Amino acid dipepetide frequency for Loa loa (Eye worm) (Filaria loa)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.028AlaAla: 5.028 ± 0.052	1.1AlaCys: 1.1 ± 0.019	3.092AlaAsp: 3.092 ± 0.028	4.193AlaGlu: 4.193 ± 0.037	2.444AlaPhe: 2.444 ± 0.026	2.961AlaGly: 2.961 ± 0.03	1.325AlaHis: 1.325 ± 0.016	3.873AlaIle: 3.873 ± 0.035	3.735AlaLys: 3.735 ± 0.034	5.843AlaLeu: 5.843 ± 0.04	1.546AlaMet: 1.546 ± 0.018	2.812AlaAsn: 2.812 ± 0.023	2.363AlaPro: 2.363 ± 0.03	2.37AlaGln: 2.37 ± 0.024	3.055AlaArg: 3.055 ± 0.029	4.78AlaSer: 4.78 ± 0.039	3.702AlaThr: 3.702 ± 0.032	4.554AlaVal: 4.554 ± 0.037	0.548AlaTrp: 0.548 ± 0.014	1.732AlaTyr: 1.732 ± 0.022	0.002AlaXaa: 0.002 ± 0.001
Cys	1.245CysAla: 1.245 ± 0.019	0.568CysCys: 0.568 ± 0.015	1.2CysAsp: 1.2 ± 0.023	1.285CysGlu: 1.285 ± 0.021	0.87CysPhe: 0.87 ± 0.014	1.343CysGly: 1.343 ± 0.024	0.563CysHis: 0.563 ± 0.013	1.341CysIle: 1.341 ± 0.023	1.241CysLys: 1.241 ± 0.022	1.822CysLeu: 1.822 ± 0.022	0.489CysMet: 0.489 ± 0.009	1.028CysAsn: 1.028 ± 0.017	1.049CysPro: 1.049 ± 0.025	0.786CysGln: 0.786 ± 0.016	1.27CysArg: 1.27 ± 0.021	1.817CysSer: 1.817 ± 0.021	1.111CysThr: 1.111 ± 0.018	1.137CysVal: 1.137 ± 0.017	0.222CysTrp: 0.222 ± 0.007	0.663CysTyr: 0.663 ± 0.012	0.001CysXaa: 0.001 ± 0.0
Asp	3.157AspAla: 3.157 ± 0.027	1.108AspCys: 1.108 ± 0.02	4.943AspAsp: 4.943 ± 0.14	4.896AspGlu: 4.896 ± 0.041	2.402AspPhe: 2.402 ± 0.056	3.477AspGly: 3.477 ± 0.046	1.139AspHis: 1.139 ± 0.016	3.559AspIle: 3.559 ± 0.027	2.956AspLys: 2.956 ± 0.028	4.654AspLeu: 4.654 ± 0.036	1.267AspMet: 1.267 ± 0.023	2.638AspAsn: 2.638 ± 0.025	2.04AspPro: 2.04 ± 0.02	1.814AspGln: 1.814 ± 0.021	2.782AspArg: 2.782 ± 0.028	3.935AspSer: 3.935 ± 0.034	2.465AspThr: 2.465 ± 0.024	3.53AspVal: 3.53 ± 0.05	0.609AspTrp: 0.609 ± 0.012	1.843AspTyr: 1.843 ± 0.026	0.003AspXaa: 0.003 ± 0.001
Glu	3.906GluAla: 3.906 ± 0.037	1.327GluCys: 1.327 ± 0.025	3.51GluAsp: 3.51 ± 0.059	5.994GluGlu: 5.994 ± 0.068	2.295GluPhe: 2.295 ± 0.027	2.972GluGly: 2.972 ± 0.037	1.582GluHis: 1.582 ± 0.025	4.692GluIle: 4.692 ± 0.046	5.597GluLys: 5.597 ± 0.061	6.178GluLeu: 6.178 ± 0.054	2.058GluMet: 2.058 ± 0.022	3.855GluAsn: 3.855 ± 0.033	2.213GluPro: 2.213 ± 0.028	3.289GluGln: 3.289 ± 0.033	4.308GluArg: 4.308 ± 0.034	4.471GluSer: 4.471 ± 0.042	3.658GluThr: 3.658 ± 0.037	3.845GluVal: 3.845 ± 0.046	0.795GluTrp: 0.795 ± 0.013	2.01GluTyr: 2.01 ± 0.022	0.003GluXaa: 0.003 ± 0.001
Phe	2.501PheAla: 2.501 ± 0.024	0.965PheCys: 0.965 ± 0.016	2.457PheAsp: 2.457 ± 0.028	2.44PheGlu: 2.44 ± 0.028	1.63PhePhe: 1.63 ± 0.023	2.533PheGly: 2.533 ± 0.028	1.033PheHis: 1.033 ± 0.015	2.635PheIle: 2.635 ± 0.026	1.964PheLys: 1.964 ± 0.026	3.622PheLeu: 3.622 ± 0.036	0.942PheMet: 0.942 ± 0.015	1.717PheAsn: 1.717 ± 0.02	1.654PhePro: 1.654 ± 0.021	1.345PheGln: 1.345 ± 0.016	2.154PheArg: 2.154 ± 0.024	3.076PheSer: 3.076 ± 0.029	2.237PheThr: 2.237 ± 0.021	2.615PheVal: 2.615 ± 0.035	0.542PheTrp: 0.542 ± 0.014	1.356PheTyr: 1.356 ± 0.019	0.002PheXaa: 0.002 ± 0.001
Gly	2.846GlyAla: 2.846 ± 0.034	1.059GlyCys: 1.059 ± 0.017	2.793GlyAsp: 2.793 ± 0.031	3.246GlyGlu: 3.246 ± 0.039	2.136GlyPhe: 2.136 ± 0.025	3.209GlyGly: 3.209 ± 0.049	1.256GlyHis: 1.256 ± 0.018	3.604GlyIle: 3.604 ± 0.03	3.37GlyLys: 3.37 ± 0.031	4.063GlyLeu: 4.063 ± 0.052	1.279GlyMet: 1.279 ± 0.016	2.727GlyAsn: 2.727 ± 0.028	2.085GlyPro: 2.085 ± 0.051	1.994GlyGln: 1.994 ± 0.025	3.201GlyArg: 3.201 ± 0.036	4.183GlySer: 4.183 ± 0.035	3.115GlyThr: 3.115 ± 0.034	2.896GlyVal: 2.896 ± 0.027	0.606GlyTrp: 0.606 ± 0.018	1.839GlyTyr: 1.839 ± 0.025	0.002GlyXaa: 0.002 ± 0.001
His	1.299HisAla: 1.299 ± 0.018	0.628HisCys: 0.628 ± 0.012	1.125HisAsp: 1.125 ± 0.016	1.436HisGlu: 1.436 ± 0.019	1.178HisPhe: 1.178 ± 0.016	1.249HisGly: 1.249 ± 0.017	0.829HisHis: 0.829 ± 0.024	1.551HisIle: 1.551 ± 0.017	1.162HisLys: 1.162 ± 0.018	2.457HisLeu: 2.457 ± 0.025	0.644HisMet: 0.644 ± 0.013	1.037HisAsn: 1.037 ± 0.014	1.173HisPro: 1.173 ± 0.017	1.043HisGln: 1.043 ± 0.018	1.451HisArg: 1.451 ± 0.018	2.05HisSer: 2.05 ± 0.025	1.188HisThr: 1.188 ± 0.019	1.372HisVal: 1.372 ± 0.018	0.356HisTrp: 0.356 ± 0.009	0.882HisTyr: 0.882 ± 0.013	0.002HisXaa: 0.002 ± 0.001
Ile	4.314IleAla: 4.314 ± 0.033	1.539IleCys: 1.539 ± 0.023	3.702IleAsp: 3.702 ± 0.035	4.128IleGlu: 4.128 ± 0.042	2.522IlePhe: 2.522 ± 0.026	3.408IleGly: 3.408 ± 0.029	1.559IleHis: 1.559 ± 0.022	5.789IleIle: 5.789 ± 0.184	3.419IleLys: 3.419 ± 0.032	5.45IleLeu: 5.45 ± 0.044	1.393IleMet: 1.393 ± 0.019	3.081IleAsn: 3.081 ± 0.029	3.174IlePro: 3.174 ± 0.032	2.423IleGln: 2.423 ± 0.029	3.715IleArg: 3.715 ± 0.032	5.385IleSer: 5.385 ± 0.035	3.941IleThr: 3.941 ± 0.038	3.843IleVal: 3.843 ± 0.03	0.703IleTrp: 0.703 ± 0.011	1.946IleTyr: 1.946 ± 0.023	0.004IleXaa: 0.004 ± 0.001
Lys	3.484LysAla: 3.484 ± 0.032	1.389LysCys: 1.389 ± 0.022	3.076LysAsp: 3.076 ± 0.031	4.828LysGlu: 4.828 ± 0.052	2.209LysPhe: 2.209 ± 0.022	2.858LysGly: 2.858 ± 0.03	1.497LysHis: 1.497 ± 0.022	4.008LysIle: 4.008 ± 0.04	5.169LysLys: 5.169 ± 0.061	6.005LysLeu: 6.005 ± 0.048	1.763LysMet: 1.763 ± 0.021	3.22LysAsn: 3.22 ± 0.027	2.59LysPro: 2.59 ± 0.04	2.873LysGln: 2.873 ± 0.033	4.259LysArg: 4.259 ± 0.036	4.196LysSer: 4.196 ± 0.035	3.31LysThr: 3.31 ± 0.03	3.238LysVal: 3.238 ± 0.031	0.741LysTrp: 0.741 ± 0.014	2.019LysTyr: 2.019 ± 0.021	0.005LysXaa: 0.005 ± 0.001
Leu	5.648LeuAla: 5.648 ± 0.044	2.017LeuCys: 2.017 ± 0.024	4.603LeuAsp: 4.603 ± 0.033	5.983LeuGlu: 5.983 ± 0.055	3.637LeuPhe: 3.637 ± 0.032	3.732LeuGly: 3.732 ± 0.04	2.434LeuHis: 2.434 ± 0.025	5.47LeuIle: 5.47 ± 0.037	5.937LeuLys: 5.937 ± 0.044	9.761LeuLeu: 9.761 ± 0.09	2.189LeuMet: 2.189 ± 0.025	4.51LeuAsn: 4.51 ± 0.032	4.651LeuPro: 4.651 ± 0.043	4.223LeuGln: 4.223 ± 0.042	5.691LeuArg: 5.691 ± 0.039	7.484LeuSer: 7.484 ± 0.049	4.871LeuThr: 4.871 ± 0.037	4.711LeuVal: 4.711 ± 0.037	1.059LeuTrp: 1.059 ± 0.02	2.743LeuTyr: 2.743 ± 0.025	0.006LeuXaa: 0.006 ± 0.001
Met	1.589MetAla: 1.589 ± 0.019	0.43MetCys: 0.43 ± 0.009	1.448MetAsp: 1.448 ± 0.019	1.93MetGlu: 1.93 ± 0.025	0.836MetPhe: 0.836 ± 0.013	1.111MetGly: 1.111 ± 0.017	0.635MetHis: 0.635 ± 0.012	1.575MetIle: 1.575 ± 0.021	1.88MetLys: 1.88 ± 0.023	2.26MetLeu: 2.26 ± 0.024	0.774MetMet: 0.774 ± 0.029	1.355MetAsn: 1.355 ± 0.017	1.075MetPro: 1.075 ± 0.017	1.168MetGln: 1.168 ± 0.017	1.432MetArg: 1.432 ± 0.018	1.74MetSer: 1.74 ± 0.022	1.348MetThr: 1.348 ± 0.016	1.411MetVal: 1.411 ± 0.017	0.235MetTrp: 0.235 ± 0.008	0.615MetTyr: 0.615 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	3.159AsnAla: 3.159 ± 0.031	1.088AsnCys: 1.088 ± 0.018	3.341AsnAsp: 3.341 ± 0.03	3.836AsnGlu: 3.836 ± 0.036	1.972AsnPhe: 1.972 ± 0.022	3.154AsnGly: 3.154 ± 0.029	1.111AsnHis: 1.111 ± 0.018	3.311AsnIle: 3.311 ± 0.031	2.645AsnLys: 2.645 ± 0.022	4.274AsnLeu: 4.274 ± 0.034	1.167AsnMet: 1.167 ± 0.016	2.889AsnAsn: 2.889 ± 0.058	2.023AsnPro: 2.023 ± 0.021	1.8AsnGln: 1.8 ± 0.024	2.669AsnArg: 2.669 ± 0.023	3.9AsnSer: 3.9 ± 0.032	2.474AsnThr: 2.474 ± 0.024	3.129AsnVal: 3.129 ± 0.028	0.554AsnTrp: 0.554 ± 0.01	1.639AsnTyr: 1.639 ± 0.021	0.003AsnXaa: 0.003 ± 0.001
Pro	2.382ProAla: 2.382 ± 0.031	0.758ProCys: 0.758 ± 0.018	2.215ProAsp: 2.215 ± 0.025	2.917ProGlu: 2.917 ± 0.033	1.808ProPhe: 1.808 ± 0.021	2.319ProGly: 2.319 ± 0.081	0.983ProHis: 0.983 ± 0.015	2.598ProIle: 2.598 ± 0.027	2.499ProLys: 2.499 ± 0.034	3.825ProLeu: 3.825 ± 0.031	0.963ProMet: 0.963 ± 0.018	2.112ProAsn: 2.112 ± 0.022	3.007ProPro: 3.007 ± 0.057	1.8ProGln: 1.8 ± 0.025	2.13ProArg: 2.13 ± 0.025	3.986ProSer: 3.986 ± 0.042	2.679ProThr: 2.679 ± 0.04	2.853ProVal: 2.853 ± 0.039	0.495ProTrp: 0.495 ± 0.011	1.459ProTyr: 1.459 ± 0.019	0.002ProXaa: 0.002 ± 0.001
Gln	2.228GlnAla: 2.228 ± 0.03	0.919GlnCys: 0.919 ± 0.018	1.517GlnAsp: 1.517 ± 0.026	2.539GlnGlu: 2.539 ± 0.034	1.681GlnPhe: 1.681 ± 0.02	1.489GlnGly: 1.489 ± 0.022	1.136GlnHis: 1.136 ± 0.015	2.699GlnIle: 2.699 ± 0.025	2.921GlnLys: 2.921 ± 0.028	4.446GlnLeu: 4.446 ± 0.041	1.25GlnMet: 1.25 ± 0.019	2.15GlnAsn: 2.15 ± 0.023	1.791GlnPro: 1.791 ± 0.026	3.837GlnGln: 3.837 ± 0.144	2.628GlnArg: 2.628 ± 0.032	2.918GlnSer: 2.918 ± 0.026	2.234GlnThr: 2.234 ± 0.024	1.999GlnVal: 1.999 ± 0.022	0.533GlnTrp: 0.533 ± 0.011	1.331GlnTyr: 1.331 ± 0.019	0.002GlnXaa: 0.002 ± 0.001
Arg	3.099ArgAla: 3.099 ± 0.03	1.316ArgCys: 1.316 ± 0.019	2.65ArgAsp: 2.65 ± 0.029	3.644ArgGlu: 3.644 ± 0.036	2.391ArgPhe: 2.391 ± 0.026	2.595ArgGly: 2.595 ± 0.029	1.506ArgHis: 1.506 ± 0.02	3.823ArgIle: 3.823 ± 0.028	4.385ArgLys: 4.385 ± 0.04	5.456ArgLeu: 5.456 ± 0.043	1.521ArgMet: 1.521 ± 0.019	3.3ArgAsn: 3.3 ± 0.029	2.247ArgPro: 2.247 ± 0.028	2.564ArgGln: 2.564 ± 0.024	4.527ArgArg: 4.527 ± 0.119	4.506ArgSer: 4.506 ± 0.035	3.128ArgThr: 3.128 ± 0.024	2.804ArgVal: 2.804 ± 0.027	0.698ArgTrp: 0.698 ± 0.013	1.958ArgTyr: 1.958 ± 0.026	0.005ArgXaa: 0.005 ± 0.001
Ser	5.025SerAla: 5.025 ± 0.038	1.576SerCys: 1.576 ± 0.024	4.442SerAsp: 4.442 ± 0.041	4.818SerGlu: 4.818 ± 0.039	3.209SerPhe: 3.209 ± 0.034	4.539SerGly: 4.539 ± 0.041	1.729SerHis: 1.729 ± 0.022	4.602SerIle: 4.602 ± 0.032	4.436SerLys: 4.436 ± 0.03	7.128SerLeu: 7.128 ± 0.039	1.793SerMet: 1.793 ± 0.019	4.024SerAsn: 4.024 ± 0.036	3.489SerPro: 3.489 ± 0.046	2.924SerGln: 2.924 ± 0.029	4.264SerArg: 4.264 ± 0.047	9.704SerSer: 9.704 ± 0.205	5.004SerThr: 5.004 ± 0.045	4.937SerVal: 4.937 ± 0.034	0.799SerTrp: 0.799 ± 0.013	2.128SerTyr: 2.128 ± 0.021	0.006SerXaa: 0.006 ± 0.001
Thr	3.891ThrAla: 3.891 ± 0.038	1.073ThrCys: 1.073 ± 0.018	2.986ThrAsp: 2.986 ± 0.033	3.51ThrGlu: 3.51 ± 0.034	2.188ThrPhe: 2.188 ± 0.02	3.129ThrGly: 3.129 ± 0.035	1.169ThrHis: 1.169 ± 0.016	3.723ThrIle: 3.723 ± 0.035	3.296ThrLys: 3.296 ± 0.033	4.8ThrLeu: 4.8 ± 0.033	1.292ThrMet: 1.292 ± 0.015	2.796ThrAsn: 2.796 ± 0.031	2.525ThrPro: 2.525 ± 0.027	1.865ThrGln: 1.865 ± 0.025	2.679ThrArg: 2.679 ± 0.024	5.01ThrSer: 5.01 ± 0.043	4.671ThrThr: 4.671 ± 0.103	4.236ThrVal: 4.236 ± 0.056	0.516ThrTrp: 0.516 ± 0.011	1.572ThrTyr: 1.572 ± 0.022	0.002ThrXaa: 0.002 ± 0.001
Val	3.92ValAla: 3.92 ± 0.032	1.198ValCys: 1.198 ± 0.018	3.618ValAsp: 3.618 ± 0.056	4.34ValGlu: 4.34 ± 0.072	2.207ValPhe: 2.207 ± 0.027	3.019ValGly: 3.019 ± 0.031	1.454ValHis: 1.454 ± 0.018	3.952ValIle: 3.952 ± 0.033	3.552ValLys: 3.552 ± 0.033	5.309ValLeu: 5.309 ± 0.037	1.439ValMet: 1.439 ± 0.015	2.764ValAsn: 2.764 ± 0.027	2.769ValPro: 2.769 ± 0.03	2.379ValGln: 2.379 ± 0.029	3.197ValArg: 3.197 ± 0.031	4.322ValSer: 4.322 ± 0.038	3.672ValThr: 3.672 ± 0.049	4.642ValVal: 4.642 ± 0.165	0.586ValTrp: 0.586 ± 0.01	1.751ValTyr: 1.751 ± 0.018	0.003ValXaa: 0.003 ± 0.001
Trp	0.526TrpAla: 0.526 ± 0.011	0.223TrpCys: 0.223 ± 0.007	0.595TrpAsp: 0.595 ± 0.013	0.61TrpGlu: 0.61 ± 0.013	0.436TrpPhe: 0.436 ± 0.01	0.416TrpGly: 0.416 ± 0.01	0.263TrpHis: 0.263 ± 0.009	0.804TrpIle: 0.804 ± 0.014	0.979TrpLys: 0.979 ± 0.017	1.118TrpLeu: 1.118 ± 0.018	0.324TrpMet: 0.324 ± 0.013	0.69TrpAsn: 0.69 ± 0.012	0.47TrpPro: 0.47 ± 0.009	0.462TrpGln: 0.462 ± 0.011	0.751TrpArg: 0.751 ± 0.012	0.881TrpSer: 0.881 ± 0.017	0.634TrpThr: 0.634 ± 0.013	0.473TrpVal: 0.473 ± 0.011	0.174TrpTrp: 0.174 ± 0.006	0.348TrpTyr: 0.348 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.808TyrAla: 1.808 ± 0.021	0.77TyrCys: 0.77 ± 0.015	1.899TyrAsp: 1.899 ± 0.024	1.98TyrGlu: 1.98 ± 0.022	1.365TyrPhe: 1.365 ± 0.018	1.992TyrGly: 1.992 ± 0.027	0.909TyrHis: 0.909 ± 0.016	1.826TyrIle: 1.826 ± 0.021	1.59TyrLys: 1.59 ± 0.018	2.883TyrLeu: 2.883 ± 0.025	0.753TyrMet: 0.753 ± 0.013	1.432TyrAsn: 1.432 ± 0.015	1.402TyrPro: 1.402 ± 0.026	1.288TyrGln: 1.288 ± 0.017	1.957TyrArg: 1.957 ± 0.024	2.227TyrSer: 2.227 ± 0.024	1.485TyrThr: 1.485 ± 0.019	1.863TyrVal: 1.863 ± 0.023	0.406TyrTrp: 0.406 ± 0.01	1.736TyrTyr: 1.736 ± 0.108	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.001	0.002XaaCys: 0.002 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.004XaaGlu: 0.004 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.003XaaIle: 0.003 ± 0.001	0.005XaaLys: 0.005 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.005XaaVal: 0.005 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12177 proteins (5044833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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