Amino acid dipepetide frequency for Rat cytomegalovirus (strain Maastricht)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.239AlaAla: 12.239 ± 0.775
1.503AlaCys: 1.503 ± 0.159
4.586AlaAsp: 4.586 ± 0.318
4.434AlaGlu: 4.434 ± 0.343
2.976AlaPhe: 2.976 ± 0.223
6.94AlaGly: 6.94 ± 0.637
1.944AlaHis: 1.944 ± 0.166
2.627AlaIle: 2.627 ± 0.247
1.837AlaLys: 1.837 ± 0.237
7.334AlaLeu: 7.334 ± 0.421
1.488AlaMet: 1.488 ± 0.139
1.929AlaAsn: 1.929 ± 0.183
4.996AlaPro: 4.996 ± 0.401
1.701AlaGln: 1.701 ± 0.215
7.699AlaArg: 7.699 ± 0.486
6.469AlaSer: 6.469 ± 0.456
5.512AlaThr: 5.512 ± 0.316
7.35AlaVal: 7.35 ± 0.52
0.926AlaTrp: 0.926 ± 0.124
2.217AlaTyr: 2.217 ± 0.187
0.0AlaXaa: 0.0 ± 0.0
Cys
1.458CysAla: 1.458 ± 0.149
0.501CysCys: 0.501 ± 0.104
1.124CysAsp: 1.124 ± 0.152
1.078CysGlu: 1.078 ± 0.132
0.714CysPhe: 0.714 ± 0.117
1.594CysGly: 1.594 ± 0.197
0.501CysHis: 0.501 ± 0.093
0.911CysIle: 0.911 ± 0.145
0.425CysLys: 0.425 ± 0.077
2.126CysLeu: 2.126 ± 0.18
0.38CysMet: 0.38 ± 0.088
0.577CysAsn: 0.577 ± 0.093
1.154CysPro: 1.154 ± 0.134
0.531CysGln: 0.531 ± 0.099
2.065CysArg: 2.065 ± 0.197
1.458CysSer: 1.458 ± 0.168
1.291CysThr: 1.291 ± 0.158
2.308CysVal: 2.308 ± 0.208
0.167CysTrp: 0.167 ± 0.074
0.531CysTyr: 0.531 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
5.953AspAla: 5.953 ± 0.41
0.638AspCys: 0.638 ± 0.088
5.102AspAsp: 5.102 ± 0.457
4.313AspGlu: 4.313 ± 0.348
2.035AspPhe: 2.035 ± 0.2
5.831AspGly: 5.831 ± 0.414
1.215AspHis: 1.215 ± 0.146
1.853AspIle: 1.853 ± 0.191
1.093AspLys: 1.093 ± 0.141
5.239AspLeu: 5.239 ± 0.371
0.941AspMet: 0.941 ± 0.134
1.276AspAsn: 1.276 ± 0.143
4.631AspPro: 4.631 ± 0.348
1.124AspGln: 1.124 ± 0.112
5.193AspArg: 5.193 ± 0.288
3.326AspSer: 3.326 ± 0.26
2.673AspThr: 2.673 ± 0.208
4.313AspVal: 4.313 ± 0.244
0.425AspTrp: 0.425 ± 0.072
1.215AspTyr: 1.215 ± 0.148
0.0AspXaa: 0.0 ± 0.0
Glu
4.768GluAla: 4.768 ± 0.342
1.154GluCys: 1.154 ± 0.138
4.404GluAsp: 4.404 ± 0.384
5.148GluGlu: 5.148 ± 0.484
1.716GluPhe: 1.716 ± 0.163
3.978GluGly: 3.978 ± 0.324
1.336GluHis: 1.336 ± 0.161
2.597GluIle: 2.597 ± 0.217
2.187GluLys: 2.187 ± 0.212
4.525GluLeu: 4.525 ± 0.337
1.382GluMet: 1.382 ± 0.129
2.111GluAsn: 2.111 ± 0.169
2.49GluPro: 2.49 ± 0.205
1.215GluGln: 1.215 ± 0.174
5.755GluArg: 5.755 ± 0.316
3.736GluSer: 3.736 ± 0.243
4.039GluThr: 4.039 ± 0.342
3.417GluVal: 3.417 ± 0.268
0.395GluTrp: 0.395 ± 0.079
1.655GluTyr: 1.655 ± 0.181
0.0GluXaa: 0.0 ± 0.0
Phe
2.809PheAla: 2.809 ± 0.234
0.957PheCys: 0.957 ± 0.108
1.959PheAsp: 1.959 ± 0.184
1.868PheGlu: 1.868 ± 0.178
2.141PhePhe: 2.141 ± 0.223
2.399PheGly: 2.399 ± 0.185
0.881PheHis: 0.881 ± 0.117
1.458PheIle: 1.458 ± 0.174
1.078PheLys: 1.078 ± 0.114
4.237PheLeu: 4.237 ± 0.289
0.592PheMet: 0.592 ± 0.113
1.321PheAsn: 1.321 ± 0.157
2.293PhePro: 2.293 ± 0.179
0.699PheGln: 0.699 ± 0.118
3.128PheArg: 3.128 ± 0.243
2.824PheSer: 2.824 ± 0.226
1.792PheThr: 1.792 ± 0.159
3.553PheVal: 3.553 ± 0.3
0.41PheTrp: 0.41 ± 0.067
1.473PheTyr: 1.473 ± 0.181
0.0PheXaa: 0.0 ± 0.0
Gly
6.469GlyAla: 6.469 ± 0.489
1.124GlyCys: 1.124 ± 0.143
5.3GlyAsp: 5.3 ± 0.363
4.874GlyGlu: 4.874 ± 0.406
2.035GlyPhe: 2.035 ± 0.217
9.05GlyGly: 9.05 ± 0.909
1.61GlyHis: 1.61 ± 0.164
2.232GlyIle: 2.232 ± 0.147
2.065GlyLys: 2.065 ± 0.225
5.436GlyLeu: 5.436 ± 0.306
1.048GlyMet: 1.048 ± 0.131
2.232GlyAsn: 2.232 ± 0.211
4.814GlyPro: 4.814 ± 0.405
1.549GlyGln: 1.549 ± 0.168
8.549GlyArg: 8.549 ± 0.697
5.922GlySer: 5.922 ± 0.383
4.874GlyThr: 4.874 ± 0.325
4.54GlyVal: 4.54 ± 0.315
0.911GlyTrp: 0.911 ± 0.143
1.716GlyTyr: 1.716 ± 0.165
0.0GlyXaa: 0.0 ± 0.0
His
1.746HisAla: 1.746 ± 0.182
0.395HisCys: 0.395 ± 0.085
1.336HisAsp: 1.336 ± 0.151
1.2HisGlu: 1.2 ± 0.159
0.759HisPhe: 0.759 ± 0.124
1.625HisGly: 1.625 ± 0.195
0.957HisHis: 0.957 ± 0.172
0.774HisIle: 0.774 ± 0.121
0.44HisLys: 0.44 ± 0.103
2.521HisLeu: 2.521 ± 0.233
0.334HisMet: 0.334 ± 0.075
0.683HisAsn: 0.683 ± 0.109
1.594HisPro: 1.594 ± 0.176
0.699HisGln: 0.699 ± 0.1
2.339HisArg: 2.339 ± 0.212
1.078HisSer: 1.078 ± 0.128
1.351HisThr: 1.351 ± 0.165
1.989HisVal: 1.989 ± 0.189
0.273HisTrp: 0.273 ± 0.056
0.744HisTyr: 0.744 ± 0.103
0.0HisXaa: 0.0 ± 0.0
Ile
2.627IleAla: 2.627 ± 0.199
0.85IleCys: 0.85 ± 0.134
1.731IleAsp: 1.731 ± 0.164
2.004IleGlu: 2.004 ± 0.246
1.579IlePhe: 1.579 ± 0.182
2.597IleGly: 2.597 ± 0.2
1.017IleHis: 1.017 ± 0.145
1.746IleIle: 1.746 ± 0.22
1.093IleLys: 1.093 ± 0.098
3.811IleLeu: 3.811 ± 0.295
0.82IleMet: 0.82 ± 0.116
1.655IleAsn: 1.655 ± 0.188
1.944IlePro: 1.944 ± 0.176
1.184IleGln: 1.184 ± 0.186
3.417IleArg: 3.417 ± 0.26
2.946IleSer: 2.946 ± 0.244
2.217IleThr: 2.217 ± 0.241
3.371IleVal: 3.371 ± 0.252
0.41IleTrp: 0.41 ± 0.087
1.306IleTyr: 1.306 ± 0.132
0.0IleXaa: 0.0 ± 0.0
Lys
1.777LysAla: 1.777 ± 0.188
0.607LysCys: 0.607 ± 0.097
1.336LysAsp: 1.336 ± 0.17
1.746LysGlu: 1.746 ± 0.212
0.805LysPhe: 0.805 ± 0.111
1.351LysGly: 1.351 ± 0.207
0.759LysHis: 0.759 ± 0.115
2.126LysIle: 2.126 ± 0.228
2.217LysLys: 2.217 ± 0.291
2.247LysLeu: 2.247 ± 0.235
0.79LysMet: 0.79 ± 0.099
1.64LysAsn: 1.64 ± 0.19
0.866LysPro: 0.866 ± 0.142
0.835LysGln: 0.835 ± 0.134
2.87LysArg: 2.87 ± 0.281
2.035LysSer: 2.035 ± 0.25
1.883LysThr: 1.883 ± 0.189
1.731LysVal: 1.731 ± 0.156
0.349LysTrp: 0.349 ± 0.078
0.805LysTyr: 0.805 ± 0.122
0.0LysXaa: 0.0 ± 0.0
Leu
7.137LeuAla: 7.137 ± 0.386
2.597LeuCys: 2.597 ± 0.239
4.404LeuAsp: 4.404 ± 0.356
4.449LeuGlu: 4.449 ± 0.286
3.887LeuPhe: 3.887 ± 0.238
5.618LeuGly: 5.618 ± 0.328
1.655LeuHis: 1.655 ± 0.172
3.386LeuIle: 3.386 ± 0.242
2.475LeuLys: 2.475 ± 0.243
9.202LeuLeu: 9.202 ± 0.489
1.746LeuMet: 1.746 ± 0.164
2.9LeuAsn: 2.9 ± 0.198
5.163LeuPro: 5.163 ± 0.351
2.217LeuGln: 2.217 ± 0.179
8.215LeuArg: 8.215 ± 0.473
7.031LeuSer: 7.031 ± 0.354
5.057LeuThr: 5.057 ± 0.344
6.196LeuVal: 6.196 ± 0.403
0.911LeuTrp: 0.911 ± 0.119
3.098LeuTyr: 3.098 ± 0.221
0.0LeuXaa: 0.0 ± 0.0
Met
1.701MetAla: 1.701 ± 0.138
0.425MetCys: 0.425 ± 0.077
1.109MetAsp: 1.109 ± 0.14
1.169MetGlu: 1.169 ± 0.124
0.881MetPhe: 0.881 ± 0.128
0.774MetGly: 0.774 ± 0.12
0.289MetHis: 0.289 ± 0.086
1.139MetIle: 1.139 ± 0.147
0.607MetLys: 0.607 ± 0.095
1.549MetLeu: 1.549 ± 0.163
0.531MetMet: 0.531 ± 0.085
0.714MetAsn: 0.714 ± 0.126
0.729MetPro: 0.729 ± 0.105
0.38MetGln: 0.38 ± 0.086
1.336MetArg: 1.336 ± 0.177
1.686MetSer: 1.686 ± 0.173
1.276MetThr: 1.276 ± 0.142
1.154MetVal: 1.154 ± 0.12
0.243MetTrp: 0.243 ± 0.057
0.638MetTyr: 0.638 ± 0.089
0.0MetXaa: 0.0 ± 0.0
Asn
2.475AsnAla: 2.475 ± 0.211
0.699AsnCys: 0.699 ± 0.106
1.519AsnAsp: 1.519 ± 0.177
1.746AsnGlu: 1.746 ± 0.19
1.078AsnPhe: 1.078 ± 0.128
2.521AsnGly: 2.521 ± 0.219
0.714AsnHis: 0.714 ± 0.112
1.291AsnIle: 1.291 ± 0.192
1.154AsnLys: 1.154 ± 0.162
2.733AsnLeu: 2.733 ± 0.192
0.516AsnMet: 0.516 ± 0.114
1.063AsnAsn: 1.063 ± 0.157
1.655AsnPro: 1.655 ± 0.142
0.774AsnGln: 0.774 ± 0.107
2.414AsnArg: 2.414 ± 0.203
1.959AsnSer: 1.959 ± 0.205
1.822AsnThr: 1.822 ± 0.19
2.916AsnVal: 2.916 ± 0.249
0.334AsnTrp: 0.334 ± 0.079
0.911AsnTyr: 0.911 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
5.588ProAla: 5.588 ± 0.508
1.033ProCys: 1.033 ± 0.129
3.599ProAsp: 3.599 ± 0.256
3.356ProGlu: 3.356 ± 0.238
2.156ProPhe: 2.156 ± 0.217
5.694ProGly: 5.694 ± 0.513
1.67ProHis: 1.67 ± 0.166
1.64ProIle: 1.64 ± 0.173
1.382ProLys: 1.382 ± 0.165
4.373ProLeu: 4.373 ± 0.244
0.941ProMet: 0.941 ± 0.122
1.336ProAsn: 1.336 ± 0.143
7.122ProPro: 7.122 ± 0.551
1.473ProGln: 1.473 ± 0.213
6.393ProArg: 6.393 ± 0.544
5.284ProSer: 5.284 ± 0.378
3.69ProThr: 3.69 ± 0.29
4.343ProVal: 4.343 ± 0.273
0.729ProTrp: 0.729 ± 0.116
1.549ProTyr: 1.549 ± 0.182
0.0ProXaa: 0.0 ± 0.0
Gln
1.488GlnAla: 1.488 ± 0.155
0.501GlnCys: 0.501 ± 0.082
1.276GlnAsp: 1.276 ± 0.173
1.26GlnGlu: 1.26 ± 0.176
0.866GlnPhe: 0.866 ± 0.133
1.397GlnGly: 1.397 ± 0.14
0.79GlnHis: 0.79 ± 0.117
1.26GlnIle: 1.26 ± 0.12
1.412GlnLys: 1.412 ± 0.169
2.384GlnLeu: 2.384 ± 0.18
0.334GlnMet: 0.334 ± 0.075
1.063GlnAsn: 1.063 ± 0.138
1.169GlnPro: 1.169 ± 0.175
0.987GlnGln: 0.987 ± 0.191
2.263GlnArg: 2.263 ± 0.239
1.215GlnSer: 1.215 ± 0.122
2.02GlnThr: 2.02 ± 0.233
1.306GlnVal: 1.306 ± 0.136
0.137GlnTrp: 0.137 ± 0.047
0.607GlnTyr: 0.607 ± 0.093
0.0GlnXaa: 0.0 ± 0.0
Arg
8.033ArgAla: 8.033 ± 0.476
2.035ArgCys: 2.035 ± 0.18
6.165ArgAsp: 6.165 ± 0.377
6.196ArgGlu: 6.196 ± 0.377
3.401ArgPhe: 3.401 ± 0.261
7.471ArgGly: 7.471 ± 0.593
2.354ArgHis: 2.354 ± 0.204
3.204ArgIle: 3.204 ± 0.258
2.475ArgLys: 2.475 ± 0.189
7.334ArgLeu: 7.334 ± 0.4
1.67ArgMet: 1.67 ± 0.136
2.323ArgAsn: 2.323 ± 0.194
6.332ArgPro: 6.332 ± 0.557
2.445ArgGln: 2.445 ± 0.169
13.424ArgArg: 13.424 ± 1.008
6.97ArgSer: 6.97 ± 0.375
5.679ArgThr: 5.679 ± 0.363
5.618ArgVal: 5.618 ± 0.402
1.169ArgTrp: 1.169 ± 0.122
2.657ArgTyr: 2.657 ± 0.198
0.0ArgXaa: 0.0 ± 0.0
Ser
6.226SerAla: 6.226 ± 0.388
1.579SerCys: 1.579 ± 0.187
3.994SerAsp: 3.994 ± 0.274
3.872SerGlu: 3.872 ± 0.202
2.521SerPhe: 2.521 ± 0.182
6.211SerGly: 6.211 ± 0.411
1.503SerHis: 1.503 ± 0.177
2.673SerIle: 2.673 ± 0.224
1.746SerLys: 1.746 ± 0.208
6.484SerLeu: 6.484 ± 0.322
1.336SerMet: 1.336 ± 0.132
1.913SerAsn: 1.913 ± 0.183
5.664SerPro: 5.664 ± 0.42
1.837SerGln: 1.837 ± 0.229
6.666SerArg: 6.666 ± 0.421
8.109SerSer: 8.109 ± 0.688
4.464SerThr: 4.464 ± 0.313
5.937SerVal: 5.937 ± 0.355
0.729SerTrp: 0.729 ± 0.112
1.625SerTyr: 1.625 ± 0.168
0.0SerXaa: 0.0 ± 0.0
Thr
5.239ThrAla: 5.239 ± 0.296
1.427ThrCys: 1.427 ± 0.176
3.143ThrAsp: 3.143 ± 0.254
3.31ThrGlu: 3.31 ± 0.3
2.703ThrPhe: 2.703 ± 0.237
3.918ThrGly: 3.918 ± 0.278
1.427ThrHis: 1.427 ± 0.182
2.642ThrIle: 2.642 ± 0.285
1.67ThrLys: 1.67 ± 0.163
5.178ThrLeu: 5.178 ± 0.479
1.245ThrMet: 1.245 ± 0.121
2.08ThrAsn: 2.08 ± 0.219
4.054ThrPro: 4.054 ± 0.311
1.579ThrGln: 1.579 ± 0.159
4.95ThrArg: 4.95 ± 0.312
4.556ThrSer: 4.556 ± 0.373
4.464ThrThr: 4.464 ± 0.43
5.512ThrVal: 5.512 ± 0.33
0.699ThrTrp: 0.699 ± 0.098
1.868ThrTyr: 1.868 ± 0.171
0.0ThrXaa: 0.0 ± 0.0
Val
6.256ValAla: 6.256 ± 0.378
2.02ValCys: 2.02 ± 0.186
3.948ValAsp: 3.948 ± 0.309
3.948ValGlu: 3.948 ± 0.301
3.781ValPhe: 3.781 ± 0.285
4.981ValGly: 4.981 ± 0.398
1.351ValHis: 1.351 ± 0.142
3.128ValIle: 3.128 ± 0.269
2.126ValLys: 2.126 ± 0.199
6.757ValLeu: 6.757 ± 0.36
1.382ValMet: 1.382 ± 0.154
1.974ValAsn: 1.974 ± 0.168
4.647ValPro: 4.647 ± 0.284
1.61ValGln: 1.61 ± 0.17
6.545ValArg: 6.545 ± 0.345
5.998ValSer: 5.998 ± 0.326
4.768ValThr: 4.768 ± 0.302
6.727ValVal: 6.727 ± 0.45
1.002ValTrp: 1.002 ± 0.145
2.673ValTyr: 2.673 ± 0.205
0.0ValXaa: 0.0 ± 0.0
Trp
0.607TrpAla: 0.607 ± 0.072
0.273TrpCys: 0.273 ± 0.073
0.44TrpAsp: 0.44 ± 0.085
0.638TrpGlu: 0.638 ± 0.135
0.638TrpPhe: 0.638 ± 0.104
0.486TrpGly: 0.486 ± 0.08
0.137TrpHis: 0.137 ± 0.047
0.44TrpIle: 0.44 ± 0.081
0.38TrpLys: 0.38 ± 0.072
1.033TrpLeu: 1.033 ± 0.128
0.289TrpMet: 0.289 ± 0.069
0.395TrpAsn: 0.395 ± 0.084
0.683TrpPro: 0.683 ± 0.112
0.228TrpGln: 0.228 ± 0.064
1.154TrpArg: 1.154 ± 0.139
0.744TrpSer: 0.744 ± 0.115
0.881TrpThr: 0.881 ± 0.129
0.623TrpVal: 0.623 ± 0.106
0.228TrpTrp: 0.228 ± 0.058
0.425TrpTyr: 0.425 ± 0.083
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.111TyrAla: 2.111 ± 0.191
0.577TyrCys: 0.577 ± 0.105
1.913TyrAsp: 1.913 ± 0.183
1.397TyrGlu: 1.397 ± 0.15
1.2TyrPhe: 1.2 ± 0.136
1.913TyrGly: 1.913 ± 0.146
0.729TyrHis: 0.729 ± 0.106
1.2TyrIle: 1.2 ± 0.143
0.911TyrLys: 0.911 ± 0.139
2.84TyrLeu: 2.84 ± 0.214
0.547TyrMet: 0.547 ± 0.078
1.109TyrAsn: 1.109 ± 0.151
1.351TyrPro: 1.351 ± 0.159
0.668TyrGln: 0.668 ± 0.095
2.597TyrArg: 2.597 ± 0.203
1.746TyrSer: 1.746 ± 0.182
1.913TyrThr: 1.913 ± 0.18
2.718TyrVal: 2.718 ± 0.217
0.273TyrTrp: 0.273 ± 0.071
1.017TyrTyr: 1.017 ± 0.15
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 167 proteins (65855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski