Amino acid dipepetide frequency for Deminuibacter soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.499AlaAla: 10.499 ± 0.121
0.87AlaCys: 0.87 ± 0.026
4.751AlaAsp: 4.751 ± 0.057
4.087AlaGlu: 4.087 ± 0.062
3.854AlaPhe: 3.854 ± 0.051
7.471AlaGly: 7.471 ± 0.109
1.743AlaHis: 1.743 ± 0.036
5.46AlaIle: 5.46 ± 0.074
4.261AlaLys: 4.261 ± 0.053
8.073AlaLeu: 8.073 ± 0.085
2.027AlaMet: 2.027 ± 0.041
3.819AlaAsn: 3.819 ± 0.053
3.2AlaPro: 3.2 ± 0.067
3.857AlaGln: 3.857 ± 0.045
3.379AlaArg: 3.379 ± 0.049
4.878AlaSer: 4.878 ± 0.062
5.339AlaThr: 5.339 ± 0.089
6.188AlaVal: 6.188 ± 0.086
1.068AlaTrp: 1.068 ± 0.026
3.356AlaTyr: 3.356 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.719CysAla: 0.719 ± 0.037
0.198CysCys: 0.198 ± 0.012
0.39CysAsp: 0.39 ± 0.016
0.369CysGlu: 0.369 ± 0.017
0.505CysPhe: 0.505 ± 0.017
0.695CysGly: 0.695 ± 0.02
0.21CysHis: 0.21 ± 0.012
0.697CysIle: 0.697 ± 0.021
0.455CysLys: 0.455 ± 0.019
0.872CysLeu: 0.872 ± 0.025
0.28CysMet: 0.28 ± 0.014
0.457CysAsn: 0.457 ± 0.017
0.323CysPro: 0.323 ± 0.013
0.235CysGln: 0.235 ± 0.014
0.387CysArg: 0.387 ± 0.016
0.635CysSer: 0.635 ± 0.028
0.608CysThr: 0.608 ± 0.024
0.55CysVal: 0.55 ± 0.018
0.126CysTrp: 0.126 ± 0.008
0.401CysTyr: 0.401 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.785AspAla: 4.785 ± 0.063
0.388AspCys: 0.388 ± 0.016
2.363AspAsp: 2.363 ± 0.047
2.862AspGlu: 2.862 ± 0.05
2.611AspPhe: 2.611 ± 0.049
3.62AspGly: 3.62 ± 0.068
0.971AspHis: 0.971 ± 0.024
3.638AspIle: 3.638 ± 0.046
3.325AspLys: 3.325 ± 0.052
4.273AspLeu: 4.273 ± 0.061
1.223AspMet: 1.223 ± 0.028
2.624AspAsn: 2.624 ± 0.051
1.912AspPro: 1.912 ± 0.054
1.558AspGln: 1.558 ± 0.028
1.846AspArg: 1.846 ± 0.038
3.148AspSer: 3.148 ± 0.058
3.035AspThr: 3.035 ± 0.057
3.386AspVal: 3.386 ± 0.05
0.77AspTrp: 0.77 ± 0.022
2.417AspTyr: 2.417 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.375GluAla: 4.375 ± 0.057
0.317GluCys: 0.317 ± 0.013
2.27GluAsp: 2.27 ± 0.044
3.053GluGlu: 3.053 ± 0.061
1.835GluPhe: 1.835 ± 0.036
2.978GluGly: 2.978 ± 0.047
1.107GluHis: 1.107 ± 0.029
3.172GluIle: 3.172 ± 0.055
3.917GluLys: 3.917 ± 0.061
5.037GluLeu: 5.037 ± 0.079
1.334GluMet: 1.334 ± 0.033
2.538GluAsn: 2.538 ± 0.04
1.594GluPro: 1.594 ± 0.031
2.84GluGln: 2.84 ± 0.049
2.28GluArg: 2.28 ± 0.041
2.225GluSer: 2.225 ± 0.037
2.88GluThr: 2.88 ± 0.044
3.198GluVal: 3.198 ± 0.052
0.719GluTrp: 0.719 ± 0.02
1.787GluTyr: 1.787 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.695PheAla: 3.695 ± 0.047
0.501PheCys: 0.501 ± 0.019
2.598PheAsp: 2.598 ± 0.046
2.27PheGlu: 2.27 ± 0.04
2.271PhePhe: 2.271 ± 0.049
3.011PheGly: 3.011 ± 0.045
0.921PheHis: 0.921 ± 0.025
3.034PheIle: 3.034 ± 0.052
2.574PheLys: 2.574 ± 0.04
3.796PheLeu: 3.796 ± 0.057
1.031PheMet: 1.031 ± 0.026
2.804PheAsn: 2.804 ± 0.043
1.779PhePro: 1.779 ± 0.037
1.383PheGln: 1.383 ± 0.029
1.936PheArg: 1.936 ± 0.036
3.483PheSer: 3.483 ± 0.053
3.5PheThr: 3.5 ± 0.052
2.784PheVal: 2.784 ± 0.043
0.594PheTrp: 0.594 ± 0.02
1.929PheTyr: 1.929 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.442GlyAla: 5.442 ± 0.064
0.797GlyCys: 0.797 ± 0.045
3.537GlyAsp: 3.537 ± 0.051
3.312GlyGlu: 3.312 ± 0.049
3.5GlyPhe: 3.5 ± 0.046
5.211GlyGly: 5.211 ± 0.084
1.391GlyHis: 1.391 ± 0.028
5.181GlyIle: 5.181 ± 0.061
4.979GlyLys: 4.979 ± 0.056
5.968GlyLeu: 5.968 ± 0.069
1.855GlyMet: 1.855 ± 0.038
4.117GlyAsn: 4.117 ± 0.074
1.641GlyPro: 1.641 ± 0.035
2.271GlyGln: 2.271 ± 0.04
2.812GlyArg: 2.812 ± 0.046
4.598GlySer: 4.598 ± 0.075
4.628GlyThr: 4.628 ± 0.096
4.608GlyVal: 4.608 ± 0.065
1.128GlyTrp: 1.128 ± 0.028
3.284GlyTyr: 3.284 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.736HisAla: 1.736 ± 0.036
0.24HisCys: 0.24 ± 0.013
1.012HisAsp: 1.012 ± 0.026
1.077HisGlu: 1.077 ± 0.031
1.362HisPhe: 1.362 ± 0.028
1.345HisGly: 1.345 ± 0.031
0.62HisHis: 0.62 ± 0.022
1.552HisIle: 1.552 ± 0.03
1.015HisLys: 1.015 ± 0.026
2.118HisLeu: 2.118 ± 0.038
0.525HisMet: 0.525 ± 0.019
1.098HisAsn: 1.098 ± 0.025
1.17HisPro: 1.17 ± 0.026
0.863HisGln: 0.863 ± 0.024
0.931HisArg: 0.931 ± 0.026
1.192HisSer: 1.192 ± 0.025
1.409HisThr: 1.409 ± 0.031
1.225HisVal: 1.225 ± 0.031
0.342HisTrp: 0.342 ± 0.012
1.063HisTyr: 1.063 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.028IleAla: 6.028 ± 0.068
0.67IleCys: 0.67 ± 0.023
3.622IleAsp: 3.622 ± 0.058
3.302IleGlu: 3.302 ± 0.054
2.43IlePhe: 2.43 ± 0.036
4.268IleGly: 4.268 ± 0.054
1.347IleHis: 1.347 ± 0.033
3.897IleIle: 3.897 ± 0.061
3.508IleLys: 3.508 ± 0.052
4.945IleLeu: 4.945 ± 0.061
1.149IleMet: 1.149 ± 0.025
3.448IleAsn: 3.448 ± 0.047
2.958IlePro: 2.958 ± 0.045
2.439IleGln: 2.439 ± 0.039
2.881IleArg: 2.881 ± 0.044
4.231IleSer: 4.231 ± 0.054
4.711IleThr: 4.711 ± 0.063
3.963IleVal: 3.963 ± 0.062
0.644IleTrp: 0.644 ± 0.019
2.249IleTyr: 2.249 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.968LysAla: 4.968 ± 0.058
0.3LysCys: 0.3 ± 0.016
3.388LysAsp: 3.388 ± 0.056
3.688LysGlu: 3.688 ± 0.056
1.82LysPhe: 1.82 ± 0.034
4.105LysGly: 4.105 ± 0.064
1.212LysHis: 1.212 ± 0.027
3.616LysIle: 3.616 ± 0.056
4.37LysLys: 4.37 ± 0.068
5.096LysLeu: 5.096 ± 0.068
1.597LysMet: 1.597 ± 0.029
3.211LysAsn: 3.211 ± 0.043
2.605LysPro: 2.605 ± 0.043
3.183LysGln: 3.183 ± 0.049
2.591LysArg: 2.591 ± 0.043
3.007LysSer: 3.007 ± 0.039
3.667LysThr: 3.667 ± 0.051
3.606LysVal: 3.606 ± 0.056
0.783LysTrp: 0.783 ± 0.023
2.273LysTyr: 2.273 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
7.486LeuAla: 7.486 ± 0.077
0.976LeuCys: 0.976 ± 0.024
4.367LeuAsp: 4.367 ± 0.052
4.224LeuGlu: 4.224 ± 0.055
4.652LeuPhe: 4.652 ± 0.06
5.744LeuGly: 5.744 ± 0.076
2.45LeuHis: 2.45 ± 0.041
4.964LeuIle: 4.964 ± 0.073
5.659LeuLys: 5.659 ± 0.062
11.04LeuLeu: 11.04 ± 0.152
2.072LeuMet: 2.072 ± 0.039
4.839LeuAsn: 4.839 ± 0.069
4.646LeuPro: 4.646 ± 0.054
5.836LeuGln: 5.836 ± 0.078
4.141LeuArg: 4.141 ± 0.063
6.056LeuSer: 6.056 ± 0.069
5.389LeuThr: 5.389 ± 0.08
6.234LeuVal: 6.234 ± 0.062
0.954LeuTrp: 0.954 ± 0.024
3.573LeuTyr: 3.573 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.949MetAla: 1.949 ± 0.036
0.168MetCys: 0.168 ± 0.01
1.098MetAsp: 1.098 ± 0.027
1.338MetGlu: 1.338 ± 0.029
0.775MetPhe: 0.775 ± 0.023
1.541MetGly: 1.541 ± 0.031
0.644MetHis: 0.644 ± 0.022
1.288MetIle: 1.288 ± 0.03
1.671MetLys: 1.671 ± 0.034
2.338MetLeu: 2.338 ± 0.041
0.605MetMet: 0.605 ± 0.02
1.175MetAsn: 1.175 ± 0.025
1.303MetPro: 1.303 ± 0.028
1.418MetGln: 1.418 ± 0.029
1.159MetArg: 1.159 ± 0.022
1.259MetSer: 1.259 ± 0.03
1.039MetThr: 1.039 ± 0.025
1.469MetVal: 1.469 ± 0.035
0.195MetTrp: 0.195 ± 0.012
0.731MetTyr: 0.731 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
4.354AsnAla: 4.354 ± 0.06
0.435AsnCys: 0.435 ± 0.016
2.831AsnAsp: 2.831 ± 0.043
2.596AsnGlu: 2.596 ± 0.043
2.206AsnPhe: 2.206 ± 0.041
4.316AsnGly: 4.316 ± 0.074
0.984AsnHis: 0.984 ± 0.026
3.596AsnIle: 3.596 ± 0.053
3.085AsnLys: 3.085 ± 0.046
4.365AsnLeu: 4.365 ± 0.055
1.164AsnMet: 1.164 ± 0.026
3.33AsnAsn: 3.33 ± 0.059
2.576AsnPro: 2.576 ± 0.063
1.889AsnGln: 1.889 ± 0.04
2.433AsnArg: 2.433 ± 0.036
2.966AsnSer: 2.966 ± 0.049
3.469AsnThr: 3.469 ± 0.059
3.123AsnVal: 3.123 ± 0.047
0.799AsnTrp: 0.799 ± 0.028
2.355AsnTyr: 2.355 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
4.838ProAla: 4.838 ± 0.073
0.276ProCys: 0.276 ± 0.012
2.64ProAsp: 2.64 ± 0.041
2.367ProGlu: 2.367 ± 0.04
2.036ProPhe: 2.036 ± 0.036
3.649ProGly: 3.649 ± 0.052
0.83ProHis: 0.83 ± 0.024
1.904ProIle: 1.904 ± 0.035
1.791ProLys: 1.791 ± 0.035
3.676ProLeu: 3.676 ± 0.052
0.82ProMet: 0.82 ± 0.022
1.819ProAsn: 1.819 ± 0.041
1.34ProPro: 1.34 ± 0.039
1.71ProGln: 1.71 ± 0.038
1.31ProArg: 1.31 ± 0.029
2.141ProSer: 2.141 ± 0.039
1.855ProThr: 1.855 ± 0.041
4.12ProVal: 4.12 ± 0.073
0.503ProTrp: 0.503 ± 0.019
1.654ProTyr: 1.654 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.649GlnAla: 3.649 ± 0.059
0.312GlnCys: 0.312 ± 0.017
1.633GlnAsp: 1.633 ± 0.036
1.952GlnGlu: 1.952 ± 0.042
1.903GlnPhe: 1.903 ± 0.032
2.409GlnGly: 2.409 ± 0.037
1.331GlnHis: 1.331 ± 0.03
1.96GlnIle: 1.96 ± 0.042
2.42GlnLys: 2.42 ± 0.039
5.66GlnLeu: 5.66 ± 0.068
1.007GlnMet: 1.007 ± 0.028
1.864GlnAsn: 1.864 ± 0.033
2.331GlnPro: 2.331 ± 0.046
4.045GlnGln: 4.045 ± 0.08
2.038GlnArg: 2.038 ± 0.042
2.351GlnSer: 2.351 ± 0.037
2.602GlnThr: 2.602 ± 0.043
3.221GlnVal: 3.221 ± 0.052
0.694GlnTrp: 0.694 ± 0.02
2.086GlnTyr: 2.086 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.804ArgAla: 2.804 ± 0.043
0.314ArgCys: 0.314 ± 0.013
2.043ArgAsp: 2.043 ± 0.037
2.327ArgGlu: 2.327 ± 0.049
2.343ArgPhe: 2.343 ± 0.038
2.2ArgGly: 2.2 ± 0.041
0.915ArgHis: 0.915 ± 0.027
3.135ArgIle: 3.135 ± 0.046
2.942ArgLys: 2.942 ± 0.049
4.276ArgLeu: 4.276 ± 0.062
1.303ArgMet: 1.303 ± 0.028
2.489ArgAsn: 2.489 ± 0.039
1.464ArgPro: 1.464 ± 0.037
1.912ArgGln: 1.912 ± 0.039
1.929ArgArg: 1.929 ± 0.039
2.328ArgSer: 2.328 ± 0.045
2.21ArgThr: 2.21 ± 0.037
2.569ArgVal: 2.569 ± 0.041
0.649ArgTrp: 0.649 ± 0.019
2.073ArgTyr: 2.073 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
4.9SerAla: 4.9 ± 0.059
0.583SerCys: 0.583 ± 0.019
2.891SerAsp: 2.891 ± 0.056
2.476SerGlu: 2.476 ± 0.045
3.338SerPhe: 3.338 ± 0.047
4.747SerGly: 4.747 ± 0.07
1.117SerHis: 1.117 ± 0.028
3.987SerIle: 3.987 ± 0.049
3.118SerLys: 3.118 ± 0.047
5.94SerLeu: 5.94 ± 0.067
1.35SerMet: 1.35 ± 0.032
3.215SerAsn: 3.215 ± 0.055
2.226SerPro: 2.226 ± 0.041
1.972SerGln: 1.972 ± 0.033
2.477SerArg: 2.477 ± 0.036
3.687SerSer: 3.687 ± 0.053
3.49SerThr: 3.49 ± 0.056
4.037SerVal: 4.037 ± 0.052
0.85SerTrp: 0.85 ± 0.026
2.615SerTyr: 2.615 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.374ThrAla: 6.374 ± 0.101
0.5ThrCys: 0.5 ± 0.02
3.408ThrAsp: 3.408 ± 0.045
2.804ThrGlu: 2.804 ± 0.045
2.493ThrPhe: 2.493 ± 0.042
5.785ThrGly: 5.785 ± 0.088
1.264ThrHis: 1.264 ± 0.028
4.149ThrIle: 4.149 ± 0.058
2.573ThrLys: 2.573 ± 0.049
5.729ThrLeu: 5.729 ± 0.065
1.046ThrMet: 1.046 ± 0.025
2.827ThrAsn: 2.827 ± 0.054
3.091ThrPro: 3.091 ± 0.051
2.331ThrGln: 2.331 ± 0.04
2.485ThrArg: 2.485 ± 0.043
3.411ThrSer: 3.411 ± 0.056
4.005ThrThr: 4.005 ± 0.085
4.511ThrVal: 4.511 ± 0.088
0.741ThrTrp: 0.741 ± 0.024
2.42ThrTyr: 2.42 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
5.5ValAla: 5.5 ± 0.068
0.722ValCys: 0.722 ± 0.034
3.047ValAsp: 3.047 ± 0.046
2.872ValGlu: 2.872 ± 0.044
3.159ValPhe: 3.159 ± 0.043
3.466ValGly: 3.466 ± 0.053
1.478ValHis: 1.478 ± 0.032
4.359ValIle: 4.359 ± 0.055
4.275ValLys: 4.275 ± 0.064
6.701ValLeu: 6.701 ± 0.072
1.541ValMet: 1.541 ± 0.035
3.846ValAsn: 3.846 ± 0.062
2.877ValPro: 2.877 ± 0.042
3.128ValGln: 3.128 ± 0.044
2.545ValArg: 2.545 ± 0.043
4.21ValSer: 4.21 ± 0.052
4.621ValThr: 4.621 ± 0.108
4.62ValVal: 4.62 ± 0.08
0.792ValTrp: 0.792 ± 0.021
2.765ValTyr: 2.765 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.801TrpAla: 0.801 ± 0.024
0.144TrpCys: 0.144 ± 0.01
0.683TrpAsp: 0.683 ± 0.02
0.654TrpGlu: 0.654 ± 0.02
0.62TrpPhe: 0.62 ± 0.022
0.861TrpGly: 0.861 ± 0.026
0.357TrpHis: 0.357 ± 0.016
0.742TrpIle: 0.742 ± 0.019
0.828TrpLys: 0.828 ± 0.025
1.509TrpLeu: 1.509 ± 0.033
0.405TrpMet: 0.405 ± 0.015
0.747TrpAsn: 0.747 ± 0.019
0.454TrpPro: 0.454 ± 0.017
0.809TrpGln: 0.809 ± 0.023
0.59TrpArg: 0.59 ± 0.018
0.671TrpSer: 0.671 ± 0.021
0.657TrpThr: 0.657 ± 0.021
0.753TrpVal: 0.753 ± 0.021
0.259TrpTrp: 0.259 ± 0.013
0.62TrpTyr: 0.62 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.28TyrAla: 3.28 ± 0.049
0.402TyrCys: 0.402 ± 0.017
2.182TyrAsp: 2.182 ± 0.048
1.831TyrGlu: 1.831 ± 0.037
2.182TyrPhe: 2.182 ± 0.039
2.838TyrGly: 2.838 ± 0.051
1.003TyrHis: 1.003 ± 0.027
2.358TyrIle: 2.358 ± 0.043
2.319TyrLys: 2.319 ± 0.041
3.891TyrLeu: 3.891 ± 0.047
0.827TyrMet: 0.827 ± 0.024
2.605TyrAsn: 2.605 ± 0.054
1.787TyrPro: 1.787 ± 0.036
1.789TyrGln: 1.789 ± 0.039
2.074TyrArg: 2.074 ± 0.037
2.541TyrSer: 2.541 ± 0.044
2.831TyrThr: 2.831 ± 0.053
2.36TyrVal: 2.36 ± 0.037
0.551TyrTrp: 0.551 ± 0.019
2.071TyrTyr: 2.071 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4790 proteins (1704224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski