Amino acid dipepetide frequency for Halorubrum distributum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.514AlaAla: 14.514 ± 0.234	0.697AlaCys: 0.697 ± 0.037	10.528AlaAsp: 10.528 ± 0.174	9.24AlaGlu: 9.24 ± 0.158	4.019AlaPhe: 4.019 ± 0.096	9.997AlaGly: 9.997 ± 0.167	1.791AlaHis: 1.791 ± 0.06	4.461AlaIle: 4.461 ± 0.083	1.879AlaLys: 1.879 ± 0.059	10.181AlaLeu: 10.181 ± 0.166	2.103AlaMet: 2.103 ± 0.066	2.302AlaAsn: 2.302 ± 0.072	4.068AlaPro: 4.068 ± 0.099	2.02AlaGln: 2.02 ± 0.059	6.231AlaArg: 6.231 ± 0.1	5.274AlaSer: 5.274 ± 0.1	6.886AlaThr: 6.886 ± 0.113	11.345AlaVal: 11.345 ± 0.168	1.17AlaTrp: 1.17 ± 0.047	2.953AlaTyr: 2.953 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.599CysAla: 0.599 ± 0.035	0.094CysCys: 0.094 ± 0.014	0.582CysAsp: 0.582 ± 0.036	0.561CysGlu: 0.561 ± 0.035	0.191CysPhe: 0.191 ± 0.018	0.834CysGly: 0.834 ± 0.043	0.154CysHis: 0.154 ± 0.017	0.191CysIle: 0.191 ± 0.014	0.13CysLys: 0.13 ± 0.016	0.505CysLeu: 0.505 ± 0.029	0.09CysMet: 0.09 ± 0.015	0.193CysAsn: 0.193 ± 0.02	0.528CysPro: 0.528 ± 0.031	0.169CysGln: 0.169 ± 0.018	0.441CysArg: 0.441 ± 0.029	0.406CysSer: 0.406 ± 0.028	0.368CysThr: 0.368 ± 0.026	0.511CysVal: 0.511 ± 0.034	0.079CysTrp: 0.079 ± 0.014	0.199CysTyr: 0.199 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	11.351AspAla: 11.351 ± 0.202	0.588AspCys: 0.588 ± 0.035	8.625AspAsp: 8.625 ± 0.187	8.627AspGlu: 8.627 ± 0.152	1.973AspPhe: 1.973 ± 0.065	8.805AspGly: 8.805 ± 0.152	1.928AspHis: 1.928 ± 0.062	2.732AspIle: 2.732 ± 0.089	1.038AspLys: 1.038 ± 0.043	7.496AspLeu: 7.496 ± 0.144	1.228AspMet: 1.228 ± 0.049	1.295AspAsn: 1.295 ± 0.059	5.133AspPro: 5.133 ± 0.11	1.737AspGln: 1.737 ± 0.063	7.149AspArg: 7.149 ± 0.15	3.591AspSer: 3.591 ± 0.089	4.085AspThr: 4.085 ± 0.081	7.65AspVal: 7.65 ± 0.132	0.984AspTrp: 0.984 ± 0.047	1.752AspTyr: 1.752 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	9.451GluAla: 9.451 ± 0.154	0.544GluCys: 0.544 ± 0.036	5.458GluAsp: 5.458 ± 0.12	7.119GluGlu: 7.119 ± 0.141	3.09GluPhe: 3.09 ± 0.09	5.846GluGly: 5.846 ± 0.113	1.738GluHis: 1.738 ± 0.062	3.892GluIle: 3.892 ± 0.083	1.898GluLys: 1.898 ± 0.073	7.303GluLeu: 7.303 ± 0.14	1.825GluMet: 1.825 ± 0.057	2.255GluAsn: 2.255 ± 0.068	4.172GluPro: 4.172 ± 0.102	2.279GluGln: 2.279 ± 0.075	7.645GluArg: 7.645 ± 0.152	5.315GluSer: 5.315 ± 0.104	6.308GluThr: 6.308 ± 0.113	6.041GluVal: 6.041 ± 0.114	1.134GluTrp: 1.134 ± 0.045	2.735GluTyr: 2.735 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	3.768PheAla: 3.768 ± 0.097	0.253PheCys: 0.253 ± 0.022	3.376PheAsp: 3.376 ± 0.083	3.115PheGlu: 3.115 ± 0.087	1.074PhePhe: 1.074 ± 0.049	3.229PheGly: 3.229 ± 0.076	0.655PheHis: 0.655 ± 0.038	1.049PheIle: 1.049 ± 0.053	0.503PheLys: 0.503 ± 0.032	2.878PheLeu: 2.878 ± 0.099	0.49PheMet: 0.49 ± 0.032	0.796PheAsn: 0.796 ± 0.047	1.342PhePro: 1.342 ± 0.05	0.837PheGln: 0.837 ± 0.038	1.962PheArg: 1.962 ± 0.064	1.667PheSer: 1.667 ± 0.06	1.917PheThr: 1.917 ± 0.057	3.18PheVal: 3.18 ± 0.081	0.441PheTrp: 0.441 ± 0.029	0.85PheTyr: 0.85 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	8.339GlyAla: 8.339 ± 0.149	0.681GlyCys: 0.681 ± 0.037	7.772GlyAsp: 7.772 ± 0.156	7.62GlyGlu: 7.62 ± 0.142	3.193GlyPhe: 3.193 ± 0.081	7.93GlyGly: 7.93 ± 0.17	1.601GlyHis: 1.601 ± 0.06	4.153GlyIle: 4.153 ± 0.095	1.872GlyLys: 1.872 ± 0.05	7.164GlyLeu: 7.164 ± 0.132	1.639GlyMet: 1.639 ± 0.057	1.913GlyAsn: 1.913 ± 0.077	3.612GlyPro: 3.612 ± 0.094	1.881GlyGln: 1.881 ± 0.063	5.097GlyArg: 5.097 ± 0.108	5.27GlySer: 5.27 ± 0.104	5.418GlyThr: 5.418 ± 0.105	7.936GlyVal: 7.936 ± 0.127	1.126GlyTrp: 1.126 ± 0.049	2.709GlyTyr: 2.709 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	2.007HisAla: 2.007 ± 0.057	0.18HisCys: 0.18 ± 0.017	1.697HisAsp: 1.697 ± 0.055	1.631HisGlu: 1.631 ± 0.055	0.597HisPhe: 0.597 ± 0.034	1.926HisGly: 1.926 ± 0.063	0.467HisHis: 0.467 ± 0.03	0.574HisIle: 0.574 ± 0.032	0.31HisLys: 0.31 ± 0.022	1.613HisLeu: 1.613 ± 0.059	0.293HisMet: 0.293 ± 0.027	0.451HisAsn: 0.451 ± 0.027	1.237HisPro: 1.237 ± 0.051	0.436HisGln: 0.436 ± 0.027	1.367HisArg: 1.367 ± 0.056	0.847HisSer: 0.847 ± 0.041	1.07HisThr: 1.07 ± 0.05	1.716HisVal: 1.716 ± 0.061	0.225HisTrp: 0.225 ± 0.019	0.578HisTyr: 0.578 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	4.861IleAla: 4.861 ± 0.091	0.28IleCys: 0.28 ± 0.024	4.033IleAsp: 4.033 ± 0.1	4.155IleGlu: 4.155 ± 0.1	0.986IlePhe: 0.986 ± 0.053	3.796IleGly: 3.796 ± 0.089	0.826IleHis: 0.826 ± 0.041	1.325IleIle: 1.325 ± 0.052	0.721IleLys: 0.721 ± 0.039	2.923IleLeu: 2.923 ± 0.098	0.49IleMet: 0.49 ± 0.029	1.003IleAsn: 1.003 ± 0.05	2.058IlePro: 2.058 ± 0.062	1.087IleGln: 1.087 ± 0.044	2.542IleArg: 2.542 ± 0.07	2.033IleSer: 2.033 ± 0.071	2.215IleThr: 2.215 ± 0.057	3.436IleVal: 3.436 ± 0.082	0.302IleTrp: 0.302 ± 0.024	0.822IleTyr: 0.822 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	1.874LysAla: 1.874 ± 0.065	0.126LysCys: 0.126 ± 0.015	1.004LysAsp: 1.004 ± 0.05	1.498LysGlu: 1.498 ± 0.06	0.561LysPhe: 0.561 ± 0.034	1.453LysGly: 1.453 ± 0.055	0.454LysHis: 0.454 ± 0.033	0.779LysIle: 0.779 ± 0.036	0.552LysLys: 0.552 ± 0.039	1.669LysLeu: 1.669 ± 0.057	0.404LysMet: 0.404 ± 0.029	0.599LysAsn: 0.599 ± 0.033	0.997LysPro: 0.997 ± 0.044	0.807LysGln: 0.807 ± 0.041	1.735LysArg: 1.735 ± 0.059	1.19LysSer: 1.19 ± 0.054	1.265LysThr: 1.265 ± 0.058	1.185LysVal: 1.185 ± 0.053	0.289LysTrp: 0.289 ± 0.024	0.638LysTyr: 0.638 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.587LeuAla: 10.587 ± 0.179	0.514LeuCys: 0.514 ± 0.029	7.836LeuAsp: 7.836 ± 0.124	5.752LeuGlu: 5.752 ± 0.108	3.062LeuPhe: 3.062 ± 0.109	7.519LeuGly: 7.519 ± 0.124	1.387LeuHis: 1.387 ± 0.045	3.261LeuIle: 3.261 ± 0.087	1.78LeuLys: 1.78 ± 0.065	8.144LeuLeu: 8.144 ± 0.158	1.247LeuMet: 1.247 ± 0.05	1.909LeuAsn: 1.909 ± 0.051	4.168LeuPro: 4.168 ± 0.092	1.934LeuGln: 1.934 ± 0.065	6.021LeuArg: 6.021 ± 0.117	5.563LeuSer: 5.563 ± 0.108	5.101LeuThr: 5.101 ± 0.093	7.782LeuVal: 7.782 ± 0.15	0.839LeuTrp: 0.839 ± 0.036	2.305LeuTyr: 2.305 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.802MetAla: 1.802 ± 0.053	0.098MetCys: 0.098 ± 0.012	1.263MetAsp: 1.263 ± 0.048	1.14MetGlu: 1.14 ± 0.043	0.49MetPhe: 0.49 ± 0.03	1.346MetGly: 1.346 ± 0.048	0.244MetHis: 0.244 ± 0.025	0.666MetIle: 0.666 ± 0.042	0.475MetLys: 0.475 ± 0.031	1.468MetLeu: 1.468 ± 0.058	0.325MetMet: 0.325 ± 0.029	0.597MetAsn: 0.597 ± 0.034	0.773MetPro: 0.773 ± 0.034	0.374MetGln: 0.374 ± 0.03	1.098MetArg: 1.098 ± 0.047	1.558MetSer: 1.558 ± 0.054	1.474MetThr: 1.474 ± 0.048	1.275MetVal: 1.275 ± 0.049	0.173MetTrp: 0.173 ± 0.018	0.484MetTyr: 0.484 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.617AsnAla: 2.617 ± 0.067	0.197AsnCys: 0.197 ± 0.021	1.727AsnAsp: 1.727 ± 0.063	1.765AsnGlu: 1.765 ± 0.062	0.665AsnPhe: 0.665 ± 0.038	1.981AsnGly: 1.981 ± 0.066	0.49AsnHis: 0.49 ± 0.029	0.933AsnIle: 0.933 ± 0.052	0.481AsnLys: 0.481 ± 0.034	1.979AsnLeu: 1.979 ± 0.061	0.404AsnMet: 0.404 ± 0.027	0.567AsnAsn: 0.567 ± 0.037	1.601AsnPro: 1.601 ± 0.058	0.695AsnGln: 0.695 ± 0.038	1.521AsnArg: 1.521 ± 0.058	1.019AsnSer: 1.019 ± 0.045	1.288AsnThr: 1.288 ± 0.049	2.33AsnVal: 2.33 ± 0.062	0.304AsnTrp: 0.304 ± 0.025	0.715AsnTyr: 0.715 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.791ProAla: 4.791 ± 0.102	0.225ProCys: 0.225 ± 0.022	5.345ProAsp: 5.345 ± 0.117	4.802ProGlu: 4.802 ± 0.105	1.601ProPhe: 1.601 ± 0.062	3.8ProGly: 3.8 ± 0.089	0.956ProHis: 0.956 ± 0.044	1.896ProIle: 1.896 ± 0.074	0.912ProLys: 0.912 ± 0.043	3.567ProLeu: 3.567 ± 0.085	0.77ProMet: 0.77 ± 0.039	1.188ProAsn: 1.188 ± 0.043	2.247ProPro: 2.247 ± 0.066	0.982ProGln: 0.982 ± 0.051	2.448ProArg: 2.448 ± 0.066	2.797ProSer: 2.797 ± 0.081	2.957ProThr: 2.957 ± 0.076	4.29ProVal: 4.29 ± 0.088	0.498ProTrp: 0.498 ± 0.031	1.183ProTyr: 1.183 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	2.197GlnAla: 2.197 ± 0.064	0.158GlnCys: 0.158 ± 0.018	1.241GlnAsp: 1.241 ± 0.052	1.778GlnGlu: 1.778 ± 0.073	1.019GlnPhe: 1.019 ± 0.047	1.515GlnGly: 1.515 ± 0.05	0.498GlnHis: 0.498 ± 0.033	1.138GlnIle: 1.138 ± 0.05	0.627GlnLys: 0.627 ± 0.036	2.251GlnLeu: 2.251 ± 0.06	0.576GlnMet: 0.576 ± 0.032	0.736GlnAsn: 0.736 ± 0.038	0.989GlnPro: 0.989 ± 0.042	0.927GlnGln: 0.927 ± 0.052	1.928GlnArg: 1.928 ± 0.056	1.504GlnSer: 1.504 ± 0.054	1.549GlnThr: 1.549 ± 0.056	1.678GlnVal: 1.678 ± 0.054	0.314GlnTrp: 0.314 ± 0.029	0.749GlnTyr: 0.749 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	6.509ArgAla: 6.509 ± 0.106	0.462ArgCys: 0.462 ± 0.029	5.506ArgAsp: 5.506 ± 0.115	7.134ArgGlu: 7.134 ± 0.114	2.549ArgPhe: 2.549 ± 0.083	4.864ArgGly: 4.864 ± 0.098	1.284ArgHis: 1.284 ± 0.045	3.036ArgIle: 3.036 ± 0.085	1.386ArgLys: 1.386 ± 0.053	6.28ArgLeu: 6.28 ± 0.113	1.245ArgMet: 1.245 ± 0.051	1.712ArgAsn: 1.712 ± 0.061	2.632ArgPro: 2.632 ± 0.067	1.703ArgGln: 1.703 ± 0.053	5.084ArgArg: 5.084 ± 0.13	3.605ArgSer: 3.605 ± 0.089	4.023ArgThr: 4.023 ± 0.1	5.728ArgVal: 5.728 ± 0.114	0.785ArgTrp: 0.785 ± 0.036	1.913ArgTyr: 1.913 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	5.272SerAla: 5.272 ± 0.095	0.332SerCys: 0.332 ± 0.028	4.723SerAsp: 4.723 ± 0.108	4.333SerGlu: 4.333 ± 0.09	1.921SerPhe: 1.921 ± 0.068	5.416SerGly: 5.416 ± 0.099	0.946SerHis: 0.946 ± 0.044	2.493SerIle: 2.493 ± 0.069	1.217SerLys: 1.217 ± 0.05	4.814SerLeu: 4.814 ± 0.1	1.034SerMet: 1.034 ± 0.041	1.312SerAsn: 1.312 ± 0.054	2.643SerPro: 2.643 ± 0.067	1.363SerGln: 1.363 ± 0.058	3.302SerArg: 3.302 ± 0.084	2.805SerSer: 2.805 ± 0.094	3.349SerThr: 3.349 ± 0.078	4.909SerVal: 4.909 ± 0.105	0.623SerTrp: 0.623 ± 0.033	1.446SerTyr: 1.446 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	6.742ThrAla: 6.742 ± 0.118	0.385ThrCys: 0.385 ± 0.028	5.381ThrAsp: 5.381 ± 0.106	4.568ThrGlu: 4.568 ± 0.101	2.18ThrPhe: 2.18 ± 0.062	5.694ThrGly: 5.694 ± 0.109	1.271ThrHis: 1.271 ± 0.054	2.591ThrIle: 2.591 ± 0.076	1.055ThrLys: 1.055 ± 0.052	5.508ThrLeu: 5.508 ± 0.109	0.972ThrMet: 0.972 ± 0.045	1.44ThrAsn: 1.44 ± 0.054	3.124ThrPro: 3.124 ± 0.08	1.314ThrGln: 1.314 ± 0.052	3.287ThrArg: 3.287 ± 0.089	2.855ThrSer: 2.855 ± 0.071	4.07ThrThr: 4.07 ± 0.103	6.817ThrVal: 6.817 ± 0.118	0.659ThrTrp: 0.659 ± 0.034	1.611ThrTyr: 1.611 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	10.575ValAla: 10.575 ± 0.162	0.666ValCys: 0.666 ± 0.033	8.259ValAsp: 8.259 ± 0.14	7.911ValGlu: 7.911 ± 0.135	2.963ValPhe: 2.963 ± 0.082	7.712ValGly: 7.712 ± 0.143	1.661ValHis: 1.661 ± 0.058	3.434ValIle: 3.434 ± 0.085	1.436ValLys: 1.436 ± 0.054	7.316ValLeu: 7.316 ± 0.145	1.348ValMet: 1.348 ± 0.048	2.005ValAsn: 2.005 ± 0.062	4.19ValPro: 4.19 ± 0.075	1.742ValGln: 1.742 ± 0.06	5.694ValArg: 5.694 ± 0.105	5.125ValSer: 5.125 ± 0.117	5.925ValThr: 5.925 ± 0.093	8.752ValVal: 8.752 ± 0.163	0.896ValTrp: 0.896 ± 0.041	2.146ValTyr: 2.146 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.967TrpAla: 0.967 ± 0.044	0.131TrpCys: 0.131 ± 0.017	0.755TrpAsp: 0.755 ± 0.043	0.847TrpGlu: 0.847 ± 0.043	0.409TrpPhe: 0.409 ± 0.027	0.903TrpGly: 0.903 ± 0.038	0.25TrpHis: 0.25 ± 0.023	0.539TrpIle: 0.539 ± 0.031	0.304TrpLys: 0.304 ± 0.029	1.132TrpLeu: 1.132 ± 0.046	0.237TrpMet: 0.237 ± 0.022	0.353TrpAsn: 0.353 ± 0.028	0.424TrpPro: 0.424 ± 0.027	0.332TrpGln: 0.332 ± 0.025	0.899TrpArg: 0.899 ± 0.041	0.646TrpSer: 0.646 ± 0.038	0.745TrpThr: 0.745 ± 0.039	0.909TrpVal: 0.909 ± 0.044	0.207TrpTrp: 0.207 ± 0.022	0.398TrpTyr: 0.398 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.839TyrAla: 2.839 ± 0.07	0.212TyrCys: 0.212 ± 0.022	2.655TyrAsp: 2.655 ± 0.084	2.452TyrGlu: 2.452 ± 0.066	0.839TyrPhe: 0.839 ± 0.037	2.362TyrGly: 2.362 ± 0.065	0.62TyrHis: 0.62 ± 0.033	0.751TyrIle: 0.751 ± 0.033	0.505TyrLys: 0.505 ± 0.037	2.518TyrLeu: 2.518 ± 0.077	0.406TyrMet: 0.406 ± 0.03	0.651TyrAsn: 0.651 ± 0.042	1.316TyrPro: 1.316 ± 0.056	0.753TyrGln: 0.753 ± 0.042	1.988TyrArg: 1.988 ± 0.058	1.185TyrSer: 1.185 ± 0.047	1.509TyrThr: 1.509 ± 0.056	2.289TyrVal: 2.289 ± 0.064	0.34TyrTrp: 0.34 ± 0.029	0.911TyrTyr: 0.911 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2492 proteins (532659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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