Amino acid dipepetide frequency for Alteromonas pelagimontana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.529AlaAla: 8.529 ± 0.104	0.93AlaCys: 0.93 ± 0.03	5.209AlaAsp: 5.209 ± 0.072	5.631AlaGlu: 5.631 ± 0.076	3.693AlaPhe: 3.693 ± 0.061	6.507AlaGly: 6.507 ± 0.079	1.785AlaHis: 1.785 ± 0.039	5.902AlaIle: 5.902 ± 0.083	4.716AlaLys: 4.716 ± 0.072	10.132AlaLeu: 10.132 ± 0.12	2.774AlaMet: 2.774 ± 0.055	3.69AlaAsn: 3.69 ± 0.06	3.264AlaPro: 3.264 ± 0.061	4.091AlaGln: 4.091 ± 0.074	4.113AlaArg: 4.113 ± 0.066	5.817AlaSer: 5.817 ± 0.075	5.114AlaThr: 5.114 ± 0.076	6.517AlaVal: 6.517 ± 0.079	0.932AlaTrp: 0.932 ± 0.027	2.553AlaTyr: 2.553 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.876CysAla: 0.876 ± 0.026	0.156CysCys: 0.156 ± 0.01	0.565CysAsp: 0.565 ± 0.023	0.605CysGlu: 0.605 ± 0.023	0.446CysPhe: 0.446 ± 0.017	0.798CysGly: 0.798 ± 0.027	0.31CysHis: 0.31 ± 0.019	0.555CysIle: 0.555 ± 0.024	0.437CysLys: 0.437 ± 0.02	0.896CysLeu: 0.896 ± 0.034	0.204CysMet: 0.204 ± 0.014	0.37CysAsn: 0.37 ± 0.018	0.418CysPro: 0.418 ± 0.019	0.457CysGln: 0.457 ± 0.019	0.497CysArg: 0.497 ± 0.022	0.662CysSer: 0.662 ± 0.024	0.449CysThr: 0.449 ± 0.021	0.613CysVal: 0.613 ± 0.024	0.134CysTrp: 0.134 ± 0.01	0.323CysTyr: 0.323 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.074AspAla: 5.074 ± 0.061	0.509AspCys: 0.509 ± 0.021	3.462AspAsp: 3.462 ± 0.064	3.948AspGlu: 3.948 ± 0.065	2.555AspPhe: 2.555 ± 0.051	3.795AspGly: 3.795 ± 0.072	1.067AspHis: 1.067 ± 0.033	4.21AspIle: 4.21 ± 0.05	3.108AspLys: 3.108 ± 0.051	4.721AspLeu: 4.721 ± 0.058	1.491AspMet: 1.491 ± 0.035	2.704AspAsn: 2.704 ± 0.055	2.213AspPro: 2.213 ± 0.052	1.698AspGln: 1.698 ± 0.036	2.318AspArg: 2.318 ± 0.05	3.433AspSer: 3.433 ± 0.06	3.103AspThr: 3.103 ± 0.063	4.267AspVal: 4.267 ± 0.061	0.931AspTrp: 0.931 ± 0.026	2.157AspTyr: 2.157 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.651GluAla: 5.651 ± 0.072	0.462GluCys: 0.462 ± 0.02	3.33GluAsp: 3.33 ± 0.052	4.053GluGlu: 4.053 ± 0.072	2.354GluPhe: 2.354 ± 0.046	3.909GluGly: 3.909 ± 0.072	1.434GluHis: 1.434 ± 0.043	3.635GluIle: 3.635 ± 0.059	3.91GluLys: 3.91 ± 0.052	6.166GluLeu: 6.166 ± 0.087	1.582GluMet: 1.582 ± 0.033	2.923GluAsn: 2.923 ± 0.052	2.005GluPro: 2.005 ± 0.043	3.551GluGln: 3.551 ± 0.055	3.378GluArg: 3.378 ± 0.058	3.687GluSer: 3.687 ± 0.062	3.113GluThr: 3.113 ± 0.05	4.145GluVal: 4.145 ± 0.069	0.801GluTrp: 0.801 ± 0.027	1.782GluTyr: 1.782 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.949PheAla: 3.949 ± 0.058	0.535PheCys: 0.535 ± 0.021	2.784PheAsp: 2.784 ± 0.05	2.412PheGlu: 2.412 ± 0.049	1.796PhePhe: 1.796 ± 0.043	3.136PheGly: 3.136 ± 0.057	0.898PheHis: 0.898 ± 0.028	2.7PheIle: 2.7 ± 0.05	1.789PheLys: 1.789 ± 0.041	3.456PheLeu: 3.456 ± 0.063	0.994PheMet: 0.994 ± 0.028	2.018PheAsn: 2.018 ± 0.047	1.564PhePro: 1.564 ± 0.038	1.25PheGln: 1.25 ± 0.034	1.786PheArg: 1.786 ± 0.042	3.393PheSer: 3.393 ± 0.052	2.683PheThr: 2.683 ± 0.048	2.719PheVal: 2.719 ± 0.039	0.554PheTrp: 0.554 ± 0.023	1.464PheTyr: 1.464 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.531GlyAla: 5.531 ± 0.093	0.813GlyCys: 0.813 ± 0.028	3.857GlyAsp: 3.857 ± 0.065	4.401GlyGlu: 4.401 ± 0.068	3.356GlyPhe: 3.356 ± 0.059	4.817GlyGly: 4.817 ± 0.084	1.511GlyHis: 1.511 ± 0.037	4.538GlyIle: 4.538 ± 0.074	4.173GlyLys: 4.173 ± 0.063	6.674GlyLeu: 6.674 ± 0.078	2.034GlyMet: 2.034 ± 0.043	2.88GlyAsn: 2.88 ± 0.061	1.782GlyPro: 1.782 ± 0.042	2.578GlyGln: 2.578 ± 0.043	3.118GlyArg: 3.118 ± 0.052	4.089GlySer: 4.089 ± 0.073	3.53GlyThr: 3.53 ± 0.063	5.063GlyVal: 5.063 ± 0.067	1.086GlyTrp: 1.086 ± 0.034	2.532GlyTyr: 2.532 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.758HisAla: 1.758 ± 0.038	0.314HisCys: 0.314 ± 0.018	1.108HisAsp: 1.108 ± 0.031	1.143HisGlu: 1.143 ± 0.03	1.161HisPhe: 1.161 ± 0.03	1.576HisGly: 1.576 ± 0.035	0.719HisHis: 0.719 ± 0.027	1.344HisIle: 1.344 ± 0.035	1.011HisLys: 1.011 ± 0.03	2.209HisLeu: 2.209 ± 0.052	0.515HisMet: 0.515 ± 0.022	0.911HisAsn: 0.911 ± 0.026	1.228HisPro: 1.228 ± 0.033	1.118HisGln: 1.118 ± 0.034	1.156HisArg: 1.156 ± 0.035	1.431HisSer: 1.431 ± 0.04	1.126HisThr: 1.126 ± 0.031	1.348HisVal: 1.348 ± 0.036	0.395HisTrp: 0.395 ± 0.018	0.923HisTyr: 0.923 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.313IleAla: 6.313 ± 0.078	0.628IleCys: 0.628 ± 0.022	4.016IleAsp: 4.016 ± 0.054	4.082IleGlu: 4.082 ± 0.056	2.232IlePhe: 2.232 ± 0.052	4.366IleGly: 4.366 ± 0.066	1.24IleHis: 1.24 ± 0.035	3.441IleIle: 3.441 ± 0.057	2.902IleLys: 2.902 ± 0.052	4.964IleLeu: 4.964 ± 0.073	1.255IleMet: 1.255 ± 0.034	2.887IleAsn: 2.887 ± 0.053	2.613IlePro: 2.613 ± 0.046	2.116IleGln: 2.116 ± 0.046	2.917IleArg: 2.917 ± 0.051	4.411IleSer: 4.411 ± 0.062	3.594IleThr: 3.594 ± 0.051	4.12IleVal: 4.12 ± 0.068	0.644IleTrp: 0.644 ± 0.024	1.728IleTyr: 1.728 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.832LysAla: 4.832 ± 0.073	0.318LysCys: 0.318 ± 0.018	2.715LysAsp: 2.715 ± 0.048	3.127LysGlu: 3.127 ± 0.055	1.562LysPhe: 1.562 ± 0.034	3.215LysGly: 3.215 ± 0.057	1.17LysHis: 1.17 ± 0.033	2.791LysIle: 2.791 ± 0.05	2.768LysLys: 2.768 ± 0.07	4.879LysLeu: 4.879 ± 0.071	1.343LysMet: 1.343 ± 0.038	2.145LysAsn: 2.145 ± 0.041	2.331LysPro: 2.331 ± 0.048	2.622LysGln: 2.622 ± 0.048	2.934LysArg: 2.934 ± 0.055	2.913LysSer: 2.913 ± 0.047	2.702LysThr: 2.702 ± 0.053	3.449LysVal: 3.449 ± 0.058	0.6LysTrp: 0.6 ± 0.023	1.381LysTyr: 1.381 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	10.034LeuAla: 10.034 ± 0.113	1.082LeuCys: 1.082 ± 0.028	5.413LeuAsp: 5.413 ± 0.071	5.686LeuGlu: 5.686 ± 0.071	4.172LeuPhe: 4.172 ± 0.077	6.349LeuGly: 6.349 ± 0.073	2.237LeuHis: 2.237 ± 0.044	5.684LeuIle: 5.684 ± 0.085	4.958LeuLys: 4.958 ± 0.071	10.247LeuLeu: 10.247 ± 0.159	2.424LeuMet: 2.424 ± 0.05	4.341LeuAsn: 4.341 ± 0.062	4.948LeuPro: 4.948 ± 0.068	4.134LeuGln: 4.134 ± 0.068	4.584LeuArg: 4.584 ± 0.065	7.352LeuSer: 7.352 ± 0.081	5.971LeuThr: 5.971 ± 0.073	6.555LeuVal: 6.555 ± 0.084	1.112LeuTrp: 1.112 ± 0.027	2.676LeuTyr: 2.676 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.589MetAla: 2.589 ± 0.055	0.185MetCys: 0.185 ± 0.015	1.17MetAsp: 1.17 ± 0.027	1.366MetGlu: 1.366 ± 0.038	0.893MetPhe: 0.893 ± 0.03	1.693MetGly: 1.693 ± 0.037	0.517MetHis: 0.517 ± 0.02	1.353MetIle: 1.353 ± 0.036	1.379MetLys: 1.379 ± 0.035	2.679MetLeu: 2.679 ± 0.056	0.711MetMet: 0.711 ± 0.026	1.049MetAsn: 1.049 ± 0.032	1.203MetPro: 1.203 ± 0.032	1.243MetGln: 1.243 ± 0.03	1.273MetArg: 1.273 ± 0.033	1.791MetSer: 1.791 ± 0.038	1.59MetThr: 1.59 ± 0.035	1.707MetVal: 1.707 ± 0.038	0.241MetTrp: 0.241 ± 0.014	0.533MetTyr: 0.533 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.804AsnAla: 3.804 ± 0.061	0.418AsnCys: 0.418 ± 0.016	2.38AsnAsp: 2.38 ± 0.048	2.432AsnGlu: 2.432 ± 0.05	1.609AsnPhe: 1.609 ± 0.038	3.099AsnGly: 3.099 ± 0.062	0.929AsnHis: 0.929 ± 0.029	2.794AsnIle: 2.794 ± 0.047	1.998AsnLys: 1.998 ± 0.048	3.911AsnLeu: 3.911 ± 0.059	0.977AsnMet: 0.977 ± 0.032	1.899AsnAsn: 1.899 ± 0.048	2.089AsnPro: 2.089 ± 0.038	1.913AsnGln: 1.913 ± 0.04	2.195AsnArg: 2.195 ± 0.045	2.569AsnSer: 2.569 ± 0.051	2.284AsnThr: 2.284 ± 0.044	2.998AsnVal: 2.998 ± 0.055	0.689AsnTrp: 0.689 ± 0.024	1.439AsnTyr: 1.439 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.76ProAla: 3.76 ± 0.064	0.279ProCys: 0.279 ± 0.016	2.722ProAsp: 2.722 ± 0.051	3.275ProGlu: 3.275 ± 0.046	1.842ProPhe: 1.842 ± 0.04	2.809ProGly: 2.809 ± 0.059	0.894ProHis: 0.894 ± 0.027	2.207ProIle: 2.207 ± 0.049	1.763ProLys: 1.763 ± 0.043	4.078ProLeu: 4.078 ± 0.066	0.976ProMet: 0.976 ± 0.028	1.584ProAsn: 1.584 ± 0.035	1.458ProPro: 1.458 ± 0.034	1.778ProGln: 1.778 ± 0.041	1.583ProArg: 1.583 ± 0.043	2.453ProSer: 2.453 ± 0.045	2.126ProThr: 2.126 ± 0.043	3.493ProVal: 3.493 ± 0.054	0.56ProTrp: 0.56 ± 0.02	1.285ProTyr: 1.285 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.347GlnAla: 4.347 ± 0.072	0.369GlnCys: 0.369 ± 0.018	1.922GlnAsp: 1.922 ± 0.042	2.526GlnGlu: 2.526 ± 0.045	1.769GlnPhe: 1.769 ± 0.039	2.71GlnGly: 2.71 ± 0.052	1.231GlnHis: 1.231 ± 0.03	2.507GlnIle: 2.507 ± 0.049	2.14GlnLys: 2.14 ± 0.048	4.778GlnLeu: 4.778 ± 0.068	1.037GlnMet: 1.037 ± 0.028	1.744GlnAsn: 1.744 ± 0.034	1.858GlnPro: 1.858 ± 0.035	3.178GlnGln: 3.178 ± 0.072	2.571GlnArg: 2.571 ± 0.051	2.71GlnSer: 2.71 ± 0.048	2.314GlnThr: 2.314 ± 0.046	2.961GlnVal: 2.961 ± 0.054	0.724GlnTrp: 0.724 ± 0.026	1.402GlnTyr: 1.402 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.749ArgAla: 3.749 ± 0.055	0.481ArgCys: 0.481 ± 0.022	2.567ArgAsp: 2.567 ± 0.045	3.232ArgGlu: 3.232 ± 0.058	2.345ArgPhe: 2.345 ± 0.046	2.733ArgGly: 2.733 ± 0.049	1.295ArgHis: 1.295 ± 0.038	3.082ArgIle: 3.082 ± 0.05	2.489ArgLys: 2.489 ± 0.05	5.234ArgLeu: 5.234 ± 0.08	1.31ArgMet: 1.31 ± 0.031	2.009ArgAsn: 2.009 ± 0.045	1.804ArgPro: 1.804 ± 0.044	2.584ArgGln: 2.584 ± 0.05	2.653ArgArg: 2.653 ± 0.055	2.829ArgSer: 2.829 ± 0.049	2.269ArgThr: 2.269 ± 0.042	3.303ArgVal: 3.303 ± 0.054	0.742ArgTrp: 0.742 ± 0.031	1.973ArgTyr: 1.973 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.013SerAla: 6.013 ± 0.069	0.604SerCys: 0.604 ± 0.023	3.686SerAsp: 3.686 ± 0.066	3.925SerGlu: 3.925 ± 0.06	2.825SerPhe: 2.825 ± 0.053	5.045SerGly: 5.045 ± 0.076	1.557SerHis: 1.557 ± 0.036	3.573SerIle: 3.573 ± 0.067	2.778SerLys: 2.778 ± 0.049	6.794SerLeu: 6.794 ± 0.079	1.552SerMet: 1.552 ± 0.034	2.422SerAsn: 2.422 ± 0.045	2.673SerPro: 2.673 ± 0.053	2.987SerGln: 2.987 ± 0.054	3.346SerArg: 3.346 ± 0.056	4.504SerSer: 4.504 ± 0.073	3.351SerThr: 3.351 ± 0.059	4.708SerVal: 4.708 ± 0.064	0.892SerTrp: 0.892 ± 0.028	2.069SerTyr: 2.069 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.078ThrAla: 5.078 ± 0.068	0.452ThrCys: 0.452 ± 0.019	3.248ThrAsp: 3.248 ± 0.054	3.071ThrGlu: 3.071 ± 0.057	2.324ThrPhe: 2.324 ± 0.047	4.24ThrGly: 4.24 ± 0.067	1.231ThrHis: 1.231 ± 0.038	3.304ThrIle: 3.304 ± 0.056	1.988ThrLys: 1.988 ± 0.043	6.482ThrLeu: 6.482 ± 0.074	1.17ThrMet: 1.17 ± 0.03	1.877ThrAsn: 1.877 ± 0.042	2.763ThrPro: 2.763 ± 0.056	2.342ThrGln: 2.342 ± 0.044	2.506ThrArg: 2.506 ± 0.044	3.488ThrSer: 3.488 ± 0.059	3.018ThrThr: 3.018 ± 0.058	4.067ThrVal: 4.067 ± 0.065	0.6ThrTrp: 0.6 ± 0.022	1.6ThrTyr: 1.6 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.618ValAla: 6.618 ± 0.072	0.715ValCys: 0.715 ± 0.023	4.187ValAsp: 4.187 ± 0.061	4.472ValGlu: 4.472 ± 0.062	2.815ValPhe: 2.815 ± 0.05	4.577ValGly: 4.577 ± 0.066	1.285ValHis: 1.285 ± 0.031	4.516ValIle: 4.516 ± 0.067	3.722ValLys: 3.722 ± 0.065	6.545ValLeu: 6.545 ± 0.082	1.854ValMet: 1.854 ± 0.043	3.236ValAsn: 3.236 ± 0.052	2.819ValPro: 2.819 ± 0.053	2.367ValGln: 2.367 ± 0.052	3.019ValArg: 3.019 ± 0.055	4.944ValSer: 4.944 ± 0.061	4.375ValThr: 4.375 ± 0.064	5.301ValVal: 5.301 ± 0.081	0.815ValTrp: 0.815 ± 0.026	1.926ValTyr: 1.926 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.885TrpAla: 0.885 ± 0.026	0.15TrpCys: 0.15 ± 0.01	0.656TrpAsp: 0.656 ± 0.02	0.684TrpGlu: 0.684 ± 0.023	0.607TrpPhe: 0.607 ± 0.021	0.803TrpGly: 0.803 ± 0.031	0.394TrpHis: 0.394 ± 0.017	0.719TrpIle: 0.719 ± 0.025	0.52TrpLys: 0.52 ± 0.02	1.762TrpLeu: 1.762 ± 0.042	0.352TrpMet: 0.352 ± 0.018	0.486TrpAsn: 0.486 ± 0.019	0.516TrpPro: 0.516 ± 0.021	1.044TrpGln: 1.044 ± 0.033	0.787TrpArg: 0.787 ± 0.025	0.719TrpSer: 0.719 ± 0.026	0.55TrpThr: 0.55 ± 0.021	0.851TrpVal: 0.851 ± 0.029	0.22TrpTrp: 0.22 ± 0.016	0.442TrpTyr: 0.442 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.507TyrAla: 2.507 ± 0.051	0.372TyrCys: 0.372 ± 0.017	1.768TyrAsp: 1.768 ± 0.045	1.795TyrGlu: 1.795 ± 0.039	1.525TyrPhe: 1.525 ± 0.035	2.184TyrGly: 2.184 ± 0.04	0.791TyrHis: 0.791 ± 0.028	1.615TyrIle: 1.615 ± 0.035	1.249TyrLys: 1.249 ± 0.033	3.352TyrLeu: 3.352 ± 0.053	0.609TyrMet: 0.609 ± 0.023	1.251TyrAsn: 1.251 ± 0.036	1.375TyrPro: 1.375 ± 0.037	1.749TyrGln: 1.749 ± 0.042	1.95TyrArg: 1.95 ± 0.043	2.109TyrSer: 2.109 ± 0.043	1.587TyrThr: 1.587 ± 0.041	1.925TyrVal: 1.925 ± 0.041	0.477TyrTrp: 0.477 ± 0.02	1.131TyrTyr: 1.131 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3617 proteins (1214117 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---