Amino acid dipepetide frequency for Candidatus Aramenus sulfurataquae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.121AlaAla: 3.121 ± 0.111	0.429AlaCys: 0.429 ± 0.033	2.601AlaAsp: 2.601 ± 0.073	4.44AlaGlu: 4.44 ± 0.098	3.4AlaPhe: 3.4 ± 0.09	4.255AlaGly: 4.255 ± 0.101	0.848AlaHis: 0.848 ± 0.048	5.613AlaIle: 5.613 ± 0.124	5.127AlaLys: 5.127 ± 0.119	7.977AlaLeu: 7.977 ± 0.151	1.82AlaMet: 1.82 ± 0.056	2.146AlaAsn: 2.146 ± 0.068	1.874AlaPro: 1.874 ± 0.068	1.467AlaGln: 1.467 ± 0.052	3.325AlaArg: 3.325 ± 0.089	4.606AlaSer: 4.606 ± 0.09	3.289AlaThr: 3.289 ± 0.091	5.954AlaVal: 5.954 ± 0.113	0.654AlaTrp: 0.654 ± 0.044	2.908AlaTyr: 2.908 ± 0.085	0.0AlaXaa: 0.0 ± 0.0
Cys	0.313CysAla: 0.313 ± 0.025	0.077CysCys: 0.077 ± 0.013	0.337CysAsp: 0.337 ± 0.026	0.462CysGlu: 0.462 ± 0.034	0.207CysPhe: 0.207 ± 0.019	0.701CysGly: 0.701 ± 0.042	0.104CysHis: 0.104 ± 0.014	0.286CysIle: 0.286 ± 0.025	0.477CysLys: 0.477 ± 0.03	0.356CysLeu: 0.356 ± 0.025	0.149CysMet: 0.149 ± 0.017	0.307CysAsn: 0.307 ± 0.024	0.575CysPro: 0.575 ± 0.035	0.119CysGln: 0.119 ± 0.017	0.288CysArg: 0.288 ± 0.022	0.407CysSer: 0.407 ± 0.031	0.292CysThr: 0.292 ± 0.027	0.512CysVal: 0.512 ± 0.033	0.07CysTrp: 0.07 ± 0.012	0.26CysTyr: 0.26 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.848AspAla: 2.848 ± 0.084	0.279AspCys: 0.279 ± 0.023	2.046AspAsp: 2.046 ± 0.076	3.935AspGlu: 3.935 ± 0.108	2.392AspPhe: 2.392 ± 0.068	2.912AspGly: 2.912 ± 0.077	0.629AspHis: 0.629 ± 0.037	2.925AspIle: 2.925 ± 0.085	3.466AspLys: 3.466 ± 0.09	5.133AspLeu: 5.133 ± 0.104	1.038AspMet: 1.038 ± 0.044	1.58AspAsn: 1.58 ± 0.054	2.503AspPro: 2.503 ± 0.079	0.9AspGln: 0.9 ± 0.04	1.987AspArg: 1.987 ± 0.061	2.543AspSer: 2.543 ± 0.066	1.582AspThr: 1.582 ± 0.053	5.489AspVal: 5.489 ± 0.105	0.552AspTrp: 0.552 ± 0.029	2.419AspTyr: 2.419 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	5.139GluAla: 5.139 ± 0.107	0.424GluCys: 0.424 ± 0.032	3.773GluAsp: 3.773 ± 0.097	7.991GluGlu: 7.991 ± 0.18	2.822GluPhe: 2.822 ± 0.078	5.333GluGly: 5.333 ± 0.108	0.738GluHis: 0.738 ± 0.04	5.892GluIle: 5.892 ± 0.127	6.467GluLys: 6.467 ± 0.132	7.569GluLeu: 7.569 ± 0.151	1.814GluMet: 1.814 ± 0.063	2.91GluAsn: 2.91 ± 0.095	1.918GluPro: 1.918 ± 0.065	1.302GluGln: 1.302 ± 0.053	4.38GluArg: 4.38 ± 0.115	3.304GluSer: 3.304 ± 0.087	2.539GluThr: 2.539 ± 0.068	8.219GluVal: 8.219 ± 0.154	0.708GluTrp: 0.708 ± 0.042	2.769GluTyr: 2.769 ± 0.074	0.0GluXaa: 0.0 ± 0.0
Phe	2.839PheAla: 2.839 ± 0.079	0.262PheCys: 0.262 ± 0.025	2.059PheAsp: 2.059 ± 0.065	2.458PheGlu: 2.458 ± 0.075	2.068PhePhe: 2.068 ± 0.075	2.81PheGly: 2.81 ± 0.072	0.708PheHis: 0.708 ± 0.038	2.592PheIle: 2.592 ± 0.085	2.784PheLys: 2.784 ± 0.075	5.101PheLeu: 5.101 ± 0.138	0.995PheMet: 0.995 ± 0.045	1.995PheAsn: 1.995 ± 0.067	2.042PhePro: 2.042 ± 0.068	1.006PheGln: 1.006 ± 0.046	1.782PheArg: 1.782 ± 0.054	3.873PheSer: 3.873 ± 0.102	2.328PheThr: 2.328 ± 0.071	3.592PheVal: 3.592 ± 0.08	0.467PheTrp: 0.467 ± 0.033	2.142PheTyr: 2.142 ± 0.071	0.0PheXaa: 0.0 ± 0.0
Gly	4.329GlyAla: 4.329 ± 0.101	0.482GlyCys: 0.482 ± 0.036	3.383GlyAsp: 3.383 ± 0.088	5.208GlyGlu: 5.208 ± 0.105	3.496GlyPhe: 3.496 ± 0.088	4.849GlyGly: 4.849 ± 0.12	0.974GlyHis: 0.974 ± 0.042	6.124GlyIle: 6.124 ± 0.115	6.244GlyLys: 6.244 ± 0.124	6.614GlyLeu: 6.614 ± 0.132	1.639GlyMet: 1.639 ± 0.057	2.85GlyAsn: 2.85 ± 0.079	1.91GlyPro: 1.91 ± 0.065	1.3GlyGln: 1.3 ± 0.054	3.432GlyArg: 3.432 ± 0.085	4.035GlySer: 4.035 ± 0.1	3.18GlyThr: 3.18 ± 0.092	6.491GlyVal: 6.491 ± 0.113	0.782GlyTrp: 0.782 ± 0.039	3.379GlyTyr: 3.379 ± 0.078	0.0GlyXaa: 0.0 ± 0.0
His	0.814HisAla: 0.814 ± 0.045	0.109HisCys: 0.109 ± 0.013	0.558HisAsp: 0.558 ± 0.031	0.908HisGlu: 0.908 ± 0.041	0.631HisPhe: 0.631 ± 0.035	1.081HisGly: 1.081 ± 0.046	0.3HisHis: 0.3 ± 0.026	0.689HisIle: 0.689 ± 0.036	0.686HisLys: 0.686 ± 0.04	1.224HisLeu: 1.224 ± 0.057	0.303HisMet: 0.303 ± 0.024	0.443HisAsn: 0.443 ± 0.025	0.772HisPro: 0.772 ± 0.037	0.281HisGln: 0.281 ± 0.023	0.586HisArg: 0.586 ± 0.034	0.818HisSer: 0.818 ± 0.038	0.537HisThr: 0.537 ± 0.038	1.343HisVal: 1.343 ± 0.053	0.149HisTrp: 0.149 ± 0.019	0.582HisTyr: 0.582 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.506IleAla: 5.506 ± 0.107	0.377IleCys: 0.377 ± 0.028	3.62IleAsp: 3.62 ± 0.087	4.715IleGlu: 4.715 ± 0.108	2.528IlePhe: 2.528 ± 0.089	4.952IleGly: 4.952 ± 0.098	0.925IleHis: 0.925 ± 0.046	4.293IleIle: 4.293 ± 0.094	4.47IleLys: 4.47 ± 0.096	6.363IleLeu: 6.363 ± 0.139	1.513IleMet: 1.513 ± 0.051	2.671IleAsn: 2.671 ± 0.077	3.43IlePro: 3.43 ± 0.093	1.439IleGln: 1.439 ± 0.053	3.718IleArg: 3.718 ± 0.09	5.568IleSer: 5.568 ± 0.117	3.496IleThr: 3.496 ± 0.089	5.913IleVal: 5.913 ± 0.11	0.433IleTrp: 0.433 ± 0.03	2.908IleTyr: 2.908 ± 0.078	0.0IleXaa: 0.0 ± 0.0
Lys	4.922LysAla: 4.922 ± 0.103	0.535LysCys: 0.535 ± 0.037	3.905LysAsp: 3.905 ± 0.089	7.371LysGlu: 7.371 ± 0.131	2.777LysPhe: 2.777 ± 0.074	5.711LysGly: 5.711 ± 0.097	0.676LysHis: 0.676 ± 0.037	4.866LysIle: 4.866 ± 0.112	5.156LysLys: 5.156 ± 0.121	7.263LysLeu: 7.263 ± 0.15	1.778LysMet: 1.778 ± 0.057	2.417LysAsn: 2.417 ± 0.07	2.451LysPro: 2.451 ± 0.074	1.217LysGln: 1.217 ± 0.063	4.27LysArg: 4.27 ± 0.099	3.498LysSer: 3.498 ± 0.08	2.848LysThr: 2.848 ± 0.076	8.535LysVal: 8.535 ± 0.146	0.703LysTrp: 0.703 ± 0.036	3.193LysTyr: 3.193 ± 0.089	0.0LysXaa: 0.0 ± 0.0
Leu	7.721LeuAla: 7.721 ± 0.134	0.535LeuCys: 0.535 ± 0.033	4.916LeuAsp: 4.916 ± 0.102	7.226LeuGlu: 7.226 ± 0.144	4.082LeuPhe: 4.082 ± 0.122	8.043LeuGly: 8.043 ± 0.14	1.226LeuHis: 1.226 ± 0.046	6.55LeuIle: 6.55 ± 0.135	7.757LeuLys: 7.757 ± 0.137	10.029LeuLeu: 10.029 ± 0.184	2.315LeuMet: 2.315 ± 0.074	4.186LeuAsn: 4.186 ± 0.082	4.208LeuPro: 4.208 ± 0.098	2.211LeuGln: 2.211 ± 0.067	5.576LeuArg: 5.576 ± 0.143	7.991LeuSer: 7.991 ± 0.122	4.707LeuThr: 4.707 ± 0.109	8.405LeuVal: 8.405 ± 0.169	0.863LeuTrp: 0.863 ± 0.042	3.856LeuTyr: 3.856 ± 0.087	0.0LeuXaa: 0.0 ± 0.0
Met	1.759MetAla: 1.759 ± 0.061	0.128MetCys: 0.128 ± 0.015	1.262MetAsp: 1.262 ± 0.048	1.927MetGlu: 1.927 ± 0.064	0.797MetPhe: 0.797 ± 0.041	1.876MetGly: 1.876 ± 0.061	0.277MetHis: 0.277 ± 0.024	1.524MetIle: 1.524 ± 0.061	1.906MetLys: 1.906 ± 0.061	2.066MetLeu: 2.066 ± 0.064	0.507MetMet: 0.507 ± 0.039	0.866MetAsn: 0.866 ± 0.04	0.963MetPro: 0.963 ± 0.048	0.488MetGln: 0.488 ± 0.031	1.426MetArg: 1.426 ± 0.049	1.667MetSer: 1.667 ± 0.06	1.102MetThr: 1.102 ± 0.047	1.656MetVal: 1.656 ± 0.059	0.226MetTrp: 0.226 ± 0.024	0.72MetTyr: 0.72 ± 0.04	0.0MetXaa: 0.0 ± 0.0
Asn	2.972AsnAla: 2.972 ± 0.086	0.32AsnCys: 0.32 ± 0.027	1.62AsnAsp: 1.62 ± 0.062	2.389AsnGlu: 2.389 ± 0.064	1.895AsnPhe: 1.895 ± 0.073	2.728AsnGly: 2.728 ± 0.088	0.411AsnHis: 0.411 ± 0.031	2.032AsnIle: 2.032 ± 0.064	2.481AsnLys: 2.481 ± 0.072	4.065AsnLeu: 4.065 ± 0.102	0.706AsnMet: 0.706 ± 0.038	1.328AsnAsn: 1.328 ± 0.057	2.136AsnPro: 2.136 ± 0.074	0.784AsnGln: 0.784 ± 0.037	1.684AsnArg: 1.684 ± 0.058	2.637AsnSer: 2.637 ± 0.075	1.637AsnThr: 1.637 ± 0.08	4.276AsnVal: 4.276 ± 0.104	0.411AsnTrp: 0.411 ± 0.031	1.989AsnTyr: 1.989 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	2.189ProAla: 2.189 ± 0.075	0.239ProCys: 0.239 ± 0.02	1.759ProAsp: 1.759 ± 0.063	3.125ProGlu: 3.125 ± 0.075	2.112ProPhe: 2.112 ± 0.068	2.752ProGly: 2.752 ± 0.079	0.62ProHis: 0.62 ± 0.035	2.839ProIle: 2.839 ± 0.072	2.692ProLys: 2.692 ± 0.071	4.125ProLeu: 4.125 ± 0.103	0.829ProMet: 0.829 ± 0.043	1.614ProAsn: 1.614 ± 0.065	1.933ProPro: 1.933 ± 0.064	1.172ProGln: 1.172 ± 0.059	1.761ProArg: 1.761 ± 0.056	3.198ProSer: 3.198 ± 0.086	2.072ProThr: 2.072 ± 0.069	3.304ProVal: 3.304 ± 0.075	0.512ProTrp: 0.512 ± 0.03	1.942ProTyr: 1.942 ± 0.066	0.0ProXaa: 0.0 ± 0.0
Gln	1.377GlnAla: 1.377 ± 0.052	0.117GlnCys: 0.117 ± 0.015	0.878GlnAsp: 0.878 ± 0.039	1.795GlnGlu: 1.795 ± 0.068	0.855GlnPhe: 0.855 ± 0.042	1.831GlnGly: 1.831 ± 0.061	0.245GlnHis: 0.245 ± 0.02	1.464GlnIle: 1.464 ± 0.054	1.426GlnLys: 1.426 ± 0.057	2.161GlnLeu: 2.161 ± 0.071	0.58GlnMet: 0.58 ± 0.036	0.776GlnAsn: 0.776 ± 0.042	0.827GlnPro: 0.827 ± 0.053	0.644GlnGln: 0.644 ± 0.046	1.157GlnArg: 1.157 ± 0.046	1.098GlnSer: 1.098 ± 0.047	0.97GlnThr: 0.97 ± 0.046	1.923GlnVal: 1.923 ± 0.067	0.219GlnTrp: 0.219 ± 0.02	0.801GlnTyr: 0.801 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.293ArgAla: 3.293 ± 0.099	0.337ArgCys: 0.337 ± 0.027	2.462ArgAsp: 2.462 ± 0.072	5.054ArgGlu: 5.054 ± 0.113	1.867ArgPhe: 1.867 ± 0.068	3.83ArgGly: 3.83 ± 0.1	0.624ArgHis: 0.624 ± 0.034	3.568ArgIle: 3.568 ± 0.082	4.293ArgLys: 4.293 ± 0.115	5.069ArgLeu: 5.069 ± 0.126	1.166ArgMet: 1.166 ± 0.051	1.918ArgAsn: 1.918 ± 0.061	1.788ArgPro: 1.788 ± 0.065	1.102ArgGln: 1.102 ± 0.042	3.087ArgArg: 3.087 ± 0.087	2.454ArgSer: 2.454 ± 0.07	1.978ArgThr: 1.978 ± 0.062	4.18ArgVal: 4.18 ± 0.099	0.471ArgTrp: 0.471 ± 0.029	1.806ArgTyr: 1.806 ± 0.067	0.0ArgXaa: 0.0 ± 0.0
Ser	3.975SerAla: 3.975 ± 0.09	0.445SerCys: 0.445 ± 0.028	2.545SerAsp: 2.545 ± 0.073	3.862SerGlu: 3.862 ± 0.087	3.451SerPhe: 3.451 ± 0.09	4.268SerGly: 4.268 ± 0.105	0.961SerHis: 0.961 ± 0.045	4.363SerIle: 4.363 ± 0.109	4.536SerLys: 4.536 ± 0.097	8.07SerLeu: 8.07 ± 0.142	1.684SerMet: 1.684 ± 0.055	2.375SerAsn: 2.375 ± 0.08	3.168SerPro: 3.168 ± 0.09	1.827SerGln: 1.827 ± 0.066	3.285SerArg: 3.285 ± 0.087	5.553SerSer: 5.553 ± 0.108	3.49SerThr: 3.49 ± 0.108	5.208SerVal: 5.208 ± 0.105	0.72SerTrp: 0.72 ± 0.036	2.79SerTyr: 2.79 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	3.259ThrAla: 3.259 ± 0.094	0.262ThrCys: 0.262 ± 0.021	1.69ThrAsp: 1.69 ± 0.054	2.528ThrGlu: 2.528 ± 0.082	2.151ThrPhe: 2.151 ± 0.065	3.434ThrGly: 3.434 ± 0.087	0.663ThrHis: 0.663 ± 0.036	3.037ThrIle: 3.037 ± 0.087	2.69ThrLys: 2.69 ± 0.073	4.994ThrLeu: 4.994 ± 0.098	1.034ThrMet: 1.034 ± 0.043	1.577ThrAsn: 1.577 ± 0.057	2.492ThrPro: 2.492 ± 0.078	1.049ThrGln: 1.049 ± 0.049	2.098ThrArg: 2.098 ± 0.071	3.622ThrSer: 3.622 ± 0.108	2.575ThrThr: 2.575 ± 0.145	3.941ThrVal: 3.941 ± 0.101	0.501ThrTrp: 0.501 ± 0.031	2.066ThrTyr: 2.066 ± 0.082	0.0ThrXaa: 0.0 ± 0.0
Val	5.952ValAla: 5.952 ± 0.119	0.556ValCys: 0.556 ± 0.032	5.009ValAsp: 5.009 ± 0.104	7.235ValGlu: 7.235 ± 0.124	3.75ValPhe: 3.75 ± 0.099	5.691ValGly: 5.691 ± 0.112	1.177ValHis: 1.177 ± 0.044	7.367ValIle: 7.367 ± 0.129	7.959ValLys: 7.959 ± 0.144	8.371ValLeu: 8.371 ± 0.136	2.157ValMet: 2.157 ± 0.063	4.133ValAsn: 4.133 ± 0.095	3.541ValPro: 3.541 ± 0.08	1.648ValGln: 1.648 ± 0.065	4.336ValArg: 4.336 ± 0.094	5.945ValSer: 5.945 ± 0.109	4.666ValThr: 4.666 ± 0.12	9.021ValVal: 9.021 ± 0.16	0.737ValTrp: 0.737 ± 0.042	3.769ValTyr: 3.769 ± 0.097	0.0ValXaa: 0.0 ± 0.0
Trp	0.667TrpAla: 0.667 ± 0.039	0.058TrpCys: 0.058 ± 0.011	0.514TrpAsp: 0.514 ± 0.037	0.688TrpGlu: 0.688 ± 0.038	0.45TrpPhe: 0.45 ± 0.029	0.688TrpGly: 0.688 ± 0.037	0.151TrpHis: 0.151 ± 0.016	0.656TrpIle: 0.656 ± 0.038	0.782TrpLys: 0.782 ± 0.04	0.976TrpLeu: 0.976 ± 0.046	0.252TrpMet: 0.252 ± 0.023	0.46TrpAsn: 0.46 ± 0.03	0.284TrpPro: 0.284 ± 0.024	0.222TrpGln: 0.222 ± 0.021	0.599TrpArg: 0.599 ± 0.036	0.554TrpSer: 0.554 ± 0.033	0.418TrpThr: 0.418 ± 0.033	0.72TrpVal: 0.72 ± 0.039	0.158TrpTrp: 0.158 ± 0.019	0.46TrpTyr: 0.46 ± 0.034	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.861TyrAla: 2.861 ± 0.08	0.326TyrCys: 0.326 ± 0.023	2.223TyrAsp: 2.223 ± 0.068	2.692TyrGlu: 2.692 ± 0.079	2.172TyrPhe: 2.172 ± 0.075	2.956TyrGly: 2.956 ± 0.085	0.558TyrHis: 0.558 ± 0.032	2.161TyrIle: 2.161 ± 0.073	2.694TyrLys: 2.694 ± 0.073	4.879TyrLeu: 4.879 ± 0.104	0.865TyrMet: 0.865 ± 0.042	1.95TyrAsn: 1.95 ± 0.073	1.974TyrPro: 1.974 ± 0.07	0.964TyrGln: 0.964 ± 0.042	1.567TyrArg: 1.567 ± 0.053	3.204TyrSer: 3.204 ± 0.079	1.955TyrThr: 1.955 ± 0.065	4.338TyrVal: 4.338 ± 0.101	0.422TyrTrp: 0.422 ± 0.03	2.236TyrTyr: 2.236 ± 0.077	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1975 proteins (530875 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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