Amino acid dipepetide frequency for Proteus phage vB_PmiP_Pm5460

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.612AlaAla: 2.612 ± 0.783
0.435AlaCys: 0.435 ± 0.189
4.861AlaAsp: 4.861 ± 0.723
5.586AlaGlu: 5.586 ± 0.562
2.757AlaPhe: 2.757 ± 0.518
6.457AlaGly: 6.457 ± 0.86
1.524AlaHis: 1.524 ± 0.372
4.788AlaIle: 4.788 ± 0.666
6.167AlaLys: 6.167 ± 0.754
6.021AlaLeu: 6.021 ± 0.641
3.482AlaMet: 3.482 ± 0.691
3.41AlaAsn: 3.41 ± 0.366
2.684AlaPro: 2.684 ± 0.512
4.933AlaGln: 4.933 ± 0.707
4.716AlaArg: 4.716 ± 0.655
6.094AlaSer: 6.094 ± 0.742
4.208AlaThr: 4.208 ± 0.538
4.716AlaVal: 4.716 ± 0.642
0.871AlaTrp: 0.871 ± 0.233
2.322AlaTyr: 2.322 ± 0.318
0.0AlaXaa: 0.0 ± 0.0
Cys
0.653CysAla: 0.653 ± 0.185
0.073CysCys: 0.073 ± 0.067
0.435CysAsp: 0.435 ± 0.21
0.798CysGlu: 0.798 ± 0.222
0.29CysPhe: 0.29 ± 0.167
0.58CysGly: 0.58 ± 0.277
0.29CysHis: 0.29 ± 0.142
0.508CysIle: 0.508 ± 0.234
1.016CysLys: 1.016 ± 0.331
1.016CysLeu: 1.016 ± 0.229
0.508CysMet: 0.508 ± 0.184
0.653CysAsn: 0.653 ± 0.3
0.435CysPro: 0.435 ± 0.196
0.29CysGln: 0.29 ± 0.147
0.58CysArg: 0.58 ± 0.251
0.218CysSer: 0.218 ± 0.107
0.435CysThr: 0.435 ± 0.212
0.725CysVal: 0.725 ± 0.228
0.073CysTrp: 0.073 ± 0.078
0.508CysTyr: 0.508 ± 0.205
0.0CysXaa: 0.0 ± 0.0
Asp
5.659AspAla: 5.659 ± 0.601
0.363AspCys: 0.363 ± 0.138
3.337AspAsp: 3.337 ± 0.444
5.369AspGlu: 5.369 ± 0.724
2.394AspPhe: 2.394 ± 0.323
4.788AspGly: 4.788 ± 0.655
1.016AspHis: 1.016 ± 0.302
3.918AspIle: 3.918 ± 0.582
4.933AspLys: 4.933 ± 0.62
5.078AspLeu: 5.078 ± 0.499
2.031AspMet: 2.031 ± 0.322
3.845AspAsn: 3.845 ± 0.632
1.596AspPro: 1.596 ± 0.3
0.798AspGln: 0.798 ± 0.255
2.394AspArg: 2.394 ± 0.295
3.627AspSer: 3.627 ± 0.523
3.845AspThr: 3.845 ± 0.586
5.296AspVal: 5.296 ± 0.601
1.016AspTrp: 1.016 ± 0.33
2.467AspTyr: 2.467 ± 0.404
0.0AspXaa: 0.0 ± 0.0
Glu
6.384GluAla: 6.384 ± 0.677
1.016GluCys: 1.016 ± 0.344
4.933GluAsp: 4.933 ± 0.519
6.602GluGlu: 6.602 ± 0.864
2.829GluPhe: 2.829 ± 0.39
5.369GluGly: 5.369 ± 0.667
1.814GluHis: 1.814 ± 0.358
3.482GluIle: 3.482 ± 0.412
4.28GluLys: 4.28 ± 0.639
6.094GluLeu: 6.094 ± 0.831
2.176GluMet: 2.176 ± 0.43
2.757GluAsn: 2.757 ± 0.519
1.669GluPro: 1.669 ± 0.363
3.918GluGln: 3.918 ± 0.585
3.772GluArg: 3.772 ± 0.582
2.612GluSer: 2.612 ± 0.424
3.047GluThr: 3.047 ± 0.495
6.892GluVal: 6.892 ± 0.744
1.306GluTrp: 1.306 ± 0.249
1.741GluTyr: 1.741 ± 0.414
0.0GluXaa: 0.0 ± 0.0
Phe
2.467PheAla: 2.467 ± 0.443
0.363PheCys: 0.363 ± 0.163
3.41PheAsp: 3.41 ± 0.597
2.322PheGlu: 2.322 ± 0.336
1.378PhePhe: 1.378 ± 0.259
3.41PheGly: 3.41 ± 0.628
0.653PheHis: 0.653 ± 0.218
2.612PheIle: 2.612 ± 0.272
3.482PheLys: 3.482 ± 0.504
3.7PheLeu: 3.7 ± 0.454
1.596PheMet: 1.596 ± 0.266
2.322PheAsn: 2.322 ± 0.408
1.161PhePro: 1.161 ± 0.255
1.088PheGln: 1.088 ± 0.296
1.741PheArg: 1.741 ± 0.266
1.959PheSer: 1.959 ± 0.347
1.669PheThr: 1.669 ± 0.304
1.814PheVal: 1.814 ± 0.401
0.073PheTrp: 0.073 ± 0.076
0.943PheTyr: 0.943 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
5.876GlyAla: 5.876 ± 0.604
1.161GlyCys: 1.161 ± 0.326
6.239GlyAsp: 6.239 ± 0.765
4.788GlyGlu: 4.788 ± 0.565
3.192GlyPhe: 3.192 ± 0.545
5.586GlyGly: 5.586 ± 0.743
1.451GlyHis: 1.451 ± 0.347
4.135GlyIle: 4.135 ± 0.552
6.82GlyLys: 6.82 ± 0.958
5.369GlyLeu: 5.369 ± 0.674
1.886GlyMet: 1.886 ± 0.334
3.337GlyAsn: 3.337 ± 0.482
0.0GlyPro: 0.0 ± 0.0
2.757GlyGln: 2.757 ± 0.379
3.265GlyArg: 3.265 ± 0.423
5.151GlySer: 5.151 ± 0.558
5.441GlyThr: 5.441 ± 0.59
4.425GlyVal: 4.425 ± 0.733
1.088GlyTrp: 1.088 ± 0.233
3.772GlyTyr: 3.772 ± 0.491
0.0GlyXaa: 0.0 ± 0.0
His
1.016HisAla: 1.016 ± 0.265
0.29HisCys: 0.29 ± 0.131
1.378HisAsp: 1.378 ± 0.383
1.451HisGlu: 1.451 ± 0.277
1.161HisPhe: 1.161 ± 0.212
1.596HisGly: 1.596 ± 0.384
0.435HisHis: 0.435 ± 0.216
1.161HisIle: 1.161 ± 0.232
1.378HisLys: 1.378 ± 0.379
2.539HisLeu: 2.539 ± 0.457
0.653HisMet: 0.653 ± 0.332
0.871HisAsn: 0.871 ± 0.306
0.29HisPro: 0.29 ± 0.133
0.725HisGln: 0.725 ± 0.272
0.653HisArg: 0.653 ± 0.249
0.871HisSer: 0.871 ± 0.284
1.016HisThr: 1.016 ± 0.206
0.871HisVal: 0.871 ± 0.285
0.145HisTrp: 0.145 ± 0.091
0.871HisTyr: 0.871 ± 0.255
0.0HisXaa: 0.0 ± 0.0
Ile
4.135IleAla: 4.135 ± 0.491
0.435IleCys: 0.435 ± 0.167
3.7IleAsp: 3.7 ± 0.474
4.353IleGlu: 4.353 ± 0.568
1.669IlePhe: 1.669 ± 0.393
4.716IleGly: 4.716 ± 0.495
1.306IleHis: 1.306 ± 0.283
4.498IleIle: 4.498 ± 0.682
4.425IleLys: 4.425 ± 0.607
3.7IleLeu: 3.7 ± 0.642
2.104IleMet: 2.104 ± 0.486
3.918IleAsn: 3.918 ± 0.475
2.104IlePro: 2.104 ± 0.422
1.741IleGln: 1.741 ± 0.282
2.829IleArg: 2.829 ± 0.431
3.482IleSer: 3.482 ± 0.403
3.41IleThr: 3.41 ± 0.568
3.265IleVal: 3.265 ± 0.477
0.435IleTrp: 0.435 ± 0.129
1.814IleTyr: 1.814 ± 0.618
0.0IleXaa: 0.0 ± 0.0
Lys
7.11LysAla: 7.11 ± 1.106
0.653LysCys: 0.653 ± 0.259
4.498LysAsp: 4.498 ± 0.596
5.659LysGlu: 5.659 ± 0.532
1.161LysPhe: 1.161 ± 0.318
4.861LysGly: 4.861 ± 0.601
1.233LysHis: 1.233 ± 0.356
3.12LysIle: 3.12 ± 0.368
3.845LysLys: 3.845 ± 0.696
6.384LysLeu: 6.384 ± 0.721
1.596LysMet: 1.596 ± 0.393
2.104LysAsn: 2.104 ± 0.385
3.7LysPro: 3.7 ± 0.435
2.902LysGln: 2.902 ± 0.385
3.7LysArg: 3.7 ± 0.53
4.571LysSer: 4.571 ± 0.45
2.829LysThr: 2.829 ± 0.419
6.021LysVal: 6.021 ± 0.758
1.088LysTrp: 1.088 ± 0.252
2.612LysTyr: 2.612 ± 0.349
0.0LysXaa: 0.0 ± 0.0
Leu
6.674LeuAla: 6.674 ± 1.016
0.58LeuCys: 0.58 ± 0.26
4.788LeuAsp: 4.788 ± 0.449
6.021LeuGlu: 6.021 ± 0.73
2.757LeuPhe: 2.757 ± 0.516
5.949LeuGly: 5.949 ± 0.578
1.306LeuHis: 1.306 ± 0.28
4.208LeuIle: 4.208 ± 0.668
5.369LeuLys: 5.369 ± 0.661
6.094LeuLeu: 6.094 ± 0.65
1.451LeuMet: 1.451 ± 0.318
4.135LeuAsn: 4.135 ± 0.495
3.627LeuPro: 3.627 ± 0.515
4.861LeuGln: 4.861 ± 0.871
4.063LeuArg: 4.063 ± 0.661
5.078LeuSer: 5.078 ± 0.638
4.353LeuThr: 4.353 ± 0.506
4.933LeuVal: 4.933 ± 0.714
0.725LeuTrp: 0.725 ± 0.2
3.12LeuTyr: 3.12 ± 0.446
0.0LeuXaa: 0.0 ± 0.0
Met
3.192MetAla: 3.192 ± 0.418
0.363MetCys: 0.363 ± 0.145
1.161MetAsp: 1.161 ± 0.369
1.814MetGlu: 1.814 ± 0.401
1.451MetPhe: 1.451 ± 0.35
1.814MetGly: 1.814 ± 0.43
0.58MetHis: 0.58 ± 0.178
1.669MetIle: 1.669 ± 0.445
2.249MetLys: 2.249 ± 0.436
2.684MetLeu: 2.684 ± 0.43
0.58MetMet: 0.58 ± 0.213
1.378MetAsn: 1.378 ± 0.313
1.016MetPro: 1.016 ± 0.197
1.233MetGln: 1.233 ± 0.325
2.031MetArg: 2.031 ± 0.37
2.902MetSer: 2.902 ± 0.425
1.306MetThr: 1.306 ± 0.277
1.596MetVal: 1.596 ± 0.263
0.58MetTrp: 0.58 ± 0.25
1.451MetTyr: 1.451 ± 0.383
0.0MetXaa: 0.0 ± 0.0
Asn
2.902AsnAla: 2.902 ± 0.446
0.871AsnCys: 0.871 ± 0.305
2.031AsnAsp: 2.031 ± 0.4
2.684AsnGlu: 2.684 ± 0.622
1.814AsnPhe: 1.814 ± 0.347
3.41AsnGly: 3.41 ± 0.423
0.58AsnHis: 0.58 ± 0.222
2.394AsnIle: 2.394 ± 0.372
3.627AsnLys: 3.627 ± 0.613
3.772AsnLeu: 3.772 ± 0.34
1.161AsnMet: 1.161 ± 0.273
2.104AsnAsn: 2.104 ± 0.325
2.104AsnPro: 2.104 ± 0.32
2.104AsnGln: 2.104 ± 0.382
3.265AsnArg: 3.265 ± 0.425
2.031AsnSer: 2.031 ± 0.386
2.974AsnThr: 2.974 ± 0.461
3.337AsnVal: 3.337 ± 0.392
0.725AsnTrp: 0.725 ± 0.199
1.378AsnTyr: 1.378 ± 0.285
0.0AsnXaa: 0.0 ± 0.0
Pro
3.047ProAla: 3.047 ± 0.422
0.435ProCys: 0.435 ± 0.189
2.684ProAsp: 2.684 ± 0.451
2.902ProGlu: 2.902 ± 0.437
1.596ProPhe: 1.596 ± 0.353
0.218ProGly: 0.218 ± 0.121
0.798ProHis: 0.798 ± 0.231
1.306ProIle: 1.306 ± 0.28
2.104ProLys: 2.104 ± 0.465
1.814ProLeu: 1.814 ± 0.346
1.016ProMet: 1.016 ± 0.231
1.378ProAsn: 1.378 ± 0.347
0.943ProPro: 0.943 ± 0.264
1.161ProGln: 1.161 ± 0.222
1.524ProArg: 1.524 ± 0.289
1.814ProSer: 1.814 ± 0.3
2.249ProThr: 2.249 ± 0.384
3.265ProVal: 3.265 ± 0.642
0.58ProTrp: 0.58 ± 0.183
1.669ProTyr: 1.669 ± 0.315
0.0ProXaa: 0.0 ± 0.0
Gln
3.772GlnAla: 3.772 ± 0.582
0.29GlnCys: 0.29 ± 0.137
2.394GlnAsp: 2.394 ± 0.402
3.41GlnGlu: 3.41 ± 0.458
1.741GlnPhe: 1.741 ± 0.395
4.063GlnGly: 4.063 ± 0.637
0.871GlnHis: 0.871 ± 0.214
2.322GlnIle: 2.322 ± 0.291
1.451GlnLys: 1.451 ± 0.257
3.7GlnLeu: 3.7 ± 0.547
1.669GlnMet: 1.669 ± 0.383
1.088GlnAsn: 1.088 ± 0.214
1.524GlnPro: 1.524 ± 0.308
2.467GlnGln: 2.467 ± 0.453
2.322GlnArg: 2.322 ± 0.425
2.031GlnSer: 2.031 ± 0.399
2.684GlnThr: 2.684 ± 0.493
1.959GlnVal: 1.959 ± 0.255
0.798GlnTrp: 0.798 ± 0.296
1.451GlnTyr: 1.451 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
4.788ArgAla: 4.788 ± 0.845
0.363ArgCys: 0.363 ± 0.168
3.482ArgAsp: 3.482 ± 0.413
3.555ArgGlu: 3.555 ± 0.458
1.741ArgPhe: 1.741 ± 0.262
4.498ArgGly: 4.498 ± 0.668
1.451ArgHis: 1.451 ± 0.366
3.772ArgIle: 3.772 ± 0.5
3.12ArgLys: 3.12 ± 0.426
3.772ArgLeu: 3.772 ± 0.543
2.249ArgMet: 2.249 ± 0.327
2.104ArgAsn: 2.104 ± 0.388
1.233ArgPro: 1.233 ± 0.26
1.451ArgGln: 1.451 ± 0.299
2.612ArgArg: 2.612 ± 0.479
2.757ArgSer: 2.757 ± 0.433
2.322ArgThr: 2.322 ± 0.445
3.482ArgVal: 3.482 ± 0.466
0.653ArgTrp: 0.653 ± 0.194
2.031ArgTyr: 2.031 ± 0.292
0.0ArgXaa: 0.0 ± 0.0
Ser
4.498SerAla: 4.498 ± 0.779
0.653SerCys: 0.653 ± 0.198
3.845SerAsp: 3.845 ± 0.446
3.7SerGlu: 3.7 ± 0.468
2.612SerPhe: 2.612 ± 0.278
5.441SerGly: 5.441 ± 0.606
0.58SerHis: 0.58 ± 0.199
4.425SerIle: 4.425 ± 0.504
3.41SerLys: 3.41 ± 0.478
4.716SerLeu: 4.716 ± 0.484
1.596SerMet: 1.596 ± 0.315
3.047SerAsn: 3.047 ± 0.415
1.814SerPro: 1.814 ± 0.331
2.249SerGln: 2.249 ± 0.456
3.192SerArg: 3.192 ± 0.454
3.482SerSer: 3.482 ± 0.67
3.337SerThr: 3.337 ± 0.617
3.918SerVal: 3.918 ± 0.687
1.088SerTrp: 1.088 ± 0.243
2.394SerTyr: 2.394 ± 0.543
0.0SerXaa: 0.0 ± 0.0
Thr
3.918ThrAla: 3.918 ± 0.657
0.363ThrCys: 0.363 ± 0.144
2.757ThrAsp: 2.757 ± 0.594
3.555ThrGlu: 3.555 ± 0.479
2.757ThrPhe: 2.757 ± 0.408
4.425ThrGly: 4.425 ± 0.62
1.161ThrHis: 1.161 ± 0.28
3.41ThrIle: 3.41 ± 0.478
3.99ThrLys: 3.99 ± 0.481
5.514ThrLeu: 5.514 ± 0.595
1.596ThrMet: 1.596 ± 0.312
1.886ThrAsn: 1.886 ± 0.388
2.176ThrPro: 2.176 ± 0.347
2.684ThrGln: 2.684 ± 0.462
2.974ThrArg: 2.974 ± 0.405
3.12ThrSer: 3.12 ± 0.481
2.539ThrThr: 2.539 ± 0.43
3.41ThrVal: 3.41 ± 0.544
0.653ThrTrp: 0.653 ± 0.282
1.596ThrTyr: 1.596 ± 0.399
0.0ThrXaa: 0.0 ± 0.0
Val
6.312ValAla: 6.312 ± 0.528
0.725ValCys: 0.725 ± 0.222
4.353ValAsp: 4.353 ± 0.458
4.643ValGlu: 4.643 ± 0.605
2.539ValPhe: 2.539 ± 0.495
4.716ValGly: 4.716 ± 0.684
1.161ValHis: 1.161 ± 0.327
3.845ValIle: 3.845 ± 0.621
4.571ValLys: 4.571 ± 0.488
4.135ValLeu: 4.135 ± 0.711
2.322ValMet: 2.322 ± 0.319
2.902ValAsn: 2.902 ± 0.374
2.394ValPro: 2.394 ± 0.361
2.829ValGln: 2.829 ± 0.612
4.135ValArg: 4.135 ± 0.56
4.861ValSer: 4.861 ± 0.579
3.482ValThr: 3.482 ± 0.6
4.861ValVal: 4.861 ± 0.811
0.725ValTrp: 0.725 ± 0.239
2.394ValTyr: 2.394 ± 0.464
0.0ValXaa: 0.0 ± 0.0
Trp
0.725TrpAla: 0.725 ± 0.219
0.363TrpCys: 0.363 ± 0.176
0.725TrpAsp: 0.725 ± 0.228
1.378TrpGlu: 1.378 ± 0.309
0.508TrpPhe: 0.508 ± 0.209
0.798TrpGly: 0.798 ± 0.201
0.653TrpHis: 0.653 ± 0.244
0.435TrpIle: 0.435 ± 0.145
1.161TrpLys: 1.161 ± 0.316
1.016TrpLeu: 1.016 ± 0.228
0.145TrpMet: 0.145 ± 0.083
0.435TrpAsn: 0.435 ± 0.171
0.871TrpPro: 0.871 ± 0.232
0.435TrpGln: 0.435 ± 0.184
0.435TrpArg: 0.435 ± 0.181
1.088TrpSer: 1.088 ± 0.353
0.508TrpThr: 0.508 ± 0.208
1.161TrpVal: 1.161 ± 0.289
0.145TrpTrp: 0.145 ± 0.086
0.218TrpTyr: 0.218 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.902TyrAla: 2.902 ± 0.439
0.29TyrCys: 0.29 ± 0.138
2.757TyrAsp: 2.757 ± 0.422
2.104TyrGlu: 2.104 ± 0.38
1.814TyrPhe: 1.814 ± 0.393
3.047TyrGly: 3.047 ± 0.549
0.508TyrHis: 0.508 ± 0.229
2.031TyrIle: 2.031 ± 0.328
2.249TyrLys: 2.249 ± 0.397
2.974TyrLeu: 2.974 ± 0.606
1.161TyrMet: 1.161 ± 0.266
1.596TyrAsn: 1.596 ± 0.268
1.161TyrPro: 1.161 ± 0.305
1.378TyrGln: 1.378 ± 0.293
1.233TyrArg: 1.233 ± 0.305
2.249TyrSer: 2.249 ± 0.426
2.829TyrThr: 2.829 ± 0.409
1.959TyrVal: 1.959 ± 0.321
0.435TyrTrp: 0.435 ± 0.218
1.233TyrTyr: 1.233 ± 0.375
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (13785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski