Amino acid dipepetide frequency for Human papillomavirus 170

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.09AlaAla: 6.09 ± 1.668
1.74AlaCys: 1.74 ± 1.005
3.045AlaAsp: 3.045 ± 1.555
3.915AlaGlu: 3.915 ± 1.481
3.915AlaPhe: 3.915 ± 1.759
3.915AlaGly: 3.915 ± 0.759
0.87AlaHis: 0.87 ± 0.85
2.61AlaIle: 2.61 ± 0.802
3.915AlaLys: 3.915 ± 1.204
5.655AlaLeu: 5.655 ± 1.791
0.87AlaMet: 0.87 ± 0.85
0.87AlaAsn: 0.87 ± 0.671
2.61AlaPro: 2.61 ± 1.487
1.74AlaGln: 1.74 ± 1.18
4.35AlaArg: 4.35 ± 2.015
1.74AlaSer: 1.74 ± 0.663
6.96AlaThr: 6.96 ± 1.258
2.175AlaVal: 2.175 ± 1.136
1.305AlaTrp: 1.305 ± 0.433
1.305AlaTyr: 1.305 ± 0.737
0.0AlaXaa: 0.0 ± 0.0
Cys
2.175CysAla: 2.175 ± 1.239
0.87CysCys: 0.87 ± 0.671
0.87CysAsp: 0.87 ± 0.436
1.305CysGlu: 1.305 ± 0.75
0.435CysPhe: 0.435 ± 0.362
0.87CysGly: 0.87 ± 0.718
0.0CysHis: 0.0 ± 0.0
1.305CysIle: 1.305 ± 0.75
2.61CysLys: 2.61 ± 1.143
1.74CysLeu: 1.74 ± 1.642
0.87CysMet: 0.87 ± 1.157
0.435CysAsn: 0.435 ± 0.362
1.305CysPro: 1.305 ± 0.819
1.74CysGln: 1.74 ± 0.729
0.87CysArg: 0.87 ± 0.563
2.61CysSer: 2.61 ± 1.888
2.61CysThr: 2.61 ± 1.774
0.0CysVal: 0.0 ± 0.0
0.87CysTrp: 0.87 ± 0.468
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.22AspAla: 5.22 ± 0.926
2.61AspCys: 2.61 ± 1.117
4.785AspAsp: 4.785 ± 0.946
2.175AspGlu: 2.175 ± 0.95
2.175AspPhe: 2.175 ± 1.916
4.35AspGly: 4.35 ± 0.885
1.305AspHis: 1.305 ± 0.68
6.09AspIle: 6.09 ± 1.742
2.61AspLys: 2.61 ± 1.288
6.525AspLeu: 6.525 ± 1.431
0.435AspMet: 0.435 ± 0.425
2.175AspAsn: 2.175 ± 1.042
3.48AspPro: 3.48 ± 1.327
1.305AspGln: 1.305 ± 0.445
2.61AspArg: 2.61 ± 1.156
3.48AspSer: 3.48 ± 1.32
4.785AspThr: 4.785 ± 1.095
1.74AspVal: 1.74 ± 0.741
0.87AspTrp: 0.87 ± 0.724
1.305AspTyr: 1.305 ± 0.836
0.0AspXaa: 0.0 ± 0.0
Glu
5.655GluAla: 5.655 ± 2.11
1.305GluCys: 1.305 ± 0.75
6.09GluAsp: 6.09 ± 0.93
2.61GluGlu: 2.61 ± 0.55
2.61GluPhe: 2.61 ± 0.802
3.045GluGly: 3.045 ± 1.196
0.87GluHis: 0.87 ± 0.7
2.61GluIle: 2.61 ± 1.027
2.61GluLys: 2.61 ± 1.038
4.785GluLeu: 4.785 ± 1.4
0.87GluMet: 0.87 ± 0.724
4.35GluAsn: 4.35 ± 1.192
3.48GluPro: 3.48 ± 0.868
3.915GluGln: 3.915 ± 0.934
1.305GluArg: 1.305 ± 0.445
5.22GluSer: 5.22 ± 0.764
5.655GluThr: 5.655 ± 1.378
3.045GluVal: 3.045 ± 0.703
0.435GluTrp: 0.435 ± 0.362
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.305PheAla: 1.305 ± 0.819
0.87PheCys: 0.87 ± 1.157
2.175PheAsp: 2.175 ± 0.512
2.175PheGlu: 2.175 ± 0.892
2.61PhePhe: 2.61 ± 1.308
3.48PheGly: 3.48 ± 0.69
1.74PheHis: 1.74 ± 1.065
2.175PheIle: 2.175 ± 0.953
4.35PheLys: 4.35 ± 1.848
2.61PheLeu: 2.61 ± 1.288
1.305PheMet: 1.305 ± 0.71
1.305PheAsn: 1.305 ± 0.38
1.74PhePro: 1.74 ± 0.213
1.305PheGln: 1.305 ± 0.616
1.74PheArg: 1.74 ± 0.634
4.35PheSer: 4.35 ± 1.883
3.045PheThr: 3.045 ± 0.564
3.915PheVal: 3.915 ± 2.262
0.87PheTrp: 0.87 ± 0.436
1.305PheTyr: 1.305 ± 1.051
0.0PheXaa: 0.0 ± 0.0
Gly
2.61GlyAla: 2.61 ± 1.432
2.175GlyCys: 2.175 ± 1.869
4.35GlyAsp: 4.35 ± 1.356
5.22GlyGlu: 5.22 ± 1.111
2.175GlyPhe: 2.175 ± 0.394
7.395GlyGly: 7.395 ± 3.488
2.175GlyHis: 2.175 ± 0.859
3.915GlyIle: 3.915 ± 1.293
2.61GlyLys: 2.61 ± 0.865
6.09GlyLeu: 6.09 ± 2.047
0.87GlyMet: 0.87 ± 0.497
3.915GlyAsn: 3.915 ± 0.52
4.35GlyPro: 4.35 ± 1.865
0.87GlyGln: 0.87 ± 0.468
4.35GlyArg: 4.35 ± 1.302
4.785GlySer: 4.785 ± 1.584
4.35GlyThr: 4.35 ± 1.865
2.175GlyVal: 2.175 ± 1.071
0.435GlyTrp: 0.435 ± 0.362
0.435GlyTyr: 0.435 ± 0.383
0.0GlyXaa: 0.0 ± 0.0
His
0.435HisAla: 0.435 ± 0.383
0.87HisCys: 0.87 ± 0.724
0.435HisAsp: 0.435 ± 0.397
1.74HisGlu: 1.74 ± 0.998
0.87HisPhe: 0.87 ± 0.724
0.87HisGly: 0.87 ± 0.642
0.0HisHis: 0.0 ± 0.0
1.305HisIle: 1.305 ± 0.688
0.87HisLys: 0.87 ± 0.724
1.74HisLeu: 1.74 ± 1.178
0.0HisMet: 0.0 ± 0.0
1.305HisAsn: 1.305 ± 0.642
1.74HisPro: 1.74 ± 0.741
0.435HisGln: 0.435 ± 0.362
1.74HisArg: 1.74 ± 0.697
1.74HisSer: 1.74 ± 0.639
0.87HisThr: 0.87 ± 0.497
0.435HisVal: 0.435 ± 0.573
0.435HisTrp: 0.435 ± 0.425
1.305HisTyr: 1.305 ± 0.836
0.0HisXaa: 0.0 ± 0.0
Ile
2.61IleAla: 2.61 ± 1.758
1.74IleCys: 1.74 ± 0.8
3.48IleAsp: 3.48 ± 1.86
5.22IleGlu: 5.22 ± 2.327
0.87IlePhe: 0.87 ± 0.436
3.915IleGly: 3.915 ± 1.348
0.435IleHis: 0.435 ± 0.362
2.175IleIle: 2.175 ± 0.692
0.87IleLys: 0.87 ± 0.497
4.785IleLeu: 4.785 ± 0.658
0.0IleMet: 0.0 ± 0.0
1.74IleAsn: 1.74 ± 0.861
3.915IlePro: 3.915 ± 2.171
1.305IleGln: 1.305 ± 0.528
1.74IleArg: 1.74 ± 1.196
6.96IleSer: 6.96 ± 1.038
5.22IleThr: 5.22 ± 1.669
7.829IleVal: 7.829 ± 1.369
0.435IleTrp: 0.435 ± 0.397
1.305IleTyr: 1.305 ± 0.737
0.0IleXaa: 0.0 ± 0.0
Lys
0.435LysAla: 0.435 ± 0.397
0.87LysCys: 0.87 ± 0.795
2.61LysAsp: 2.61 ± 1.325
0.87LysGlu: 0.87 ± 0.436
1.305LysPhe: 1.305 ± 0.657
4.35LysGly: 4.35 ± 1.737
1.74LysHis: 1.74 ± 1.034
1.74LysIle: 1.74 ± 0.808
3.045LysLys: 3.045 ± 0.733
5.655LysLeu: 5.655 ± 1.478
1.305LysMet: 1.305 ± 0.68
2.175LysAsn: 2.175 ± 0.394
0.435LysPro: 0.435 ± 0.425
3.48LysGln: 3.48 ± 1.191
6.525LysArg: 6.525 ± 1.048
6.09LysSer: 6.09 ± 2.342
1.305LysThr: 1.305 ± 1.087
3.915LysVal: 3.915 ± 1.119
0.435LysTrp: 0.435 ± 0.425
3.045LysTyr: 3.045 ± 1.298
0.0LysXaa: 0.0 ± 0.0
Leu
7.829LeuAla: 7.829 ± 1.52
2.175LeuCys: 2.175 ± 1.356
6.96LeuAsp: 6.96 ± 1.931
4.785LeuGlu: 4.785 ± 1.747
5.655LeuPhe: 5.655 ± 0.962
4.785LeuGly: 4.785 ± 1.766
1.74LeuHis: 1.74 ± 0.655
4.35LeuIle: 4.35 ± 0.823
5.22LeuLys: 5.22 ± 2.154
8.264LeuLeu: 8.264 ± 1.938
1.74LeuMet: 1.74 ± 0.869
3.915LeuAsn: 3.915 ± 1.483
3.045LeuPro: 3.045 ± 0.923
5.655LeuGln: 5.655 ± 2.74
3.915LeuArg: 3.915 ± 1.166
7.829LeuSer: 7.829 ± 2.708
3.48LeuThr: 3.48 ± 1.364
4.785LeuVal: 4.785 ± 2.007
0.435LeuTrp: 0.435 ± 0.578
6.525LeuTyr: 6.525 ± 1.309
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.435MetCys: 0.435 ± 0.425
0.0MetAsp: 0.0 ± 0.0
1.305MetGlu: 1.305 ± 0.788
0.435MetPhe: 0.435 ± 0.362
0.87MetGly: 0.87 ± 0.724
0.435MetHis: 0.435 ± 0.573
0.435MetIle: 0.435 ± 0.362
0.435MetLys: 0.435 ± 0.578
0.435MetLeu: 0.435 ± 0.397
0.0MetMet: 0.0 ± 0.0
1.305MetAsn: 1.305 ± 0.781
0.435MetPro: 0.435 ± 0.362
0.435MetGln: 0.435 ± 0.425
0.87MetArg: 0.87 ± 0.724
2.61MetSer: 2.61 ± 1.308
0.87MetThr: 0.87 ± 0.497
1.305MetVal: 1.305 ± 0.616
0.435MetTrp: 0.435 ± 0.397
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.74AsnAla: 1.74 ± 0.569
0.87AsnCys: 0.87 ± 0.431
3.045AsnAsp: 3.045 ± 0.856
0.87AsnGlu: 0.87 ± 0.431
2.61AsnPhe: 2.61 ± 0.586
2.175AsnGly: 2.175 ± 0.773
1.305AsnHis: 1.305 ± 0.737
3.48AsnIle: 3.48 ± 1.516
2.175AsnLys: 2.175 ± 0.524
4.35AsnLeu: 4.35 ± 1.131
0.87AsnMet: 0.87 ± 0.498
1.74AsnAsn: 1.74 ± 0.872
3.045AsnPro: 3.045 ± 0.981
2.175AsnGln: 2.175 ± 1.083
2.61AsnArg: 2.61 ± 0.572
3.915AsnSer: 3.915 ± 0.895
3.915AsnThr: 3.915 ± 1.198
2.175AsnVal: 2.175 ± 0.773
0.87AsnTrp: 0.87 ± 0.436
1.74AsnTyr: 1.74 ± 0.587
0.0AsnXaa: 0.0 ± 0.0
Pro
2.61ProAla: 2.61 ± 0.844
1.305ProCys: 1.305 ± 0.929
3.915ProAsp: 3.915 ± 2.207
5.22ProGlu: 5.22 ± 1.845
0.435ProPhe: 0.435 ± 0.362
2.61ProGly: 2.61 ± 1.37
0.0ProHis: 0.0 ± 0.0
2.175ProIle: 2.175 ± 1.202
3.045ProLys: 3.045 ± 0.716
5.22ProLeu: 5.22 ± 0.806
0.435ProMet: 0.435 ± 0.383
3.045ProAsn: 3.045 ± 1.132
7.829ProPro: 7.829 ± 2.825
2.61ProGln: 2.61 ± 1.33
3.045ProArg: 3.045 ± 1.642
3.045ProSer: 3.045 ± 0.82
2.61ProThr: 2.61 ± 1.044
2.175ProVal: 2.175 ± 0.875
0.0ProTrp: 0.0 ± 0.0
2.175ProTyr: 2.175 ± 1.256
0.0ProXaa: 0.0 ± 0.0
Gln
2.175GlnAla: 2.175 ± 0.512
0.87GlnCys: 0.87 ± 0.563
3.045GlnAsp: 3.045 ± 0.635
3.48GlnGlu: 3.48 ± 0.999
1.305GlnPhe: 1.305 ± 0.38
2.175GlnGly: 2.175 ± 0.875
0.0GlnHis: 0.0 ± 0.0
3.915GlnIle: 3.915 ± 0.863
0.87GlnLys: 0.87 ± 0.795
6.09GlnLeu: 6.09 ± 1.623
0.0GlnMet: 0.0 ± 0.0
1.74GlnAsn: 1.74 ± 0.741
0.87GlnPro: 0.87 ± 0.431
2.61GlnGln: 2.61 ± 0.761
2.61GlnArg: 2.61 ± 1.69
3.045GlnSer: 3.045 ± 1.432
2.61GlnThr: 2.61 ± 1.308
2.61GlnVal: 2.61 ± 0.865
0.0GlnTrp: 0.0 ± 0.0
2.175GlnTyr: 2.175 ± 0.631
0.0GlnXaa: 0.0 ± 0.0
Arg
2.61ArgAla: 2.61 ± 1.037
1.74ArgCys: 1.74 ± 0.491
1.74ArgAsp: 1.74 ± 0.622
3.48ArgGlu: 3.48 ± 1.383
3.045ArgPhe: 3.045 ± 0.917
3.48ArgGly: 3.48 ± 1.311
1.305ArgHis: 1.305 ± 0.836
2.175ArgIle: 2.175 ± 1.393
3.915ArgLys: 3.915 ± 0.735
5.655ArgLeu: 5.655 ± 1.194
1.305ArgMet: 1.305 ± 0.661
2.61ArgAsn: 2.61 ± 1.5
3.045ArgPro: 3.045 ± 1.338
2.61ArgGln: 2.61 ± 0.891
6.525ArgArg: 6.525 ± 3.539
4.785ArgSer: 4.785 ± 1.273
1.74ArgThr: 1.74 ± 0.666
3.915ArgVal: 3.915 ± 1.267
0.0ArgTrp: 0.0 ± 0.0
1.305ArgTyr: 1.305 ± 0.781
0.0ArgXaa: 0.0 ± 0.0
Ser
5.655SerAla: 5.655 ± 1.932
0.435SerCys: 0.435 ± 0.578
4.35SerAsp: 4.35 ± 0.69
6.96SerGlu: 6.96 ± 1.512
3.48SerPhe: 3.48 ± 1.731
5.655SerGly: 5.655 ± 1.096
1.74SerHis: 1.74 ± 0.861
4.785SerIle: 4.785 ± 1.019
3.48SerLys: 3.48 ± 0.847
8.699SerLeu: 8.699 ± 2.284
1.305SerMet: 1.305 ± 1.001
6.09SerAsn: 6.09 ± 2.156
3.915SerPro: 3.915 ± 1.644
0.87SerGln: 0.87 ± 0.436
5.22SerArg: 5.22 ± 0.806
10.439SerSer: 10.439 ± 2.887
6.09SerThr: 6.09 ± 2.147
5.655SerVal: 5.655 ± 0.915
0.87SerTrp: 0.87 ± 0.795
2.175SerTyr: 2.175 ± 0.795
0.0SerXaa: 0.0 ± 0.0
Thr
2.175ThrAla: 2.175 ± 1.194
1.305ThrCys: 1.305 ± 0.528
3.045ThrAsp: 3.045 ± 1.616
5.655ThrGlu: 5.655 ± 0.833
3.915ThrPhe: 3.915 ± 1.365
4.785ThrGly: 4.785 ± 1.46
1.74ThrHis: 1.74 ± 0.663
3.915ThrIle: 3.915 ± 2.052
2.175ThrLys: 2.175 ± 0.692
6.96ThrLeu: 6.96 ± 1.126
0.0ThrMet: 0.0 ± 0.0
2.61ThrAsn: 2.61 ± 0.891
3.915ThrPro: 3.915 ± 0.735
3.48ThrGln: 3.48 ± 1.483
1.74ThrArg: 1.74 ± 0.682
7.395ThrSer: 7.395 ± 2.403
3.045ThrThr: 3.045 ± 1.612
5.655ThrVal: 5.655 ± 1.199
0.435ThrTrp: 0.435 ± 0.362
0.435ThrTyr: 0.435 ± 0.425
0.0ThrXaa: 0.0 ± 0.0
Val
5.22ValAla: 5.22 ± 1.461
0.435ValCys: 0.435 ± 0.362
3.915ValAsp: 3.915 ± 1.232
1.74ValGlu: 1.74 ± 0.987
3.48ValPhe: 3.48 ± 0.6
4.785ValGly: 4.785 ± 0.972
0.87ValHis: 0.87 ± 0.477
4.35ValIle: 4.35 ± 1.29
2.61ValLys: 2.61 ± 0.61
3.48ValLeu: 3.48 ± 0.855
0.0ValMet: 0.0 ± 0.0
1.305ValAsn: 1.305 ± 0.642
3.48ValPro: 3.48 ± 1.588
3.48ValGln: 3.48 ± 1.013
3.045ValArg: 3.045 ± 1.466
5.655ValSer: 5.655 ± 0.793
3.48ValThr: 3.48 ± 0.763
3.045ValVal: 3.045 ± 1.348
0.435ValTrp: 0.435 ± 0.425
3.48ValTyr: 3.48 ± 1.289
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.87TrpAsp: 0.87 ± 0.497
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.87TrpIle: 0.87 ± 0.724
0.87TrpLys: 0.87 ± 0.436
1.305TrpLeu: 1.305 ± 0.68
0.435TrpMet: 0.435 ± 0.425
1.305TrpAsn: 1.305 ± 0.781
0.435TrpPro: 0.435 ± 0.425
0.435TrpGln: 0.435 ± 0.362
0.87TrpArg: 0.87 ± 0.749
0.87TrpSer: 0.87 ± 0.497
0.87TrpThr: 0.87 ± 0.795
0.87TrpVal: 0.87 ± 0.468
0.0TrpTrp: 0.0 ± 0.0
0.87TrpTyr: 0.87 ± 0.468
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.045TyrAla: 3.045 ± 0.838
0.87TyrCys: 0.87 ± 0.749
1.305TyrAsp: 1.305 ± 0.421
1.74TyrGlu: 1.74 ± 1.589
3.045TyrPhe: 3.045 ± 1.416
1.74TyrGly: 1.74 ± 1.018
0.87TyrHis: 0.87 ± 0.468
2.175TyrIle: 2.175 ± 0.631
3.045TyrLys: 3.045 ± 0.962
3.045TyrLeu: 3.045 ± 1.505
0.0TyrMet: 0.0 ± 0.0
1.74TyrAsn: 1.74 ± 0.627
0.435TyrPro: 0.435 ± 0.397
1.74TyrGln: 1.74 ± 0.587
1.305TyrArg: 1.305 ± 0.38
1.74TyrSer: 1.74 ± 0.213
0.87TyrThr: 0.87 ± 0.795
0.87TyrVal: 0.87 ± 0.497
1.305TyrTrp: 1.305 ± 0.836
3.045TyrTyr: 3.045 ± 1.206
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski