Amino acid dipepetide frequency for Gordonia phage Tanis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.625AlaAla: 7.625 ± 1.166
0.379AlaCys: 0.379 ± 0.152
4.651AlaAsp: 4.651 ± 0.372
5.354AlaGlu: 5.354 ± 0.43
3.731AlaPhe: 3.731 ± 0.477
6.597AlaGly: 6.597 ± 1.055
1.19AlaHis: 1.19 ± 0.275
6.219AlaIle: 6.219 ± 0.728
5.84AlaLys: 5.84 ± 0.836
8.166AlaLeu: 8.166 ± 1.174
2.866AlaMet: 2.866 ± 0.804
3.623AlaAsn: 3.623 ± 0.479
2.325AlaPro: 2.325 ± 0.366
2.488AlaGln: 2.488 ± 0.324
4.272AlaArg: 4.272 ± 0.593
5.462AlaSer: 5.462 ± 0.51
4.651AlaThr: 4.651 ± 0.521
6.597AlaVal: 6.597 ± 0.762
0.865AlaTrp: 0.865 ± 0.254
3.082AlaTyr: 3.082 ± 0.374
0.0AlaXaa: 0.0 ± 0.0
Cys
0.379CysAla: 0.379 ± 0.164
0.054CysCys: 0.054 ± 0.051
0.379CysAsp: 0.379 ± 0.155
0.27CysGlu: 0.27 ± 0.11
0.108CysPhe: 0.108 ± 0.082
0.433CysGly: 0.433 ± 0.163
0.108CysHis: 0.108 ± 0.092
0.27CysIle: 0.27 ± 0.131
0.487CysLys: 0.487 ± 0.193
0.811CysLeu: 0.811 ± 0.224
0.0CysMet: 0.0 ± 0.0
0.27CysAsn: 0.27 ± 0.127
0.27CysPro: 0.27 ± 0.156
0.324CysGln: 0.324 ± 0.144
0.324CysArg: 0.324 ± 0.15
0.324CysSer: 0.324 ± 0.113
0.216CysThr: 0.216 ± 0.096
0.703CysVal: 0.703 ± 0.237
0.108CysTrp: 0.108 ± 0.069
0.162CysTyr: 0.162 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
5.516AspAla: 5.516 ± 0.605
0.433AspCys: 0.433 ± 0.191
3.839AspAsp: 3.839 ± 0.609
6.219AspGlu: 6.219 ± 0.614
2.433AspPhe: 2.433 ± 0.455
4.867AspGly: 4.867 ± 0.556
1.568AspHis: 1.568 ± 0.305
3.245AspIle: 3.245 ± 0.412
2.542AspLys: 2.542 ± 0.363
5.624AspLeu: 5.624 ± 0.631
1.73AspMet: 1.73 ± 0.265
2.596AspAsn: 2.596 ± 0.388
3.353AspPro: 3.353 ± 0.389
2.163AspGln: 2.163 ± 0.386
2.596AspArg: 2.596 ± 0.396
4.597AspSer: 4.597 ± 0.534
3.299AspThr: 3.299 ± 0.411
3.839AspVal: 3.839 ± 0.439
0.541AspTrp: 0.541 ± 0.162
1.893AspTyr: 1.893 ± 0.35
0.0AspXaa: 0.0 ± 0.0
Glu
5.84GluAla: 5.84 ± 0.445
0.433GluCys: 0.433 ± 0.156
4.002GluAsp: 4.002 ± 0.459
5.732GluGlu: 5.732 ± 0.773
2.704GluPhe: 2.704 ± 0.525
4.759GluGly: 4.759 ± 0.574
0.973GluHis: 0.973 ± 0.196
4.488GluIle: 4.488 ± 0.475
4.543GluLys: 4.543 ± 0.673
5.786GluLeu: 5.786 ± 0.577
2.433GluMet: 2.433 ± 0.31
2.974GluAsn: 2.974 ± 0.385
2.379GluPro: 2.379 ± 0.424
2.596GluGln: 2.596 ± 0.325
2.974GluArg: 2.974 ± 0.468
4.813GluSer: 4.813 ± 0.702
3.894GluThr: 3.894 ± 0.607
5.516GluVal: 5.516 ± 0.515
