Amino acid dipepetide frequency for Streptococcus satellite phage Javan317

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.602AlaCys: 0.602 ± 0.408
2.406AlaAsp: 2.406 ± 0.798
3.308AlaGlu: 3.308 ± 1.095
2.105AlaPhe: 2.105 ± 0.697
1.805AlaGly: 1.805 ± 0.69
0.301AlaHis: 0.301 ± 0.291
1.805AlaIle: 1.805 ± 0.907
6.316AlaLys: 6.316 ± 1.448
4.812AlaLeu: 4.812 ± 1.293
2.105AlaMet: 2.105 ± 0.951
3.308AlaAsn: 3.308 ± 0.749
0.602AlaPro: 0.602 ± 0.443
0.902AlaGln: 0.902 ± 0.637
2.707AlaArg: 2.707 ± 0.859
1.504AlaSer: 1.504 ± 0.768
4.211AlaThr: 4.211 ± 0.858
2.406AlaVal: 2.406 ± 0.755
0.0AlaTrp: 0.0 ± 0.0
3.008AlaTyr: 3.008 ± 0.832
0.0AlaXaa: 0.0 ± 0.0
Cys
0.602CysAla: 0.602 ± 0.382
0.0CysCys: 0.0 ± 0.0
0.902CysAsp: 0.902 ± 0.453
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.902CysGly: 0.902 ± 0.503
0.0CysHis: 0.0 ± 0.0
0.301CysIle: 0.301 ± 0.248
0.301CysLys: 0.301 ± 0.314
1.203CysLeu: 1.203 ± 0.632
0.301CysMet: 0.301 ± 0.264
0.0CysAsn: 0.0 ± 0.0
0.602CysPro: 0.602 ± 0.35
0.301CysGln: 0.301 ± 0.243
0.0CysArg: 0.0 ± 0.0
0.602CysSer: 0.602 ± 0.408
0.301CysThr: 0.301 ± 0.271
0.301CysVal: 0.301 ± 0.308
0.0CysTrp: 0.0 ± 0.0
0.602CysTyr: 0.602 ± 0.349
0.0CysXaa: 0.0 ± 0.0
Asp
0.602AspAla: 0.602 ± 0.451
0.902AspCys: 0.902 ± 0.446
3.91AspAsp: 3.91 ± 1.385
2.406AspGlu: 2.406 ± 0.651
6.617AspPhe: 6.617 ± 1.393
3.609AspGly: 3.609 ± 0.773
0.0AspHis: 0.0 ± 0.0
7.519AspIle: 7.519 ± 1.879
9.624AspLys: 9.624 ± 1.564
6.316AspLeu: 6.316 ± 1.03
0.902AspMet: 0.902 ± 0.497
3.609AspAsn: 3.609 ± 0.872
0.301AspPro: 0.301 ± 0.314
0.902AspGln: 0.902 ± 0.367
1.504AspArg: 1.504 ± 0.606
3.91AspSer: 3.91 ± 0.858
2.406AspThr: 2.406 ± 1.003
4.211AspVal: 4.211 ± 0.892
0.301AspTrp: 0.301 ± 0.308
3.008AspTyr: 3.008 ± 1.02
0.0AspXaa: 0.0 ± 0.0
Glu
3.008GluAla: 3.008 ± 1.041
0.902GluCys: 0.902 ± 0.443
5.414GluAsp: 5.414 ± 1.371
4.211GluGlu: 4.211 ± 0.956
3.91GluPhe: 3.91 ± 1.011
2.105GluGly: 2.105 ± 0.814
0.902GluHis: 0.902 ± 0.478
7.218GluIle: 7.218 ± 1.327
9.323GluLys: 9.323 ± 1.981
9.624GluLeu: 9.624 ± 2.052
1.504GluMet: 1.504 ± 0.555
5.414GluAsn: 5.414 ± 1.241
0.902GluPro: 0.902 ± 0.689
3.91GluGln: 3.91 ± 0.922
3.008GluArg: 3.008 ± 0.908
3.91GluSer: 3.91 ± 1.012
3.91GluThr: 3.91 ± 1.046
2.707GluVal: 2.707 ± 0.862
0.301GluTrp: 0.301 ± 0.248
3.308GluTyr: 3.308 ± 0.896
0.0GluXaa: 0.0 ± 0.0
Phe
0.902PheAla: 0.902 ± 0.604
0.301PheCys: 0.301 ± 0.308
4.211PheAsp: 4.211 ± 0.769
5.113PheGlu: 5.113 ± 1.306
5.714PhePhe: 5.714 ± 1.905
2.406PheGly: 2.406 ± 0.809
0.902PheHis: 0.902 ± 0.505
2.406PheIle: 2.406 ± 0.745
5.113PheLys: 5.113 ± 1.291
5.414PheLeu: 5.414 ± 1.143
0.602PheMet: 0.602 ± 0.398
2.406PheAsn: 2.406 ± 1.098
0.902PhePro: 0.902 ± 0.536
2.105PheGln: 2.105 ± 0.81
1.805PheArg: 1.805 ± 0.72
5.113PheSer: 5.113 ± 1.205
2.406PheThr: 2.406 ± 0.643
3.308PheVal: 3.308 ± 1.188
0.602PheTrp: 0.602 ± 0.363
1.203PheTyr: 1.203 ± 0.589
0.0PheXaa: 0.0 ± 0.0
Gly
1.805GlyAla: 1.805 ± 0.792
0.301GlyCys: 0.301 ± 0.271
1.504GlyAsp: 1.504 ± 0.736
1.504GlyGlu: 1.504 ± 0.78
2.105GlyPhe: 2.105 ± 0.629
2.105GlyGly: 2.105 ± 1.105
1.504GlyHis: 1.504 ± 0.722
4.211GlyIle: 4.211 ± 0.936
5.414GlyLys: 5.414 ± 1.543
3.308GlyLeu: 3.308 ± 0.889
0.902GlyMet: 0.902 ± 0.474
2.406GlyAsn: 2.406 ± 0.867
0.0GlyPro: 0.0 ± 0.0
1.504GlyGln: 1.504 ± 0.555
0.902GlyArg: 0.902 ± 0.476
3.008GlySer: 3.008 ± 1.121
2.707GlyThr: 2.707 ± 0.877
2.406GlyVal: 2.406 ± 0.771
0.602GlyTrp: 0.602 ± 0.43
3.308GlyTyr: 3.308 ± 1.097
0.0GlyXaa: 0.0 ± 0.0
His
2.406HisAla: 2.406 ± 1.365
0.0HisCys: 0.0 ± 0.0
0.602HisAsp: 0.602 ± 0.349
0.902HisGlu: 0.902 ± 0.524
0.602HisPhe: 0.602 ± 0.457
0.0HisGly: 0.0 ± 0.0
0.301HisHis: 0.301 ± 0.311
2.105HisIle: 2.105 ± 0.736
1.504HisLys: 1.504 ± 0.588
2.105HisLeu: 2.105 ± 0.94
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.301HisPro: 0.301 ± 0.248
0.902HisGln: 0.902 ± 0.488
0.602HisArg: 0.602 ± 0.45
1.504HisSer: 1.504 ± 0.76
2.707HisThr: 2.707 ± 0.845
0.301HisVal: 0.301 ± 0.27
0.0HisTrp: 0.0 ± 0.0
0.902HisTyr: 0.902 ± 0.467
0.0HisXaa: 0.0 ± 0.0
Ile
1.805IleAla: 1.805 ± 0.877
0.301IleCys: 0.301 ± 0.291
4.511IleAsp: 4.511 ± 1.116
6.917IleGlu: 6.917 ± 1.401
4.211IlePhe: 4.211 ± 1.236
3.308IleGly: 3.308 ± 0.753
1.805IleHis: 1.805 ± 0.662
4.511IleIle: 4.511 ± 1.149
8.421IleLys: 8.421 ± 1.147
9.624IleLeu: 9.624 ± 1.83
1.203IleMet: 1.203 ± 0.451
7.519IleAsn: 7.519 ± 1.566
2.406IlePro: 2.406 ± 0.481
3.008IleGln: 3.008 ± 0.867
2.406IleArg: 2.406 ± 0.874
7.218IleSer: 7.218 ± 1.263
5.113IleThr: 5.113 ± 1.041
1.504IleVal: 1.504 ± 0.724
0.301IleTrp: 0.301 ± 0.291
2.707IleTyr: 2.707 ± 0.674
0.0IleXaa: 0.0 ± 0.0
Lys
6.617LysAla: 6.617 ± 1.429
0.602LysCys: 0.602 ± 0.426
5.414LysAsp: 5.414 ± 1.115
11.429LysGlu: 11.429 ± 1.616
3.008LysPhe: 3.008 ± 1.055
4.812LysGly: 4.812 ± 1.236
2.105LysHis: 2.105 ± 0.781
10.827LysIle: 10.827 ± 1.613
9.323LysLys: 9.323 ± 1.389
5.414LysLeu: 5.414 ± 0.652
3.609LysMet: 3.609 ± 1.191
7.218LysAsn: 7.218 ± 1.238
3.308LysPro: 3.308 ± 1.013
5.714LysGln: 5.714 ± 1.224
7.218LysArg: 7.218 ± 1.211
5.714LysSer: 5.714 ± 1.257
6.917LysThr: 6.917 ± 1.461
5.113LysVal: 5.113 ± 1.438
0.902LysTrp: 0.902 ± 0.589
4.511LysTyr: 4.511 ± 1.242
0.0LysXaa: 0.0 ± 0.0
Leu
4.511LeuAla: 4.511 ± 1.124
1.203LeuCys: 1.203 ± 0.573
7.519LeuAsp: 7.519 ± 1.254
8.722LeuGlu: 8.722 ± 1.306
5.714LeuPhe: 5.714 ± 1.355
6.617LeuGly: 6.617 ± 0.799
2.406LeuHis: 2.406 ± 0.954
7.218LeuIle: 7.218 ± 1.292
9.624LeuLys: 9.624 ± 1.323
6.917LeuLeu: 6.917 ± 1.486
2.105LeuMet: 2.105 ± 0.589
5.714LeuAsn: 5.714 ± 1.395
3.609LeuPro: 3.609 ± 1.147
3.008LeuGln: 3.008 ± 0.608
3.308LeuArg: 3.308 ± 0.99
6.316LeuSer: 6.316 ± 1.115
4.511LeuThr: 4.511 ± 1.356
6.316LeuVal: 6.316 ± 1.314
0.301LeuTrp: 0.301 ± 0.33
1.805LeuTyr: 1.805 ± 0.765
0.0LeuXaa: 0.0 ± 0.0
Met
1.504MetAla: 1.504 ± 0.761
0.0MetCys: 0.0 ± 0.0
3.008MetAsp: 3.008 ± 0.967
2.105MetGlu: 2.105 ± 0.841
0.602MetPhe: 0.602 ± 0.402
0.301MetGly: 0.301 ± 0.342
0.0MetHis: 0.0 ± 0.0
1.203MetIle: 1.203 ± 0.539
0.902MetLys: 0.902 ± 0.422
1.504MetLeu: 1.504 ± 0.462
0.0MetMet: 0.0 ± 0.0
1.504MetAsn: 1.504 ± 0.589
0.902MetPro: 0.902 ± 0.455
1.203MetGln: 1.203 ± 0.555
1.805MetArg: 1.805 ± 0.861
0.602MetSer: 0.602 ± 0.441
1.805MetThr: 1.805 ± 0.863
1.805MetVal: 1.805 ± 0.49
0.0MetTrp: 0.0 ± 0.0
0.602MetTyr: 0.602 ± 0.364
0.0MetXaa: 0.0 ± 0.0
Asn
3.609AsnAla: 3.609 ± 0.921
0.301AsnCys: 0.301 ± 0.271
3.008AsnAsp: 3.008 ± 1.182
2.707AsnGlu: 2.707 ± 1.25
4.812AsnPhe: 4.812 ± 0.955
3.008AsnGly: 3.008 ± 1.011
2.406AsnHis: 2.406 ± 0.749
3.91AsnIle: 3.91 ± 1.28
6.015AsnLys: 6.015 ± 1.169
6.015AsnLeu: 6.015 ± 1.208
1.504AsnMet: 1.504 ± 0.681
3.91AsnAsn: 3.91 ± 1.172
3.008AsnPro: 3.008 ± 0.919
2.406AsnGln: 2.406 ± 0.946
2.105AsnArg: 2.105 ± 0.829
3.308AsnSer: 3.308 ± 1.032
4.812AsnThr: 4.812 ± 1.524
2.406AsnVal: 2.406 ± 0.887
0.902AsnTrp: 0.902 ± 0.542
3.91AsnTyr: 3.91 ± 0.688
0.0AsnXaa: 0.0 ± 0.0
Pro
0.902ProAla: 0.902 ± 0.55
0.0ProCys: 0.0 ± 0.0
2.105ProAsp: 2.105 ± 0.723
2.406ProGlu: 2.406 ± 0.849
1.203ProPhe: 1.203 ± 0.533
0.602ProGly: 0.602 ± 0.366
0.0ProHis: 0.0 ± 0.0
2.105ProIle: 2.105 ± 0.785
3.91ProLys: 3.91 ± 1.059
0.902ProLeu: 0.902 ± 0.439
0.0ProMet: 0.0 ± 0.0
1.203ProAsn: 1.203 ± 0.504
0.602ProPro: 0.602 ± 0.356
0.602ProGln: 0.602 ± 0.612
1.203ProArg: 1.203 ± 0.505
1.805ProSer: 1.805 ± 0.692
0.902ProThr: 0.902 ± 0.529
1.203ProVal: 1.203 ± 0.484
0.301ProTrp: 0.301 ± 0.286
0.902ProTyr: 0.902 ± 0.382
0.0ProXaa: 0.0 ± 0.0
Gln
5.113GlnAla: 5.113 ± 1.548
0.602GlnCys: 0.602 ± 0.381
2.406GlnAsp: 2.406 ± 0.827
3.308GlnGlu: 3.308 ± 0.852
1.203GlnPhe: 1.203 ± 0.732
0.301GlnGly: 0.301 ± 0.264
1.203GlnHis: 1.203 ± 0.56
1.805GlnIle: 1.805 ± 0.395
4.511GlnLys: 4.511 ± 0.959
3.609GlnLeu: 3.609 ± 0.963
1.203GlnMet: 1.203 ± 0.728
2.105GlnAsn: 2.105 ± 0.613
0.301GlnPro: 0.301 ± 0.311
0.902GlnGln: 0.902 ± 0.479
3.008GlnArg: 3.008 ± 0.658
0.902GlnSer: 0.902 ± 0.489
2.707GlnThr: 2.707 ± 0.967
2.707GlnVal: 2.707 ± 0.73
0.602GlnTrp: 0.602 ± 0.412
1.805GlnTyr: 1.805 ± 0.549
0.0GlnXaa: 0.0 ± 0.0
Arg
1.805ArgAla: 1.805 ± 0.668
0.0ArgCys: 0.0 ± 0.0
3.609ArgAsp: 3.609 ± 0.669
3.308ArgGlu: 3.308 ± 0.887
2.406ArgPhe: 2.406 ± 0.936
1.203ArgGly: 1.203 ± 0.669
0.602ArgHis: 0.602 ± 0.366
3.008ArgIle: 3.008 ± 0.906
6.917ArgLys: 6.917 ± 1.429
4.511ArgLeu: 4.511 ± 0.848
0.902ArgMet: 0.902 ± 0.478
3.609ArgAsn: 3.609 ± 0.887
0.301ArgPro: 0.301 ± 0.248
3.308ArgGln: 3.308 ± 1.109
2.105ArgArg: 2.105 ± 0.705
1.504ArgSer: 1.504 ± 0.627
2.406ArgThr: 2.406 ± 0.818
0.602ArgVal: 0.602 ± 0.324
0.0ArgTrp: 0.0 ± 0.0
2.707ArgTyr: 2.707 ± 1.144
0.0ArgXaa: 0.0 ± 0.0
Ser
2.105SerAla: 2.105 ± 0.797
0.301SerCys: 0.301 ± 0.248
3.609SerAsp: 3.609 ± 0.599
5.414SerGlu: 5.414 ± 1.177
2.406SerPhe: 2.406 ± 0.905
3.008SerGly: 3.008 ± 0.937
1.805SerHis: 1.805 ± 0.647
3.609SerIle: 3.609 ± 1.1
8.12SerLys: 8.12 ± 1.996
6.316SerLeu: 6.316 ± 1.586
1.504SerMet: 1.504 ± 0.672
3.609SerAsn: 3.609 ± 0.932
1.504SerPro: 1.504 ± 0.559
3.008SerGln: 3.008 ± 0.837
1.504SerArg: 1.504 ± 0.676
3.91SerSer: 3.91 ± 1.244
2.707SerThr: 2.707 ± 0.803
3.308SerVal: 3.308 ± 1.05
1.203SerTrp: 1.203 ± 0.585
2.707SerTyr: 2.707 ± 0.725
0.0SerXaa: 0.0 ± 0.0
Thr
3.008ThrAla: 3.008 ± 0.821
0.0ThrCys: 0.0 ± 0.0
1.805ThrAsp: 1.805 ± 0.856
3.008ThrGlu: 3.008 ± 0.98
1.805ThrPhe: 1.805 ± 0.712
3.609ThrGly: 3.609 ± 0.885
0.602ThrHis: 0.602 ± 0.541
6.316ThrIle: 6.316 ± 1.72
4.211ThrLys: 4.211 ± 1.142
6.316ThrLeu: 6.316 ± 1.01
0.902ThrMet: 0.902 ± 0.464
3.308ThrAsn: 3.308 ± 0.599
1.805ThrPro: 1.805 ± 0.72
2.707ThrGln: 2.707 ± 1.143
4.511ThrArg: 4.511 ± 1.563
2.707ThrSer: 2.707 ± 1.011
3.008ThrThr: 3.008 ± 0.856
4.511ThrVal: 4.511 ± 1.241
0.301ThrTrp: 0.301 ± 0.335
2.406ThrTyr: 2.406 ± 1.339
0.0ThrXaa: 0.0 ± 0.0
Val
1.504ValAla: 1.504 ± 0.617
0.301ValCys: 0.301 ± 0.308
4.511ValAsp: 4.511 ± 1.358
5.113ValGlu: 5.113 ± 1.369
1.203ValPhe: 1.203 ± 0.656
0.602ValGly: 0.602 ± 0.358
0.602ValHis: 0.602 ± 0.486
4.511ValIle: 4.511 ± 0.845
5.113ValLys: 5.113 ± 1.397
5.113ValLeu: 5.113 ± 1.094
0.0ValMet: 0.0 ± 0.0
3.609ValAsn: 3.609 ± 1.045
0.902ValPro: 0.902 ± 0.534
1.805ValGln: 1.805 ± 0.687
1.805ValArg: 1.805 ± 0.814
5.414ValSer: 5.414 ± 1.344
2.105ValThr: 2.105 ± 0.812
2.707ValVal: 2.707 ± 0.704
0.0ValTrp: 0.0 ± 0.0
2.707ValTyr: 2.707 ± 0.691
0.0ValXaa: 0.0 ± 0.0
Trp
0.902TrpAla: 0.902 ± 0.391
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.805TrpGlu: 1.805 ± 0.781
0.0TrpPhe: 0.0 ± 0.0
0.301TrpGly: 0.301 ± 0.286
0.0TrpHis: 0.0 ± 0.0
0.602TrpIle: 0.602 ± 0.427
0.301TrpLys: 0.301 ± 0.248
0.902TrpLeu: 0.902 ± 0.6
0.301TrpMet: 0.301 ± 0.307
0.301TrpAsn: 0.301 ± 0.27
0.0TrpPro: 0.0 ± 0.0
0.301TrpGln: 0.301 ± 0.271
0.0TrpArg: 0.0 ± 0.0
0.301TrpSer: 0.301 ± 0.271
0.0TrpThr: 0.0 ± 0.0
0.902TrpVal: 0.902 ± 0.477
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.504TyrAla: 1.504 ± 0.799
0.602TyrCys: 0.602 ± 0.581
2.105TyrAsp: 2.105 ± 0.63
1.805TyrGlu: 1.805 ± 0.727
3.308TyrPhe: 3.308 ± 0.922
0.902TyrGly: 0.902 ± 0.476
0.301TyrHis: 0.301 ± 0.243
3.609TyrIle: 3.609 ± 0.932
5.113TyrLys: 5.113 ± 1.303
7.519TyrLeu: 7.519 ± 1.336
1.504TyrMet: 1.504 ± 0.668
3.308TyrAsn: 3.308 ± 0.706
0.602TyrPro: 0.602 ± 0.349
1.805TyrGln: 1.805 ± 0.524
3.308TyrArg: 3.308 ± 1.405
2.406TyrSer: 2.406 ± 0.804
1.203TyrThr: 1.203 ± 0.637
0.902TyrVal: 0.902 ± 0.494
0.301TyrTrp: 0.301 ± 0.308
1.805TyrTyr: 1.805 ± 0.858
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski