Amino acid dipepetide frequency for Amanita thiersii Skay4041

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.951AlaAla: 6.951 ± 0.058
1.011AlaCys: 1.011 ± 0.016
3.434AlaAsp: 3.434 ± 0.031
4.146AlaGlu: 4.146 ± 0.034
3.043AlaPhe: 3.043 ± 0.028
4.896AlaGly: 4.896 ± 0.037
1.742AlaHis: 1.742 ± 0.021
4.263AlaIle: 4.263 ± 0.03
3.573AlaLys: 3.573 ± 0.032
7.43AlaLeu: 7.43 ± 0.049
1.807AlaMet: 1.807 ± 0.02
2.77AlaAsn: 2.77 ± 0.028
4.049AlaPro: 4.049 ± 0.036
3.083AlaGln: 3.083 ± 0.028
4.405AlaArg: 4.405 ± 0.036
6.759AlaSer: 6.759 ± 0.044
4.943AlaThr: 4.943 ± 0.041
4.847AlaVal: 4.847 ± 0.033
1.051AlaTrp: 1.051 ± 0.016
2.112AlaTyr: 2.112 ± 0.024
0.0AlaXaa: 0.0 ± 0.0
Cys
0.866CysAla: 0.866 ± 0.015
0.251CysCys: 0.251 ± 0.008
0.614CysAsp: 0.614 ± 0.012
0.599CysGlu: 0.599 ± 0.012
0.551CysPhe: 0.551 ± 0.012
0.902CysGly: 0.902 ± 0.019
0.345CysHis: 0.345 ± 0.009
0.746CysIle: 0.746 ± 0.013
0.516CysLys: 0.516 ± 0.011
1.281CysLeu: 1.281 ± 0.02
0.337CysMet: 0.337 ± 0.009
0.463CysAsn: 0.463 ± 0.012
0.71CysPro: 0.71 ± 0.014
0.452CysGln: 0.452 ± 0.012
0.716CysArg: 0.716 ± 0.012
0.973CysSer: 0.973 ± 0.016
0.739CysThr: 0.739 ± 0.015
0.768CysVal: 0.768 ± 0.013
0.2CysTrp: 0.2 ± 0.007
0.435CysTyr: 0.435 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
4.041AspAla: 4.041 ± 0.032
0.591AspCys: 0.591 ± 0.014
3.833AspAsp: 3.833 ± 0.043
4.082AspGlu: 4.082 ± 0.041
1.993AspPhe: 1.993 ± 0.022
3.687AspGly: 3.687 ± 0.029
1.244AspHis: 1.244 ± 0.02
3.233AspIle: 3.233 ± 0.028
2.454AspLys: 2.454 ± 0.026
4.752AspLeu: 4.752 ± 0.034
1.206AspMet: 1.206 ± 0.017
2.001AspAsn: 2.001 ± 0.023
3.318AspPro: 3.318 ± 0.027
1.721AspGln: 1.721 ± 0.023
2.688AspArg: 2.688 ± 0.034
3.984AspSer: 3.984 ± 0.033
2.985AspThr: 2.985 ± 0.028
3.674AspVal: 3.674 ± 0.029
0.884AspTrp: 0.884 ± 0.015
1.562AspTyr: 1.562 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
4.508GluAla: 4.508 ± 0.041
0.649GluCys: 0.649 ± 0.011
3.71GluAsp: 3.71 ± 0.035
5.251GluGlu: 5.251 ± 0.049
1.943GluPhe: 1.943 ± 0.023
3.498GluGly: 3.498 ± 0.035
1.41GluHis: 1.41 ± 0.02
3.019GluIle: 3.019 ± 0.026
3.316GluLys: 3.316 ± 0.033
5.322GluLeu: 5.322 ± 0.035
1.387GluMet: 1.387 ± 0.016
2.056GluAsn: 2.056 ± 0.022
2.485GluPro: 2.485 ± 0.027
2.274GluGln: 2.274 ± 0.027
3.912GluArg: 3.912 ± 0.044
3.989GluSer: 3.989 ± 0.031
3.086GluThr: 3.086 ± 0.031
3.534GluVal: 3.534 ± 0.032
0.839GluTrp: 0.839 ± 0.016
1.652GluTyr: 1.652 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.861PheAla: 2.861 ± 0.026
0.536PheCys: 0.536 ± 0.01
2.189PheAsp: 2.189 ± 0.022
1.983PheGlu: 1.983 ± 0.027
1.638PhePhe: 1.638 ± 0.022
2.704PheGly: 2.704 ± 0.029
0.912PheHis: 0.912 ± 0.017
2.061PheIle: 2.061 ± 0.025
1.691PheLys: 1.691 ± 0.02
3.671PheLeu: 3.671 ± 0.034
0.831PheMet: 0.831 ± 0.014
1.534PheAsn: 1.534 ± 0.021
2.053PhePro: 2.053 ± 0.024
1.344PheGln: 1.344 ± 0.018
1.908PheArg: 1.908 ± 0.022
3.31PheSer: 3.31 ± 0.029
2.278PheThr: 2.278 ± 0.025
2.501PheVal: 2.501 ± 0.026
0.583PheTrp: 0.583 ± 0.012
1.12PheTyr: 1.12 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
4.476GlyAla: 4.476 ± 0.041
0.809GlyCys: 0.809 ± 0.014
3.261GlyAsp: 3.261 ± 0.027
3.279GlyGlu: 3.279 ± 0.034
2.545GlyPhe: 2.545 ± 0.028
5.532GlyGly: 5.532 ± 0.065
1.654GlyHis: 1.654 ± 0.02
3.482GlyIle: 3.482 ± 0.031
3.337GlyLys: 3.337 ± 0.035
5.492GlyLeu: 5.492 ± 0.043
1.495GlyMet: 1.495 ± 0.024
2.527GlyAsn: 2.527 ± 0.026
3.01GlyPro: 3.01 ± 0.029
2.353GlyGln: 2.353 ± 0.025
3.823GlyArg: 3.823 ± 0.038
5.678GlySer: 5.678 ± 0.046
3.987GlyThr: 3.987 ± 0.034
4.291GlyVal: 4.291 ± 0.033
1.076GlyTrp: 1.076 ± 0.018
1.93GlyTyr: 1.93 ± 0.024
0.0GlyXaa: 0.0 ± 0.0
His
1.844HisAla: 1.844 ± 0.022
0.335HisCys: 0.335 ± 0.01
1.339HisAsp: 1.339 ± 0.019
1.357HisGlu: 1.357 ± 0.019
0.998HisPhe: 0.998 ± 0.015
1.599HisGly: 1.599 ± 0.022
1.049HisHis: 1.049 ± 0.024
1.451HisIle: 1.451 ± 0.02
1.034HisLys: 1.034 ± 0.018
2.526HisLeu: 2.526 ± 0.031
0.54HisMet: 0.54 ± 0.012
0.946HisAsn: 0.946 ± 0.016
1.917HisPro: 1.917 ± 0.026
1.053HisGln: 1.053 ± 0.018
1.551HisArg: 1.551 ± 0.02
2.202HisSer: 2.202 ± 0.026
1.471HisThr: 1.471 ± 0.02
1.655HisVal: 1.655 ± 0.017
0.337HisTrp: 0.337 ± 0.009
0.791HisTyr: 0.791 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
4.09IleAla: 4.09 ± 0.032
0.779IleCys: 0.779 ± 0.014
2.925IleAsp: 2.925 ± 0.024
2.905IleGlu: 2.905 ± 0.024
2.031IlePhe: 2.031 ± 0.024
3.126IleGly: 3.126 ± 0.033
1.449IleHis: 1.449 ± 0.017
2.857IleIle: 2.857 ± 0.028
2.524IleLys: 2.524 ± 0.029
5.021IleLeu: 5.021 ± 0.039
1.071IleMet: 1.071 ± 0.016
2.072IleAsn: 2.072 ± 0.02
3.47IlePro: 3.47 ± 0.032
2.211IleGln: 2.211 ± 0.027
3.073IleArg: 3.073 ± 0.029
4.414IleSer: 4.414 ± 0.035
3.295IleThr: 3.295 ± 0.031
3.4IleVal: 3.4 ± 0.034
0.785IleTrp: 0.785 ± 0.014
1.568IleTyr: 1.568 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.805LysAla: 3.805 ± 0.036
0.563LysCys: 0.563 ± 0.012
2.727LysAsp: 2.727 ± 0.029
3.317LysGlu: 3.317 ± 0.032
1.542LysPhe: 1.542 ± 0.017
2.973LysGly: 2.973 ± 0.029
1.2LysHis: 1.2 ± 0.018
2.333LysIle: 2.333 ± 0.026
3.283LysLys: 3.283 ± 0.037
4.247LysLeu: 4.247 ± 0.033
1.011LysMet: 1.011 ± 0.015
1.766LysAsn: 1.766 ± 0.024
2.571LysPro: 2.571 ± 0.028
2.081LysGln: 2.081 ± 0.023
3.521LysArg: 3.521 ± 0.035
3.439LysSer: 3.439 ± 0.033
2.629LysThr: 2.629 ± 0.023
2.926LysVal: 2.926 ± 0.031
0.786LysTrp: 0.786 ± 0.015
1.424LysTyr: 1.424 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
7.37LeuAla: 7.37 ± 0.048
1.231LeuCys: 1.231 ± 0.017
5.266LeuAsp: 5.266 ± 0.038
5.366LeuGlu: 5.366 ± 0.041
3.689LeuPhe: 3.689 ± 0.034
5.55LeuGly: 5.55 ± 0.039
2.544LeuHis: 2.544 ± 0.024
4.445LeuIle: 4.445 ± 0.034
4.335LeuLys: 4.335 ± 0.031
9.183LeuLeu: 9.183 ± 0.067
1.794LeuMet: 1.794 ± 0.024
3.572LeuAsn: 3.572 ± 0.028
6.067LeuPro: 6.067 ± 0.042
3.896LeuGln: 3.896 ± 0.035
5.676LeuArg: 5.676 ± 0.04
8.25LeuSer: 8.25 ± 0.056
5.361LeuThr: 5.361 ± 0.04
5.756LeuVal: 5.756 ± 0.041
1.155LeuTrp: 1.155 ± 0.016
2.613LeuTyr: 2.613 ± 0.028
0.0LeuXaa: 0.0 ± 0.0
Met
1.912MetAla: 1.912 ± 0.026
0.23MetCys: 0.23 ± 0.008
1.264MetAsp: 1.264 ± 0.017
1.231MetGlu: 1.231 ± 0.017
0.788MetPhe: 0.788 ± 0.013
1.305MetGly: 1.305 ± 0.019
0.526MetHis: 0.526 ± 0.013
1.058MetIle: 1.058 ± 0.018
1.088MetLys: 1.088 ± 0.017
1.838MetLeu: 1.838 ± 0.023
0.554MetMet: 0.554 ± 0.013
0.865MetAsn: 0.865 ± 0.015
1.185MetPro: 1.185 ± 0.018
0.934MetGln: 0.934 ± 0.017
1.271MetArg: 1.271 ± 0.018
2.006MetSer: 2.006 ± 0.02
1.376MetThr: 1.376 ± 0.02
1.328MetVal: 1.328 ± 0.019
0.269MetTrp: 0.269 ± 0.009
0.553MetTyr: 0.553 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.112AsnAla: 3.112 ± 0.024
0.493AsnCys: 0.493 ± 0.012
2.007AsnAsp: 2.007 ± 0.023
2.103AsnGlu: 2.103 ± 0.023
1.369AsnPhe: 1.369 ± 0.017
2.824AsnGly: 2.824 ± 0.029
1.0AsnHis: 1.0 ± 0.015
2.217AsnIle: 2.217 ± 0.025
1.838AsnLys: 1.838 ± 0.026
3.418AsnLeu: 3.418 ± 0.029
0.805AsnMet: 0.805 ± 0.013
1.756AsnAsn: 1.756 ± 0.023
2.487AsnPro: 2.487 ± 0.025
1.511AsnGln: 1.511 ± 0.029
1.968AsnArg: 1.968 ± 0.023
3.059AsnSer: 3.059 ± 0.035
2.508AsnThr: 2.508 ± 0.025
2.587AsnVal: 2.587 ± 0.025
0.579AsnTrp: 0.579 ± 0.013
1.053AsnTyr: 1.053 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
4.286ProAla: 4.286 ± 0.036
0.535ProCys: 0.535 ± 0.013
3.103ProAsp: 3.103 ± 0.029
3.341ProGlu: 3.341 ± 0.032
2.205ProPhe: 2.205 ± 0.025
3.492ProGly: 3.492 ± 0.027
1.602ProHis: 1.602 ± 0.021
3.002ProIle: 3.002 ± 0.028
2.527ProLys: 2.527 ± 0.026
5.435ProLeu: 5.435 ± 0.036
1.049ProMet: 1.049 ± 0.016
2.493ProAsn: 2.493 ± 0.028
6.06ProPro: 6.06 ± 0.078
2.483ProGln: 2.483 ± 0.033
3.222ProArg: 3.222 ± 0.034
6.866ProSer: 6.866 ± 0.054
4.365ProThr: 4.365 ± 0.041
3.726ProVal: 3.726 ± 0.035
0.671ProTrp: 0.671 ± 0.012
1.566ProTyr: 1.566 ± 0.02
0.0ProXaa: 0.0 ± 0.0
Gln
3.189GlnAla: 3.189 ± 0.033
0.495GlnCys: 0.495 ± 0.012
2.004GlnAsp: 2.004 ± 0.023
2.387GlnGlu: 2.387 ± 0.026
1.301GlnPhe: 1.301 ± 0.018
2.338GlnGly: 2.338 ± 0.025
1.167GlnHis: 1.167 ± 0.019
2.009GlnIle: 2.009 ± 0.019
1.858GlnLys: 1.858 ± 0.02
3.695GlnLeu: 3.695 ± 0.035
0.877GlnMet: 0.877 ± 0.014
1.582GlnAsn: 1.582 ± 0.027
2.462GlnPro: 2.462 ± 0.03
2.67GlnGln: 2.67 ± 0.055
2.571GlnArg: 2.571 ± 0.026
3.258GlnSer: 3.258 ± 0.032
2.454GlnThr: 2.454 ± 0.028
2.416GlnVal: 2.416 ± 0.024
0.608GlnTrp: 0.608 ± 0.012
1.142GlnTyr: 1.142 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
4.266ArgAla: 4.266 ± 0.037
0.751ArgCys: 0.751 ± 0.015
3.122ArgAsp: 3.122 ± 0.035
3.649ArgGlu: 3.649 ± 0.035
2.125ArgPhe: 2.125 ± 0.024
3.391ArgGly: 3.391 ± 0.033
1.536ArgHis: 1.536 ± 0.02
3.147ArgIle: 3.147 ± 0.027
3.384ArgLys: 3.384 ± 0.03
5.574ArgLeu: 5.574 ± 0.041
1.363ArgMet: 1.363 ± 0.015
2.256ArgAsn: 2.256 ± 0.023
3.287ArgPro: 3.287 ± 0.034
2.478ArgGln: 2.478 ± 0.025
4.8ArgArg: 4.8 ± 0.043
4.952ArgSer: 4.952 ± 0.041
3.388ArgThr: 3.388 ± 0.031
3.514ArgVal: 3.514 ± 0.031
0.861ArgTrp: 0.861 ± 0.016
1.665ArgTyr: 1.665 ± 0.021
0.0ArgXaa: 0.0 ± 0.0
Ser
6.313SerAla: 6.313 ± 0.044
0.987SerCys: 0.987 ± 0.017
4.168SerAsp: 4.168 ± 0.034
3.914SerGlu: 3.914 ± 0.035
3.257SerPhe: 3.257 ± 0.032
5.592SerGly: 5.592 ± 0.041
2.24SerHis: 2.24 ± 0.023
4.441SerIle: 4.441 ± 0.034
3.677SerLys: 3.677 ± 0.029
8.219SerLeu: 8.219 ± 0.048
1.829SerMet: 1.829 ± 0.021
3.346SerAsn: 3.346 ± 0.032
6.267SerPro: 6.267 ± 0.06
3.427SerGln: 3.427 ± 0.035
5.089SerArg: 5.089 ± 0.048
10.14SerSer: 10.14 ± 0.09
6.322SerThr: 6.322 ± 0.048
4.954SerVal: 4.954 ± 0.038
1.074SerTrp: 1.074 ± 0.017
2.155SerTyr: 2.155 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
4.648ThrAla: 4.648 ± 0.035
0.803ThrCys: 0.803 ± 0.015
2.748ThrAsp: 2.748 ± 0.03
2.936ThrGlu: 2.936 ± 0.029
2.481ThrPhe: 2.481 ± 0.027
4.042ThrGly: 4.042 ± 0.035
1.563ThrHis: 1.563 ± 0.021
3.498ThrIle: 3.498 ± 0.028
2.641ThrLys: 2.641 ± 0.028
6.02ThrLeu: 6.02 ± 0.037
1.237ThrMet: 1.237 ± 0.016
2.393ThrAsn: 2.393 ± 0.023
4.653ThrPro: 4.653 ± 0.047
2.286ThrGln: 2.286 ± 0.024
3.359ThrArg: 3.359 ± 0.026
5.954ThrSer: 5.954 ± 0.043
4.902ThrThr: 4.902 ± 0.056
3.815ThrVal: 3.815 ± 0.03
0.856ThrTrp: 0.856 ± 0.014
1.682ThrTyr: 1.682 ± 0.023
0.0ThrXaa: 0.0 ± 0.0
Val
4.745ValAla: 4.745 ± 0.036
0.815ValCys: 0.815 ± 0.014
3.602ValAsp: 3.602 ± 0.032
3.655ValGlu: 3.655 ± 0.029
2.503ValPhe: 2.503 ± 0.027
3.876ValGly: 3.876 ± 0.034
1.611ValHis: 1.611 ± 0.02
3.435ValIle: 3.435 ± 0.035
3.032ValLys: 3.032 ± 0.029
5.943ValLeu: 5.943 ± 0.045
1.384ValMet: 1.384 ± 0.019
2.447ValAsn: 2.447 ± 0.022
3.824ValPro: 3.824 ± 0.032
2.588ValGln: 2.588 ± 0.025
3.334ValArg: 3.334 ± 0.029
4.895ValSer: 4.895 ± 0.036
3.801ValThr: 3.801 ± 0.032
4.517ValVal: 4.517 ± 0.034
0.869ValTrp: 0.869 ± 0.017
1.856ValTyr: 1.856 ± 0.019
0.0ValXaa: 0.0 ± 0.0
Trp
0.956TrpAla: 0.956 ± 0.016
0.201TrpCys: 0.201 ± 0.007
0.909TrpAsp: 0.909 ± 0.017
0.852TrpGlu: 0.852 ± 0.015
0.559TrpPhe: 0.559 ± 0.011
0.837TrpGly: 0.837 ± 0.014
0.35TrpHis: 0.35 ± 0.01
0.768TrpIle: 0.768 ± 0.014
0.832TrpLys: 0.832 ± 0.014
1.305TrpLeu: 1.305 ± 0.021
0.331TrpMet: 0.331 ± 0.008
0.643TrpAsn: 0.643 ± 0.013
0.549TrpPro: 0.549 ± 0.011
0.503TrpGln: 0.503 ± 0.011
1.011TrpArg: 1.011 ± 0.017
1.117TrpSer: 1.117 ± 0.017
0.879TrpThr: 0.879 ± 0.013
0.841TrpVal: 0.841 ± 0.013
0.263TrpTrp: 0.263 ± 0.008
0.45TrpTyr: 0.45 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.079TyrAla: 2.079 ± 0.022
0.402TyrCys: 0.402 ± 0.009
1.706TyrAsp: 1.706 ± 0.021
1.487TyrGlu: 1.487 ± 0.017
1.148TyrPhe: 1.148 ± 0.016
1.871TyrGly: 1.871 ± 0.025
0.851TyrHis: 0.851 ± 0.013
1.602TyrIle: 1.602 ± 0.018
1.202TyrLys: 1.202 ± 0.018
2.748TyrLeu: 2.748 ± 0.027
0.671TyrMet: 0.671 ± 0.014
1.205TyrAsn: 1.205 ± 0.018
1.604TyrPro: 1.604 ± 0.023
1.137TyrGln: 1.137 ± 0.018
1.611TyrArg: 1.611 ± 0.021
2.164TyrSer: 2.164 ± 0.026
1.749TyrThr: 1.749 ± 0.023
1.682TyrVal: 1.682 ± 0.018
0.41TyrTrp: 0.41 ± 0.01
0.936TyrTyr: 0.936 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10343 proteins (4370377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski