Amino acid dipepetide frequency for Auritidibacter sp. NML120636

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.428AlaAla: 11.428 ± 0.158
0.631AlaCys: 0.631 ± 0.03
6.753AlaAsp: 6.753 ± 0.114
8.813AlaGlu: 8.813 ± 0.13
2.971AlaPhe: 2.971 ± 0.072
9.646AlaGly: 9.646 ± 0.132
2.463AlaHis: 2.463 ± 0.061
4.981AlaIle: 4.981 ± 0.093
2.743AlaLys: 2.743 ± 0.071
10.703AlaLeu: 10.703 ± 0.151
2.554AlaMet: 2.554 ± 0.063
2.35AlaAsn: 2.35 ± 0.058
4.761AlaPro: 4.761 ± 0.089
4.9AlaGln: 4.9 ± 0.08
6.821AlaArg: 6.821 ± 0.107
6.269AlaSer: 6.269 ± 0.105
7.951AlaThr: 7.951 ± 0.115
9.425AlaVal: 9.425 ± 0.142
1.416AlaTrp: 1.416 ± 0.042
2.12AlaTyr: 2.12 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.647CysAla: 0.647 ± 0.033
0.071CysCys: 0.071 ± 0.009
0.356CysAsp: 0.356 ± 0.023
0.321CysGlu: 0.321 ± 0.02
0.217CysPhe: 0.217 ± 0.018
0.613CysGly: 0.613 ± 0.03
0.183CysHis: 0.183 ± 0.015
0.221CysIle: 0.221 ± 0.018
0.071CysLys: 0.071 ± 0.009
0.585CysLeu: 0.585 ± 0.031
0.108CysMet: 0.108 ± 0.011
0.112CysAsn: 0.112 ± 0.011
0.298CysPro: 0.298 ± 0.023
0.239CysGln: 0.239 ± 0.017
0.365CysArg: 0.365 ± 0.024
0.46CysSer: 0.46 ± 0.026
0.358CysThr: 0.358 ± 0.023
0.469CysVal: 0.469 ± 0.023
0.085CysTrp: 0.085 ± 0.011
0.155CysTyr: 0.155 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.209AspAla: 6.209 ± 0.108
0.274AspCys: 0.274 ± 0.02
4.031AspAsp: 4.031 ± 0.094
4.763AspGlu: 4.763 ± 0.088
1.957AspPhe: 1.957 ± 0.061
4.46AspGly: 4.46 ± 0.095
2.006AspHis: 2.006 ± 0.058
2.675AspIle: 2.675 ± 0.065
1.305AspLys: 1.305 ± 0.05
5.998AspLeu: 5.998 ± 0.106
0.968AspMet: 0.968 ± 0.034
1.468AspAsn: 1.468 ± 0.049
4.269AspPro: 4.269 ± 0.091
3.36AspGln: 3.36 ± 0.074
3.976AspArg: 3.976 ± 0.079
3.319AspSer: 3.319 ± 0.08
3.617AspThr: 3.617 ± 0.07
4.416AspVal: 4.416 ± 0.079
0.84AspTrp: 0.84 ± 0.038
1.578AspTyr: 1.578 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
6.864GluAla: 6.864 ± 0.105
0.303GluCys: 0.303 ± 0.022
3.977GluAsp: 3.977 ± 0.09
4.105GluGlu: 4.105 ± 0.096
2.08GluPhe: 2.08 ± 0.057
3.657GluGly: 3.657 ± 0.093
2.01GluHis: 2.01 ± 0.049
3.617GluIle: 3.617 ± 0.075
1.975GluLys: 1.975 ± 0.054
6.97GluLeu: 6.97 ± 0.09
1.225GluMet: 1.225 ± 0.041
1.943GluAsn: 1.943 ± 0.047
3.206GluPro: 3.206 ± 0.08
3.594GluGln: 3.594 ± 0.081
3.888GluArg: 3.888 ± 0.08
3.575GluSer: 3.575 ± 0.073
3.829GluThr: 3.829 ± 0.091
4.828GluVal: 4.828 ± 0.084
0.747GluTrp: 0.747 ± 0.029
1.376GluTyr: 1.376 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.333PheAla: 3.333 ± 0.072
0.233PheCys: 0.233 ± 0.018
2.15PheAsp: 2.15 ± 0.061
1.657PheGlu: 1.657 ± 0.05
1.152PhePhe: 1.152 ± 0.048
3.175PheGly: 3.175 ± 0.08
0.711PheHis: 0.711 ± 0.03
1.493PheIle: 1.493 ± 0.051
0.602PheLys: 0.602 ± 0.029
2.65PheLeu: 2.65 ± 0.072
0.609PheMet: 0.609 ± 0.029
0.873PheAsn: 0.873 ± 0.036
1.402PhePro: 1.402 ± 0.045
1.027PheGln: 1.027 ± 0.04
1.654PheArg: 1.654 ± 0.044
2.264PheSer: 2.264 ± 0.057
2.298PheThr: 2.298 ± 0.057
2.347PheVal: 2.347 ± 0.054
0.504PheTrp: 0.504 ± 0.028
0.731PheTyr: 0.731 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.939GlyAla: 7.939 ± 0.107
0.557GlyCys: 0.557 ± 0.032
4.184GlyAsp: 4.184 ± 0.091
4.79GlyGlu: 4.79 ± 0.1
3.083GlyPhe: 3.083 ± 0.071
5.998GlyGly: 5.998 ± 0.109
2.051GlyHis: 2.051 ± 0.054
4.561GlyIle: 4.561 ± 0.092
2.343GlyLys: 2.343 ± 0.069
8.453GlyLeu: 8.453 ± 0.126
1.951GlyMet: 1.951 ± 0.061
1.873GlyAsn: 1.873 ± 0.055
3.515GlyPro: 3.515 ± 0.069
3.242GlyGln: 3.242 ± 0.063
4.826GlyArg: 4.826 ± 0.092
5.146GlySer: 5.146 ± 0.097
5.338GlyThr: 5.338 ± 0.085
6.525GlyVal: 6.525 ± 0.099
1.433GlyTrp: 1.433 ± 0.043
2.283GlyTyr: 2.283 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.467HisAla: 2.467 ± 0.07
0.197HisCys: 0.197 ± 0.017
1.687HisAsp: 1.687 ± 0.049
1.34HisGlu: 1.34 ± 0.042
0.672HisPhe: 0.672 ± 0.034
2.199HisGly: 2.199 ± 0.054
1.01HisHis: 1.01 ± 0.045
0.964HisIle: 0.964 ± 0.036
0.489HisLys: 0.489 ± 0.024
2.474HisLeu: 2.474 ± 0.063
0.444HisMet: 0.444 ± 0.026
0.651HisAsn: 0.651 ± 0.029
1.859HisPro: 1.859 ± 0.061
1.347HisGln: 1.347 ± 0.049
2.192HisArg: 2.192 ± 0.073
1.306HisSer: 1.306 ± 0.04
1.51HisThr: 1.51 ± 0.046
1.763HisVal: 1.763 ± 0.048
0.374HisTrp: 0.374 ± 0.024
0.633HisTyr: 0.633 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.709IleAla: 5.709 ± 0.091
0.359IleCys: 0.359 ± 0.022
3.463IleAsp: 3.463 ± 0.072
2.766IleGlu: 2.766 ± 0.064
1.527IlePhe: 1.527 ± 0.05
4.516IleGly: 4.516 ± 0.093
1.041IleHis: 1.041 ± 0.04
2.472IleIle: 2.472 ± 0.072
1.123IleLys: 1.123 ± 0.044
4.227IleLeu: 4.227 ± 0.088
0.838IleMet: 0.838 ± 0.038
1.496IleAsn: 1.496 ± 0.045
2.711IlePro: 2.711 ± 0.066
1.472IleGln: 1.472 ± 0.043
2.838IleArg: 2.838 ± 0.065
3.401IleSer: 3.401 ± 0.075
3.587IleThr: 3.587 ± 0.075
3.867IleVal: 3.867 ± 0.086
0.588IleTrp: 0.588 ± 0.032
1.064IleTyr: 1.064 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
2.58LysAla: 2.58 ± 0.066
0.108LysCys: 0.108 ± 0.012
1.506LysAsp: 1.506 ± 0.051
1.305LysGlu: 1.305 ± 0.046
0.641LysPhe: 0.641 ± 0.032
1.49LysGly: 1.49 ± 0.052
0.645LysHis: 0.645 ± 0.032
1.506LysIle: 1.506 ± 0.05
1.296LysLys: 1.296 ± 0.056
2.513LysLeu: 2.513 ± 0.067
0.562LysMet: 0.562 ± 0.027
0.932LysAsn: 0.932 ± 0.036
1.474LysPro: 1.474 ± 0.056
0.887LysGln: 0.887 ± 0.037
1.571LysArg: 1.571 ± 0.052
1.398LysSer: 1.398 ± 0.043
1.76LysThr: 1.76 ± 0.05
2.136LysVal: 2.136 ± 0.061
0.258LysTrp: 0.258 ± 0.019
0.585LysTyr: 0.585 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
11.974LeuAla: 11.974 ± 0.171
0.65LeuCys: 0.65 ± 0.031
6.315LeuAsp: 6.315 ± 0.1
5.65LeuGlu: 5.65 ± 0.105
2.869LeuPhe: 2.869 ± 0.073
8.285LeuGly: 8.285 ± 0.145
2.218LeuHis: 2.218 ± 0.051
5.004LeuIle: 5.004 ± 0.094
2.424LeuLys: 2.424 ± 0.061
8.954LeuLeu: 8.954 ± 0.177
2.069LeuMet: 2.069 ± 0.058
2.778LeuAsn: 2.778 ± 0.063
5.067LeuPro: 5.067 ± 0.09
3.292LeuGln: 3.292 ± 0.063
5.988LeuArg: 5.988 ± 0.106
6.427LeuSer: 6.427 ± 0.098
6.642LeuThr: 6.642 ± 0.105
8.391LeuVal: 8.391 ± 0.122
1.165LeuTrp: 1.165 ± 0.043
1.81LeuTyr: 1.81 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.486MetAla: 2.486 ± 0.063
0.123MetCys: 0.123 ± 0.012
1.034MetAsp: 1.034 ± 0.034
0.929MetGlu: 0.929 ± 0.042
0.627MetPhe: 0.627 ± 0.029
1.467MetGly: 1.467 ± 0.04
0.437MetHis: 0.437 ± 0.027
1.159MetIle: 1.159 ± 0.034
0.56MetLys: 0.56 ± 0.028
2.1MetLeu: 2.1 ± 0.055
0.58MetMet: 0.58 ± 0.027
0.672MetAsn: 0.672 ± 0.029
1.06MetPro: 1.06 ± 0.041
0.631MetGln: 0.631 ± 0.029
1.31MetArg: 1.31 ± 0.042
1.595MetSer: 1.595 ± 0.051
1.872MetThr: 1.872 ± 0.053
1.865MetVal: 1.865 ± 0.049
0.285MetTrp: 0.285 ± 0.02
0.36MetTyr: 0.36 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.795AsnAla: 2.795 ± 0.073
0.147AsnCys: 0.147 ± 0.016
1.467AsnAsp: 1.467 ± 0.043
1.402AsnGlu: 1.402 ± 0.047
0.805AsnPhe: 0.805 ± 0.034
2.094AsnGly: 2.094 ± 0.055
0.637AsnHis: 0.637 ± 0.031
1.261AsnIle: 1.261 ± 0.046
0.601AsnLys: 0.601 ± 0.024
2.456AsnLeu: 2.456 ± 0.066
0.587AsnMet: 0.587 ± 0.025
0.75AsnAsn: 0.75 ± 0.035
1.939AsnPro: 1.939 ± 0.064
1.14AsnGln: 1.14 ± 0.044
1.728AsnArg: 1.728 ± 0.052
1.432AsnSer: 1.432 ± 0.036
1.644AsnThr: 1.644 ± 0.053
1.715AsnVal: 1.715 ± 0.054
0.415AsnTrp: 0.415 ± 0.027
0.753AsnTyr: 0.753 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
5.818ProAla: 5.818 ± 0.092
0.226ProCys: 0.226 ± 0.021
3.844ProAsp: 3.844 ± 0.079
4.685ProGlu: 4.685 ± 0.095
1.422ProPhe: 1.422 ± 0.042
4.763ProGly: 4.763 ± 0.093
1.375ProHis: 1.375 ± 0.044
1.986ProIle: 1.986 ± 0.046
1.27ProLys: 1.27 ± 0.053
4.325ProLeu: 4.325 ± 0.091
0.948ProMet: 0.948 ± 0.038
1.226ProAsn: 1.226 ± 0.039
1.903ProPro: 1.903 ± 0.061
2.308ProGln: 2.308 ± 0.058
2.943ProArg: 2.943 ± 0.072
3.105ProSer: 3.105 ± 0.077
3.459ProThr: 3.459 ± 0.072
4.745ProVal: 4.745 ± 0.086
0.724ProTrp: 0.724 ± 0.034
1.062ProTyr: 1.062 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
5.283GlnAla: 5.283 ± 0.102
0.197GlnCys: 0.197 ± 0.018
2.28GlnAsp: 2.28 ± 0.059
2.097GlnGlu: 2.097 ± 0.058
1.091GlnPhe: 1.091 ± 0.036
2.577GlnGly: 2.577 ± 0.063
1.338GlnHis: 1.338 ± 0.043
2.094GlnIle: 2.094 ± 0.059
1.035GlnLys: 1.035 ± 0.042
4.68GlnLeu: 4.68 ± 0.081
0.865GlnMet: 0.865 ± 0.036
0.99GlnAsn: 0.99 ± 0.041
2.291GlnPro: 2.291 ± 0.064
2.586GlnGln: 2.586 ± 0.085
3.632GlnArg: 3.632 ± 0.089
1.982GlnSer: 1.982 ± 0.053
2.281GlnThr: 2.281 ± 0.061
3.346GlnVal: 3.346 ± 0.064
0.606GlnTrp: 0.606 ± 0.03
0.844GlnTyr: 0.844 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.762ArgAla: 6.762 ± 0.13
0.393ArgCys: 0.393 ± 0.027
3.654ArgAsp: 3.654 ± 0.08
3.97ArgGlu: 3.97 ± 0.081
2.059ArgPhe: 2.059 ± 0.061
4.45ArgGly: 4.45 ± 0.077
1.834ArgHis: 1.834 ± 0.051
3.098ArgIle: 3.098 ± 0.065
1.734ArgLys: 1.734 ± 0.055
6.35ArgLeu: 6.35 ± 0.106
1.507ArgMet: 1.507 ± 0.039
1.643ArgAsn: 1.643 ± 0.049
3.104ArgPro: 3.104 ± 0.065
2.878ArgGln: 2.878 ± 0.069
5.013ArgArg: 5.013 ± 0.118
3.756ArgSer: 3.756 ± 0.073
3.739ArgThr: 3.739 ± 0.076
4.708ArgVal: 4.708 ± 0.086
1.159ArgTrp: 1.159 ± 0.043
1.671ArgTyr: 1.671 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.618SerAla: 6.618 ± 0.107
0.313SerCys: 0.313 ± 0.023
3.389SerAsp: 3.389 ± 0.071
3.668SerGlu: 3.668 ± 0.082
1.911SerPhe: 1.911 ± 0.047
5.852SerGly: 5.852 ± 0.098
1.436SerHis: 1.436 ± 0.05
2.657SerIle: 2.657 ± 0.056
1.419SerLys: 1.419 ± 0.047
5.541SerLeu: 5.541 ± 0.105
1.562SerMet: 1.562 ± 0.051
1.358SerAsn: 1.358 ± 0.039
3.272SerPro: 3.272 ± 0.068
2.622SerGln: 2.622 ± 0.067
3.721SerArg: 3.721 ± 0.072
4.413SerSer: 4.413 ± 0.098
4.14SerThr: 4.14 ± 0.079
4.738SerVal: 4.738 ± 0.085
0.983SerTrp: 0.983 ± 0.037
1.489SerTyr: 1.489 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
7.556ThrAla: 7.556 ± 0.103
0.313ThrCys: 0.313 ± 0.022
4.107ThrAsp: 4.107 ± 0.078
4.417ThrGlu: 4.417 ± 0.091
1.784ThrPhe: 1.784 ± 0.052
6.329ThrGly: 6.329 ± 0.101
1.514ThrHis: 1.514 ± 0.053
3.084ThrIle: 3.084 ± 0.072
1.449ThrLys: 1.449 ± 0.051
6.043ThrLeu: 6.043 ± 0.09
1.2ThrMet: 1.2 ± 0.045
1.556ThrAsn: 1.556 ± 0.051
3.948ThrPro: 3.948 ± 0.079
2.306ThrGln: 2.306 ± 0.054
3.628ThrArg: 3.628 ± 0.069
4.024ThrSer: 4.024 ± 0.075
4.624ThrThr: 4.624 ± 0.083
6.13ThrVal: 6.13 ± 0.108
0.863ThrTrp: 0.863 ± 0.035
1.4ThrTyr: 1.4 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
9.689ValAla: 9.689 ± 0.12
0.545ValCys: 0.545 ± 0.027
5.08ValAsp: 5.08 ± 0.088
5.05ValGlu: 5.05 ± 0.084
2.595ValPhe: 2.595 ± 0.059
5.649ValGly: 5.649 ± 0.107
1.774ValHis: 1.774 ± 0.054
4.667ValIle: 4.667 ± 0.08
1.891ValLys: 1.891 ± 0.06
8.928ValLeu: 8.928 ± 0.134
1.91ValMet: 1.91 ± 0.057
2.088ValAsn: 2.088 ± 0.049
4.186ValPro: 4.186 ± 0.076
2.548ValGln: 2.548 ± 0.063
4.523ValArg: 4.523 ± 0.076
5.099ValSer: 5.099 ± 0.086
5.557ValThr: 5.557 ± 0.104
7.732ValVal: 7.732 ± 0.136
0.946ValTrp: 0.946 ± 0.036
1.532ValTyr: 1.532 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
1.395TrpAla: 1.395 ± 0.042
0.142TrpCys: 0.142 ± 0.013
0.82TrpAsp: 0.82 ± 0.033
0.754TrpGlu: 0.754 ± 0.036
0.559TrpPhe: 0.559 ± 0.029
0.897TrpGly: 0.897 ± 0.041
0.312TrpHis: 0.312 ± 0.021
0.796TrpIle: 0.796 ± 0.033
0.419TrpLys: 0.419 ± 0.026
1.673TrpLeu: 1.673 ± 0.055
0.334TrpMet: 0.334 ± 0.024
0.483TrpAsn: 0.483 ± 0.029
0.629TrpPro: 0.629 ± 0.031
0.631TrpGln: 0.631 ± 0.027
0.904TrpArg: 0.904 ± 0.039
0.796TrpSer: 0.796 ± 0.031
0.701TrpThr: 0.701 ± 0.029
1.196TrpVal: 1.196 ± 0.041
0.334TrpTrp: 0.334 ± 0.024
0.309TrpTyr: 0.309 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.146TyrAla: 2.146 ± 0.052
0.151TyrCys: 0.151 ± 0.015
1.391TyrAsp: 1.391 ± 0.043
1.287TyrGlu: 1.287 ± 0.05
0.844TyrPhe: 0.844 ± 0.039
1.971TyrGly: 1.971 ± 0.052
0.583TyrHis: 0.583 ± 0.032
0.77TyrIle: 0.77 ± 0.036
0.405TyrLys: 0.405 ± 0.024
2.351TyrLeu: 2.351 ± 0.065
0.334TyrMet: 0.334 ± 0.022
0.524TyrAsn: 0.524 ± 0.026
1.246TyrPro: 1.246 ± 0.045
1.085TyrGln: 1.085 ± 0.041
1.96TyrArg: 1.96 ± 0.06
1.334TyrSer: 1.334 ± 0.044
1.368TyrThr: 1.368 ± 0.048
1.65TyrVal: 1.65 ± 0.05
0.358TyrTrp: 0.358 ± 0.02
0.545TyrTyr: 0.545 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2118 proteins (715878 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski