Amino acid dipepetide frequency for Maledivibacter halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.197AlaAla: 4.197 ± 0.073	0.712AlaCys: 0.712 ± 0.025	2.65AlaAsp: 2.65 ± 0.04	3.235AlaGlu: 3.235 ± 0.062	2.53AlaPhe: 2.53 ± 0.043	4.038AlaGly: 4.038 ± 0.066	0.891AlaHis: 0.891 ± 0.024	5.826AlaIle: 5.826 ± 0.062	4.582AlaLys: 4.582 ± 0.057	5.84AlaLeu: 5.84 ± 0.07	1.701AlaMet: 1.701 ± 0.038	2.534AlaAsn: 2.534 ± 0.038	1.485AlaPro: 1.485 ± 0.034	1.498AlaGln: 1.498 ± 0.03	2.01AlaArg: 2.01 ± 0.035	3.384AlaSer: 3.384 ± 0.046	2.589AlaThr: 2.589 ± 0.04	4.3AlaVal: 4.3 ± 0.068	0.358AlaTrp: 0.358 ± 0.015	2.025AlaTyr: 2.025 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.545CysAla: 0.545 ± 0.021	0.153CysCys: 0.153 ± 0.011	0.648CysAsp: 0.648 ± 0.023	0.649CysGlu: 0.649 ± 0.02	0.431CysPhe: 0.431 ± 0.016	1.043CysGly: 1.043 ± 0.031	0.235CysHis: 0.235 ± 0.012	1.043CysIle: 1.043 ± 0.026	0.887CysLys: 0.887 ± 0.026	0.8CysLeu: 0.8 ± 0.024	0.265CysMet: 0.265 ± 0.014	0.607CysAsn: 0.607 ± 0.02	0.455CysPro: 0.455 ± 0.021	0.244CysGln: 0.244 ± 0.012	0.402CysArg: 0.402 ± 0.016	0.696CysSer: 0.696 ± 0.022	0.497CysThr: 0.497 ± 0.019	0.557CysVal: 0.557 ± 0.017	0.085CysTrp: 0.085 ± 0.008	0.376CysTyr: 0.376 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.41AspAla: 2.41 ± 0.041	0.566AspCys: 0.566 ± 0.019	2.774AspAsp: 2.774 ± 0.057	4.678AspGlu: 4.678 ± 0.065	2.689AspPhe: 2.689 ± 0.042	3.326AspGly: 3.326 ± 0.051	0.693AspHis: 0.693 ± 0.023	6.741AspIle: 6.741 ± 0.073	5.195AspLys: 5.195 ± 0.051	4.91AspLeu: 4.91 ± 0.057	1.595AspMet: 1.595 ± 0.037	3.103AspAsn: 3.103 ± 0.047	1.514AspPro: 1.514 ± 0.034	0.892AspGln: 0.892 ± 0.027	1.947AspArg: 1.947 ± 0.039	2.956AspSer: 2.956 ± 0.044	2.397AspThr: 2.397 ± 0.04	3.376AspVal: 3.376 ± 0.047	0.438AspTrp: 0.438 ± 0.019	2.561AspTyr: 2.561 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.371GluAla: 4.371 ± 0.058	0.544GluCys: 0.544 ± 0.02	4.373GluAsp: 4.373 ± 0.063	6.823GluGlu: 6.823 ± 0.097	2.92GluPhe: 2.92 ± 0.049	4.315GluGly: 4.315 ± 0.058	0.848GluHis: 0.848 ± 0.026	8.088GluIle: 8.088 ± 0.082	8.411GluLys: 8.411 ± 0.084	6.647GluLeu: 6.647 ± 0.068	2.05GluMet: 2.05 ± 0.041	5.056GluAsn: 5.056 ± 0.062	1.484GluPro: 1.484 ± 0.039	1.447GluGln: 1.447 ± 0.033	2.783GluArg: 2.783 ± 0.053	3.434GluSer: 3.434 ± 0.047	3.009GluThr: 3.009 ± 0.045	4.6GluVal: 4.6 ± 0.06	0.475GluTrp: 0.475 ± 0.018	3.103GluTyr: 3.103 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.327PheAla: 2.327 ± 0.043	0.464PheCys: 0.464 ± 0.016	2.484PheAsp: 2.484 ± 0.043	2.801PheGlu: 2.801 ± 0.039	1.96PhePhe: 1.96 ± 0.038	3.055PheGly: 3.055 ± 0.048	0.602PheHis: 0.602 ± 0.019	4.667PheIle: 4.667 ± 0.067	3.678PheLys: 3.678 ± 0.051	3.931PheLeu: 3.931 ± 0.058	1.14PheMet: 1.14 ± 0.028	2.683PheAsn: 2.683 ± 0.049	1.311PhePro: 1.311 ± 0.028	0.98PheGln: 0.98 ± 0.022	1.317PheArg: 1.317 ± 0.03	3.035PheSer: 3.035 ± 0.041	2.325PheThr: 2.325 ± 0.04	2.585PheVal: 2.585 ± 0.045	0.345PheTrp: 0.345 ± 0.015	1.691PheTyr: 1.691 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.306GlyAla: 4.306 ± 0.062	0.908GlyCys: 0.908 ± 0.024	3.166GlyAsp: 3.166 ± 0.062	4.459GlyGlu: 4.459 ± 0.059	3.167GlyPhe: 3.167 ± 0.056	4.613GlyGly: 4.613 ± 0.068	1.089GlyHis: 1.089 ± 0.027	7.271GlyIle: 7.271 ± 0.071	5.818GlyLys: 5.818 ± 0.063	6.109GlyLeu: 6.109 ± 0.083	1.9GlyMet: 1.9 ± 0.037	3.306GlyAsn: 3.306 ± 0.047	1.471GlyPro: 1.471 ± 0.035	1.501GlyGln: 1.501 ± 0.029	2.395GlyArg: 2.395 ± 0.038	3.671GlySer: 3.671 ± 0.053	3.464GlyThr: 3.464 ± 0.056	4.565GlyVal: 4.565 ± 0.063	0.597GlyTrp: 0.597 ± 0.021	3.059GlyTyr: 3.059 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	0.692HisAla: 0.692 ± 0.019	0.218HisCys: 0.218 ± 0.012	0.774HisAsp: 0.774 ± 0.021	0.977HisGlu: 0.977 ± 0.026	0.671HisPhe: 0.671 ± 0.022	1.071HisGly: 1.071 ± 0.028	0.308HisHis: 0.308 ± 0.016	1.439HisIle: 1.439 ± 0.032	1.083HisLys: 1.083 ± 0.025	1.284HisLeu: 1.284 ± 0.028	0.397HisMet: 0.397 ± 0.015	0.858HisAsn: 0.858 ± 0.022	0.695HisPro: 0.695 ± 0.024	0.353HisGln: 0.353 ± 0.014	0.64HisArg: 0.64 ± 0.02	0.891HisSer: 0.891 ± 0.024	0.694HisThr: 0.694 ± 0.022	0.794HisVal: 0.794 ± 0.021	0.133HisTrp: 0.133 ± 0.01	0.589HisTyr: 0.589 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.014IleAla: 6.014 ± 0.07	1.152IleCys: 1.152 ± 0.027	6.443IleAsp: 6.443 ± 0.071	7.903IleGlu: 7.903 ± 0.076	4.386IlePhe: 4.386 ± 0.064	6.849IleGly: 6.849 ± 0.071	1.477IleHis: 1.477 ± 0.03	10.346IleIle: 10.346 ± 0.099	9.067IleLys: 9.067 ± 0.095	9.459IleLeu: 9.459 ± 0.106	2.491IleMet: 2.491 ± 0.035	6.205IleAsn: 6.205 ± 0.073	3.803IlePro: 3.803 ± 0.047	2.248IleGln: 2.248 ± 0.033	3.49IleArg: 3.49 ± 0.045	6.974IleSer: 6.974 ± 0.082	4.926IleThr: 4.926 ± 0.059	6.422IleVal: 6.422 ± 0.059	0.649IleTrp: 0.649 ± 0.023	3.71IleTyr: 3.71 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.99LysAla: 4.99 ± 0.071	0.777LysCys: 0.777 ± 0.024	5.753LysAsp: 5.753 ± 0.066	9.142LysGlu: 9.142 ± 0.102	3.113LysPhe: 3.113 ± 0.045	5.496LysGly: 5.496 ± 0.062	1.237LysHis: 1.237 ± 0.027	8.964LysIle: 8.964 ± 0.09	8.902LysLys: 8.902 ± 0.082	7.764LysLeu: 7.764 ± 0.067	2.438LysMet: 2.438 ± 0.041	6.222LysAsn: 6.222 ± 0.076	2.295LysPro: 2.295 ± 0.036	2.018LysGln: 2.018 ± 0.038	3.437LysArg: 3.437 ± 0.05	4.869LysSer: 4.869 ± 0.051	4.026LysThr: 4.026 ± 0.05	5.509LysVal: 5.509 ± 0.055	0.671LysTrp: 0.671 ± 0.024	4.133LysTyr: 4.133 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	5.34LeuAla: 5.34 ± 0.067	0.989LeuCys: 0.989 ± 0.026	5.034LeuAsp: 5.034 ± 0.06	6.526LeuGlu: 6.526 ± 0.073	3.869LeuPhe: 3.869 ± 0.058	6.422LeuGly: 6.422 ± 0.082	1.169LeuHis: 1.169 ± 0.028	8.724LeuIle: 8.724 ± 0.075	8.703LeuLys: 8.703 ± 0.086	8.01LeuLeu: 8.01 ± 0.087	2.427LeuMet: 2.427 ± 0.037	5.426LeuAsn: 5.426 ± 0.069	2.991LeuPro: 2.991 ± 0.052	2.058LeuGln: 2.058 ± 0.038	3.225LeuArg: 3.225 ± 0.049	6.413LeuSer: 6.413 ± 0.067	4.335LeuThr: 4.335 ± 0.056	5.306LeuVal: 5.306 ± 0.056	0.62LeuTrp: 0.62 ± 0.022	3.29LeuTyr: 3.29 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.869MetAla: 1.869 ± 0.039	0.215MetCys: 0.215 ± 0.012	1.516MetAsp: 1.516 ± 0.032	1.977MetGlu: 1.977 ± 0.042	0.975MetPhe: 0.975 ± 0.028	1.994MetGly: 1.994 ± 0.039	0.362MetHis: 0.362 ± 0.017	2.41MetIle: 2.41 ± 0.04	2.761MetLys: 2.761 ± 0.041	2.241MetLeu: 2.241 ± 0.034	0.759MetMet: 0.759 ± 0.023	1.67MetAsn: 1.67 ± 0.032	0.918MetPro: 0.918 ± 0.023	0.586MetGln: 0.586 ± 0.02	0.89MetArg: 0.89 ± 0.023	1.572MetSer: 1.572 ± 0.029	1.324MetThr: 1.324 ± 0.027	1.684MetVal: 1.684 ± 0.034	0.144MetTrp: 0.144 ± 0.01	0.803MetTyr: 0.803 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.575AsnAla: 2.575 ± 0.041	0.636AsnCys: 0.636 ± 0.022	2.738AsnAsp: 2.738 ± 0.042	4.272AsnGlu: 4.272 ± 0.053	2.295AsnPhe: 2.295 ± 0.043	3.33AsnGly: 3.33 ± 0.041	0.9AsnHis: 0.9 ± 0.023	7.24AsnIle: 7.24 ± 0.077	5.74AsnLys: 5.74 ± 0.071	5.306AsnLeu: 5.306 ± 0.061	1.578AsnMet: 1.578 ± 0.031	3.913AsnAsn: 3.913 ± 0.069	2.308AsnPro: 2.308 ± 0.043	1.437AsnGln: 1.437 ± 0.033	2.396AsnArg: 2.396 ± 0.041	3.502AsnSer: 3.502 ± 0.058	2.696AsnThr: 2.696 ± 0.044	3.29AsnVal: 3.29 ± 0.046	0.479AsnTrp: 0.479 ± 0.019	2.494AsnTyr: 2.494 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	1.571ProAla: 1.571 ± 0.036	0.308ProCys: 0.308 ± 0.012	1.614ProAsp: 1.614 ± 0.036	2.295ProGlu: 2.295 ± 0.044	1.485ProPhe: 1.485 ± 0.03	1.975ProGly: 1.975 ± 0.035	0.589ProHis: 0.589 ± 0.018	3.038ProIle: 3.038 ± 0.043	2.443ProLys: 2.443 ± 0.039	2.842ProLeu: 2.842 ± 0.044	0.806ProMet: 0.806 ± 0.024	1.643ProAsn: 1.643 ± 0.036	0.822ProPro: 0.822 ± 0.024	0.887ProGln: 0.887 ± 0.023	0.998ProArg: 0.998 ± 0.028	1.806ProSer: 1.806 ± 0.029	1.52ProThr: 1.52 ± 0.035	2.228ProVal: 2.228 ± 0.041	0.257ProTrp: 0.257 ± 0.013	1.314ProTyr: 1.314 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	1.356GlnAla: 1.356 ± 0.033	0.233GlnCys: 0.233 ± 0.013	1.105GlnAsp: 1.105 ± 0.026	1.757GlnGlu: 1.757 ± 0.033	0.876GlnPhe: 0.876 ± 0.023	1.524GlnGly: 1.524 ± 0.033	0.319GlnHis: 0.319 ± 0.015	2.243GlnIle: 2.243 ± 0.037	2.004GlnLys: 2.004 ± 0.033	2.063GlnLeu: 2.063 ± 0.033	0.699GlnMet: 0.699 ± 0.02	1.429GlnAsn: 1.429 ± 0.032	0.605GlnPro: 0.605 ± 0.02	0.653GlnGln: 0.653 ± 0.021	1.056GlnArg: 1.056 ± 0.029	1.317GlnSer: 1.317 ± 0.027	0.974GlnThr: 0.974 ± 0.027	1.397GlnVal: 1.397 ± 0.031	0.215GlnTrp: 0.215 ± 0.013	0.96GlnTyr: 0.96 ± 0.023	0.001GlnXaa: 0.001 ± 0.001
Arg	2.013ArgAla: 2.013 ± 0.038	0.396ArgCys: 0.396 ± 0.017	1.874ArgAsp: 1.874 ± 0.035	3.035ArgGlu: 3.035 ± 0.05	1.577ArgPhe: 1.577 ± 0.032	2.251ArgGly: 2.251 ± 0.04	0.506ArgHis: 0.506 ± 0.016	3.61ArgIle: 3.61 ± 0.045	3.605ArgLys: 3.605 ± 0.053	3.3ArgLeu: 3.3 ± 0.047	0.975ArgMet: 0.975 ± 0.023	2.166ArgAsn: 2.166 ± 0.033	1.041ArgPro: 1.041 ± 0.029	0.969ArgGln: 0.969 ± 0.025	1.607ArgArg: 1.607 ± 0.038	1.705ArgSer: 1.705 ± 0.036	1.56ArgThr: 1.56 ± 0.032	2.275ArgVal: 2.275 ± 0.039	0.273ArgTrp: 0.273 ± 0.013	1.563ArgTyr: 1.563 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	2.897SerAla: 2.897 ± 0.046	0.632SerCys: 0.632 ± 0.021	2.899SerAsp: 2.899 ± 0.038	3.704SerGlu: 3.704 ± 0.054	3.07SerPhe: 3.07 ± 0.05	4.147SerGly: 4.147 ± 0.058	0.985SerHis: 0.985 ± 0.025	6.483SerIle: 6.483 ± 0.076	5.563SerLys: 5.563 ± 0.072	5.721SerLeu: 5.721 ± 0.062	1.626SerMet: 1.626 ± 0.031	3.462SerAsn: 3.462 ± 0.051	1.858SerPro: 1.858 ± 0.037	1.627SerGln: 1.627 ± 0.029	2.191SerArg: 2.191 ± 0.039	3.86SerSer: 3.86 ± 0.06	2.925SerThr: 2.925 ± 0.048	3.412SerVal: 3.412 ± 0.049	0.485SerTrp: 0.485 ± 0.018	2.362SerTyr: 2.362 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	2.985ThrAla: 2.985 ± 0.047	0.46ThrCys: 0.46 ± 0.02	2.41ThrAsp: 2.41 ± 0.038	2.754ThrGlu: 2.754 ± 0.043	2.026ThrPhe: 2.026 ± 0.039	3.79ThrGly: 3.79 ± 0.052	0.769ThrHis: 0.769 ± 0.024	4.94ThrIle: 4.94 ± 0.062	3.651ThrLys: 3.651 ± 0.049	4.428ThrLeu: 4.428 ± 0.06	1.119ThrMet: 1.119 ± 0.029	2.502ThrAsn: 2.502 ± 0.044	1.835ThrPro: 1.835 ± 0.034	1.09ThrGln: 1.09 ± 0.027	1.564ThrArg: 1.564 ± 0.035	2.866ThrSer: 2.866 ± 0.049	2.419ThrThr: 2.419 ± 0.048	3.198ThrVal: 3.198 ± 0.05	0.356ThrTrp: 0.356 ± 0.018	1.766ThrTyr: 1.766 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	3.688ValAla: 3.688 ± 0.056	0.669ValCys: 0.669 ± 0.022	3.68ValAsp: 3.68 ± 0.049	4.485ValGlu: 4.485 ± 0.056	3.012ValPhe: 3.012 ± 0.043	4.241ValGly: 4.241 ± 0.063	0.842ValHis: 0.842 ± 0.024	6.135ValIle: 6.135 ± 0.062	5.456ValLys: 5.456 ± 0.059	5.97ValLeu: 5.97 ± 0.062	1.531ValMet: 1.531 ± 0.031	3.36ValAsn: 3.36 ± 0.048	2.045ValPro: 2.045 ± 0.04	1.265ValGln: 1.265 ± 0.028	2.061ValArg: 2.061 ± 0.04	3.926ValSer: 3.926 ± 0.05	2.952ValThr: 2.952 ± 0.047	4.312ValVal: 4.312 ± 0.062	0.387ValTrp: 0.387 ± 0.015	2.286ValTyr: 2.286 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.415TrpAla: 0.415 ± 0.017	0.083TrpCys: 0.083 ± 0.007	0.409TrpAsp: 0.409 ± 0.017	0.507TrpGlu: 0.507 ± 0.017	0.37TrpPhe: 0.37 ± 0.016	0.598TrpGly: 0.598 ± 0.021	0.129TrpHis: 0.129 ± 0.009	0.707TrpIle: 0.707 ± 0.024	0.614TrpLys: 0.614 ± 0.021	0.632TrpLeu: 0.632 ± 0.02	0.188TrpMet: 0.188 ± 0.011	0.478TrpAsn: 0.478 ± 0.019	0.167TrpPro: 0.167 ± 0.011	0.213TrpGln: 0.213 ± 0.012	0.266TrpArg: 0.266 ± 0.013	0.439TrpSer: 0.439 ± 0.017	0.369TrpThr: 0.369 ± 0.018	0.428TrpVal: 0.428 ± 0.016	0.097TrpTrp: 0.097 ± 0.009	0.271TrpTyr: 0.271 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.824TyrAla: 1.824 ± 0.035	0.502TyrCys: 0.502 ± 0.017	2.416TyrAsp: 2.416 ± 0.042	2.807TyrGlu: 2.807 ± 0.039	1.96TyrPhe: 1.96 ± 0.04	2.755TyrGly: 2.755 ± 0.043	0.61TyrHis: 0.61 ± 0.02	4.098TyrIle: 4.098 ± 0.055	3.594TyrLys: 3.594 ± 0.049	3.618TyrLeu: 3.618 ± 0.047	0.984TyrMet: 0.984 ± 0.024	2.499TyrAsn: 2.499 ± 0.046	1.339TyrPro: 1.339 ± 0.027	0.822TyrGln: 0.822 ± 0.026	1.626TyrArg: 1.626 ± 0.037	2.592TyrSer: 2.592 ± 0.038	1.93TyrThr: 1.93 ± 0.04	2.066TyrVal: 2.066 ± 0.032	0.315TyrTrp: 0.315 ± 0.015	1.83TyrTyr: 1.83 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 5301 proteins (1615962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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