ± 0.107
7.047LeuGly: 7.047 ± 0.137
1.844LeuHis: 1.844 ± 0.071
7.173LeuIle: 7.173 ± 0.124
6.901LeuLys: 6.901 ± 0.117
9.229LeuLeu: 9.229 ± 0.204
2.314LeuMet: 2.314 ± 0.068
5.323LeuAsn: 5.323 ± 0.103
4.469LeuPro: 4.469 ± 0.104
3.009LeuGln: 3.009 ± 0.082
4.575LeuArg: 4.575 ± 0.122
7.353LeuSer: 7.353 ± 0.143
5.015LeuThr: 5.015 ± 0.105
6.25LeuVal: 6.25 ± 0.119
0.913LeuTrp: 0.913 ± 0.055
2.671LeuTyr: 2.671 ± 0.079
0.002LeuXaa: 0.002 ± 0.002
Met
2.07MetAla: 2.07 ± 0.066
0.194MetCys: 0.194 ± 0.019
1.223MetAsp: 1.223 ± 0.048
1.203MetGlu: 1.203 ± 0.048
0.883MetPhe: 0.883 ± 0.042
1.842MetGly: 1.842 ± 0.065
0.589MetHis: 0.589 ± 0.04
1.57MetIle: 1.57 ± 0.052
1.506MetLys: 1.506 ± 0.061
2.322MetLeu: 2.322 ± 0.068
0.553MetMet: 0.553 ± 0.037
1.229MetAsn: 1.229 ± 0.054
1.067MetPro: 1.067 ± 0.047
0.977MetGln: 0.977 ± 0.039
1.285MetArg: 1.285 ± 0.054
1.836MetSer: 1.836 ± 0.053
1.225MetThr: 1.225 ± 0.052
1.528MetVal: 1.528 ± 0.065
0.212MetTrp: 0.212 ± 0.02
0.645MetTyr: 0.645 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.331AsnAla: 3.331 ± 0.093
0.48AsnCys: 0.48 ± 0.038
2.396AsnAsp: 2.396 ± 0.069
2.773AsnGlu: 2.773 ± 0.083
2.198AsnPhe: 2.198 ± 0.079
2.991AsnGly: 2.991 ± 0.089
0.893AsnHis: 0.893 ± 0.043
3.746AsnIle: 3.746 ± 0.097
3.484AsnLys: 3.484 ± 0.112
5.169AsnLeu: 5.169 ± 0.118
1.207AsnMet: 1.207 ± 0.045
2.497AsnAsn: 2.497 ± 0.084
2.707AsnPro: 2.707 ± 0.079
1.674AsnGln: 1.674 ± 0.07
2.17AsnArg: 2.17 ± 0.078
3.628AsnSer: 3.628 ± 0.093
2.35AsnThr: 2.35 ± 0.091
2.847AsnVal: 2.847 ± 0.075
0.581AsnTrp: 0.581 ± 0.036
1.632AsnTyr: 1.632 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.681ProAla: 2.681 ± 0.087
0.286ProCys: 0.286 ± 0.028
2.473ProAsp: 2.473 ± 0.063
3.49ProGlu: 3.49 ± 0.103
1.692ProPhe: 1.692 ± 0.056
2.234ProGly: 2.234 ± 0.074
0.861ProHis: 0.861 ± 0.044
2.933ProIle: 2.933 ± 0.077
2.965ProLys: 2.965 ± 0.087
3.77ProLeu: 3.77 ± 0.091
0.913ProMet: 0.913 ± 0.04
2.218ProAsn: 2.218 ± 0.069
1.441ProPro: 1.441 ± 0.066
1.702ProGln: 1.702 ± 0.071
1.437ProArg: 1.437 ± 0.052
2.897ProSer: 2.897 ± 0.081
2.026ProThr: 2.026 ± 0.067
2.843ProVal: 2.843 ± 0.087
0.444ProTrp: 0.444 ± 0.034
1.345ProTyr: 1.345 ± 0.053
0.002ProXaa: 0.002 ± 0.002
Gln
3.007GlnAla: 3.007 ± 0.088
0.212GlnCys: 0.212 ± 0.019
1.684GlnAsp: 1.684 ± 0.056
2.152GlnGlu: 2.152 ± 0.085
1.315GlnPhe: 1.315 ± 0.049
1.998GlnGly: 1.998 ± 0.063
0.525GlnHis: 0.525 ± 0.03
2.781GlnIle: 2.781 ± 0.084
2.376GlnLys: 2.376 ± 0.073
3.113GlnLeu: 3.113 ± 0.092
0.865GlnMet: 0.865 ± 0.035
2.03GlnAsn: 2.03 ± 0.078
1.039GlnPro: 1.039 ± 0.046
1.069GlnGln: 1.069 ± 0.061
1.538GlnArg: 1.538 ± 0.063
2.342GlnSer: 2.342 ± 0.065
1.762GlnThr: 1.762 ± 0.062
2.22GlnVal: 2.22 ± 0.072
0.392GlnTrp: 0.392 ± 0.024
1.105GlnTyr: 1.105 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.229ArgAla: 3.229 ± 0.08
0.35ArgCys: 0.35 ± 0.029
2.681ArgAsp: 2.681 ± 0.071
3.347ArgGlu: 3.347 ± 0.098
2.016ArgPhe: 2.016 ± 0.066
2.913ArgGly: 2.913 ± 0.076
0.813ArgHis: 0.813 ± 0.041
3.421ArgIle: 3.421 ± 0.085
3.083ArgLys: 3.083 ± 0.074
4.444ArgLeu: 4.444 ± 0.117
1.221ArgMet: 1.221 ± 0.058
2.214ArgAsn: 2.214 ± 0.06
1.648ArgPro: 1.648 ± 0.057
1.397ArgGln: 1.397 ± 0.065
2.268ArgArg: 2.268 ± 0.07
2.629ArgSer: 2.629 ± 0.077
2.088ArgThr: 2.088 ± 0.066
3.137ArgVal: 3.137 ± 0.086
0.408ArgTrp: 0.408 ± 0.024
1.67ArgTyr: 1.67 ± 0.063
0.002ArgXaa: 0.002 ± 0.002
Ser
4.657SerAla: 4.657 ± 0.099
0.623SerCys: 0.623 ± 0.042
3.92SerAsp: 3.92 ± 0.094
4.699SerGlu: 4.699 ± 0.11
2.839SerPhe: 2.839 ± 0.082
5.257SerGly: 5.257 ± 0.13
1.387SerHis: 1.387 ± 0.056
5.155SerIle: 5.155 ± 0.099
5.425SerLys: 5.425 ± 0.122
6.751SerLeu: 6.751 ± 0.142
1.6SerMet: 1.6 ± 0.051
3.79SerAsn: 3.79 ± 0.082
2.541SerPro: 2.541 ± 0.08
2.386SerGln: 2.386 ± 0.067
3.159SerArg: 3.159 ± 0.084
4.861SerSer: 4.861 ± 0.123
3.57SerThr: 3.57 ± 0.083
4.37SerVal: 4.37 ± 0.094
0.777SerTrp: 0.777 ± 0.038
2.17SerTyr: 2.17 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
3.602ThrAla: 3.602 ± 0.101
0.432ThrCys: 0.432 ± 0.033
2.597ThrAsp: 2.597 ± 0.077
3.159ThrGlu: 3.159 ± 0.088
2.012ThrPhe: 2.012 ± 0.065
3.764ThrGly: 3.764 ± 0.13
1.105ThrHis: 1.105 ± 0.045
3.54ThrIle: 3.54 ± 0.086
3.325ThrLys: 3.325 ± 0.089
5.395ThrLeu: 5.395 ± 0.112
1.031ThrMet: 1.031 ± 0.046
2.376ThrAsn: 2.376 ± 0.083
2.45ThrPro: 2.45 ± 0.08
1.882ThrGln: 1.882 ± 0.06
2.07ThrArg: 2.07 ± 0.075
3.359ThrSer: 3.359 ± 0.084
2.591ThrThr: 2.591 ± 0.082
3.453ThrVal: 3.453 ± 0.089
0.488ThrTrp: 0.488 ± 0.031
1.447ThrTyr: 1.447 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.454ValAla: 5.454 ± 0.114
0.645ValCys: 0.645 ± 0.036
4.102ValAsp: 4.102 ± 0.102
4.312ValGlu: 4.312 ± 0.112
2.875ValPhe: 2.875 ± 0.076
4.781ValGly: 4.781 ± 0.109
1.305ValHis: 1.305 ± 0.052
4.879ValIle: 4.879 ± 0.1
3.786ValLys: 3.786 ± 0.096
6.507ValLeu: 6.507 ± 0.125
1.65ValMet: 1.65 ± 0.066
2.811ValAsn: 2.811 ± 0.093
2.791ValPro: 2.791 ± 0.076
2.142ValGln: 2.142 ± 0.066
3.063ValArg: 3.063 ± 0.077
4.655ValSer: 4.655 ± 0.096
3.229ValThr: 3.229 ± 0.089
5.103ValVal: 5.103 ± 0.123
0.701ValTrp: 0.701 ± 0.038
1.846ValTyr: 1.846 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.763TrpAla: 0.763 ± 0.048
0.114TrpCys: 0.114 ± 0.017
0.623TrpAsp: 0.623 ± 0.033
0.557TrpGlu: 0.557 ± 0.037
0.509TrpPhe: 0.509 ± 0.028
0.715TrpGly: 0.715 ± 0.041
0.264TrpHis: 0.264 ± 0.022
0.849TrpIle: 0.849 ± 0.047
0.595TrpLys: 0.595 ± 0.035
1.213TrpLeu: 1.213 ± 0.058
0.318TrpMet: 0.318 ± 0.023
0.462TrpAsn: 0.462 ± 0.034
0.352TrpPro: 0.352 ± 0.028
0.36TrpGln: 0.36 ± 0.026
0.505TrpArg: 0.505 ± 0.037
0.665TrpSer: 0.665 ± 0.04
0.495TrpThr: 0.495 ± 0.037
0.785TrpVal: 0.785 ± 0.039
0.134TrpTrp: 0.134 ± 0.016
0.372TrpTyr: 0.372 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.354TyrAla: 2.354 ± 0.076
0.316TyrCys: 0.316 ± 0.024
1.95TyrAsp: 1.95 ± 0.077
2.326TyrGlu: 2.326 ± 0.07
1.6TyrPhe: 1.6 ± 0.061
2.274TyrGly: 2.274 ± 0.066
0.613TyrHis: 0.613 ± 0.033
2.036TyrIle: 2.036 ± 0.069
2.218TyrLys: 2.218 ± 0.077
3.337TyrLeu: 3.337 ± 0.093
0.647TyrMet: 0.647 ± 0.037
1.223TyrAsn: 1.223 ± 0.058
1.287TyrPro: 1.287 ± 0.054
0.987TyrGln: 0.987 ± 0.049
1.516TyrArg: 1.516 ± 0.057
2.246TyrSer: 2.246 ± 0.078
1.481TyrThr: 1.481 ± 0.052
1.928TyrVal: 1.928 ± 0.061
0.37TyrTrp: 0.37 ± 0.026
1.039TyrTyr: 1.039 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.002XaaGlu: 0.002 ± 0.002
0.004XaaPhe: 0.004 ± 0.003
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.004XaaLys: 0.004 ± 0.003
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1523 proteins (499495 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski