Amino acid dipepetide frequency for Cactus mild mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.096AlaAla: 7.096 ± 1.816
1.419AlaCys: 1.419 ± 0.664
4.257AlaAsp: 4.257 ± 1.474
4.257AlaGlu: 4.257 ± 0.29
2.365AlaPhe: 2.365 ± 1.385
3.784AlaGly: 3.784 ± 0.886
0.473AlaHis: 0.473 ± 0.277
5.676AlaIle: 5.676 ± 2.505
4.73AlaLys: 4.73 ± 1.607
8.515AlaLeu: 8.515 ± 1.383
0.946AlaMet: 0.946 ± 0.368
2.365AlaAsn: 2.365 ± 1.038
2.838AlaPro: 2.838 ± 0.447
5.676AlaGln: 5.676 ± 1.716
1.419AlaArg: 1.419 ± 0.67
3.311AlaSer: 3.311 ± 1.706
5.203AlaThr: 5.203 ± 1.727
4.257AlaVal: 4.257 ± 1.254
0.946AlaTrp: 0.946 ± 0.604
1.892AlaTyr: 1.892 ± 0.62
0.0AlaXaa: 0.0 ± 0.0
Cys
2.365CysAla: 2.365 ± 0.741
0.946CysCys: 0.946 ± 0.554
2.838CysAsp: 2.838 ± 0.447
0.946CysGlu: 0.946 ± 0.363
0.0CysPhe: 0.0 ± 0.0
1.892CysGly: 1.892 ± 1.288
0.946CysHis: 0.946 ± 0.841
0.946CysIle: 0.946 ± 0.748
1.892CysLys: 1.892 ± 0.62
0.946CysLeu: 0.946 ± 0.573
0.946CysMet: 0.946 ± 1.173
1.419CysAsn: 1.419 ± 0.831
0.473CysPro: 0.473 ± 0.277
0.0CysGln: 0.0 ± 0.24
1.419CysArg: 1.419 ± 0.426
0.0CysSer: 0.0 ± 0.0
3.784CysThr: 3.784 ± 0.54
1.892CysVal: 1.892 ± 1.37
0.0CysTrp: 0.0 ± 0.0
0.473CysTyr: 0.473 ± 0.277
0.0CysXaa: 0.0 ± 0.0
Asp
4.73AspAla: 4.73 ± 1.087
0.946AspCys: 0.946 ± 0.363
3.311AspAsp: 3.311 ± 0.523
3.311AspGlu: 3.311 ± 1.939
4.73AspPhe: 4.73 ± 0.745
5.203AspGly: 5.203 ± 1.273
0.946AspHis: 0.946 ± 0.363
5.676AspIle: 5.676 ± 1.047
5.676AspLys: 5.676 ± 2.236
5.676AspLeu: 5.676 ± 1.825
0.0AspMet: 0.0 ± 0.0
1.892AspAsn: 1.892 ± 0.749
2.365AspPro: 2.365 ± 1.783
1.892AspGln: 1.892 ± 0.818
2.365AspArg: 2.365 ± 1.38
4.73AspSer: 4.73 ± 1.036
4.257AspThr: 4.257 ± 1.254
7.569AspVal: 7.569 ± 2.888
0.0AspTrp: 0.0 ± 0.0
1.892AspTyr: 1.892 ± 0.62
0.0AspXaa: 0.0 ± 0.0
Glu
5.676GluAla: 5.676 ± 1.539
0.0GluCys: 0.0 ± 0.0
1.419GluAsp: 1.419 ± 0.823
1.419GluGlu: 1.419 ± 0.512
3.784GluPhe: 3.784 ± 0.925
0.473GluGly: 0.473 ± 0.277
1.419GluHis: 1.419 ± 0.512
2.365GluIle: 2.365 ± 0.86
1.892GluLys: 1.892 ± 0.749
4.257GluLeu: 4.257 ± 2.002
0.946GluMet: 0.946 ± 0.342
0.946GluAsn: 0.946 ± 0.363
2.365GluPro: 2.365 ± 0.773
0.946GluGln: 0.946 ± 0.519
2.838GluArg: 2.838 ± 0.54
3.784GluSer: 3.784 ± 0.701
2.838GluThr: 2.838 ± 1.262
2.838GluVal: 2.838 ± 0.774
1.892GluTrp: 1.892 ± 0.727
1.892GluTyr: 1.892 ± 0.727
0.0GluXaa: 0.0 ± 0.0
Phe
2.838PheAla: 2.838 ± 0.767
2.838PheCys: 2.838 ± 1.09
3.784PheAsp: 3.784 ± 1.296
4.257PheGlu: 4.257 ± 0.966
2.365PhePhe: 2.365 ± 1.161
0.946PheGly: 0.946 ± 0.363
1.419PheHis: 1.419 ± 0.831
2.838PheIle: 2.838 ± 1.09
2.365PheLys: 2.365 ± 0.587
6.149PheLeu: 6.149 ± 0.672
0.0PheMet: 0.0 ± 0.0
2.365PheAsn: 2.365 ± 0.358
2.838PhePro: 2.838 ± 1.262
2.365PheGln: 2.365 ± 1.038
3.784PheArg: 3.784 ± 1.039
3.784PheSer: 3.784 ± 1.039
2.838PheThr: 2.838 ± 0.54
2.365PheVal: 2.365 ± 1.253
0.946PheTrp: 0.946 ± 0.554
1.892PheTyr: 1.892 ± 0.727
0.0PheXaa: 0.0 ± 0.0
Gly
3.311GlyAla: 3.311 ± 0.394
1.892GlyCys: 1.892 ± 0.746
6.623GlyAsp: 6.623 ± 1.18
0.946GlyGlu: 0.946 ± 0.554
3.311GlyPhe: 3.311 ± 2.545
2.838GlyGly: 2.838 ± 1.209
1.419GlyHis: 1.419 ± 1.331
1.892GlyIle: 1.892 ± 0.62
4.257GlyLys: 4.257 ± 1.064
3.311GlyLeu: 3.311 ± 1.432
0.473GlyMet: 0.473 ± 0.277
1.892GlyAsn: 1.892 ± 0.818
1.419GlyPro: 1.419 ± 1.202
0.0GlyGln: 0.0 ± 0.0
1.892GlyArg: 1.892 ± 1.132
4.73GlySer: 4.73 ± 1.076
3.311GlyThr: 3.311 ± 1.121
4.73GlyVal: 4.73 ± 0.896
1.419GlyTrp: 1.419 ± 0.823
1.419GlyTyr: 1.419 ± 0.426
0.0GlyXaa: 0.0 ± 0.0
His
1.419HisAla: 1.419 ± 0.831
1.419HisCys: 1.419 ± 0.812
0.946HisAsp: 0.946 ± 0.554
0.473HisGlu: 0.473 ± 0.277
0.0HisPhe: 0.0 ± 0.0
1.419HisGly: 1.419 ± 0.426
0.473HisHis: 0.473 ± 0.277
0.946HisIle: 0.946 ± 1.333
0.946HisLys: 0.946 ± 0.554
3.784HisLeu: 3.784 ± 0.843
0.473HisMet: 0.473 ± 0.486
0.473HisAsn: 0.473 ± 0.277
1.419HisPro: 1.419 ± 0.831
0.946HisGln: 0.946 ± 0.573
1.419HisArg: 1.419 ± 0.512
1.892HisSer: 1.892 ± 0.818
1.419HisThr: 1.419 ± 0.664
2.365HisVal: 2.365 ± 0.741
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.311IleAla: 3.311 ± 0.781
1.419IleCys: 1.419 ± 0.512
4.73IleAsp: 4.73 ± 1.036
2.365IleGlu: 2.365 ± 0.587
5.203IlePhe: 5.203 ± 1.379
1.892IleGly: 1.892 ± 0.727
0.473IleHis: 0.473 ± 0.277
1.892IleIle: 1.892 ± 0.344
3.311IleLys: 3.311 ± 2.098
3.311IleLeu: 3.311 ± 1.765
1.419IleMet: 1.419 ± 0.604
3.784IleAsn: 3.784 ± 1.153
3.784IlePro: 3.784 ± 1.239
0.473IleGln: 0.473 ± 0.277
1.892IleArg: 1.892 ± 1.208
4.257IleSer: 4.257 ± 1.064
2.365IleThr: 2.365 ± 0.358
2.838IleVal: 2.838 ± 1.024
1.419IleTrp: 1.419 ± 0.812
2.365IleTyr: 2.365 ± 0.586
0.0IleXaa: 0.0 ± 0.0
Lys
3.784LysAla: 3.784 ± 1.453
1.419LysCys: 1.419 ± 0.512
5.203LysAsp: 5.203 ± 1.494
1.419LysGlu: 1.419 ± 0.812
1.892LysPhe: 1.892 ± 1.132
1.892LysGly: 1.892 ± 1.132
0.946LysHis: 0.946 ± 0.573
4.73LysIle: 4.73 ± 1.012
1.892LysLys: 1.892 ± 0.344
4.73LysLeu: 4.73 ± 2.329
2.365LysMet: 2.365 ± 1.385
1.419LysAsn: 1.419 ± 0.831
2.365LysPro: 2.365 ± 0.849
2.365LysGln: 2.365 ± 0.86
4.257LysArg: 4.257 ± 0.668
7.096LysSer: 7.096 ± 0.903
4.257LysThr: 4.257 ± 1.474
6.149LysVal: 6.149 ± 1.803
0.473LysTrp: 0.473 ± 0.666
2.365LysTyr: 2.365 ± 1.252
0.0LysXaa: 0.0 ± 0.0
Leu
6.149LeuAla: 6.149 ± 2.245
1.419LeuCys: 1.419 ± 0.604
3.311LeuAsp: 3.311 ± 1.488
4.257LeuGlu: 4.257 ± 1.397
1.892LeuPhe: 1.892 ± 0.727
3.784LeuGly: 3.784 ± 0.701
3.311LeuHis: 3.311 ± 0.394
4.257LeuIle: 4.257 ± 0.29
7.569LeuLys: 7.569 ± 2.065
6.149LeuLeu: 6.149 ± 1.455
2.838LeuMet: 2.838 ± 0.416
4.257LeuAsn: 4.257 ± 0.825
4.257LeuPro: 4.257 ± 2.437
2.838LeuGln: 2.838 ± 1.409
6.623LeuArg: 6.623 ± 1.026
8.515LeuSer: 8.515 ± 3.676
7.569LeuThr: 7.569 ± 1.403
5.203LeuVal: 5.203 ± 1.801
1.419LeuTrp: 1.419 ± 0.426
3.311LeuTyr: 3.311 ± 0.831
0.0LeuXaa: 0.0 ± 0.0
Met
1.892MetAla: 1.892 ± 0.587
0.946MetCys: 0.946 ± 0.363
0.473MetAsp: 0.473 ± 0.277
0.473MetGlu: 0.473 ± 0.277
0.473MetPhe: 0.473 ± 0.666
1.419MetGly: 1.419 ± 0.512
0.473MetHis: 0.473 ± 0.277
0.946MetIle: 0.946 ± 0.363
0.0MetLys: 0.0 ± 0.0
2.365MetLeu: 2.365 ± 1.385
0.473MetMet: 0.473 ± 0.277
0.473MetAsn: 0.473 ± 0.277
0.946MetPro: 0.946 ± 0.363
0.946MetGln: 0.946 ± 0.363
0.473MetArg: 0.473 ± 0.666
1.419MetSer: 1.419 ± 1.211
1.419MetThr: 1.419 ± 0.426
1.419MetVal: 1.419 ± 0.831
0.0MetTrp: 0.0 ± 0.0
0.473MetTyr: 0.473 ± 0.486
0.0MetXaa: 0.0 ± 0.0
Asn
3.784AsnAla: 3.784 ± 1.047
0.473AsnCys: 0.473 ± 0.486
2.365AsnAsp: 2.365 ± 0.586
3.784AsnGlu: 3.784 ± 0.61
4.73AsnPhe: 4.73 ± 0.745
2.838AsnGly: 2.838 ± 1.209
0.473AsnHis: 0.473 ± 0.277
2.365AsnIle: 2.365 ± 0.773
2.838AsnLys: 2.838 ± 1.209
4.257AsnLeu: 4.257 ± 1.442
0.473AsnMet: 0.473 ± 0.486
2.365AsnAsn: 2.365 ± 0.358
3.784AsnPro: 3.784 ± 0.925
0.0AsnGln: 0.0 ± 0.0
1.419AsnArg: 1.419 ± 0.67
3.311AsnSer: 3.311 ± 1.51
3.784AsnThr: 3.784 ± 1.486
4.73AsnVal: 4.73 ± 1.525
0.0AsnTrp: 0.0 ± 0.0
2.365AsnTyr: 2.365 ± 0.773
0.0AsnXaa: 0.0 ± 0.0
Pro
2.838ProAla: 2.838 ± 0.774
1.892ProCys: 1.892 ± 0.344
1.419ProAsp: 1.419 ± 1.071
2.365ProGlu: 2.365 ± 1.027
1.419ProPhe: 1.419 ± 0.604
3.311ProGly: 3.311 ± 1.329
2.365ProHis: 2.365 ± 0.741
3.311ProIle: 3.311 ± 0.394
1.892ProLys: 1.892 ± 0.727
3.311ProLeu: 3.311 ± 2.293
0.946ProMet: 0.946 ± 0.748
3.311ProAsn: 3.311 ± 1.121
1.419ProPro: 1.419 ± 0.604
0.946ProGln: 0.946 ± 0.554
3.311ProArg: 3.311 ± 0.523
1.419ProSer: 1.419 ± 0.812
2.838ProThr: 2.838 ± 0.772
3.311ProVal: 3.311 ± 1.026
0.0ProTrp: 0.0 ± 0.0
0.946ProTyr: 0.946 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
3.784GlnAla: 3.784 ± 2.57
0.946GlnCys: 0.946 ± 0.554
1.419GlnAsp: 1.419 ± 0.604
0.0GlnGlu: 0.0 ± 0.0
0.946GlnPhe: 0.946 ± 0.363
1.419GlnGly: 1.419 ± 0.512
0.473GlnHis: 0.473 ± 0.277
0.473GlnIle: 0.473 ± 0.277
1.892GlnLys: 1.892 ± 1.108
4.73GlnLeu: 4.73 ± 1.932
0.946GlnMet: 0.946 ± 0.554
2.838GlnAsn: 2.838 ± 1.09
1.419GlnPro: 1.419 ± 1.071
1.419GlnGln: 1.419 ± 0.664
2.838GlnArg: 2.838 ± 0.447
1.419GlnSer: 1.419 ± 0.67
2.365GlnThr: 2.365 ± 0.849
0.473GlnVal: 0.473 ± 0.666
0.473GlnTrp: 0.473 ± 0.277
0.473GlnTyr: 0.473 ± 0.486
0.0GlnXaa: 0.0 ± 0.0
Arg
1.892ArgAla: 1.892 ± 1.108
1.892ArgCys: 1.892 ± 0.819
3.784ArgAsp: 3.784 ± 1.239
1.419ArgGlu: 1.419 ± 0.604
3.311ArgPhe: 3.311 ± 1.835
3.311ArgGly: 3.311 ± 0.781
0.946ArgHis: 0.946 ± 0.554
0.473ArgIle: 0.473 ± 0.665
4.73ArgLys: 4.73 ± 1.036
3.311ArgLeu: 3.311 ± 1.275
1.419ArgMet: 1.419 ± 0.426
5.203ArgAsn: 5.203 ± 1.166
0.946ArgPro: 0.946 ± 0.554
1.419ArgGln: 1.419 ± 0.426
3.311ArgArg: 3.311 ± 0.394
1.892ArgSer: 1.892 ± 0.746
4.257ArgThr: 4.257 ± 2.958
4.257ArgVal: 4.257 ± 0.29
0.473ArgTrp: 0.473 ± 0.666
2.365ArgTyr: 2.365 ± 0.773
0.0ArgXaa: 0.0 ± 0.0
Ser
4.73SerAla: 4.73 ± 1.848
1.892SerCys: 1.892 ± 0.818
4.257SerAsp: 4.257 ± 1.297
2.838SerGlu: 2.838 ± 0.416
2.838SerPhe: 2.838 ± 0.54
2.838SerGly: 2.838 ± 0.872
0.946SerHis: 0.946 ± 0.573
3.784SerIle: 3.784 ± 0.689
4.73SerLys: 4.73 ± 1.333
7.569SerLeu: 7.569 ± 2.983
0.473SerMet: 0.473 ± 0.486
2.365SerAsn: 2.365 ± 0.949
0.946SerPro: 0.946 ± 0.573
2.365SerGln: 2.365 ± 0.741
4.73SerArg: 4.73 ± 1.575
5.203SerSer: 5.203 ± 1.976
3.784SerThr: 3.784 ± 0.54
11.826SerVal: 11.826 ± 2.855
0.946SerTrp: 0.946 ± 0.604
0.946SerTyr: 0.946 ± 0.604
0.0SerXaa: 0.0 ± 0.0
Thr
3.784ThrAla: 3.784 ± 0.886
1.419ThrCys: 1.419 ± 0.823
2.365ThrAsp: 2.365 ± 0.849
4.257ThrGlu: 4.257 ± 1.277
6.623ThrPhe: 6.623 ± 1.801
3.784ThrGly: 3.784 ± 0.905
0.473ThrHis: 0.473 ± 0.277
3.784ThrIle: 3.784 ± 1.209
1.892ThrLys: 1.892 ± 1.208
5.203ThrLeu: 5.203 ± 0.472
0.473ThrMet: 0.473 ± 0.503
3.784ThrAsn: 3.784 ± 1.709
1.419ThrPro: 1.419 ± 0.426
4.257ThrGln: 4.257 ± 3.606
1.892ThrArg: 1.892 ± 1.288
4.73ThrSer: 4.73 ± 1.525
4.257ThrThr: 4.257 ± 0.694
7.569ThrVal: 7.569 ± 0.904
0.946ThrTrp: 0.946 ± 0.604
4.257ThrTyr: 4.257 ± 0.762
0.0ThrXaa: 0.0 ± 0.0
Val
5.676ValAla: 5.676 ± 2.417
0.946ValCys: 0.946 ± 0.573
10.88ValAsp: 10.88 ± 2.433
1.892ValGlu: 1.892 ± 0.749
2.838ValPhe: 2.838 ± 1.118
5.676ValGly: 5.676 ± 1.465
2.365ValHis: 2.365 ± 1.385
3.311ValIle: 3.311 ± 1.087
3.311ValLys: 3.311 ± 0.457
8.042ValLeu: 8.042 ± 4.575
0.946ValMet: 0.946 ± 0.554
5.676ValAsn: 5.676 ± 1.465
4.257ValPro: 4.257 ± 2.911
0.946ValGln: 0.946 ± 0.363
3.311ValArg: 3.311 ± 1.064
6.623ValSer: 6.623 ± 0.761
4.73ValThr: 4.73 ± 1.715
8.515ValVal: 8.515 ± 2.61
2.365ValTrp: 2.365 ± 0.741
4.257ValTyr: 4.257 ± 2.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.473TrpAla: 0.473 ± 0.486
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.419TrpGlu: 1.419 ± 1.071
2.365TrpPhe: 2.365 ± 0.627
0.946TrpGly: 0.946 ± 0.554
0.946TrpHis: 0.946 ± 0.973
0.473TrpIle: 0.473 ± 0.277
1.419TrpLys: 1.419 ± 0.426
1.419TrpLeu: 1.419 ± 0.426
0.0TrpMet: 0.0 ± 0.0
0.946TrpAsn: 0.946 ± 0.363
0.473TrpPro: 0.473 ± 0.277
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.473TrpSer: 0.473 ± 0.277
0.946TrpThr: 0.946 ± 0.604
1.419TrpVal: 1.419 ± 0.823
0.473TrpTrp: 0.473 ± 0.277
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.892TyrAla: 1.892 ± 0.62
0.0TyrCys: 0.0 ± 0.0
3.784TyrAsp: 3.784 ± 0.319
1.892TyrGlu: 1.892 ± 0.62
1.892TyrPhe: 1.892 ± 0.62
1.419TyrGly: 1.419 ± 1.045
0.946TyrHis: 0.946 ± 0.972
2.365TyrIle: 2.365 ± 1.244
3.784TyrLys: 3.784 ± 0.701
1.892TyrLeu: 1.892 ± 1.63
0.473TyrMet: 0.473 ± 0.277
2.365TyrAsn: 2.365 ± 0.949
2.838TyrPro: 2.838 ± 1.09
0.946TyrGln: 0.946 ± 0.554
1.419TyrArg: 1.419 ± 0.664
1.419TyrSer: 1.419 ± 0.512
1.419TyrThr: 1.419 ± 0.67
2.838TyrVal: 2.838 ± 0.872
0.0TyrTrp: 0.0 ± 0.0
1.419TyrTyr: 1.419 ± 0.426
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski