Amino acid dipepetide frequency for Candidatus Nitrospira inopinata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.869AlaAla: 10.869 ± 0.158	1.131AlaCys: 1.131 ± 0.038	5.191AlaAsp: 5.191 ± 0.068	6.197AlaGlu: 6.197 ± 0.092	3.13AlaPhe: 3.13 ± 0.064	8.457AlaGly: 8.457 ± 0.091	2.116AlaHis: 2.116 ± 0.048	5.122AlaIle: 5.122 ± 0.076	4.333AlaLys: 4.333 ± 0.075	10.453AlaLeu: 10.453 ± 0.129	2.726AlaMet: 2.726 ± 0.054	2.126AlaAsn: 2.126 ± 0.05	4.12AlaPro: 4.12 ± 0.067	3.532AlaGln: 3.532 ± 0.067	7.005AlaArg: 7.005 ± 0.099	5.402AlaSer: 5.402 ± 0.078	4.859AlaThr: 4.859 ± 0.073	8.548AlaVal: 8.548 ± 0.11	1.34AlaTrp: 1.34 ± 0.038	2.4AlaTyr: 2.4 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.979CysAla: 0.979 ± 0.032	0.184CysCys: 0.184 ± 0.015	0.489CysAsp: 0.489 ± 0.021	0.541CysGlu: 0.541 ± 0.022	0.401CysPhe: 0.401 ± 0.022	0.968CysGly: 0.968 ± 0.031	0.423CysHis: 0.423 ± 0.025	0.362CysIle: 0.362 ± 0.019	0.293CysLys: 0.293 ± 0.018	1.126CysLeu: 1.126 ± 0.038	0.184CysMet: 0.184 ± 0.013	0.247CysAsn: 0.247 ± 0.016	0.632CysPro: 0.632 ± 0.027	0.326CysGln: 0.326 ± 0.021	0.926CysArg: 0.926 ± 0.033	0.64CysSer: 0.64 ± 0.024	0.448CysThr: 0.448 ± 0.024	0.742CysVal: 0.742 ± 0.026	0.119CysTrp: 0.119 ± 0.011	0.265CysTyr: 0.265 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.699AspAla: 4.699 ± 0.075	0.566AspCys: 0.566 ± 0.025	2.65AspAsp: 2.65 ± 0.052	3.508AspGlu: 3.508 ± 0.061	1.869AspPhe: 1.869 ± 0.052	4.415AspGly: 4.415 ± 0.08	1.433AspHis: 1.433 ± 0.034	2.371AspIle: 2.371 ± 0.056	1.645AspLys: 1.645 ± 0.048	6.043AspLeu: 6.043 ± 0.085	0.991AspMet: 0.991 ± 0.031	1.101AspAsn: 1.101 ± 0.036	3.404AspPro: 3.404 ± 0.065	1.972AspGln: 1.972 ± 0.052	4.948AspArg: 4.948 ± 0.081	2.346AspSer: 2.346 ± 0.047	2.11AspThr: 2.11 ± 0.058	4.323AspVal: 4.323 ± 0.071	0.755AspTrp: 0.755 ± 0.027	1.414AspTyr: 1.414 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.92GluAla: 6.92 ± 0.097	0.435GluCys: 0.435 ± 0.02	2.715GluAsp: 2.715 ± 0.054	4.469GluGlu: 4.469 ± 0.083	2.038GluPhe: 2.038 ± 0.043	4.491GluGly: 4.491 ± 0.069	1.367GluHis: 1.367 ± 0.042	3.433GluIle: 3.433 ± 0.075	2.656GluLys: 2.656 ± 0.064	6.034GluLeu: 6.034 ± 0.077	1.484GluMet: 1.484 ± 0.042	1.323GluAsn: 1.323 ± 0.044	2.936GluPro: 2.936 ± 0.061	2.948GluGln: 2.948 ± 0.058	6.022GluArg: 6.022 ± 0.085	3.533GluSer: 3.533 ± 0.07	3.478GluThr: 3.478 ± 0.063	4.151GluVal: 4.151 ± 0.064	0.955GluTrp: 0.955 ± 0.036	1.333GluTyr: 1.333 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.271PheAla: 3.271 ± 0.067	0.459PheCys: 0.459 ± 0.022	2.18PheAsp: 2.18 ± 0.048	2.115PheGlu: 2.115 ± 0.048	1.502PhePhe: 1.502 ± 0.04	3.089PheGly: 3.089 ± 0.063	0.985PheHis: 0.985 ± 0.032	1.623PheIle: 1.623 ± 0.04	1.207PheLys: 1.207 ± 0.039	3.816PheLeu: 3.816 ± 0.07	0.757PheMet: 0.757 ± 0.027	1.034PheAsn: 1.034 ± 0.039	1.809PhePro: 1.809 ± 0.044	1.161PheGln: 1.161 ± 0.033	2.391PheArg: 2.391 ± 0.052	2.338PheSer: 2.338 ± 0.053	1.923PheThr: 1.923 ± 0.048	2.803PheVal: 2.803 ± 0.059	0.494PheTrp: 0.494 ± 0.025	0.996PheTyr: 0.996 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.999GlyAla: 6.999 ± 0.1	0.992GlyCys: 0.992 ± 0.035	3.926GlyAsp: 3.926 ± 0.071	4.773GlyGlu: 4.773 ± 0.07	3.167GlyPhe: 3.167 ± 0.063	6.683GlyGly: 6.683 ± 0.1	1.893GlyHis: 1.893 ± 0.039	4.395GlyIle: 4.395 ± 0.075	3.675GlyLys: 3.675 ± 0.077	8.532GlyLeu: 8.532 ± 0.102	2.15GlyMet: 2.15 ± 0.065	2.072GlyAsn: 2.072 ± 0.074	3.293GlyPro: 3.293 ± 0.056	2.646GlyGln: 2.646 ± 0.061	6.35GlyArg: 6.35 ± 0.086	4.715GlySer: 4.715 ± 0.068	4.759GlyThr: 4.759 ± 0.088	6.186GlyVal: 6.186 ± 0.104	1.296GlyTrp: 1.296 ± 0.039	2.306GlyTyr: 2.306 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.165HisAla: 2.165 ± 0.048	0.325HisCys: 0.325 ± 0.023	1.261HisAsp: 1.261 ± 0.036	1.423HisGlu: 1.423 ± 0.041	0.759HisPhe: 0.759 ± 0.026	1.966HisGly: 1.966 ± 0.046	0.714HisHis: 0.714 ± 0.026	1.004HisIle: 1.004 ± 0.03	0.633HisLys: 0.633 ± 0.024	2.427HisLeu: 2.427 ± 0.052	0.463HisMet: 0.463 ± 0.021	0.483HisAsn: 0.483 ± 0.024	1.564HisPro: 1.564 ± 0.045	0.873HisGln: 0.873 ± 0.029	1.958HisArg: 1.958 ± 0.044	1.063HisSer: 1.063 ± 0.033	1.039HisThr: 1.039 ± 0.035	1.902HisVal: 1.902 ± 0.045	0.3HisTrp: 0.3 ± 0.017	0.619HisTyr: 0.619 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.197IleAla: 5.197 ± 0.078	0.464IleCys: 0.464 ± 0.024	3.234IleAsp: 3.234 ± 0.061	3.918IleGlu: 3.918 ± 0.066	1.541IlePhe: 1.541 ± 0.039	4.935IleGly: 4.935 ± 0.077	1.19IleHis: 1.19 ± 0.034	2.295IleIle: 2.295 ± 0.054	2.188IleLys: 2.188 ± 0.061	4.679IleLeu: 4.679 ± 0.075	0.973IleMet: 0.973 ± 0.031	1.395IleAsn: 1.395 ± 0.042	2.872IlePro: 2.872 ± 0.06	1.657IleGln: 1.657 ± 0.034	3.69IleArg: 3.69 ± 0.065	2.459IleSer: 2.459 ± 0.055	2.637IleThr: 2.637 ± 0.048	4.432IleVal: 4.432 ± 0.07	0.537IleTrp: 0.537 ± 0.026	1.074IleTyr: 1.074 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.954LysAla: 3.954 ± 0.077	0.203LysCys: 0.203 ± 0.014	2.107LysAsp: 2.107 ± 0.05	2.909LysGlu: 2.909 ± 0.055	1.041LysPhe: 1.041 ± 0.038	3.11LysGly: 3.11 ± 0.063	0.77LysHis: 0.77 ± 0.03	2.167LysIle: 2.167 ± 0.048	2.07LysLys: 2.07 ± 0.058	3.577LysLeu: 3.577 ± 0.072	0.91LysMet: 0.91 ± 0.033	1.11LysAsn: 1.11 ± 0.042	2.226LysPro: 2.226 ± 0.048	1.621LysGln: 1.621 ± 0.043	3.142LysArg: 3.142 ± 0.06	2.049LysSer: 2.049 ± 0.047	2.576LysThr: 2.576 ± 0.062	2.753LysVal: 2.753 ± 0.059	0.383LysTrp: 0.383 ± 0.019	0.759LysTyr: 0.759 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.426LeuAla: 11.426 ± 0.123	1.133LeuCys: 1.133 ± 0.033	5.814LeuAsp: 5.814 ± 0.076	5.941LeuGlu: 5.941 ± 0.084	3.98LeuPhe: 3.98 ± 0.065	7.422LeuGly: 7.422 ± 0.099	2.265LeuHis: 2.265 ± 0.047	5.363LeuIle: 5.363 ± 0.073	4.307LeuLys: 4.307 ± 0.074	11.151LeuLeu: 11.151 ± 0.135	2.3LeuMet: 2.3 ± 0.048	2.786LeuAsn: 2.786 ± 0.053	5.368LeuPro: 5.368 ± 0.068	3.177LeuGln: 3.177 ± 0.055	7.507LeuArg: 7.507 ± 0.087	6.701LeuSer: 6.701 ± 0.096	6.052LeuThr: 6.052 ± 0.086	7.85LeuVal: 7.85 ± 0.106	1.262LeuTrp: 1.262 ± 0.04	2.661LeuTyr: 2.661 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.713MetAla: 2.713 ± 0.061	0.15MetCys: 0.15 ± 0.013	1.144MetAsp: 1.144 ± 0.035	1.432MetGlu: 1.432 ± 0.035	0.59MetPhe: 0.59 ± 0.027	1.927MetGly: 1.927 ± 0.045	0.329MetHis: 0.329 ± 0.019	1.263MetIle: 1.263 ± 0.038	1.285MetLys: 1.285 ± 0.041	2.086MetLeu: 2.086 ± 0.042	0.598MetMet: 0.598 ± 0.026	0.794MetAsn: 0.794 ± 0.025	1.37MetPro: 1.37 ± 0.038	0.714MetGln: 0.714 ± 0.026	1.591MetArg: 1.591 ± 0.044	1.346MetSer: 1.346 ± 0.038	1.725MetThr: 1.725 ± 0.04	1.821MetVal: 1.821 ± 0.052	0.221MetTrp: 0.221 ± 0.015	0.379MetTyr: 0.379 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.087AsnAla: 2.087 ± 0.047	0.252AsnCys: 0.252 ± 0.016	1.27AsnAsp: 1.27 ± 0.043	1.384AsnGlu: 1.384 ± 0.039	0.851AsnPhe: 0.851 ± 0.029	2.338AsnGly: 2.338 ± 0.058	0.615AsnHis: 0.615 ± 0.03	1.13AsnIle: 1.13 ± 0.038	0.824AsnLys: 0.824 ± 0.028	2.79AsnLeu: 2.79 ± 0.051	0.555AsnMet: 0.555 ± 0.021	0.685AsnAsn: 0.685 ± 0.028	1.867AsnPro: 1.867 ± 0.056	0.934AsnGln: 0.934 ± 0.035	2.174AsnArg: 2.174 ± 0.044	1.051AsnSer: 1.051 ± 0.037	1.141AsnThr: 1.141 ± 0.033	2.159AsnVal: 2.159 ± 0.045	0.317AsnTrp: 0.317 ± 0.017	0.649AsnTyr: 0.649 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.023ProAla: 5.023 ± 0.076	0.484ProCys: 0.484 ± 0.022	3.39ProAsp: 3.39 ± 0.065	3.363ProGlu: 3.363 ± 0.055	2.11ProPhe: 2.11 ± 0.049	4.051ProGly: 4.051 ± 0.077	1.214ProHis: 1.214 ± 0.038	2.721ProIle: 2.721 ± 0.055	1.754ProLys: 1.754 ± 0.046	5.287ProLeu: 5.287 ± 0.076	1.278ProMet: 1.278 ± 0.038	1.442ProAsn: 1.442 ± 0.041	3.174ProPro: 3.174 ± 0.073	1.584ProGln: 1.584 ± 0.038	2.955ProArg: 2.955 ± 0.064	3.617ProSer: 3.617 ± 0.07	2.886ProThr: 2.886 ± 0.063	4.231ProVal: 4.231 ± 0.066	0.706ProTrp: 0.706 ± 0.031	1.258ProTyr: 1.258 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.269GlnAla: 4.269 ± 0.075	0.298GlnCys: 0.298 ± 0.021	1.727GlnAsp: 1.727 ± 0.041	2.433GlnGlu: 2.433 ± 0.044	1.203GlnPhe: 1.203 ± 0.035	2.7GlnGly: 2.7 ± 0.052	0.682GlnHis: 0.682 ± 0.025	1.782GlnIle: 1.782 ± 0.052	1.261GlnLys: 1.261 ± 0.035	3.124GlnLeu: 3.124 ± 0.065	0.789GlnMet: 0.789 ± 0.027	0.738GlnAsn: 0.738 ± 0.029	1.841GlnPro: 1.841 ± 0.048	1.429GlnGln: 1.429 ± 0.041	2.881GlnArg: 2.881 ± 0.068	1.861GlnSer: 1.861 ± 0.041	1.929GlnThr: 1.929 ± 0.042	2.643GlnVal: 2.643 ± 0.046	0.557GlnTrp: 0.557 ± 0.022	0.794GlnTyr: 0.794 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.824ArgAla: 6.824 ± 0.106	0.79ArgCys: 0.79 ± 0.033	3.875ArgAsp: 3.875 ± 0.076	5.098ArgGlu: 5.098 ± 0.084	3.094ArgPhe: 3.094 ± 0.066	4.813ArgGly: 4.813 ± 0.072	1.926ArgHis: 1.926 ± 0.047	4.044ArgIle: 4.044 ± 0.064	2.75ArgLys: 2.75 ± 0.051	9.059ArgLeu: 9.059 ± 0.12	1.946ArgMet: 1.946 ± 0.044	1.844ArgAsn: 1.844 ± 0.043	3.661ArgPro: 3.661 ± 0.065	2.983ArgGln: 2.983 ± 0.059	6.546ArgArg: 6.546 ± 0.098	4.399ArgSer: 4.399 ± 0.078	3.825ArgThr: 3.825 ± 0.066	5.367ArgVal: 5.367 ± 0.081	1.266ArgTrp: 1.266 ± 0.041	2.228ArgTyr: 2.228 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.241SerAla: 5.241 ± 0.073	0.644SerCys: 0.644 ± 0.025	2.921SerAsp: 2.921 ± 0.059	2.874SerGlu: 2.874 ± 0.05	2.37SerPhe: 2.37 ± 0.053	4.997SerGly: 4.997 ± 0.073	1.341SerHis: 1.341 ± 0.042	2.943SerIle: 2.943 ± 0.066	1.927SerLys: 1.927 ± 0.041	6.277SerLeu: 6.277 ± 0.091	1.446SerMet: 1.446 ± 0.037	1.331SerAsn: 1.331 ± 0.041	3.45SerPro: 3.45 ± 0.062	1.798SerGln: 1.798 ± 0.04	4.119SerArg: 4.119 ± 0.059	3.64SerSer: 3.64 ± 0.072	2.833SerThr: 2.833 ± 0.052	4.291SerVal: 4.291 ± 0.067	0.822SerTrp: 0.822 ± 0.032	1.368SerTyr: 1.368 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.327ThrAla: 5.327 ± 0.083	0.54ThrCys: 0.54 ± 0.021	2.8ThrAsp: 2.8 ± 0.055	2.883ThrGlu: 2.883 ± 0.055	2.023ThrPhe: 2.023 ± 0.04	5.067ThrGly: 5.067 ± 0.075	1.157ThrHis: 1.157 ± 0.035	3.317ThrIle: 3.317 ± 0.064	2.023ThrLys: 2.023 ± 0.045	5.603ThrLeu: 5.603 ± 0.084	1.291ThrMet: 1.291 ± 0.042	1.377ThrAsn: 1.377 ± 0.045	3.026ThrPro: 3.026 ± 0.068	1.52ThrGln: 1.52 ± 0.043	3.015ThrArg: 3.015 ± 0.06	2.721ThrSer: 2.721 ± 0.053	3.045ThrThr: 3.045 ± 0.055	5.32ThrVal: 5.32 ± 0.081	0.629ThrTrp: 0.629 ± 0.026	1.299ThrTyr: 1.299 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.779ValAla: 7.779 ± 0.099	0.79ValCys: 0.79 ± 0.028	3.759ValAsp: 3.759 ± 0.061	5.081ValGlu: 5.081 ± 0.076	2.715ValPhe: 2.715 ± 0.054	6.369ValGly: 6.369 ± 0.092	1.584ValHis: 1.584 ± 0.043	4.356ValIle: 4.356 ± 0.069	3.185ValLys: 3.185 ± 0.066	8.149ValLeu: 8.149 ± 0.105	1.829ValMet: 1.829 ± 0.046	2.119ValAsn: 2.119 ± 0.044	4.087ValPro: 4.087 ± 0.064	2.554ValGln: 2.554 ± 0.046	5.746ValArg: 5.746 ± 0.083	4.719ValSer: 4.719 ± 0.072	4.89ValThr: 4.89 ± 0.08	6.844ValVal: 6.844 ± 0.114	0.907ValTrp: 0.907 ± 0.032	1.714ValTyr: 1.714 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.104TrpAla: 1.104 ± 0.036	0.151TrpCys: 0.151 ± 0.014	0.619TrpAsp: 0.619 ± 0.024	0.808TrpGlu: 0.808 ± 0.028	0.558TrpPhe: 0.558 ± 0.023	0.916TrpGly: 0.916 ± 0.034	0.303TrpHis: 0.303 ± 0.018	0.754TrpIle: 0.754 ± 0.033	0.626TrpLys: 0.626 ± 0.028	1.55TrpLeu: 1.55 ± 0.043	0.392TrpMet: 0.392 ± 0.021	0.454TrpAsn: 0.454 ± 0.022	0.586TrpPro: 0.586 ± 0.029	0.482TrpGln: 0.482 ± 0.023	1.053TrpArg: 1.053 ± 0.032	0.838TrpSer: 0.838 ± 0.032	0.752TrpThr: 0.752 ± 0.031	0.942TrpVal: 0.942 ± 0.034	0.269TrpTrp: 0.269 ± 0.019	0.384TrpTyr: 0.384 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.21TyrAla: 2.21 ± 0.057	0.302TyrCys: 0.302 ± 0.017	1.494TyrAsp: 1.494 ± 0.051	1.571TyrGlu: 1.571 ± 0.042	1.011TyrPhe: 1.011 ± 0.031	2.094TyrGly: 2.094 ± 0.038	0.635TyrHis: 0.635 ± 0.025	0.919TyrIle: 0.919 ± 0.032	0.795TyrLys: 0.795 ± 0.031	2.705TyrLeu: 2.705 ± 0.051	0.416TyrMet: 0.416 ± 0.021	0.609TyrAsn: 0.609 ± 0.028	1.243TyrPro: 1.243 ± 0.036	1.029TyrGln: 1.029 ± 0.034	2.319TyrArg: 2.319 ± 0.051	1.194TyrSer: 1.194 ± 0.04	1.075TyrThr: 1.075 ± 0.033	1.87TyrVal: 1.87 ± 0.047	0.408TyrTrp: 0.408 ± 0.022	0.799TyrTyr: 0.799 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3371 proteins (990833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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