1.352GluTrp: 1.352 ± 0.243
2.271GluTyr: 2.271 ± 0.477
0.0GluXaa: 0.0 ± 0.0
Phe
2.65PheAla: 2.65 ± 0.434
0.433PheCys: 0.433 ± 0.142
3.461PheAsp: 3.461 ± 0.392
3.136PheGlu: 3.136 ± 0.486
1.514PhePhe: 1.514 ± 0.296
2.596PheGly: 2.596 ± 0.341
0.379PheHis: 0.379 ± 0.136
1.785PheIle: 1.785 ± 0.287
1.568PheLys: 1.568 ± 0.39
3.136PheLeu: 3.136 ± 0.377
1.082PheMet: 1.082 ± 0.28
2.001PheAsn: 2.001 ± 0.358
1.027PhePro: 1.027 ± 0.178
0.973PheGln: 0.973 ± 0.228
2.055PheArg: 2.055 ± 0.281
2.163PheSer: 2.163 ± 0.423
1.947PheThr: 1.947 ± 0.331
2.163PheVal: 2.163 ± 0.379
0.433PheTrp: 0.433 ± 0.152
1.027PheTyr: 1.027 ± 0.243
0.0PheXaa: 0.0 ± 0.0
Gly
6.327GlyAla: 6.327 ± 0.871
0.541GlyCys: 0.541 ± 0.208
4.975GlyAsp: 4.975 ± 0.512
4.272GlyGlu: 4.272 ± 0.398
2.542GlyPhe: 2.542 ± 0.437
6.165GlyGly: 6.165 ± 0.771
1.46GlyHis: 1.46 ± 0.33
4.434GlyIle: 4.434 ± 1.126
3.677GlyLys: 3.677 ± 0.428
5.3GlyLeu: 5.3 ± 1.132
2.379GlyMet: 2.379 ± 0.435
2.866GlyAsn: 2.866 ± 0.448
2.109GlyPro: 2.109 ± 0.333
2.596GlyGln: 2.596 ± 0.389
3.191GlyArg: 3.191 ± 0.383
5.137GlySer: 5.137 ± 0.735
5.083GlyThr: 5.083 ± 0.622
6.165GlyVal: 6.165 ± 0.744
1.19GlyTrp: 1.19 ± 0.27
2.596GlyTyr: 2.596 ± 0.404
0.0GlyXaa: 0.0 ± 0.0
His
1.082HisAla: 1.082 ± 0.342
0.108HisCys: 0.108 ± 0.079
1.082HisAsp: 1.082 ± 0.28
1.298HisGlu: 1.298 ± 0.302
0.487HisPhe: 0.487 ± 0.186
1.568HisGly: 1.568 ± 0.39
0.541HisHis: 0.541 ± 0.178
1.622HisIle: 1.622 ± 0.323
0.865HisLys: 0.865 ± 0.268
1.676HisLeu: 1.676 ± 0.275
0.703HisMet: 0.703 ± 0.205
0.703HisAsn: 0.703 ± 0.22
1.298HisPro: 1.298 ± 0.322
0.487HisGln: 0.487 ± 0.179
1.136HisArg: 1.136 ± 0.234
1.352HisSer: 1.352 ± 0.294
0.919HisThr: 0.919 ± 0.219
1.19HisVal: 1.19 ± 0.255
0.162HisTrp: 0.162 ± 0.09
0.757HisTyr: 0.757 ± 0.182
0.0HisXaa: 0.0 ± 0.0
Ile
5.786IleAla: 5.786 ± 0.66
0.487IleCys: 0.487 ± 0.192
4.813IleAsp: 4.813 ± 0.401
3.785IleGlu: 3.785 ± 0.408
1.947IlePhe: 1.947 ± 0.392
4.218IleGly: 4.218 ± 0.844
1.136IleHis: 1.136 ± 0.253
3.353IleIle: 3.353 ± 0.726
3.353IleLys: 3.353 ± 0.394
5.354IleLeu: 5.354 ± 0.561
1.46IleMet: 1.46 ± 0.304
2.325IleAsn: 2.325 ± 0.358
2.001IlePro: 2.001 ± 0.349
2.812IleGln: 2.812 ± 0.354
2.433IleArg: 2.433 ± 0.404
3.299IleSer: 3.299 ± 0.406
3.623IleThr: 3.623 ± 0.463
4.11IleVal: 4.11 ± 0.47
1.027IleTrp: 1.027 ± 0.242
1.947IleTyr: 1.947 ± 0.307
0.0IleXaa: 0.0 ± 0.0
Lys
5.949LysAla: 5.949 ± 0.718
0.054LysCys: 0.054 ± 0.065
3.082LysAsp: 3.082 ± 0.494
3.623LysGlu: 3.623 ± 0.429
1.676LysPhe: 1.676 ± 0.467
3.623LysGly: 3.623 ± 0.602
1.352LysHis: 1.352 ± 0.316
3.461LysIle: 3.461 ± 0.305
3.569LysLys: 3.569 ± 0.54
4.921LysLeu: 4.921 ± 0.599
1.406LysMet: 1.406 ± 0.219
2.974LysAsn: 2.974 ± 0.372
2.542LysPro: 2.542 ± 0.468
2.812LysGln: 2.812 ± 0.4
3.136LysArg: 3.136 ± 0.527
3.731LysSer: 3.731 ± 0.565
3.894LysThr: 3.894 ± 0.412
4.272LysVal: 4.272 ± 0.498
1.082LysTrp: 1.082 ± 0.268
1.73LysTyr: 1.73 ± 0.341
0.0LysXaa: 0.0 ± 0.0
Leu
7.3LeuAla: 7.3 ± 1.42
0.595LeuCys: 0.595 ± 0.181
5.462LeuAsp: 5.462 ± 0.504
5.029LeuGlu: 5.029 ± 0.592
2.704LeuPhe: 2.704 ± 0.496
6.003LeuGly: 6.003 ± 1.191
1.406LeuHis: 1.406 ± 0.333
4.705LeuIle: 4.705 ± 0.484
4.921LeuLys: 4.921 ± 0.626
4.38LeuLeu: 4.38 ± 0.688
2.433LeuMet: 2.433 ± 0.4
4.759LeuAsn: 4.759 ± 0.624
2.542LeuPro: 2.542 ± 0.276
2.542LeuGln: 2.542 ± 0.297
4.164LeuArg: 4.164 ± 0.352
5.949LeuSer: 5.949 ± 0.64
5.84LeuThr: 5.84 ± 0.764
6.219LeuVal: 6.219 ± 0.533
0.811LeuTrp: 0.811 ± 0.237
3.191LeuTyr: 3.191 ± 0.559
0.0LeuXaa: 0.0 ± 0.0
Met
2.758MetAla: 2.758 ± 0.57
0.216MetCys: 0.216 ± 0.105
1.893MetAsp: 1.893 ± 0.263
1.514MetGlu: 1.514 ± 0.329
0.541MetPhe: 0.541 ± 0.144
2.109MetGly: 2.109 ± 0.56
0.757MetHis: 0.757 ± 0.215
1.568MetIle: 1.568 ± 0.269
1.893MetLys: 1.893 ± 0.317
2.163MetLeu: 2.163 ± 0.304
0.919MetMet: 0.919 ± 0.235
1.244MetAsn: 1.244 ± 0.242
1.136MetPro: 1.136 ± 0.212
0.973MetGln: 0.973 ± 0.206
1.352MetArg: 1.352 ± 0.277
2.433MetSer: 2.433 ± 0.42
2.271MetThr: 2.271 ± 0.294
1.622MetVal: 1.622 ± 0.267
0.433MetTrp: 0.433 ± 0.172
0.487MetTyr: 0.487 ± 0.136
0.0MetXaa: 0.0 ± 0.0
Asn
3.136AsnAla: 3.136 ± 0.494
0.324AsnCys: 0.324 ± 0.139
2.974AsnAsp: 2.974 ± 0.432
3.028AsnGlu: 3.028 ± 0.337
1.46AsnPhe: 1.46 ± 0.307
3.948AsnGly: 3.948 ± 0.535
1.027AsnHis: 1.027 ± 0.241
2.271AsnIle: 2.271 ± 0.31
2.379AsnLys: 2.379 ± 0.351
3.569AsnLeu: 3.569 ± 0.381
1.136AsnMet: 1.136 ± 0.229
2.271AsnAsn: 2.271 ± 0.344
3.082AsnPro: 3.082 ± 0.446
1.676AsnGln: 1.676 ± 0.289
2.488AsnArg: 2.488 ± 0.384
2.812AsnSer: 2.812 ± 0.404
2.055AsnThr: 2.055 ± 0.335
3.461AsnVal: 3.461 ± 0.359
0.216AsnTrp: 0.216 ± 0.117
1.406AsnTyr: 1.406 ± 0.321
0.0AsnXaa: 0.0 ± 0.0
Pro
3.082ProAla: 3.082 ± 0.373
0.433ProCys: 0.433 ± 0.154
2.704ProAsp: 2.704 ± 0.475
2.974ProGlu: 2.974 ± 0.393
1.73ProPhe: 1.73 ± 0.28
2.433ProGly: 2.433 ± 0.356
0.757ProHis: 0.757 ± 0.194
1.785ProIle: 1.785 ± 0.294
2.542ProLys: 2.542 ± 0.339
1.893ProLeu: 1.893 ± 0.279
1.298ProMet: 1.298 ± 0.219
1.73ProAsn: 1.73 ± 0.354
1.676ProPro: 1.676 ± 0.34
1.622ProGln: 1.622 ± 0.272
1.73ProArg: 1.73 ± 0.32
2.596ProSer: 2.596 ± 0.368
3.028ProThr: 3.028 ± 0.457
3.569ProVal: 3.569 ± 0.444
0.595ProTrp: 0.595 ± 0.175
1.568ProTyr: 1.568 ± 0.295
0.0ProXaa: 0.0 ± 0.0
Gln
3.515GlnAla: 3.515 ± 0.461
0.108GlnCys: 0.108 ± 0.075
1.352GlnAsp: 1.352 ± 0.246
1.785GlnGlu: 1.785 ± 0.275
1.027GlnPhe: 1.027 ± 0.29
1.893GlnGly: 1.893 ± 0.333
0.865GlnHis: 0.865 ± 0.236
2.758GlnIle: 2.758 ± 0.291
2.163GlnLys: 2.163 ± 0.345
3.407GlnLeu: 3.407 ± 0.413
0.919GlnMet: 0.919 ± 0.199
1.514GlnAsn: 1.514 ± 0.312
1.19GlnPro: 1.19 ± 0.386
1.352GlnGln: 1.352 ± 0.278
1.947GlnArg: 1.947 ± 0.293
2.163GlnSer: 2.163 ± 0.387
2.596GlnThr: 2.596 ± 0.298
2.109GlnVal: 2.109 ± 0.365
0.433GlnTrp: 0.433 ± 0.158
1.406GlnTyr: 1.406 ± 0.25
0.0GlnXaa: 0.0 ± 0.0
Arg
2.92ArgAla: 2.92 ± 0.376
0.324ArgCys: 0.324 ± 0.114
2.812ArgAsp: 2.812 ± 0.404
3.894ArgGlu: 3.894 ± 0.46
2.217ArgPhe: 2.217 ± 0.401
2.596ArgGly: 2.596 ± 0.388
1.244ArgHis: 1.244 ± 0.286
2.974ArgIle: 2.974 ± 0.334
3.623ArgLys: 3.623 ± 0.582
3.948ArgLeu: 3.948 ± 0.425
1.406ArgMet: 1.406 ± 0.292
2.488ArgAsn: 2.488 ± 0.514
2.65ArgPro: 2.65 ± 0.367
2.271ArgGln: 2.271 ± 0.502
2.704ArgArg: 2.704 ± 0.47
2.758ArgSer: 2.758 ± 0.335
2.758ArgThr: 2.758 ± 0.391
3.785ArgVal: 3.785 ± 0.437
0.703ArgTrp: 0.703 ± 0.239
1.406ArgTyr: 1.406 ± 0.285
0.0ArgXaa: 0.0 ± 0.0
Ser
5.137SerAla: 5.137 ± 0.624
0.108SerCys: 0.108 ± 0.079
4.11SerAsp: 4.11 ± 0.525
5.3SerGlu: 5.3 ± 0.473
2.65SerPhe: 2.65 ± 0.298
5.191SerGly: 5.191 ± 0.702
1.244SerHis: 1.244 ± 0.262
3.731SerIle: 3.731 ± 0.38
3.894SerLys: 3.894 ± 0.394
6.165SerLeu: 6.165 ± 0.567
1.73SerMet: 1.73 ± 0.261
2.596SerAsn: 2.596 ± 0.38
1.947SerPro: 1.947 ± 0.372
2.055SerGln: 2.055 ± 0.281
3.136SerArg: 3.136 ± 0.296
5.462SerSer: 5.462 ± 0.652
4.651SerThr: 4.651 ± 0.531
4.218SerVal: 4.218 ± 0.514
1.136SerTrp: 1.136 ± 0.264
2.542SerTyr: 2.542 ± 0.468
0.0SerXaa: 0.0 ± 0.0
Thr
5.678ThrAla: 5.678 ± 0.707
0.27ThrCys: 0.27 ± 0.118
2.92ThrAsp: 2.92 ± 0.328
4.759ThrGlu: 4.759 ± 0.672
2.271ThrPhe: 2.271 ± 0.325
4.975ThrGly: 4.975 ± 0.546
0.865ThrHis: 0.865 ± 0.188
4.218ThrIle: 4.218 ± 0.591
4.218ThrLys: 4.218 ± 0.537
5.029ThrLeu: 5.029 ± 0.485
1.568ThrMet: 1.568 ± 0.302
2.758ThrAsn: 2.758 ± 0.339
3.407ThrPro: 3.407 ± 0.497
1.406ThrGln: 1.406 ± 0.319
2.596ThrArg: 2.596 ± 0.374
4.11ThrSer: 4.11 ± 0.55
4.543ThrThr: 4.543 ± 0.467
4.975ThrVal: 4.975 ± 0.589
0.541ThrTrp: 0.541 ± 0.163
1.893ThrTyr: 1.893 ± 0.323
0.0ThrXaa: 0.0 ± 0.0
Val
6.868ValAla: 6.868 ± 0.59
0.379ValCys: 0.379 ± 0.134
5.246ValAsp: 5.246 ± 0.613
5.678ValGlu: 5.678 ± 0.72
2.217ValPhe: 2.217 ± 0.343
5.137ValGly: 5.137 ± 0.599
1.136ValHis: 1.136 ± 0.237
3.785ValIle: 3.785 ± 0.445
3.839ValLys: 3.839 ± 0.458
5.462ValLeu: 5.462 ± 0.648
2.001ValMet: 2.001 ± 0.324
2.704ValAsn: 2.704 ± 0.398
2.704ValPro: 2.704 ± 0.343
2.001ValGln: 2.001 ± 0.304
4.705ValArg: 4.705 ± 0.519
4.921ValSer: 4.921 ± 0.572
4.921ValThr: 4.921 ± 0.566
6.219ValVal: 6.219 ± 0.657
0.973ValTrp: 0.973 ± 0.211
3.136ValTyr: 3.136 ± 0.488
0.0ValXaa: 0.0 ± 0.0
Trp
0.973TrpAla: 0.973 ± 0.271
0.108TrpCys: 0.108 ± 0.071
0.703TrpAsp: 0.703 ± 0.291
0.973TrpGlu: 0.973 ± 0.215
0.379TrpPhe: 0.379 ± 0.125
1.082TrpGly: 1.082 ± 0.211
0.487TrpHis: 0.487 ± 0.149
0.541TrpIle: 0.541 ± 0.186
0.433TrpLys: 0.433 ± 0.145
1.082TrpLeu: 1.082 ± 0.273
0.324TrpMet: 0.324 ± 0.118
1.027TrpAsn: 1.027 ± 0.252
0.703TrpPro: 0.703 ± 0.2
0.379TrpGln: 0.379 ± 0.157
0.811TrpArg: 0.811 ± 0.217
0.595TrpSer: 0.595 ± 0.157
0.757TrpThr: 0.757 ± 0.187
0.973TrpVal: 0.973 ± 0.215
0.162TrpTrp: 0.162 ± 0.095
0.649TrpTyr: 0.649 ± 0.208
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.461TyrAla: 3.461 ± 0.534
0.216TyrCys: 0.216 ± 0.122
2.433TyrAsp: 2.433 ± 0.513
1.839TyrGlu: 1.839 ± 0.369
1.19TyrPhe: 1.19 ± 0.227
2.812TyrGly: 2.812 ± 0.436
0.541TyrHis: 0.541 ± 0.164
2.055TyrIle: 2.055 ± 0.427
2.542TyrLys: 2.542 ± 0.432
3.082TyrLeu: 3.082 ± 0.339
0.433TyrMet: 0.433 ± 0.151
1.298TyrAsn: 1.298 ± 0.279
1.406TyrPro: 1.406 ± 0.327
0.973TyrGln: 0.973 ± 0.201
1.73TyrArg: 1.73 ± 0.249
2.325TyrSer: 2.325 ± 0.421
2.055TyrThr: 2.055 ± 0.404
2.379TyrVal: 2.379 ± 0.346
0.379TyrTrp: 0.379 ± 0.118
0.919TyrTyr: 0.919 ± 0.243
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 93 proteins (18493 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski