Amino acid dipepetide frequency for Gemmiger formicilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.092AlaAla: 16.092 ± 0.221
1.7AlaCys: 1.7 ± 0.049
6.876AlaAsp: 6.876 ± 0.103
6.858AlaGlu: 6.858 ± 0.089
3.638AlaPhe: 3.638 ± 0.062
7.997AlaGly: 7.997 ± 0.112
1.843AlaHis: 1.843 ± 0.042
4.754AlaIle: 4.754 ± 0.089
4.773AlaLys: 4.773 ± 0.078
11.155AlaLeu: 11.155 ± 0.144
2.883AlaMet: 2.883 ± 0.063
3.115AlaAsn: 3.115 ± 0.062
4.173AlaPro: 4.173 ± 0.081
3.874AlaGln: 3.874 ± 0.063
5.288AlaArg: 5.288 ± 0.094
4.321AlaSer: 4.321 ± 0.08
4.45AlaThr: 4.45 ± 0.068
8.734AlaVal: 8.734 ± 0.123
1.085AlaTrp: 1.085 ± 0.039
3.068AlaTyr: 3.068 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
1.907CysAla: 1.907 ± 0.053
0.332CysCys: 0.332 ± 0.02
0.969CysAsp: 0.969 ± 0.033
0.899CysGlu: 0.899 ± 0.03
0.643CysPhe: 0.643 ± 0.028
1.936CysGly: 1.936 ± 0.049
0.316CysHis: 0.316 ± 0.019
0.91CysIle: 0.91 ± 0.031
0.795CysLys: 0.795 ± 0.031
1.397CysLeu: 1.397 ± 0.049
0.405CysMet: 0.405 ± 0.021
0.549CysAsn: 0.549 ± 0.025
0.812CysPro: 0.812 ± 0.036
0.429CysGln: 0.429 ± 0.021
1.092CysArg: 1.092 ± 0.038
0.875CysSer: 0.875 ± 0.032
1.051CysThr: 1.051 ± 0.038
1.213CysVal: 1.213 ± 0.042
0.182CysTrp: 0.182 ± 0.016
0.641CysTyr: 0.641 ± 0.025
0.001CysXaa: 0.001 ± 0.001
Asp
6.622AspAla: 6.622 ± 0.106
0.967AspCys: 0.967 ± 0.033
3.35AspAsp: 3.35 ± 0.066
4.101AspGlu: 4.101 ± 0.07
2.572AspPhe: 2.572 ± 0.056
5.335AspGly: 5.335 ± 0.101
0.943AspHis: 0.943 ± 0.032
3.258AspIle: 3.258 ± 0.063
2.814AspLys: 2.814 ± 0.065
5.026AspLeu: 5.026 ± 0.08
1.373AspMet: 1.373 ± 0.042
1.896AspAsn: 1.896 ± 0.059
2.615AspPro: 2.615 ± 0.049
1.2AspGln: 1.2 ± 0.037
2.647AspArg: 2.647 ± 0.062
2.913AspSer: 2.913 ± 0.062
3.856AspThr: 3.856 ± 0.069
3.676AspVal: 3.676 ± 0.067
0.807AspTrp: 0.807 ± 0.03
2.627AspTyr: 2.627 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.4GluAla: 5.4 ± 0.09
0.737GluCys: 0.737 ± 0.03
3.143GluAsp: 3.143 ± 0.062
3.724GluGlu: 3.724 ± 0.08
1.914GluPhe: 1.914 ± 0.046
3.49GluGly: 3.49 ± 0.069
1.321GluHis: 1.321 ± 0.043
3.657GluIle: 3.657 ± 0.078
4.092GluLys: 4.092 ± 0.084
6.063GluLeu: 6.063 ± 0.088
1.899GluMet: 1.899 ± 0.045
3.034GluAsn: 3.034 ± 0.059
2.265GluPro: 2.265 ± 0.058
2.643GluGln: 2.643 ± 0.063
3.235GluArg: 3.235 ± 0.068
2.839GluSer: 2.839 ± 0.055
3.56GluThr: 3.56 ± 0.067
3.607GluVal: 3.607 ± 0.059
0.601GluTrp: 0.601 ± 0.024
2.24GluTyr: 2.24 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
4.114PheAla: 4.114 ± 0.077
0.888PheCys: 0.888 ± 0.03
2.502PheAsp: 2.502 ± 0.059
2.018PheGlu: 2.018 ± 0.049
1.605PhePhe: 1.605 ± 0.046
3.081PheGly: 3.081 ± 0.067
0.685PheHis: 0.685 ± 0.028
1.921PheIle: 1.921 ± 0.046
1.453PheLys: 1.453 ± 0.042
3.43PheLeu: 3.43 ± 0.066
0.858PheMet: 0.858 ± 0.035
1.32PheAsn: 1.32 ± 0.038
1.342PhePro: 1.342 ± 0.039
0.902PheGln: 0.902 ± 0.029
1.68PheArg: 1.68 ± 0.041
2.403PheSer: 2.403 ± 0.049
2.721PheThr: 2.721 ± 0.057
2.783PheVal: 2.783 ± 0.052
0.526PheTrp: 0.526 ± 0.024
1.496PheTyr: 1.496 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
6.78GlyAla: 6.78 ± 0.104
1.618GlyCys: 1.618 ± 0.042
3.721GlyAsp: 3.721 ± 0.068
4.293GlyGlu: 4.293 ± 0.07
2.95GlyPhe: 2.95 ± 0.055
5.988GlyGly: 5.988 ± 0.107
1.517GlyHis: 1.517 ± 0.047
4.776GlyIle: 4.776 ± 0.1
4.245GlyLys: 4.245 ± 0.077
6.845GlyLeu: 6.845 ± 0.101
2.263GlyMet: 2.263 ± 0.053
2.462GlyAsn: 2.462 ± 0.066
1.89GlyPro: 1.89 ± 0.055
2.573GlyGln: 2.573 ± 0.051
3.897GlyArg: 3.897 ± 0.071
4.499GlySer: 4.499 ± 0.078
4.768GlyThr: 4.768 ± 0.097
5.766GlyVal: 5.766 ± 0.1
1.022GlyTrp: 1.022 ± 0.039
3.301GlyTyr: 3.301 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.628HisAla: 1.628 ± 0.039
0.427HisCys: 0.427 ± 0.021
1.113HisAsp: 1.113 ± 0.033
1.058HisGlu: 1.058 ± 0.031
0.84HisPhe: 0.84 ± 0.033
1.53HisGly: 1.53 ± 0.037
0.454HisHis: 0.454 ± 0.033
1.24HisIle: 1.24 ± 0.04
0.817HisLys: 0.817 ± 0.033
1.735HisLeu: 1.735 ± 0.047
0.417HisMet: 0.417 ± 0.019
0.738HisAsn: 0.738 ± 0.031
1.147HisPro: 1.147 ± 0.038
0.503HisGln: 0.503 ± 0.025
1.114HisArg: 1.114 ± 0.029
0.973HisSer: 0.973 ± 0.036
1.314HisThr: 1.314 ± 0.038
1.06HisVal: 1.06 ± 0.03
0.251HisTrp: 0.251 ± 0.018
0.834HisTyr: 0.834 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.259IleAla: 5.259 ± 0.076
0.959IleCys: 0.959 ± 0.037
3.393IleAsp: 3.393 ± 0.062
3.185IleGlu: 3.185 ± 0.076
2.036IlePhe: 2.036 ± 0.05
3.804IleGly: 3.804 ± 0.086
0.958IleHis: 0.958 ± 0.029
2.691IleIle: 2.691 ± 0.065
2.227IleLys: 2.227 ± 0.052
5.312IleLeu: 5.312 ± 0.092
1.245IleMet: 1.245 ± 0.042
1.889IleAsn: 1.889 ± 0.039
2.631IlePro: 2.631 ± 0.059
1.532IleGln: 1.532 ± 0.046
2.851IleArg: 2.851 ± 0.063
3.225IleSer: 3.225 ± 0.064
3.51IleThr: 3.51 ± 0.063
3.979IleVal: 3.979 ± 0.072
0.587IleTrp: 0.587 ± 0.025
1.929IleTyr: 1.929 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.944LysAla: 4.944 ± 0.09
0.532LysCys: 0.532 ± 0.02
2.599LysAsp: 2.599 ± 0.063
3.204LysGlu: 3.204 ± 0.082
1.464LysPhe: 1.464 ± 0.038
2.905LysGly: 2.905 ± 0.066
0.826LysHis: 0.826 ± 0.033
2.829LysIle: 2.829 ± 0.064
3.296LysLys: 3.296 ± 0.073
4.404LysLeu: 4.404 ± 0.075
1.514LysMet: 1.514 ± 0.04
2.232LysAsn: 2.232 ± 0.054
2.079LysPro: 2.079 ± 0.052
1.977LysGln: 1.977 ± 0.044
2.6LysArg: 2.6 ± 0.055
2.384LysSer: 2.384 ± 0.054
3.201LysThr: 3.201 ± 0.064
3.027LysVal: 3.027 ± 0.063
0.483LysTrp: 0.483 ± 0.026
1.938LysTyr: 1.938 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
10.768LeuAla: 10.768 ± 0.142
2.308LeuCys: 2.308 ± 0.057
5.807LeuAsp: 5.807 ± 0.087
4.79LeuGlu: 4.79 ± 0.088
3.787LeuPhe: 3.787 ± 0.092
6.588LeuGly: 6.588 ± 0.109
2.148LeuHis: 2.148 ± 0.046
4.483LeuIle: 4.483 ± 0.092
4.059LeuLys: 4.059 ± 0.075
10.584LeuLeu: 10.584 ± 0.187
2.46LeuMet: 2.46 ± 0.056
3.417LeuAsn: 3.417 ± 0.064
5.337LeuPro: 5.337 ± 0.079
3.699LeuGln: 3.699 ± 0.062
5.619LeuArg: 5.619 ± 0.101
5.251LeuSer: 5.251 ± 0.086
6.453LeuThr: 6.453 ± 0.09
6.384LeuVal: 6.384 ± 0.104
1.123LeuTrp: 1.123 ± 0.036
3.578LeuTyr: 3.578 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.908MetAla: 2.908 ± 0.062
0.296MetCys: 0.296 ± 0.019
1.602MetAsp: 1.602 ± 0.045
1.542MetGlu: 1.542 ± 0.043
0.851MetPhe: 0.851 ± 0.029
1.807MetGly: 1.807 ± 0.052
0.431MetHis: 0.431 ± 0.022
1.287MetIle: 1.287 ± 0.037
1.593MetLys: 1.593 ± 0.039
2.673MetLeu: 2.673 ± 0.061
0.791MetMet: 0.791 ± 0.035
1.142MetAsn: 1.142 ± 0.034
1.383MetPro: 1.383 ± 0.041
1.294MetGln: 1.294 ± 0.036
1.283MetArg: 1.283 ± 0.036
1.416MetSer: 1.416 ± 0.041
1.746MetThr: 1.746 ± 0.041
1.637MetVal: 1.637 ± 0.051
0.234MetTrp: 0.234 ± 0.016
0.744MetTyr: 0.744 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.707AsnAla: 3.707 ± 0.069
0.591AsnCys: 0.591 ± 0.024
2.05AsnAsp: 2.05 ± 0.052
1.97AsnGlu: 1.97 ± 0.053
1.297AsnPhe: 1.297 ± 0.038
3.509AsnGly: 3.509 ± 0.082
0.71AsnHis: 0.71 ± 0.03
2.175AsnIle: 2.175 ± 0.057
1.581AsnLys: 1.581 ± 0.048
3.241AsnLeu: 3.241 ± 0.062
0.907AsnMet: 0.907 ± 0.031
1.254AsnAsn: 1.254 ± 0.055
1.768AsnPro: 1.768 ± 0.046
1.087AsnGln: 1.087 ± 0.038
1.833AsnArg: 1.833 ± 0.048
1.801AsnSer: 1.801 ± 0.05
2.191AsnThr: 2.191 ± 0.06
2.368AsnVal: 2.368 ± 0.051
0.424AsnTrp: 0.424 ± 0.02
1.463AsnTyr: 1.463 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
5.157ProAla: 5.157 ± 0.106
0.643ProCys: 0.643 ± 0.028
3.196ProAsp: 3.196 ± 0.066
3.374ProGlu: 3.374 ± 0.073
1.678ProPhe: 1.678 ± 0.044
3.34ProGly: 3.34 ± 0.071
0.833ProHis: 0.833 ± 0.03
2.055ProIle: 2.055 ± 0.047
1.901ProLys: 1.901 ± 0.057
3.894ProLeu: 3.894 ± 0.064
1.031ProMet: 1.031 ± 0.034
1.405ProAsn: 1.405 ± 0.035
1.473ProPro: 1.473 ± 0.053
1.771ProGln: 1.771 ± 0.044
1.907ProArg: 1.907 ± 0.05
1.807ProSer: 1.807 ± 0.05
2.392ProThr: 2.392 ± 0.061
3.457ProVal: 3.457 ± 0.064
0.46ProTrp: 0.46 ± 0.025
1.578ProTyr: 1.578 ± 0.048
0.001ProXaa: 0.001 ± 0.001
Gln
3.23GlnAla: 3.23 ± 0.062
0.446GlnCys: 0.446 ± 0.02
1.719GlnAsp: 1.719 ± 0.042
2.041GlnGlu: 2.041 ± 0.051
1.202GlnPhe: 1.202 ± 0.039
2.272GlnGly: 2.272 ± 0.051
0.712GlnHis: 0.712 ± 0.027
1.974GlnIle: 1.974 ± 0.047
2.122GlnLys: 2.122 ± 0.054
3.524GlnLeu: 3.524 ± 0.069
1.094GlnMet: 1.094 ± 0.035
1.635GlnAsn: 1.635 ± 0.044
1.582GlnPro: 1.582 ± 0.052
1.714GlnGln: 1.714 ± 0.048
2.065GlnArg: 2.065 ± 0.048
1.81GlnSer: 1.81 ± 0.045
2.188GlnThr: 2.188 ± 0.058
2.002GlnVal: 2.002 ± 0.05
0.39GlnTrp: 0.39 ± 0.02
1.431GlnTyr: 1.431 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
5.099ArgAla: 5.099 ± 0.1
0.934ArgCys: 0.934 ± 0.033
2.837ArgAsp: 2.837 ± 0.066
3.458ArgGlu: 3.458 ± 0.073
1.999ArgPhe: 1.999 ± 0.046
3.419ArgGly: 3.419 ± 0.067
1.122ArgHis: 1.122 ± 0.041
2.869ArgIle: 2.869 ± 0.056
2.778ArgLys: 2.778 ± 0.06
5.22ArgLeu: 5.22 ± 0.084
1.549ArgMet: 1.549 ± 0.042
1.739ArgAsn: 1.739 ± 0.046
2.203ArgPro: 2.203 ± 0.054
2.143ArgGln: 2.143 ± 0.048
3.827ArgArg: 3.827 ± 0.082
2.589ArgSer: 2.589 ± 0.047
3.204ArgThr: 3.204 ± 0.069
3.312ArgVal: 3.312 ± 0.057
0.651ArgTrp: 0.651 ± 0.028
2.097ArgTyr: 2.097 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.233SerAla: 5.233 ± 0.085
0.778SerCys: 0.778 ± 0.03
2.958SerAsp: 2.958 ± 0.06
2.873SerGlu: 2.873 ± 0.066
2.122SerPhe: 2.122 ± 0.05
4.63SerGly: 4.63 ± 0.081
0.915SerHis: 0.915 ± 0.035
2.961SerIle: 2.961 ± 0.065
2.112SerLys: 2.112 ± 0.052
4.825SerLeu: 4.825 ± 0.073
1.417SerMet: 1.417 ± 0.045
1.697SerAsn: 1.697 ± 0.049
2.014SerPro: 2.014 ± 0.053
1.487SerGln: 1.487 ± 0.046
2.731SerArg: 2.731 ± 0.058
2.723SerSer: 2.723 ± 0.067
3.115SerThr: 3.115 ± 0.065
3.85SerVal: 3.85 ± 0.063
0.608SerTrp: 0.608 ± 0.028
2.154SerTyr: 2.154 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
7.324ThrAla: 7.324 ± 0.102
0.809ThrCys: 0.809 ± 0.028
3.751ThrAsp: 3.751 ± 0.075
3.402ThrGlu: 3.402 ± 0.065
2.127ThrPhe: 2.127 ± 0.05
4.962ThrGly: 4.962 ± 0.079
1.11ThrHis: 1.11 ± 0.034
3.19ThrIle: 3.19 ± 0.071
2.43ThrLys: 2.43 ± 0.058
6.404ThrLeu: 6.404 ± 0.105
1.518ThrMet: 1.518 ± 0.04
1.914ThrAsn: 1.914 ± 0.054
3.521ThrPro: 3.521 ± 0.07
1.831ThrGln: 1.831 ± 0.048
2.761ThrArg: 2.761 ± 0.047
2.692ThrSer: 2.692 ± 0.062
3.362ThrThr: 3.362 ± 0.086
5.364ThrVal: 5.364 ± 0.102
0.579ThrTrp: 0.579 ± 0.026
1.939ThrTyr: 1.939 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
5.939ValAla: 5.939 ± 0.106
1.49ValCys: 1.49 ± 0.05
3.891ValAsp: 3.891 ± 0.077
3.962ValGlu: 3.962 ± 0.07
2.89ValPhe: 2.89 ± 0.062
4.785ValGly: 4.785 ± 0.092
1.221ValHis: 1.221 ± 0.039
3.692ValIle: 3.692 ± 0.076
3.146ValLys: 3.146 ± 0.058
7.909ValLeu: 7.909 ± 0.118
1.858ValMet: 1.858 ± 0.05
2.415ValAsn: 2.415 ± 0.056
3.225ValPro: 3.225 ± 0.054
2.646ValGln: 2.646 ± 0.06
3.801ValArg: 3.801 ± 0.082
4.141ValSer: 4.141 ± 0.079
4.705ValThr: 4.705 ± 0.085
5.039ValVal: 5.039 ± 0.092
0.851ValTrp: 0.851 ± 0.027
2.498ValTyr: 2.498 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.972TrpAla: 0.972 ± 0.036
0.23TrpCys: 0.23 ± 0.017
0.631TrpAsp: 0.631 ± 0.029
0.611TrpGlu: 0.611 ± 0.028
0.523TrpPhe: 0.523 ± 0.026
0.847TrpGly: 0.847 ± 0.028
0.299TrpHis: 0.299 ± 0.018
0.452TrpIle: 0.452 ± 0.022
0.49TrpLys: 0.49 ± 0.024
1.382TrpLeu: 1.382 ± 0.044
0.337TrpMet: 0.337 ± 0.019
0.52TrpAsn: 0.52 ± 0.028
0.428TrpPro: 0.428 ± 0.02
0.722TrpGln: 0.722 ± 0.035
0.634TrpArg: 0.634 ± 0.023
0.5TrpSer: 0.5 ± 0.023
0.552TrpThr: 0.552 ± 0.023
0.72TrpVal: 0.72 ± 0.028
0.14TrpTrp: 0.14 ± 0.013
0.432TrpTyr: 0.432 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.596TyrAla: 3.596 ± 0.066
0.668TyrCys: 0.668 ± 0.025
2.486TyrAsp: 2.486 ± 0.058
2.103TyrGlu: 2.103 ± 0.046
1.591TyrPhe: 1.591 ± 0.045
2.95TyrGly: 2.95 ± 0.056
0.829TyrHis: 0.829 ± 0.033
2.029TyrIle: 2.029 ± 0.048
1.71TyrLys: 1.71 ± 0.047
3.622TyrLeu: 3.622 ± 0.058
0.841TyrMet: 0.841 ± 0.028
1.555TyrAsn: 1.555 ± 0.042
1.466TyrPro: 1.466 ± 0.045
1.127TyrGln: 1.127 ± 0.037
2.183TyrArg: 2.183 ± 0.047
2.041TyrSer: 2.041 ± 0.049
2.648TyrThr: 2.648 ± 0.074
2.128TyrVal: 2.128 ± 0.05
0.417TyrTrp: 0.417 ± 0.021
1.67TyrTyr: 1.67 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.003
Statistics based on 2819 proteins (923584 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski