Amino acid dipepetide frequency for Streptomyces phaeoluteigriseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.118AlaAla: 20.118 ± 0.146	1.09AlaCys: 1.09 ± 0.026	8.263AlaAsp: 8.263 ± 0.07	8.706AlaGlu: 8.706 ± 0.105	3.564AlaPhe: 3.564 ± 0.042	12.594AlaGly: 12.594 ± 0.102	2.882AlaHis: 2.882 ± 0.04	3.345AlaIle: 3.345 ± 0.044	2.869AlaLys: 2.869 ± 0.053	14.166AlaLeu: 14.166 ± 0.1	2.415AlaMet: 2.415 ± 0.04	1.908AlaAsn: 1.908 ± 0.038	6.704AlaPro: 6.704 ± 0.075	3.737AlaGln: 3.737 ± 0.05	10.26AlaArg: 10.26 ± 0.095	5.959AlaSer: 5.959 ± 0.068	6.949AlaThr: 6.949 ± 0.069	12.27AlaVal: 12.27 ± 0.108	1.866AlaTrp: 1.866 ± 0.036	2.783AlaTyr: 2.783 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.027	0.099CysCys: 0.099 ± 0.008	0.484CysAsp: 0.484 ± 0.017	0.413CysGlu: 0.413 ± 0.016	0.228CysPhe: 0.228 ± 0.012	0.945CysGly: 0.945 ± 0.024	0.196CysHis: 0.196 ± 0.011	0.164CysIle: 0.164 ± 0.011	0.098CysLys: 0.098 ± 0.007	0.751CysLeu: 0.751 ± 0.019	0.118CysMet: 0.118 ± 0.009	0.144CysAsn: 0.144 ± 0.008	0.513CysPro: 0.513 ± 0.019	0.171CysGln: 0.171 ± 0.009	0.61CysArg: 0.61 ± 0.021	0.472CysSer: 0.472 ± 0.017	0.522CysThr: 0.522 ± 0.018	0.691CysVal: 0.691 ± 0.02	0.122CysTrp: 0.122 ± 0.008	0.149CysTyr: 0.149 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.597AspAla: 7.597 ± 0.066	0.43AspCys: 0.43 ± 0.014	3.713AspAsp: 3.713 ± 0.054	3.992AspGlu: 3.992 ± 0.048	1.686AspPhe: 1.686 ± 0.031	6.478AspGly: 6.478 ± 0.07	1.511AspHis: 1.511 ± 0.03	1.903AspIle: 1.903 ± 0.031	1.247AspLys: 1.247 ± 0.029	6.362AspLeu: 6.362 ± 0.056	0.875AspMet: 0.875 ± 0.02	1.02AspAsn: 1.02 ± 0.026	4.499AspPro: 4.499 ± 0.056	1.53AspGln: 1.53 ± 0.035	5.067AspArg: 5.067 ± 0.059	2.644AspSer: 2.644 ± 0.037	3.368AspThr: 3.368 ± 0.044	4.842AspVal: 4.842 ± 0.051	1.069AspTrp: 1.069 ± 0.024	1.131AspTyr: 1.131 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.409GluAla: 7.409 ± 0.094	0.35GluCys: 0.35 ± 0.012	2.969GluAsp: 2.969 ± 0.042	3.717GluGlu: 3.717 ± 0.066	1.532GluPhe: 1.532 ± 0.033	4.394GluGly: 4.394 ± 0.05	1.551GluHis: 1.551 ± 0.035	2.326GluIle: 2.326 ± 0.037	1.533GluLys: 1.533 ± 0.03	6.596GluLeu: 6.596 ± 0.07	0.909GluMet: 0.909 ± 0.024	1.079GluAsn: 1.079 ± 0.026	3.41GluPro: 3.41 ± 0.047	2.24GluGln: 2.24 ± 0.031	5.538GluArg: 5.538 ± 0.066	2.607GluSer: 2.607 ± 0.038	3.014GluThr: 3.014 ± 0.044	4.655GluVal: 4.655 ± 0.053	0.775GluTrp: 0.775 ± 0.019	1.184GluTyr: 1.184 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.632PheAla: 3.632 ± 0.046	0.268PheCys: 0.268 ± 0.012	2.001PheAsp: 2.001 ± 0.036	1.444PheGlu: 1.444 ± 0.028	0.893PhePhe: 0.893 ± 0.023	3.037PheGly: 3.037 ± 0.048	0.637PheHis: 0.637 ± 0.02	0.718PheIle: 0.718 ± 0.022	0.525PheLys: 0.525 ± 0.017	2.692PheLeu: 2.692 ± 0.042	0.405PheMet: 0.405 ± 0.015	0.579PheAsn: 0.579 ± 0.018	1.437PhePro: 1.437 ± 0.028	0.679PheGln: 0.679 ± 0.02	1.907PheArg: 1.907 ± 0.034	1.456PheSer: 1.456 ± 0.035	2.075PheThr: 2.075 ± 0.034	2.29PheVal: 2.29 ± 0.038	0.423PheTrp: 0.423 ± 0.017	0.595PheTyr: 0.595 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.616GlyAla: 10.616 ± 0.089	0.814GlyCys: 0.814 ± 0.018	5.291GlyAsp: 5.291 ± 0.061	5.232GlyGlu: 5.232 ± 0.062	2.929GlyPhe: 2.929 ± 0.043	8.703GlyGly: 8.703 ± 0.106	2.309GlyHis: 2.309 ± 0.036	3.374GlyIle: 3.374 ± 0.044	2.379GlyLys: 2.379 ± 0.041	9.292GlyLeu: 9.292 ± 0.08	1.963GlyMet: 1.963 ± 0.036	1.735GlyAsn: 1.735 ± 0.039	4.998GlyPro: 4.998 ± 0.056	2.634GlyGln: 2.634 ± 0.042	7.976GlyArg: 7.976 ± 0.073	5.362GlySer: 5.362 ± 0.059	6.502GlyThr: 6.502 ± 0.073	7.618GlyVal: 7.618 ± 0.069	1.717GlyTrp: 1.717 ± 0.035	2.242GlyTyr: 2.242 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.678HisAla: 2.678 ± 0.041	0.218HisCys: 0.218 ± 0.012	1.363HisAsp: 1.363 ± 0.025	1.291HisGlu: 1.291 ± 0.025	0.672HisPhe: 0.672 ± 0.02	2.469HisGly: 2.469 ± 0.038	0.702HisHis: 0.702 ± 0.021	0.688HisIle: 0.688 ± 0.019	0.362HisLys: 0.362 ± 0.014	2.452HisLeu: 2.452 ± 0.036	0.341HisMet: 0.341 ± 0.014	0.361HisAsn: 0.361 ± 0.014	1.793HisPro: 1.793 ± 0.031	0.667HisGln: 0.667 ± 0.019	2.178HisArg: 2.178 ± 0.036	1.036HisSer: 1.036 ± 0.026	1.412HisThr: 1.412 ± 0.029	1.761HisVal: 1.761 ± 0.024	0.366HisTrp: 0.366 ± 0.015	0.499HisTyr: 0.499 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.605IleAla: 4.605 ± 0.056	0.281IleCys: 0.281 ± 0.013	2.312IleAsp: 2.312 ± 0.04	1.897IleGlu: 1.897 ± 0.038	0.678IlePhe: 0.678 ± 0.019	3.472IleGly: 3.472 ± 0.048	0.618IleHis: 0.618 ± 0.018	0.851IleIle: 0.851 ± 0.027	0.737IleLys: 0.737 ± 0.021	2.408IleLeu: 2.408 ± 0.04	0.479IleMet: 0.479 ± 0.019	0.691IleAsn: 0.691 ± 0.02	1.737IlePro: 1.737 ± 0.034	0.748IleGln: 0.748 ± 0.02	2.207IleArg: 2.207 ± 0.035	1.625IleSer: 1.625 ± 0.033	2.227IleThr: 2.227 ± 0.039	2.744IleVal: 2.744 ± 0.038	0.367IleTrp: 0.367 ± 0.013	0.524IleTyr: 0.524 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.022LysAla: 3.022 ± 0.05	0.119LysCys: 0.119 ± 0.01	1.419LysAsp: 1.419 ± 0.032	1.238LysGlu: 1.238 ± 0.03	0.421LysPhe: 0.421 ± 0.017	1.863LysGly: 1.863 ± 0.041	0.427LysHis: 0.427 ± 0.015	0.879LysIle: 0.879 ± 0.025	0.862LysLys: 0.862 ± 0.029	2.068LysLeu: 2.068 ± 0.038	0.385LysMet: 0.385 ± 0.012	0.522LysAsn: 0.522 ± 0.017	1.308LysPro: 1.308 ± 0.031	0.709LysGln: 0.709 ± 0.023	1.449LysArg: 1.449 ± 0.031	1.139LysSer: 1.139 ± 0.026	1.303LysThr: 1.303 ± 0.032	1.978LysVal: 1.978 ± 0.037	0.277LysTrp: 0.277 ± 0.012	0.492LysTyr: 0.492 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.554LeuAla: 14.554 ± 0.107	0.868LeuCys: 0.868 ± 0.019	6.767LeuAsp: 6.767 ± 0.079	4.846LeuGlu: 4.846 ± 0.059	2.626LeuPhe: 2.626 ± 0.041	9.018LeuGly: 9.018 ± 0.073	2.292LeuHis: 2.292 ± 0.039	3.179LeuIle: 3.179 ± 0.047	2.076LeuLys: 2.076 ± 0.038	11.127LeuLeu: 11.127 ± 0.112	1.642LeuMet: 1.642 ± 0.029	1.691LeuAsn: 1.691 ± 0.029	6.45LeuPro: 6.45 ± 0.07	2.129LeuGln: 2.129 ± 0.037	8.639LeuArg: 8.639 ± 0.082	5.289LeuSer: 5.289 ± 0.056	7.033LeuThr: 7.033 ± 0.068	8.862LeuVal: 8.862 ± 0.08	1.312LeuTrp: 1.312 ± 0.027	1.943LeuTyr: 1.943 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.239MetAla: 2.239 ± 0.039	0.124MetCys: 0.124 ± 0.008	0.917MetAsp: 0.917 ± 0.023	0.772MetGlu: 0.772 ± 0.019	0.472MetPhe: 0.472 ± 0.017	1.319MetGly: 1.319 ± 0.029	0.355MetHis: 0.355 ± 0.014	0.651MetIle: 0.651 ± 0.021	0.44MetLys: 0.44 ± 0.018	1.641MetLeu: 1.641 ± 0.027	0.293MetMet: 0.293 ± 0.013	0.447MetAsn: 0.447 ± 0.015	1.108MetPro: 1.108 ± 0.026	0.429MetGln: 0.429 ± 0.016	1.458MetArg: 1.458 ± 0.027	1.337MetSer: 1.337 ± 0.027	1.612MetThr: 1.612 ± 0.031	1.305MetVal: 1.305 ± 0.026	0.222MetTrp: 0.222 ± 0.011	0.333MetTyr: 0.333 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.208AsnAla: 2.208 ± 0.034	0.165AsnCys: 0.165 ± 0.009	0.963AsnAsp: 0.963 ± 0.023	0.831AsnGlu: 0.831 ± 0.02	0.488AsnPhe: 0.488 ± 0.018	1.908AsnGly: 1.908 ± 0.037	0.417AsnHis: 0.417 ± 0.016	0.649AsnIle: 0.649 ± 0.021	0.424AsnLys: 0.424 ± 0.017	1.643AsnLeu: 1.643 ± 0.034	0.301AsnMet: 0.301 ± 0.014	0.473AsnAsn: 0.473 ± 0.018	1.343AsnPro: 1.343 ± 0.028	0.533AsnGln: 0.533 ± 0.019	1.293AsnArg: 1.293 ± 0.027	0.964AsnSer: 0.964 ± 0.029	1.14AsnThr: 1.14 ± 0.032	1.411AsnVal: 1.411 ± 0.029	0.313AsnTrp: 0.313 ± 0.013	0.412AsnTyr: 0.412 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.289ProAla: 8.289 ± 0.089	0.362ProCys: 0.362 ± 0.014	4.447ProAsp: 4.447 ± 0.052	4.284ProGlu: 4.284 ± 0.052	1.543ProPhe: 1.543 ± 0.03	6.423ProGly: 6.423 ± 0.063	1.43ProHis: 1.43 ± 0.028	1.229ProIle: 1.229 ± 0.025	1.164ProLys: 1.164 ± 0.027	5.242ProLeu: 5.242 ± 0.064	0.998ProMet: 0.998 ± 0.022	0.905ProAsn: 0.905 ± 0.024	3.529ProPro: 3.529 ± 0.059	1.716ProGln: 1.716 ± 0.031	4.03ProArg: 4.03 ± 0.049	3.242ProSer: 3.242 ± 0.048	3.26ProThr: 3.26 ± 0.046	5.564ProVal: 5.564 ± 0.057	0.895ProTrp: 0.895 ± 0.025	1.474ProTyr: 1.474 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.695GlnAla: 3.695 ± 0.044	0.163GlnCys: 0.163 ± 0.01	1.474GlnAsp: 1.474 ± 0.027	1.494GlnGlu: 1.494 ± 0.027	0.689GlnPhe: 0.689 ± 0.018	2.367GlnGly: 2.367 ± 0.042	0.648GlnHis: 0.648 ± 0.019	1.071GlnIle: 1.071 ± 0.026	0.665GlnLys: 0.665 ± 0.021	2.999GlnLeu: 2.999 ± 0.04	0.516GlnMet: 0.516 ± 0.016	0.503GlnAsn: 0.503 ± 0.02	1.568GlnPro: 1.568 ± 0.03	1.267GlnGln: 1.267 ± 0.037	2.327GlnArg: 2.327 ± 0.04	1.267GlnSer: 1.267 ± 0.029	1.3GlnThr: 1.3 ± 0.024	2.403GlnVal: 2.403 ± 0.042	0.458GlnTrp: 0.458 ± 0.016	0.625GlnTyr: 0.625 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.833ArgAla: 9.833 ± 0.096	0.606ArgCys: 0.606 ± 0.018	4.381ArgAsp: 4.381 ± 0.059	4.857ArgGlu: 4.857 ± 0.053	2.387ArgPhe: 2.387 ± 0.037	5.974ArgGly: 5.974 ± 0.058	2.234ArgHis: 2.234 ± 0.036	3.188ArgIle: 3.188 ± 0.043	1.663ArgLys: 1.663 ± 0.033	8.893ArgLeu: 8.893 ± 0.086	1.775ArgMet: 1.775 ± 0.029	1.358ArgAsn: 1.358 ± 0.027	5.033ArgPro: 5.033 ± 0.069	2.335ArgGln: 2.335 ± 0.036	8.066ArgArg: 8.066 ± 0.089	4.077ArgSer: 4.077 ± 0.049	5.549ArgThr: 5.549 ± 0.056	6.068ArgVal: 6.068 ± 0.064	1.411ArgTrp: 1.411 ± 0.025	1.813ArgTyr: 1.813 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.833SerAla: 6.833 ± 0.068	0.401SerCys: 0.401 ± 0.014	2.825SerAsp: 2.825 ± 0.041	2.503SerGlu: 2.503 ± 0.04	1.51SerPhe: 1.51 ± 0.035	5.878SerGly: 5.878 ± 0.067	1.045SerHis: 1.045 ± 0.022	1.416SerIle: 1.416 ± 0.028	1.031SerLys: 1.031 ± 0.025	4.864SerLeu: 4.864 ± 0.057	1.088SerMet: 1.088 ± 0.024	0.888SerAsn: 0.888 ± 0.023	3.241SerPro: 3.241 ± 0.044	1.278SerGln: 1.278 ± 0.028	3.652SerArg: 3.652 ± 0.042	2.917SerSer: 2.917 ± 0.053	3.149SerThr: 3.149 ± 0.047	4.41SerVal: 4.41 ± 0.05	0.878SerTrp: 0.878 ± 0.024	1.25SerTyr: 1.25 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.141ThrAla: 9.141 ± 0.091	0.468ThrCys: 0.468 ± 0.014	3.827ThrAsp: 3.827 ± 0.048	3.35ThrGlu: 3.35 ± 0.04	1.686ThrPhe: 1.686 ± 0.03	6.792ThrGly: 6.792 ± 0.066	1.263ThrHis: 1.263 ± 0.029	1.664ThrIle: 1.664 ± 0.031	1.172ThrLys: 1.172 ± 0.028	5.803ThrLeu: 5.803 ± 0.057	0.969ThrMet: 0.969 ± 0.023	1.037ThrAsn: 1.037 ± 0.026	4.213ThrPro: 4.213 ± 0.051	1.344ThrGln: 1.344 ± 0.029	4.057ThrArg: 4.057 ± 0.051	3.264ThrSer: 3.264 ± 0.042	3.919ThrThr: 3.919 ± 0.057	6.263ThrVal: 6.263 ± 0.067	0.922ThrTrp: 0.922 ± 0.023	1.397ThrTyr: 1.397 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.507ValAla: 10.507 ± 0.081	0.787ValCys: 0.787 ± 0.023	5.12ValAsp: 5.12 ± 0.053	4.843ValGlu: 4.843 ± 0.054	2.497ValPhe: 2.497 ± 0.039	6.661ValGly: 6.661 ± 0.066	2.03ValHis: 2.03 ± 0.034	2.85ValIle: 2.85 ± 0.042	1.824ValLys: 1.824 ± 0.036	9.533ValLeu: 9.533 ± 0.067	1.443ValMet: 1.443 ± 0.031	1.687ValAsn: 1.687 ± 0.033	5.31ValPro: 5.31 ± 0.056	2.102ValGln: 2.102 ± 0.032	7.546ValArg: 7.546 ± 0.072	4.429ValSer: 4.429 ± 0.048	5.899ValThr: 5.899 ± 0.069	8.199ValVal: 8.199 ± 0.07	1.194ValTrp: 1.194 ± 0.028	1.647ValTyr: 1.647 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.617TrpAla: 1.617 ± 0.031	0.173TrpCys: 0.173 ± 0.01	0.816TrpAsp: 0.816 ± 0.022	0.751TrpGlu: 0.751 ± 0.02	0.508TrpPhe: 0.508 ± 0.016	1.065TrpGly: 1.065 ± 0.026	0.37TrpHis: 0.37 ± 0.015	0.566TrpIle: 0.566 ± 0.017	0.387TrpLys: 0.387 ± 0.017	1.758TrpLeu: 1.758 ± 0.034	0.31TrpMet: 0.31 ± 0.013	0.445TrpAsn: 0.445 ± 0.015	0.793TrpPro: 0.793 ± 0.021	0.648TrpGln: 0.648 ± 0.019	1.341TrpArg: 1.341 ± 0.027	0.976TrpSer: 0.976 ± 0.023	1.072TrpThr: 1.072 ± 0.025	0.991TrpVal: 0.991 ± 0.022	0.332TrpTrp: 0.332 ± 0.015	0.366TrpTyr: 0.366 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.775TyrAla: 2.775 ± 0.042	0.184TyrCys: 0.184 ± 0.009	1.611TyrAsp: 1.611 ± 0.037	1.327TyrGlu: 1.327 ± 0.031	0.684TyrPhe: 0.684 ± 0.023	2.326TyrGly: 2.326 ± 0.034	0.394TyrHis: 0.394 ± 0.015	0.497TyrIle: 0.497 ± 0.017	0.423TyrLys: 0.423 ± 0.016	2.055TyrLeu: 2.055 ± 0.033	0.247TyrMet: 0.247 ± 0.012	0.407TyrAsn: 0.407 ± 0.013	1.04TyrPro: 1.04 ± 0.023	0.603TyrGln: 0.603 ± 0.021	1.897TyrArg: 1.897 ± 0.035	0.993TyrSer: 0.993 ± 0.021	1.247TyrThr: 1.247 ± 0.028	1.783TyrVal: 1.783 ± 0.032	0.367TyrTrp: 0.367 ± 0.013	0.472TyrTyr: 0.472 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6311 proteins (1882047 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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