Amino acid dipepetide frequency for Roseimaritima ulvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.753AlaAla: 14.753 ± 0.144	1.168AlaCys: 1.168 ± 0.027	7.18AlaAsp: 7.18 ± 0.066	7.293AlaGlu: 7.293 ± 0.086	3.355AlaPhe: 3.355 ± 0.041	8.497AlaGly: 8.497 ± 0.095	1.719AlaHis: 1.719 ± 0.029	5.39AlaIle: 5.39 ± 0.06	3.385AlaLys: 3.385 ± 0.054	8.899AlaLeu: 8.899 ± 0.073	2.726AlaMet: 2.726 ± 0.048	2.991AlaAsn: 2.991 ± 0.051	4.604AlaPro: 4.604 ± 0.06	3.795AlaGln: 3.795 ± 0.042	5.712AlaArg: 5.712 ± 0.063	6.481AlaSer: 6.481 ± 0.061	6.171AlaThr: 6.171 ± 0.07	7.854AlaVal: 7.854 ± 0.065	1.425AlaTrp: 1.425 ± 0.028	2.121AlaTyr: 2.121 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.726CysAla: 0.726 ± 0.017	0.275CysCys: 0.275 ± 0.016	0.714CysAsp: 0.714 ± 0.018	0.646CysGlu: 0.646 ± 0.022	0.427CysPhe: 0.427 ± 0.014	1.091CysGly: 1.091 ± 0.031	0.435CysHis: 0.435 ± 0.018	0.407CysIle: 0.407 ± 0.013	0.274CysLys: 0.274 ± 0.011	1.207CysLeu: 1.207 ± 0.03	0.181CysMet: 0.181 ± 0.009	0.292CysAsn: 0.292 ± 0.012	0.588CysPro: 0.588 ± 0.018	0.49CysGln: 0.49 ± 0.016	0.771CysArg: 0.771 ± 0.023	0.69CysSer: 0.69 ± 0.019	0.5CysThr: 0.5 ± 0.014	0.812CysVal: 0.812 ± 0.022	0.185CysTrp: 0.185 ± 0.008	0.286CysTyr: 0.286 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.156AspAla: 7.156 ± 0.073	0.628AspCys: 0.628 ± 0.018	4.343AspAsp: 4.343 ± 0.066	4.125AspGlu: 4.125 ± 0.046	2.332AspPhe: 2.332 ± 0.04	5.652AspGly: 5.652 ± 0.098	1.373AspHis: 1.373 ± 0.029	2.43AspIle: 2.43 ± 0.039	1.633AspLys: 1.633 ± 0.028	5.883AspLeu: 5.883 ± 0.069	1.022AspMet: 1.022 ± 0.022	1.779AspAsn: 1.779 ± 0.039	3.877AspPro: 3.877 ± 0.056	2.9AspGln: 2.9 ± 0.038	4.312AspArg: 4.312 ± 0.043	3.811AspSer: 3.811 ± 0.061	3.036AspThr: 3.036 ± 0.058	4.516AspVal: 4.516 ± 0.066	1.102AspTrp: 1.102 ± 0.023	1.613AspTyr: 1.613 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.126GluAla: 6.126 ± 0.07	0.45GluCys: 0.45 ± 0.015	3.018GluAsp: 3.018 ± 0.039	2.974GluGlu: 2.974 ± 0.057	2.068GluPhe: 2.068 ± 0.032	3.708GluGly: 3.708 ± 0.042	1.422GluHis: 1.422 ± 0.031	3.036GluIle: 3.036 ± 0.04	1.984GluLys: 1.984 ± 0.039	6.545GluLeu: 6.545 ± 0.058	1.4GluMet: 1.4 ± 0.03	1.819GluAsn: 1.819 ± 0.03	3.071GluPro: 3.071 ± 0.049	3.768GluGln: 3.768 ± 0.052	3.983GluArg: 3.983 ± 0.058	3.707GluSer: 3.707 ± 0.044	3.541GluThr: 3.541 ± 0.046	3.947GluVal: 3.947 ± 0.042	0.651GluTrp: 0.651 ± 0.018	1.285GluTyr: 1.285 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.782PheAla: 3.782 ± 0.045	0.46PheCys: 0.46 ± 0.014	2.805PheAsp: 2.805 ± 0.043	2.171PheGlu: 2.171 ± 0.035	1.273PhePhe: 1.273 ± 0.026	3.019PheGly: 3.019 ± 0.04	0.813PheHis: 0.813 ± 0.019	1.287PheIle: 1.287 ± 0.026	0.834PheLys: 0.834 ± 0.02	3.135PheLeu: 3.135 ± 0.043	0.599PheMet: 0.599 ± 0.015	1.085PheAsn: 1.085 ± 0.027	1.595PhePro: 1.595 ± 0.029	1.403PheGln: 1.403 ± 0.025	2.306PheArg: 2.306 ± 0.031	2.273PheSer: 2.273 ± 0.037	1.884PheThr: 1.884 ± 0.043	2.704PheVal: 2.704 ± 0.037	0.519PheTrp: 0.519 ± 0.016	0.877PheTyr: 0.877 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.825GlyAla: 5.825 ± 0.076	1.038GlyCys: 1.038 ± 0.029	4.803GlyAsp: 4.803 ± 0.089	4.53GlyGlu: 4.53 ± 0.047	2.99GlyPhe: 2.99 ± 0.044	6.854GlyGly: 6.854 ± 0.12	1.653GlyHis: 1.653 ± 0.029	3.578GlyIle: 3.578 ± 0.048	3.091GlyLys: 3.091 ± 0.047	7.157GlyLeu: 7.157 ± 0.062	1.875GlyMet: 1.875 ± 0.039	2.584GlyAsn: 2.584 ± 0.071	3.355GlyPro: 3.355 ± 0.041	3.636GlyGln: 3.636 ± 0.045	5.209GlyArg: 5.209 ± 0.058	4.948GlySer: 4.948 ± 0.069	4.611GlyThr: 4.611 ± 0.093	5.413GlyVal: 5.413 ± 0.067	1.334GlyTrp: 1.334 ± 0.026	2.084GlyTyr: 2.084 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.185HisAla: 2.185 ± 0.034	0.358HisCys: 0.358 ± 0.011	1.415HisAsp: 1.415 ± 0.028	1.155HisGlu: 1.155 ± 0.024	0.908HisPhe: 0.908 ± 0.021	1.845HisGly: 1.845 ± 0.031	0.689HisHis: 0.689 ± 0.019	0.821HisIle: 0.821 ± 0.02	0.518HisLys: 0.518 ± 0.016	2.133HisLeu: 2.133 ± 0.035	0.353HisMet: 0.353 ± 0.012	0.674HisAsn: 0.674 ± 0.018	1.537HisPro: 1.537 ± 0.032	1.011HisGln: 1.011 ± 0.024	1.808HisArg: 1.808 ± 0.036	1.308HisSer: 1.308 ± 0.026	0.994HisThr: 0.994 ± 0.022	1.495HisVal: 1.495 ± 0.03	0.482HisTrp: 0.482 ± 0.016	0.661HisTyr: 0.661 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.346IleAla: 5.346 ± 0.052	0.549IleCys: 0.549 ± 0.016	3.819IleAsp: 3.819 ± 0.059	3.547IleGlu: 3.547 ± 0.042	1.227IlePhe: 1.227 ± 0.025	3.759IleGly: 3.759 ± 0.049	1.034IleHis: 1.034 ± 0.024	1.604IleIle: 1.604 ± 0.027	1.237IleLys: 1.237 ± 0.027	3.68IleLeu: 3.68 ± 0.044	0.617IleMet: 0.617 ± 0.019	1.359IleAsn: 1.359 ± 0.032	2.235IlePro: 2.235 ± 0.031	1.706IleGln: 1.706 ± 0.029	3.345IleArg: 3.345 ± 0.04	2.667IleSer: 2.667 ± 0.043	2.447IleThr: 2.447 ± 0.045	3.611IleVal: 3.611 ± 0.041	0.551IleTrp: 0.551 ± 0.016	1.072IleTyr: 1.072 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.705LysAla: 2.705 ± 0.047	0.249LysCys: 0.249 ± 0.01	1.42LysAsp: 1.42 ± 0.027	1.367LysGlu: 1.367 ± 0.032	0.998LysPhe: 0.998 ± 0.022	1.654LysGly: 1.654 ± 0.033	0.794LysHis: 0.794 ± 0.021	1.493LysIle: 1.493 ± 0.032	1.232LysLys: 1.232 ± 0.034	3.336LysLeu: 3.336 ± 0.055	0.76LysMet: 0.76 ± 0.018	0.945LysAsn: 0.945 ± 0.023	2.069LysPro: 2.069 ± 0.043	1.798LysGln: 1.798 ± 0.034	2.318LysArg: 2.318 ± 0.042	1.794LysSer: 1.794 ± 0.037	1.916LysThr: 1.916 ± 0.039	1.931LysVal: 1.931 ± 0.033	0.443LysTrp: 0.443 ± 0.014	0.766LysTyr: 0.766 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	11.643LeuAla: 11.643 ± 0.092	1.118LeuCys: 1.118 ± 0.025	6.33LeuAsp: 6.33 ± 0.064	5.554LeuGlu: 5.554 ± 0.055	3.232LeuPhe: 3.232 ± 0.04	7.006LeuGly: 7.006 ± 0.072	2.097LeuHis: 2.097 ± 0.033	4.206LeuIle: 4.206 ± 0.046	3.16LeuLys: 3.16 ± 0.052	10.633LeuLeu: 10.633 ± 0.103	1.969LeuMet: 1.969 ± 0.034	2.823LeuAsn: 2.823 ± 0.046	5.98LeuPro: 5.98 ± 0.062	4.98LeuGln: 4.98 ± 0.056	7.03LeuArg: 7.03 ± 0.081	6.451LeuSer: 6.451 ± 0.058	5.842LeuThr: 5.842 ± 0.067	7.058LeuVal: 7.058 ± 0.062	1.303LeuTrp: 1.303 ± 0.03	2.11LeuTyr: 2.11 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.126MetAla: 2.126 ± 0.031	0.19MetCys: 0.19 ± 0.009	1.022MetAsp: 1.022 ± 0.021	1.014MetGlu: 1.014 ± 0.025	0.707MetPhe: 0.707 ± 0.017	1.447MetGly: 1.447 ± 0.037	0.515MetHis: 0.515 ± 0.016	1.053MetIle: 1.053 ± 0.024	0.75MetLys: 0.75 ± 0.021	2.569MetLeu: 2.569 ± 0.035	0.551MetMet: 0.551 ± 0.016	0.791MetAsn: 0.791 ± 0.018	1.346MetPro: 1.346 ± 0.028	1.122MetGln: 1.122 ± 0.023	1.481MetArg: 1.481 ± 0.028	1.367MetSer: 1.367 ± 0.027	1.304MetThr: 1.304 ± 0.026	1.474MetVal: 1.474 ± 0.027	0.245MetTrp: 0.245 ± 0.011	0.398MetTyr: 0.398 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.933AsnAla: 2.933 ± 0.051	0.328AsnCys: 0.328 ± 0.012	1.926AsnAsp: 1.926 ± 0.054	1.609AsnGlu: 1.609 ± 0.031	0.997AsnPhe: 0.997 ± 0.023	2.487AsnGly: 2.487 ± 0.065	0.725AsnHis: 0.725 ± 0.019	1.244AsnIle: 1.244 ± 0.028	0.74AsnLys: 0.74 ± 0.02	2.816AsnLeu: 2.816 ± 0.045	0.543AsnMet: 0.543 ± 0.015	0.971AsnAsn: 0.971 ± 0.035	1.923AsnPro: 1.923 ± 0.033	1.377AsnGln: 1.377 ± 0.027	2.204AsnArg: 2.204 ± 0.032	1.726AsnSer: 1.726 ± 0.04	1.58AsnThr: 1.58 ± 0.047	2.218AsnVal: 2.218 ± 0.042	0.485AsnTrp: 0.485 ± 0.014	0.79AsnTyr: 0.79 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.459ProAla: 6.459 ± 0.079	0.375ProCys: 0.375 ± 0.015	3.611ProAsp: 3.611 ± 0.042	3.644ProGlu: 3.644 ± 0.044	1.716ProPhe: 1.716 ± 0.026	3.995ProGly: 3.995 ± 0.057	1.251ProHis: 1.251 ± 0.028	2.423ProIle: 2.423 ± 0.031	1.54ProLys: 1.54 ± 0.035	5.359ProLeu: 5.359 ± 0.055	1.169ProMet: 1.169 ± 0.023	1.669ProAsn: 1.669 ± 0.027	3.574ProPro: 3.574 ± 0.057	2.839ProGln: 2.839 ± 0.04	3.051ProArg: 3.051 ± 0.044	3.576ProSer: 3.576 ± 0.042	3.229ProThr: 3.229 ± 0.041	3.787ProVal: 3.787 ± 0.048	0.768ProTrp: 0.768 ± 0.02	1.184ProTyr: 1.184 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	5.144GlnAla: 5.144 ± 0.057	0.412GlnCys: 0.412 ± 0.014	2.106GlnAsp: 2.106 ± 0.035	1.903GlnGlu: 1.903 ± 0.032	1.557GlnPhe: 1.557 ± 0.024	2.74GlnGly: 2.74 ± 0.039	1.289GlnHis: 1.289 ± 0.026	2.344GlnIle: 2.344 ± 0.034	1.161GlnLys: 1.161 ± 0.025	5.369GlnLeu: 5.369 ± 0.062	1.034GlnMet: 1.034 ± 0.021	1.159GlnAsn: 1.159 ± 0.022	3.186GlnPro: 3.186 ± 0.051	3.442GlnGln: 3.442 ± 0.059	4.128GlnArg: 4.128 ± 0.051	2.751GlnSer: 2.751 ± 0.037	2.95GlnThr: 2.95 ± 0.039	3.054GlnVal: 3.054 ± 0.037	0.893GlnTrp: 0.893 ± 0.024	1.098GlnTyr: 1.098 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	5.264ArgAla: 5.264 ± 0.05	0.84ArgCys: 0.84 ± 0.025	3.993ArgAsp: 3.993 ± 0.044	3.878ArgGlu: 3.878 ± 0.057	2.937ArgPhe: 2.937 ± 0.038	4.509ArgGly: 4.509 ± 0.056	1.527ArgHis: 1.527 ± 0.03	3.416ArgIle: 3.416 ± 0.044	2.138ArgLys: 2.138 ± 0.042	7.791ArgLeu: 7.791 ± 0.073	1.808ArgMet: 1.808 ± 0.029	1.975ArgAsn: 1.975 ± 0.033	3.405ArgPro: 3.405 ± 0.05	3.481ArgGln: 3.481 ± 0.052	5.885ArgArg: 5.885 ± 0.068	4.245ArgSer: 4.245 ± 0.055	3.282ArgThr: 3.282 ± 0.041	4.82ArgVal: 4.82 ± 0.05	1.421ArgTrp: 1.421 ± 0.03	2.043ArgTyr: 2.043 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.669SerAla: 5.669 ± 0.06	0.636SerCys: 0.636 ± 0.022	4.19SerAsp: 4.19 ± 0.055	3.707SerGlu: 3.707 ± 0.042	2.084SerPhe: 2.084 ± 0.036	5.668SerGly: 5.668 ± 0.073	1.308SerHis: 1.308 ± 0.024	2.75SerIle: 2.75 ± 0.034	1.763SerLys: 1.763 ± 0.037	6.521SerLeu: 6.521 ± 0.07	1.368SerMet: 1.368 ± 0.026	1.887SerAsn: 1.887 ± 0.044	3.691SerPro: 3.691 ± 0.043	2.819SerGln: 2.819 ± 0.04	3.905SerArg: 3.905 ± 0.049	4.029SerSer: 4.029 ± 0.062	3.267SerThr: 3.267 ± 0.051	4.398SerVal: 4.398 ± 0.061	0.876SerTrp: 0.876 ± 0.02	1.365SerTyr: 1.365 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.365ThrAla: 6.365 ± 0.074	0.483ThrCys: 0.483 ± 0.016	3.494ThrAsp: 3.494 ± 0.05	2.918ThrGlu: 2.918 ± 0.038	2.015ThrPhe: 2.015 ± 0.044	4.409ThrGly: 4.409 ± 0.082	1.172ThrHis: 1.172 ± 0.024	3.017ThrIle: 3.017 ± 0.059	1.503ThrLys: 1.503 ± 0.031	5.997ThrLeu: 5.997 ± 0.067	1.141ThrMet: 1.141 ± 0.02	1.6ThrAsn: 1.6 ± 0.041	3.603ThrPro: 3.603 ± 0.042	2.039ThrGln: 2.039 ± 0.032	3.15ThrArg: 3.15 ± 0.045	3.245ThrSer: 3.245 ± 0.055	3.189ThrThr: 3.189 ± 0.059	4.571ThrVal: 4.571 ± 0.087	0.746ThrTrp: 0.746 ± 0.021	1.332ThrTyr: 1.332 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.918ValAla: 7.918 ± 0.073	0.924ValCys: 0.924 ± 0.022	4.924ValAsp: 4.924 ± 0.069	4.341ValGlu: 4.341 ± 0.048	2.474ValPhe: 2.474 ± 0.032	5.268ValGly: 5.268 ± 0.059	1.49ValHis: 1.49 ± 0.028	3.339ValIle: 3.339 ± 0.041	1.886ValLys: 1.886 ± 0.032	7.225ValLeu: 7.225 ± 0.07	1.487ValMet: 1.487 ± 0.028	2.016ValAsn: 2.016 ± 0.046	3.696ValPro: 3.696 ± 0.044	2.936ValGln: 2.936 ± 0.032	4.912ValArg: 4.912 ± 0.052	4.504ValSer: 4.504 ± 0.064	4.186ValThr: 4.186 ± 0.083	5.863ValVal: 5.863 ± 0.06	1.053ValTrp: 1.053 ± 0.022	1.689ValTyr: 1.689 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.175TrpAla: 1.175 ± 0.026	0.191TrpCys: 0.191 ± 0.009	0.795TrpAsp: 0.795 ± 0.021	0.689TrpGlu: 0.689 ± 0.017	0.579TrpPhe: 0.579 ± 0.017	0.969TrpGly: 0.969 ± 0.026	0.415TrpHis: 0.415 ± 0.014	0.776TrpIle: 0.776 ± 0.019	0.583TrpLys: 0.583 ± 0.017	1.865TrpLeu: 1.865 ± 0.033	0.467TrpMet: 0.467 ± 0.015	0.531TrpAsn: 0.531 ± 0.017	0.719TrpPro: 0.719 ± 0.02	0.929TrpGln: 0.929 ± 0.02	1.054TrpArg: 1.054 ± 0.022	0.969TrpSer: 0.969 ± 0.022	0.869TrpThr: 0.869 ± 0.023	0.953TrpVal: 0.953 ± 0.019	0.286TrpTrp: 0.286 ± 0.013	0.376TrpTyr: 0.376 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.22TyrAla: 2.22 ± 0.033	0.328TyrCys: 0.328 ± 0.012	1.615TyrAsp: 1.615 ± 0.034	1.439TyrGlu: 1.439 ± 0.026	0.949TyrPhe: 0.949 ± 0.019	1.991TyrGly: 1.991 ± 0.027	0.628TyrHis: 0.628 ± 0.019	0.796TyrIle: 0.796 ± 0.019	0.578TyrLys: 0.578 ± 0.019	2.403TyrLeu: 2.403 ± 0.031	0.4TyrMet: 0.4 ± 0.015	0.671TyrAsn: 0.671 ± 0.02	1.163TyrPro: 1.163 ± 0.026	1.251TyrGln: 1.251 ± 0.026	2.097TyrArg: 2.097 ± 0.036	1.356TyrSer: 1.356 ± 0.028	1.19TyrThr: 1.19 ± 0.033	1.649TyrVal: 1.649 ± 0.031	0.427TyrTrp: 0.427 ± 0.015	0.739TyrTyr: 0.739 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5779 proteins (2373878 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---