Amino acid dipepetide frequency for Micavibrio aeruginosavorus (strain ARL-13)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.696AlaAla: 12.696 ± 0.191
1.069AlaCys: 1.069 ± 0.043
6.69AlaAsp: 6.69 ± 0.104
6.148AlaGlu: 6.148 ± 0.123
3.665AlaPhe: 3.665 ± 0.071
8.708AlaGly: 8.708 ± 0.137
2.338AlaHis: 2.338 ± 0.067
5.859AlaIle: 5.859 ± 0.099
4.595AlaLys: 4.595 ± 0.102
10.909AlaLeu: 10.909 ± 0.155
3.816AlaMet: 3.816 ± 0.082
3.381AlaAsn: 3.381 ± 0.088
5.117AlaPro: 5.117 ± 0.116
4.258AlaGln: 4.258 ± 0.086
6.366AlaArg: 6.366 ± 0.093
5.143AlaSer: 5.143 ± 0.1
5.588AlaThr: 5.588 ± 0.105
7.369AlaVal: 7.369 ± 0.123
1.127AlaTrp: 1.127 ± 0.04
2.619AlaTyr: 2.619 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
1.081CysAla: 1.081 ± 0.043
0.133CysCys: 0.133 ± 0.015
0.586CysAsp: 0.586 ± 0.031
0.434CysGlu: 0.434 ± 0.025
0.364CysPhe: 0.364 ± 0.022
0.965CysGly: 0.965 ± 0.042
0.204CysHis: 0.204 ± 0.017
0.458CysIle: 0.458 ± 0.025
0.333CysLys: 0.333 ± 0.023
0.711CysLeu: 0.711 ± 0.032
0.207CysMet: 0.207 ± 0.017
0.337CysAsn: 0.337 ± 0.023
0.522CysPro: 0.522 ± 0.03
0.242CysGln: 0.242 ± 0.018
0.499CysArg: 0.499 ± 0.027
0.471CysSer: 0.471 ± 0.029
0.534CysThr: 0.534 ± 0.029
0.749CysVal: 0.749 ± 0.031
0.11CysTrp: 0.11 ± 0.017
0.229CysTyr: 0.229 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
6.803AspAla: 6.803 ± 0.106
0.518AspCys: 0.518 ± 0.029
4.457AspAsp: 4.457 ± 0.111
3.683AspGlu: 3.683 ± 0.078
2.637AspPhe: 2.637 ± 0.067
5.432AspGly: 5.432 ± 0.128
1.724AspHis: 1.724 ± 0.059
4.242AspIle: 4.242 ± 0.091
2.708AspLys: 2.708 ± 0.075
6.147AspLeu: 6.147 ± 0.091
2.131AspMet: 2.131 ± 0.054
2.128AspAsn: 2.128 ± 0.067
3.229AspPro: 3.229 ± 0.07
2.404AspGln: 2.404 ± 0.062
4.074AspArg: 4.074 ± 0.084
2.764AspSer: 2.764 ± 0.063
3.385AspThr: 3.385 ± 0.096
5.034AspVal: 5.034 ± 0.08
0.807AspTrp: 0.807 ± 0.039
1.816AspTyr: 1.816 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
5.401GluAla: 5.401 ± 0.098
0.38GluCys: 0.38 ± 0.024
3.061GluAsp: 3.061 ± 0.07
3.021GluGlu: 3.021 ± 0.09
1.803GluPhe: 1.803 ± 0.053
3.672GluGly: 3.672 ± 0.078
1.089GluHis: 1.089 ± 0.04
3.508GluIle: 3.508 ± 0.075
3.587GluLys: 3.587 ± 0.094
4.162GluLeu: 4.162 ± 0.073
1.843GluMet: 1.843 ± 0.043
2.267GluAsn: 2.267 ± 0.062
1.971GluPro: 1.971 ± 0.054
2.412GluGln: 2.412 ± 0.058
3.449GluArg: 3.449 ± 0.08
3.002GluSer: 3.002 ± 0.068
3.402GluThr: 3.402 ± 0.074
2.872GluVal: 2.872 ± 0.073
0.663GluTrp: 0.663 ± 0.032
1.283GluTyr: 1.283 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.65PheAla: 3.65 ± 0.079
0.472PheCys: 0.472 ± 0.024
2.685PheAsp: 2.685 ± 0.068
2.001PheGlu: 2.001 ± 0.056
1.601PhePhe: 1.601 ± 0.055
3.255PheGly: 3.255 ± 0.064
0.752PheHis: 0.752 ± 0.035
2.179PheIle: 2.179 ± 0.065
1.5PheLys: 1.5 ± 0.045
3.141PheLeu: 3.141 ± 0.075
1.228PheMet: 1.228 ± 0.038
1.64PheAsn: 1.64 ± 0.05
1.436PhePro: 1.436 ± 0.044
1.024PheGln: 1.024 ± 0.036
1.901PheArg: 1.901 ± 0.053
2.39PheSer: 2.39 ± 0.062
2.147PheThr: 2.147 ± 0.056
2.686PheVal: 2.686 ± 0.062
0.493PheTrp: 0.493 ± 0.028
1.094PheTyr: 1.094 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
8.005GlyAla: 8.005 ± 0.144
0.817GlyCys: 0.817 ± 0.036
4.898GlyAsp: 4.898 ± 0.117
3.869GlyGlu: 3.869 ± 0.077
3.318GlyPhe: 3.318 ± 0.082
7.231GlyGly: 7.231 ± 0.223
1.939GlyHis: 1.939 ± 0.052
4.375GlyIle: 4.375 ± 0.102
3.727GlyLys: 3.727 ± 0.087
7.677GlyLeu: 7.677 ± 0.12
2.545GlyMet: 2.545 ± 0.078
2.755GlyAsn: 2.755 ± 0.115
3.056GlyPro: 3.056 ± 0.071
2.948GlyGln: 2.948 ± 0.065
4.499GlyArg: 4.499 ± 0.083
4.203GlySer: 4.203 ± 0.103
5.038GlyThr: 5.038 ± 0.128
5.994GlyVal: 5.994 ± 0.11
1.121GlyTrp: 1.121 ± 0.049
2.365GlyTyr: 2.365 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
2.362HisAla: 2.362 ± 0.073
0.216HisCys: 0.216 ± 0.015
1.537HisAsp: 1.537 ± 0.048
1.141HisGlu: 1.141 ± 0.041
0.91HisPhe: 0.91 ± 0.04
1.896HisGly: 1.896 ± 0.051
0.691HisHis: 0.691 ± 0.033
1.315HisIle: 1.315 ± 0.043
0.858HisLys: 0.858 ± 0.041
1.944HisLeu: 1.944 ± 0.051
0.657HisMet: 0.657 ± 0.03
0.815HisAsn: 0.815 ± 0.034
1.323HisPro: 1.323 ± 0.042
0.608HisGln: 0.608 ± 0.028
1.237HisArg: 1.237 ± 0.043
1.01HisSer: 1.01 ± 0.039
1.004HisThr: 1.004 ± 0.036
1.534HisVal: 1.534 ± 0.052
0.254HisTrp: 0.254 ± 0.018
0.707HisTyr: 0.707 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.303IleAla: 6.303 ± 0.098
0.578IleCys: 0.578 ± 0.029
4.119IleAsp: 4.119 ± 0.086
3.704IleGlu: 3.704 ± 0.076
2.015IlePhe: 2.015 ± 0.063
4.612IleGly: 4.612 ± 0.093
1.336IleHis: 1.336 ± 0.046
3.232IleIle: 3.232 ± 0.072
2.392IleLys: 2.392 ± 0.067
5.262IleLeu: 5.262 ± 0.098
1.603IleMet: 1.603 ± 0.05
2.244IleAsn: 2.244 ± 0.062
2.87IlePro: 2.87 ± 0.068
1.855IleGln: 1.855 ± 0.056
3.598IleArg: 3.598 ± 0.076
3.08IleSer: 3.08 ± 0.063
3.537IleThr: 3.537 ± 0.075
4.236IleVal: 4.236 ± 0.089
0.561IleTrp: 0.561 ± 0.027
1.482IleTyr: 1.482 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.929LysAla: 4.929 ± 0.102
0.262LysCys: 0.262 ± 0.022
3.091LysAsp: 3.091 ± 0.074
2.236LysGlu: 2.236 ± 0.064
1.429LysPhe: 1.429 ± 0.053
3.088LysGly: 3.088 ± 0.069
0.883LysHis: 0.883 ± 0.037
3.272LysIle: 3.272 ± 0.074
3.018LysLys: 3.018 ± 0.101
3.614LysLeu: 3.614 ± 0.078
1.525LysMet: 1.525 ± 0.05
2.163LysAsn: 2.163 ± 0.064
2.571LysPro: 2.571 ± 0.067
1.553LysGln: 1.553 ± 0.046
2.568LysArg: 2.568 ± 0.066
2.689LysSer: 2.689 ± 0.061
3.298LysThr: 3.298 ± 0.067
2.542LysVal: 2.542 ± 0.074
0.413LysTrp: 0.413 ± 0.026
0.984LysTyr: 0.984 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
9.448LeuAla: 9.448 ± 0.141
0.999LeuCys: 0.999 ± 0.036
5.995LeuAsp: 5.995 ± 0.113
4.298LeuGlu: 4.298 ± 0.085
3.47LeuPhe: 3.47 ± 0.079
6.587LeuGly: 6.587 ± 0.104
2.003LeuHis: 2.003 ± 0.057
4.914LeuIle: 4.914 ± 0.095
4.602LeuLys: 4.602 ± 0.084
7.28LeuLeu: 7.28 ± 0.132
2.611LeuMet: 2.611 ± 0.068
3.773LeuAsn: 3.773 ± 0.076
4.538LeuPro: 4.538 ± 0.102
3.02LeuGln: 3.02 ± 0.056
5.465LeuArg: 5.465 ± 0.092
6.302LeuSer: 6.302 ± 0.094
5.027LeuThr: 5.027 ± 0.086
5.881LeuVal: 5.881 ± 0.115
0.922LeuTrp: 0.922 ± 0.037
2.419LeuTyr: 2.419 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
3.756MetAla: 3.756 ± 0.076
0.21MetCys: 0.21 ± 0.015
2.147MetAsp: 2.147 ± 0.058
1.542MetGlu: 1.542 ± 0.049
0.913MetPhe: 0.913 ± 0.037
2.389MetGly: 2.389 ± 0.062
0.519MetHis: 0.519 ± 0.028
1.94MetIle: 1.94 ± 0.049
1.646MetLys: 1.646 ± 0.048
2.529MetLeu: 2.529 ± 0.063
1.21MetMet: 1.21 ± 0.041
1.371MetAsn: 1.371 ± 0.042
1.674MetPro: 1.674 ± 0.054
1.245MetGln: 1.245 ± 0.045
1.906MetArg: 1.906 ± 0.057
1.733MetSer: 1.733 ± 0.046
2.42MetThr: 2.42 ± 0.065
2.257MetVal: 2.257 ± 0.057
0.251MetTrp: 0.251 ± 0.02
0.477MetTyr: 0.477 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
4.126AsnAla: 4.126 ± 0.096
0.316AsnCys: 0.316 ± 0.024
2.685AsnAsp: 2.685 ± 0.077
1.724AsnGlu: 1.724 ± 0.05
1.334AsnPhe: 1.334 ± 0.047
3.489AsnGly: 3.489 ± 0.112
0.753AsnHis: 0.753 ± 0.034
2.329AsnIle: 2.329 ± 0.062
1.519AsnLys: 1.519 ± 0.048
3.184AsnLeu: 3.184 ± 0.073
1.135AsnMet: 1.135 ± 0.038
1.603AsnAsn: 1.603 ± 0.061
2.436AsnPro: 2.436 ± 0.069
1.104AsnGln: 1.104 ± 0.043
2.119AsnArg: 2.119 ± 0.059
1.568AsnSer: 1.568 ± 0.063
2.202AsnThr: 2.202 ± 0.066
2.635AsnVal: 2.635 ± 0.076
0.425AsnTrp: 0.425 ± 0.025
0.932AsnTyr: 0.932 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
5.567ProAla: 5.567 ± 0.121
0.402ProCys: 0.402 ± 0.023
3.933ProAsp: 3.933 ± 0.083
3.009ProGlu: 3.009 ± 0.067
1.866ProPhe: 1.866 ± 0.054
3.783ProGly: 3.783 ± 0.069
1.205ProHis: 1.205 ± 0.042
2.146ProIle: 2.146 ± 0.059
2.03ProLys: 2.03 ± 0.069
3.92ProLeu: 3.92 ± 0.08
1.448ProMet: 1.448 ± 0.048
1.596ProAsn: 1.596 ± 0.05
2.178ProPro: 2.178 ± 0.071
1.694ProGln: 1.694 ± 0.051
2.226ProArg: 2.226 ± 0.067
2.733ProSer: 2.733 ± 0.065
2.545ProThr: 2.545 ± 0.067
4.176ProVal: 4.176 ± 0.1
0.493ProTrp: 0.493 ± 0.028
1.287ProTyr: 1.287 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.982GlnAla: 3.982 ± 0.087
0.292GlnCys: 0.292 ± 0.02
2.111GlnAsp: 2.111 ± 0.057
1.588GlnGlu: 1.588 ± 0.044
1.16GlnPhe: 1.16 ± 0.042
2.438GlnGly: 2.438 ± 0.061
0.653GlnHis: 0.653 ± 0.033
2.267GlnIle: 2.267 ± 0.056
2.052GlnLys: 2.052 ± 0.058
2.53GlnLeu: 2.53 ± 0.068
1.32GlnMet: 1.32 ± 0.04
1.615GlnAsn: 1.615 ± 0.057
1.526GlnPro: 1.526 ± 0.04
1.402GlnGln: 1.402 ± 0.056
2.103GlnArg: 2.103 ± 0.056
2.224GlnSer: 2.224 ± 0.054
2.319GlnThr: 2.319 ± 0.058
2.158GlnVal: 2.158 ± 0.057
0.401GlnTrp: 0.401 ± 0.022
0.917GlnTyr: 0.917 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
6.256ArgAla: 6.256 ± 0.095
0.395ArgCys: 0.395 ± 0.025
4.368ArgAsp: 4.368 ± 0.089
3.281ArgGlu: 3.281 ± 0.073
2.269ArgPhe: 2.269 ± 0.054
4.037ArgGly: 4.037 ± 0.077
1.349ArgHis: 1.349 ± 0.042
3.439ArgIle: 3.439 ± 0.065
2.642ArgLys: 2.642 ± 0.067
5.668ArgLeu: 5.668 ± 0.1
2.017ArgMet: 2.017 ± 0.052
2.128ArgAsn: 2.128 ± 0.064
2.653ArgPro: 2.653 ± 0.078
2.052ArgGln: 2.052 ± 0.063
3.617ArgArg: 3.617 ± 0.086
2.628ArgSer: 2.628 ± 0.063
3.098ArgThr: 3.098 ± 0.063
4.16ArgVal: 4.16 ± 0.084
0.598ArgTrp: 0.598 ± 0.027
1.596ArgTyr: 1.596 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.94SerAla: 5.94 ± 0.101
0.514SerCys: 0.514 ± 0.03
3.357SerAsp: 3.357 ± 0.076
2.581SerGlu: 2.581 ± 0.066
2.269SerPhe: 2.269 ± 0.061
5.455SerGly: 5.455 ± 0.117
1.102SerHis: 1.102 ± 0.036
3.155SerIle: 3.155 ± 0.061
2.021SerLys: 2.021 ± 0.059
4.778SerLeu: 4.778 ± 0.096
1.664SerMet: 1.664 ± 0.046
1.843SerAsn: 1.843 ± 0.064
2.478SerPro: 2.478 ± 0.062
1.57SerGln: 1.57 ± 0.054
2.874SerArg: 2.874 ± 0.067
3.048SerSer: 3.048 ± 0.089
3.012SerThr: 3.012 ± 0.073
3.973SerVal: 3.973 ± 0.067
0.61SerTrp: 0.61 ± 0.028
1.457SerTyr: 1.457 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
6.127ThrAla: 6.127 ± 0.104
0.468ThrCys: 0.468 ± 0.03
3.407ThrAsp: 3.407 ± 0.073
2.758ThrGlu: 2.758 ± 0.068
2.069ThrPhe: 2.069 ± 0.061
5.351ThrGly: 5.351 ± 0.105
1.229ThrHis: 1.229 ± 0.039
3.711ThrIle: 3.711 ± 0.08
2.139ThrLys: 2.139 ± 0.062
6.084ThrLeu: 6.084 ± 0.098
1.705ThrMet: 1.705 ± 0.051
1.988ThrAsn: 1.988 ± 0.064
3.795ThrPro: 3.795 ± 0.073
1.968ThrGln: 1.968 ± 0.052
3.051ThrArg: 3.051 ± 0.069
2.814ThrSer: 2.814 ± 0.068
3.423ThrThr: 3.423 ± 0.079
4.137ThrVal: 4.137 ± 0.101
0.633ThrTrp: 0.633 ± 0.036
1.542ThrTyr: 1.542 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
7.31ValAla: 7.31 ± 0.116
0.667ValCys: 0.667 ± 0.03
4.421ValAsp: 4.421 ± 0.081
4.007ValGlu: 4.007 ± 0.086
2.728ValPhe: 2.728 ± 0.075
4.899ValGly: 4.899 ± 0.109
1.381ValHis: 1.381 ± 0.04
4.278ValIle: 4.278 ± 0.08
3.115ValLys: 3.115 ± 0.089
6.675ValLeu: 6.675 ± 0.112
2.333ValMet: 2.333 ± 0.049
2.378ValAsn: 2.378 ± 0.059
3.268ValPro: 3.268 ± 0.076
2.382ValGln: 2.382 ± 0.057
4.259ValArg: 4.259 ± 0.082
3.973ValSer: 3.973 ± 0.077
4.292ValThr: 4.292 ± 0.088
5.05ValVal: 5.05 ± 0.105
0.752ValTrp: 0.752 ± 0.035
1.689ValTyr: 1.689 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.102TrpAla: 1.102 ± 0.044
0.11TrpCys: 0.11 ± 0.012
0.691TrpAsp: 0.691 ± 0.028
0.438TrpGlu: 0.438 ± 0.026
0.456TrpPhe: 0.456 ± 0.029
0.799TrpGly: 0.799 ± 0.038
0.281TrpHis: 0.281 ± 0.021
0.636TrpIle: 0.636 ± 0.033
0.487TrpLys: 0.487 ± 0.025
1.116TrpLeu: 1.116 ± 0.042
0.436TrpMet: 0.436 ± 0.025
0.484TrpAsn: 0.484 ± 0.028
0.515TrpPro: 0.515 ± 0.028
0.411TrpGln: 0.411 ± 0.026
0.781TrpArg: 0.781 ± 0.031
0.606TrpSer: 0.606 ± 0.03
0.609TrpThr: 0.609 ± 0.035
0.743TrpVal: 0.743 ± 0.035
0.177TrpTrp: 0.177 ± 0.016
0.281TrpTyr: 0.281 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.616TyrAla: 2.616 ± 0.065
0.352TyrCys: 0.352 ± 0.027
1.882TyrAsp: 1.882 ± 0.054
1.385TyrGlu: 1.385 ± 0.04
0.999TyrPhe: 0.999 ± 0.038
2.295TyrGly: 2.295 ± 0.08
0.589TyrHis: 0.589 ± 0.029
1.365TyrIle: 1.365 ± 0.043
1.158TyrLys: 1.158 ± 0.042
2.22TyrLeu: 2.22 ± 0.062
0.703TyrMet: 0.703 ± 0.032
1.107TyrAsn: 1.107 ± 0.039
1.082TyrPro: 1.082 ± 0.041
0.903TyrGln: 0.903 ± 0.039
1.659TyrArg: 1.659 ± 0.044
1.323TyrSer: 1.323 ± 0.048
1.519TyrThr: 1.519 ± 0.052
1.67TyrVal: 1.67 ± 0.053
0.348TyrTrp: 0.348 ± 0.024
0.828TyrTyr: 0.828 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2432 proteins (743786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski