Amino acid dipepetide frequency for Butyrivibrio hungatei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.966AlaAla: 5.966 ± 0.1	1.03AlaCys: 1.03 ± 0.031	4.676AlaAsp: 4.676 ± 0.071	5.046AlaGlu: 5.046 ± 0.087	3.251AlaPhe: 3.251 ± 0.065	5.357AlaGly: 5.357 ± 0.081	1.046AlaHis: 1.046 ± 0.034	5.504AlaIle: 5.504 ± 0.085	4.975AlaLys: 4.975 ± 0.069	6.405AlaLeu: 6.405 ± 0.084	2.25AlaMet: 2.25 ± 0.049	2.919AlaAsn: 2.919 ± 0.053	2.004AlaPro: 2.004 ± 0.055	2.005AlaGln: 2.005 ± 0.051	2.643AlaArg: 2.643 ± 0.045	4.431AlaSer: 4.431 ± 0.069	3.651AlaThr: 3.651 ± 0.072	5.458AlaVal: 5.458 ± 0.087	0.531AlaTrp: 0.531 ± 0.023	2.843AlaTyr: 2.843 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.938CysAla: 0.938 ± 0.031	0.235CysCys: 0.235 ± 0.015	0.981CysAsp: 0.981 ± 0.032	0.842CysGlu: 0.842 ± 0.027	0.616CysPhe: 0.616 ± 0.023	1.317CysGly: 1.317 ± 0.039	0.292CysHis: 0.292 ± 0.018	1.051CysIle: 1.051 ± 0.032	0.898CysLys: 0.898 ± 0.031	1.083CysLeu: 1.083 ± 0.038	0.396CysMet: 0.396 ± 0.02	0.611CysAsn: 0.611 ± 0.026	0.523CysPro: 0.523 ± 0.026	0.319CysGln: 0.319 ± 0.017	0.475CysArg: 0.475 ± 0.02	0.826CysSer: 0.826 ± 0.031	0.659CysThr: 0.659 ± 0.024	0.931CysVal: 0.931 ± 0.031	0.108CysTrp: 0.108 ± 0.01	0.583CysTyr: 0.583 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.546AspAla: 4.546 ± 0.083	0.741AspCys: 0.741 ± 0.029	3.966AspAsp: 3.966 ± 0.077	5.494AspGlu: 5.494 ± 0.076	2.999AspPhe: 2.999 ± 0.056	4.764AspGly: 4.764 ± 0.098	1.01AspHis: 1.01 ± 0.037	5.39AspIle: 5.39 ± 0.075	4.916AspLys: 4.916 ± 0.081	4.748AspLeu: 4.748 ± 0.072	2.081AspMet: 2.081 ± 0.047	3.101AspAsn: 3.101 ± 0.059	2.02AspPro: 2.02 ± 0.052	1.4AspGln: 1.4 ± 0.035	2.459AspArg: 2.459 ± 0.056	3.725AspSer: 3.725 ± 0.069	3.271AspThr: 3.271 ± 0.054	4.421AspVal: 4.421 ± 0.068	0.579AspTrp: 0.579 ± 0.029	3.458AspTyr: 3.458 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	5.397GluAla: 5.397 ± 0.092	0.81GluCys: 0.81 ± 0.026	4.686GluAsp: 4.686 ± 0.081	6.227GluGlu: 6.227 ± 0.101	2.806GluPhe: 2.806 ± 0.054	4.281GluGly: 4.281 ± 0.062	1.311GluHis: 1.311 ± 0.035	5.566GluIle: 5.566 ± 0.082	6.615GluLys: 6.615 ± 0.083	6.656GluLeu: 6.656 ± 0.082	2.222GluMet: 2.222 ± 0.047	4.067GluAsn: 4.067 ± 0.07	1.796GluPro: 1.796 ± 0.044	2.093GluGln: 2.093 ± 0.048	2.742GluArg: 2.742 ± 0.054	3.5GluSer: 3.5 ± 0.059	3.559GluThr: 3.559 ± 0.065	4.614GluVal: 4.614 ± 0.072	0.615GluTrp: 0.615 ± 0.024	3.477GluTyr: 3.477 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.064PheAla: 3.064 ± 0.066	0.699PheCys: 0.699 ± 0.027	3.189PheAsp: 3.189 ± 0.062	2.912PheGlu: 2.912 ± 0.052	2.201PhePhe: 2.201 ± 0.054	3.175PheGly: 3.175 ± 0.068	0.728PheHis: 0.728 ± 0.024	3.393PheIle: 3.393 ± 0.061	2.707PheLys: 2.707 ± 0.057	3.753PheLeu: 3.753 ± 0.074	1.331PheMet: 1.331 ± 0.03	1.911PheAsn: 1.911 ± 0.043	1.32PhePro: 1.32 ± 0.034	0.933PheGln: 0.933 ± 0.029	1.589PheArg: 1.589 ± 0.04	2.951PheSer: 2.951 ± 0.06	2.446PheThr: 2.446 ± 0.056	3.354PheVal: 3.354 ± 0.058	0.48PheTrp: 0.48 ± 0.022	1.983PheTyr: 1.983 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.765GlyAla: 4.765 ± 0.086	1.167GlyCys: 1.167 ± 0.038	3.982GlyAsp: 3.982 ± 0.065	4.399GlyGlu: 4.399 ± 0.074	3.265GlyPhe: 3.265 ± 0.062	4.367GlyGly: 4.367 ± 0.084	1.215GlyHis: 1.215 ± 0.035	5.996GlyIle: 5.996 ± 0.087	5.44GlyLys: 5.44 ± 0.086	5.472GlyLeu: 5.472 ± 0.076	2.249GlyMet: 2.249 ± 0.048	3.35GlyAsn: 3.35 ± 0.051	1.301GlyPro: 1.301 ± 0.042	1.84GlyGln: 1.84 ± 0.052	2.546GlyArg: 2.546 ± 0.054	4.177GlySer: 4.177 ± 0.068	3.98GlyThr: 3.98 ± 0.07	4.697GlyVal: 4.697 ± 0.074	0.615GlyTrp: 0.615 ± 0.028	3.45GlyTyr: 3.45 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.95HisAla: 0.95 ± 0.031	0.24HisCys: 0.24 ± 0.014	1.016HisAsp: 1.016 ± 0.034	1.083HisGlu: 1.083 ± 0.031	0.798HisPhe: 0.798 ± 0.027	1.206HisGly: 1.206 ± 0.033	0.367HisHis: 0.367 ± 0.031	1.261HisIle: 1.261 ± 0.031	1.003HisLys: 1.003 ± 0.031	1.287HisLeu: 1.287 ± 0.039	0.51HisMet: 0.51 ± 0.02	0.794HisAsn: 0.794 ± 0.026	0.757HisPro: 0.757 ± 0.023	0.441HisGln: 0.441 ± 0.021	0.65HisArg: 0.65 ± 0.023	0.956HisSer: 0.956 ± 0.034	0.802HisThr: 0.802 ± 0.033	1.081HisVal: 1.081 ± 0.029	0.153HisTrp: 0.153 ± 0.012	0.761HisTyr: 0.761 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.865IleAla: 5.865 ± 0.086	1.29IleCys: 1.29 ± 0.042	5.227IleAsp: 5.227 ± 0.083	5.047IleGlu: 5.047 ± 0.082	3.229IlePhe: 3.229 ± 0.073	5.129IleGly: 5.129 ± 0.072	1.168IleHis: 1.168 ± 0.038	5.957IleIle: 5.957 ± 0.095	5.172IleLys: 5.172 ± 0.076	6.642IleLeu: 6.642 ± 0.104	2.166IleMet: 2.166 ± 0.05	3.504IleAsn: 3.504 ± 0.059	3.101IlePro: 3.101 ± 0.063	1.862IleGln: 1.862 ± 0.038	3.071IleArg: 3.071 ± 0.059	5.558IleSer: 5.558 ± 0.079	4.471IleThr: 4.471 ± 0.071	5.445IleVal: 5.445 ± 0.074	0.663IleTrp: 0.663 ± 0.03	3.233IleTyr: 3.233 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.413LysAla: 5.413 ± 0.091	0.805LysCys: 0.805 ± 0.028	4.908LysAsp: 4.908 ± 0.067	7.072LysGlu: 7.072 ± 0.096	2.319LysPhe: 2.319 ± 0.052	4.154LysGly: 4.154 ± 0.062	1.063LysHis: 1.063 ± 0.031	5.059LysIle: 5.059 ± 0.069	6.742LysLys: 6.742 ± 0.11	5.966LysLeu: 5.966 ± 0.079	2.266LysMet: 2.266 ± 0.051	3.841LysAsn: 3.841 ± 0.062	1.957LysPro: 1.957 ± 0.044	1.901LysGln: 1.901 ± 0.046	3.037LysArg: 3.037 ± 0.054	3.74LysSer: 3.74 ± 0.066	3.695LysThr: 3.695 ± 0.055	4.742LysVal: 4.742 ± 0.076	0.697LysTrp: 0.697 ± 0.029	3.393LysTyr: 3.393 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	6.083LeuAla: 6.083 ± 0.087	1.281LeuCys: 1.281 ± 0.038	5.326LeuAsp: 5.326 ± 0.086	5.452LeuGlu: 5.452 ± 0.085	4.065LeuPhe: 4.065 ± 0.08	5.735LeuGly: 5.735 ± 0.083	1.313LeuHis: 1.313 ± 0.033	6.207LeuIle: 6.207 ± 0.089	6.012LeuLys: 6.012 ± 0.082	7.544LeuLeu: 7.544 ± 0.119	2.577LeuMet: 2.577 ± 0.051	3.786LeuAsn: 3.786 ± 0.056	2.961LeuPro: 2.961 ± 0.052	2.25LeuGln: 2.25 ± 0.043	3.102LeuArg: 3.102 ± 0.058	6.425LeuSer: 6.425 ± 0.089	4.602LeuThr: 4.602 ± 0.069	5.692LeuVal: 5.692 ± 0.088	0.686LeuTrp: 0.686 ± 0.03	3.504LeuTyr: 3.504 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.439MetAla: 2.439 ± 0.048	0.391MetCys: 0.391 ± 0.021	1.897MetAsp: 1.897 ± 0.043	2.018MetGlu: 2.018 ± 0.05	1.131MetPhe: 1.131 ± 0.035	1.98MetGly: 1.98 ± 0.05	0.5MetHis: 0.5 ± 0.021	2.332MetIle: 2.332 ± 0.055	2.348MetLys: 2.348 ± 0.051	2.615MetLeu: 2.615 ± 0.055	0.988MetMet: 0.988 ± 0.035	1.663MetAsn: 1.663 ± 0.044	1.087MetPro: 1.087 ± 0.036	0.99MetGln: 0.99 ± 0.031	1.138MetArg: 1.138 ± 0.037	1.922MetSer: 1.922 ± 0.047	1.61MetThr: 1.61 ± 0.043	1.924MetVal: 1.924 ± 0.044	0.241MetTrp: 0.241 ± 0.017	1.055MetTyr: 1.055 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.444AsnAla: 3.444 ± 0.047	0.577AsnCys: 0.577 ± 0.024	2.73AsnAsp: 2.73 ± 0.053	3.281AsnGlu: 3.281 ± 0.06	1.822AsnPhe: 1.822 ± 0.048	3.819AsnGly: 3.819 ± 0.08	0.755AsnHis: 0.755 ± 0.028	3.998AsnIle: 3.998 ± 0.063	3.239AsnLys: 3.239 ± 0.06	3.762AsnLeu: 3.762 ± 0.073	1.581AsnMet: 1.581 ± 0.039	2.346AsnAsn: 2.346 ± 0.057	1.882AsnPro: 1.882 ± 0.046	1.184AsnGln: 1.184 ± 0.036	1.827AsnArg: 1.827 ± 0.041	2.912AsnSer: 2.912 ± 0.058	2.586AsnThr: 2.586 ± 0.053	3.371AsnVal: 3.371 ± 0.065	0.465AsnTrp: 0.465 ± 0.024	2.128AsnTyr: 2.128 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.176ProAla: 2.176 ± 0.064	0.353ProCys: 0.353 ± 0.019	2.379ProAsp: 2.379 ± 0.055	3.063ProGlu: 3.063 ± 0.06	1.489ProPhe: 1.489 ± 0.043	2.014ProGly: 2.014 ± 0.046	0.487ProHis: 0.487 ± 0.021	2.176ProIle: 2.176 ± 0.051	1.887ProLys: 1.887 ± 0.044	2.484ProLeu: 2.484 ± 0.052	0.86ProMet: 0.86 ± 0.03	1.263ProAsn: 1.263 ± 0.036	0.574ProPro: 0.574 ± 0.03	0.91ProGln: 0.91 ± 0.032	0.926ProArg: 0.926 ± 0.033	1.947ProSer: 1.947 ± 0.047	1.539ProThr: 1.539 ± 0.052	2.627ProVal: 2.627 ± 0.059	0.322ProTrp: 0.322 ± 0.019	1.429ProTyr: 1.429 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.856GlnAla: 1.856 ± 0.047	0.291GlnCys: 0.291 ± 0.02	1.557GlnAsp: 1.557 ± 0.037	1.935GlnGlu: 1.935 ± 0.045	1.054GlnPhe: 1.054 ± 0.031	1.614GlnGly: 1.614 ± 0.04	0.415GlnHis: 0.415 ± 0.02	2.245GlnIle: 2.245 ± 0.052	2.205GlnLys: 2.205 ± 0.045	2.226GlnLeu: 2.226 ± 0.052	0.919GlnMet: 0.919 ± 0.029	1.407GlnAsn: 1.407 ± 0.041	0.755GlnPro: 0.755 ± 0.036	0.964GlnGln: 0.964 ± 0.043	1.083GlnArg: 1.083 ± 0.03	1.383GlnSer: 1.383 ± 0.041	1.389GlnThr: 1.389 ± 0.039	1.633GlnVal: 1.633 ± 0.044	0.247GlnTrp: 0.247 ± 0.016	1.296GlnTyr: 1.296 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.572ArgAla: 2.572 ± 0.043	0.513ArgCys: 0.513 ± 0.025	2.375ArgAsp: 2.375 ± 0.047	2.882ArgGlu: 2.882 ± 0.058	1.77ArgPhe: 1.77 ± 0.047	2.178ArgGly: 2.178 ± 0.055	0.678ArgHis: 0.678 ± 0.025	3.186ArgIle: 3.186 ± 0.063	2.973ArgLys: 2.973 ± 0.061	3.18ArgLeu: 3.18 ± 0.061	1.233ArgMet: 1.233 ± 0.039	1.992ArgAsn: 1.992 ± 0.045	1.171ArgPro: 1.171 ± 0.037	1.166ArgGln: 1.166 ± 0.034	1.672ArgArg: 1.672 ± 0.048	1.949ArgSer: 1.949 ± 0.055	1.974ArgThr: 1.974 ± 0.042	2.362ArgVal: 2.362 ± 0.047	0.336ArgTrp: 0.336 ± 0.022	1.812ArgTyr: 1.812 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.235SerAla: 4.235 ± 0.08	0.766SerCys: 0.766 ± 0.025	4.372SerAsp: 4.372 ± 0.076	4.566SerGlu: 4.566 ± 0.07	3.357SerPhe: 3.357 ± 0.069	4.767SerGly: 4.767 ± 0.069	0.963SerHis: 0.963 ± 0.033	4.655SerIle: 4.655 ± 0.068	4.24SerLys: 4.24 ± 0.068	5.273SerLeu: 5.273 ± 0.07	1.701SerMet: 1.701 ± 0.043	2.739SerAsn: 2.739 ± 0.058	1.611SerPro: 1.611 ± 0.04	1.675SerGln: 1.675 ± 0.045	2.361SerArg: 2.361 ± 0.051	4.306SerSer: 4.306 ± 0.091	3.141SerThr: 3.141 ± 0.065	4.276SerVal: 4.276 ± 0.066	0.552SerTrp: 0.552 ± 0.025	2.777SerTyr: 2.777 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.96ThrAla: 3.96 ± 0.07	0.595ThrCys: 0.595 ± 0.02	3.543ThrAsp: 3.543 ± 0.065	3.57ThrGlu: 3.57 ± 0.071	2.345ThrPhe: 2.345 ± 0.056	4.319ThrGly: 4.319 ± 0.069	0.811ThrHis: 0.811 ± 0.03	4.186ThrIle: 4.186 ± 0.054	3.231ThrLys: 3.231 ± 0.064	4.511ThrLeu: 4.511 ± 0.071	1.426ThrMet: 1.426 ± 0.046	2.342ThrAsn: 2.342 ± 0.06	1.985ThrPro: 1.985 ± 0.05	1.386ThrGln: 1.386 ± 0.036	1.825ThrArg: 1.825 ± 0.048	3.348ThrSer: 3.348 ± 0.074	3.016ThrThr: 3.016 ± 0.062	4.148ThrVal: 4.148 ± 0.074	0.484ThrTrp: 0.484 ± 0.023	2.371ThrTyr: 2.371 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.962ValAla: 4.962 ± 0.071	1.133ValCys: 1.133 ± 0.031	4.469ValAsp: 4.469 ± 0.073	4.314ValGlu: 4.314 ± 0.072	3.153ValPhe: 3.153 ± 0.061	4.295ValGly: 4.295 ± 0.071	0.984ValHis: 0.984 ± 0.035	5.68ValIle: 5.68 ± 0.084	4.711ValLys: 4.711 ± 0.068	6.343ValLeu: 6.343 ± 0.086	2.02ValMet: 2.02 ± 0.043	3.248ValAsn: 3.248 ± 0.069	2.39ValPro: 2.39 ± 0.047	1.595ValGln: 1.595 ± 0.048	2.582ValArg: 2.582 ± 0.052	4.827ValSer: 4.827 ± 0.079	4.249ValThr: 4.249 ± 0.077	5.219ValVal: 5.219 ± 0.085	0.553ValTrp: 0.553 ± 0.025	2.835ValTyr: 2.835 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.553TrpAla: 0.553 ± 0.022	0.134TrpCys: 0.134 ± 0.014	0.556TrpAsp: 0.556 ± 0.027	0.597TrpGlu: 0.597 ± 0.024	0.378TrpPhe: 0.378 ± 0.021	0.684TrpGly: 0.684 ± 0.027	0.204TrpHis: 0.204 ± 0.017	0.692TrpIle: 0.692 ± 0.028	0.578TrpLys: 0.578 ± 0.027	0.784TrpLeu: 0.784 ± 0.031	0.264TrpMet: 0.264 ± 0.016	0.573TrpAsn: 0.573 ± 0.025	0.223TrpPro: 0.223 ± 0.016	0.304TrpGln: 0.304 ± 0.017	0.332TrpArg: 0.332 ± 0.02	0.467TrpSer: 0.467 ± 0.021	0.436TrpThr: 0.436 ± 0.022	0.529TrpVal: 0.529 ± 0.021	0.121TrpTrp: 0.121 ± 0.01	0.419TrpTyr: 0.419 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.806TyrAla: 2.806 ± 0.049	0.633TyrCys: 0.633 ± 0.022	3.26TyrAsp: 3.26 ± 0.065	3.238TyrGlu: 3.238 ± 0.058	2.07TyrPhe: 2.07 ± 0.047	3.117TyrGly: 3.117 ± 0.061	0.805TyrHis: 0.805 ± 0.027	3.262TyrIle: 3.262 ± 0.062	2.877TyrLys: 2.877 ± 0.048	3.871TyrLeu: 3.871 ± 0.073	1.228TyrMet: 1.228 ± 0.037	2.251TyrAsn: 2.251 ± 0.052	1.487TyrPro: 1.487 ± 0.044	1.259TyrGln: 1.259 ± 0.038	1.914TyrArg: 1.914 ± 0.048	2.983TyrSer: 2.983 ± 0.059	2.327TyrThr: 2.327 ± 0.05	3.038TyrVal: 3.038 ± 0.062	0.381TyrTrp: 0.381 ± 0.02	2.255TyrTyr: 2.255 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3003 proteins (1018659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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