Amino acid dipepetide frequency for Burkholderia virus phi6442

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.812AlaAla: 17.812 ± 2.787
1.461AlaCys: 1.461 ± 0.428
7.028AlaAsp: 7.028 ± 0.64
7.097AlaGlu: 7.097 ± 1.013
3.549AlaPhe: 3.549 ± 0.429
10.646AlaGly: 10.646 ± 0.837
2.296AlaHis: 2.296 ± 0.378
5.775AlaIle: 5.775 ± 0.545
5.984AlaLys: 5.984 ± 0.65
10.994AlaLeu: 10.994 ± 0.956
2.574AlaMet: 2.574 ± 0.376
3.479AlaAsn: 3.479 ± 0.402
4.036AlaPro: 4.036 ± 0.675
5.706AlaGln: 5.706 ± 1.328
9.95AlaArg: 9.95 ± 1.398
6.54AlaSer: 6.54 ± 0.804
5.497AlaThr: 5.497 ± 1.03
8.837AlaVal: 8.837 ± 0.76
2.157AlaTrp: 2.157 ± 0.308
2.227AlaTyr: 2.227 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.835CysAla: 0.835 ± 0.216
0.278CysCys: 0.278 ± 0.178
0.765CysAsp: 0.765 ± 0.227
1.252CysGlu: 1.252 ± 0.277
0.417CysPhe: 0.417 ± 0.192
0.905CysGly: 0.905 ± 0.337
0.209CysHis: 0.209 ± 0.155
0.417CysIle: 0.417 ± 0.165
0.487CysLys: 0.487 ± 0.183
0.974CysLeu: 0.974 ± 0.298
0.348CysMet: 0.348 ± 0.191
0.417CysAsn: 0.417 ± 0.16
0.348CysPro: 0.348 ± 0.143
0.974CysGln: 0.974 ± 0.272
1.322CysArg: 1.322 ± 0.382
0.626CysSer: 0.626 ± 0.247
0.696CysThr: 0.696 ± 0.21
1.044CysVal: 1.044 ± 0.339
0.139CysTrp: 0.139 ± 0.097
0.348CysTyr: 0.348 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
8.071AspAla: 8.071 ± 0.792
1.183AspCys: 1.183 ± 0.31
4.731AspAsp: 4.731 ± 0.56
4.523AspGlu: 4.523 ± 0.495
1.6AspPhe: 1.6 ± 0.31
5.914AspGly: 5.914 ± 0.954
0.905AspHis: 0.905 ± 0.285
2.366AspIle: 2.366 ± 0.461
2.157AspLys: 2.157 ± 0.341
4.384AspLeu: 4.384 ± 0.51
0.974AspMet: 0.974 ± 0.218
1.392AspAsn: 1.392 ± 0.3
2.992AspPro: 2.992 ± 0.596
2.435AspGln: 2.435 ± 0.416
4.175AspArg: 4.175 ± 0.481
1.879AspSer: 1.879 ± 0.391
2.435AspThr: 2.435 ± 0.341
4.105AspVal: 4.105 ± 0.525
1.044AspTrp: 1.044 ± 0.33
1.461AspTyr: 1.461 ± 0.303
0.0AspXaa: 0.0 ± 0.0
Glu
6.471GluAla: 6.471 ± 0.745
0.417GluCys: 0.417 ± 0.149
2.853GluAsp: 2.853 ± 0.61
2.435GluGlu: 2.435 ± 0.523
1.531GluPhe: 1.531 ± 0.356
3.34GluGly: 3.34 ± 0.39
1.252GluHis: 1.252 ± 0.311
3.549GluIle: 3.549 ± 0.448
2.505GluLys: 2.505 ± 0.477
5.914GluLeu: 5.914 ± 0.687
1.531GluMet: 1.531 ± 0.35
1.67GluAsn: 1.67 ± 0.336
2.922GluPro: 2.922 ± 0.479
3.131GluGln: 3.131 ± 0.442
6.262GluArg: 6.262 ± 0.56
3.827GluSer: 3.827 ± 0.46
2.644GluThr: 2.644 ± 0.353
4.175GluVal: 4.175 ± 0.652
1.392GluTrp: 1.392 ± 0.262
1.809GluTyr: 1.809 ± 0.368
0.0GluXaa: 0.0 ± 0.0
Phe
3.062PheAla: 3.062 ± 0.463
0.348PheCys: 0.348 ± 0.141
2.227PheAsp: 2.227 ± 0.452
2.644PheGlu: 2.644 ± 0.457
0.835PhePhe: 0.835 ± 0.237
3.479PheGly: 3.479 ± 0.507
0.626PheHis: 0.626 ± 0.172
1.044PheIle: 1.044 ± 0.386
1.322PheLys: 1.322 ± 0.32
2.087PheLeu: 2.087 ± 0.451
0.835PheMet: 0.835 ± 0.276
1.322PheAsn: 1.322 ± 0.267
1.461PhePro: 1.461 ± 0.343
1.183PheGln: 1.183 ± 0.256
1.948PheArg: 1.948 ± 0.375
2.366PheSer: 2.366 ± 0.424
1.948PheThr: 1.948 ± 0.356
1.461PheVal: 1.461 ± 0.312
0.557PheTrp: 0.557 ± 0.18
0.487PheTyr: 0.487 ± 0.151
0.0PheXaa: 0.0 ± 0.0
Gly
9.115GlyAla: 9.115 ± 0.724
0.974GlyCys: 0.974 ± 0.276
4.662GlyAsp: 4.662 ± 0.588
3.896GlyGlu: 3.896 ± 0.512
2.157GlyPhe: 2.157 ± 0.381
7.654GlyGly: 7.654 ± 0.986
1.183GlyHis: 1.183 ± 0.33
4.175GlyIle: 4.175 ± 0.52
4.523GlyLys: 4.523 ± 0.537
6.819GlyLeu: 6.819 ± 0.647
2.296GlyMet: 2.296 ± 0.389
2.992GlyAsn: 2.992 ± 0.476
2.574GlyPro: 2.574 ± 0.399
2.783GlyGln: 2.783 ± 0.393
5.984GlyArg: 5.984 ± 0.548
4.871GlySer: 4.871 ± 0.705
3.966GlyThr: 3.966 ± 0.466
6.68GlyVal: 6.68 ± 0.669
1.531GlyTrp: 1.531 ± 0.396
2.227GlyTyr: 2.227 ± 0.369
0.0GlyXaa: 0.0 ± 0.0
His
2.435HisAla: 2.435 ± 0.522
0.139HisCys: 0.139 ± 0.093
0.696HisAsp: 0.696 ± 0.202
1.252HisGlu: 1.252 ± 0.288
0.278HisPhe: 0.278 ± 0.174
1.044HisGly: 1.044 ± 0.297
0.348HisHis: 0.348 ± 0.141
0.696HisIle: 0.696 ± 0.291
0.696HisLys: 0.696 ± 0.166
1.322HisLeu: 1.322 ± 0.397
0.696HisMet: 0.696 ± 0.187
0.348HisAsn: 0.348 ± 0.148
0.905HisPro: 0.905 ± 0.258
0.835HisGln: 0.835 ± 0.198
1.948HisArg: 1.948 ± 0.412
1.531HisSer: 1.531 ± 0.36
0.905HisThr: 0.905 ± 0.257
0.905HisVal: 0.905 ± 0.216
0.139HisTrp: 0.139 ± 0.094
0.557HisTyr: 0.557 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
7.167IleAla: 7.167 ± 0.714
0.765IleCys: 0.765 ± 0.261
4.94IleAsp: 4.94 ± 0.557
4.731IleGlu: 4.731 ± 0.798
1.044IlePhe: 1.044 ± 0.281
4.175IleGly: 4.175 ± 0.453
0.487IleHis: 0.487 ± 0.151
0.905IleIle: 0.905 ± 0.219
1.739IleLys: 1.739 ± 0.265
2.783IleLeu: 2.783 ± 0.453
0.974IleMet: 0.974 ± 0.276
1.67IleAsn: 1.67 ± 0.29
2.366IlePro: 2.366 ± 0.529
1.392IleGln: 1.392 ± 0.301
2.853IleArg: 2.853 ± 0.467
2.853IleSer: 2.853 ± 0.434
2.574IleThr: 2.574 ± 0.519
3.896IleVal: 3.896 ± 0.522
0.835IleTrp: 0.835 ± 0.229
1.044IleTyr: 1.044 ± 0.31
0.0IleXaa: 0.0 ± 0.0
Lys
4.662LysAla: 4.662 ± 0.606
0.278LysCys: 0.278 ± 0.148
1.322LysAsp: 1.322 ± 0.262
1.948LysGlu: 1.948 ± 0.344
1.392LysPhe: 1.392 ± 0.278
3.062LysGly: 3.062 ± 0.55
0.626LysHis: 0.626 ± 0.241
1.879LysIle: 1.879 ± 0.431
2.227LysLys: 2.227 ± 0.399
4.105LysLeu: 4.105 ± 0.561
1.252LysMet: 1.252 ± 0.285
1.461LysAsn: 1.461 ± 0.298
1.879LysPro: 1.879 ± 0.483
1.461LysGln: 1.461 ± 0.316
4.036LysArg: 4.036 ± 0.706
2.853LysSer: 2.853 ± 0.409
2.714LysThr: 2.714 ± 0.385
3.201LysVal: 3.201 ± 0.572
0.487LysTrp: 0.487 ± 0.183
1.948LysTyr: 1.948 ± 0.334
0.0LysXaa: 0.0 ± 0.0
Leu
10.089LeuAla: 10.089 ± 1.232
1.044LeuCys: 1.044 ± 0.34
5.497LeuAsp: 5.497 ± 0.535
5.358LeuGlu: 5.358 ± 0.868
2.296LeuPhe: 2.296 ± 0.407
5.149LeuGly: 5.149 ± 0.646
1.879LeuHis: 1.879 ± 0.385
3.966LeuIle: 3.966 ± 0.448
2.644LeuLys: 2.644 ± 0.37
5.706LeuLeu: 5.706 ± 0.754
1.67LeuMet: 1.67 ± 0.318
2.644LeuAsn: 2.644 ± 0.35
3.827LeuPro: 3.827 ± 0.64
2.853LeuGln: 2.853 ± 0.388
7.863LeuArg: 7.863 ± 0.703
5.845LeuSer: 5.845 ± 0.844
3.827LeuThr: 3.827 ± 0.497
4.801LeuVal: 4.801 ± 0.5
0.765LeuTrp: 0.765 ± 0.206
2.087LeuTyr: 2.087 ± 0.335
0.0LeuXaa: 0.0 ± 0.0
Met
3.688MetAla: 3.688 ± 0.486
0.139MetCys: 0.139 ± 0.104
0.835MetAsp: 0.835 ± 0.235
0.696MetGlu: 0.696 ± 0.227
0.626MetPhe: 0.626 ± 0.259
1.252MetGly: 1.252 ± 0.286
0.417MetHis: 0.417 ± 0.226
1.183MetIle: 1.183 ± 0.264
1.392MetLys: 1.392 ± 0.33
1.113MetLeu: 1.113 ± 0.271
0.557MetMet: 0.557 ± 0.19
1.044MetAsn: 1.044 ± 0.26
1.322MetPro: 1.322 ± 0.31
0.557MetGln: 0.557 ± 0.235
1.809MetArg: 1.809 ± 0.395
2.783MetSer: 2.783 ± 0.427
2.087MetThr: 2.087 ± 0.345
1.6MetVal: 1.6 ± 0.302
0.696MetTrp: 0.696 ± 0.188
0.417MetTyr: 0.417 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
4.105AsnAla: 4.105 ± 0.691
0.557AsnCys: 0.557 ± 0.174
2.018AsnAsp: 2.018 ± 0.277
1.739AsnGlu: 1.739 ± 0.369
1.113AsnPhe: 1.113 ± 0.256
3.27AsnGly: 3.27 ± 0.611
0.905AsnHis: 0.905 ± 0.257
1.67AsnIle: 1.67 ± 0.249
0.626AsnLys: 0.626 ± 0.188
2.644AsnLeu: 2.644 ± 0.352
0.626AsnMet: 0.626 ± 0.224
1.113AsnAsn: 1.113 ± 0.341
1.809AsnPro: 1.809 ± 0.395
0.974AsnGln: 0.974 ± 0.222
1.67AsnArg: 1.67 ± 0.309
1.6AsnSer: 1.6 ± 0.302
1.531AsnThr: 1.531 ± 0.251
2.227AsnVal: 2.227 ± 0.42
0.487AsnTrp: 0.487 ± 0.218
0.905AsnTyr: 0.905 ± 0.278
0.0AsnXaa: 0.0 ± 0.0
Pro
4.175ProAla: 4.175 ± 0.537
0.835ProCys: 0.835 ± 0.283
2.227ProAsp: 2.227 ± 0.428
2.505ProGlu: 2.505 ± 0.442
1.461ProPhe: 1.461 ± 0.35
4.314ProGly: 4.314 ± 0.469
0.835ProHis: 0.835 ± 0.229
2.644ProIle: 2.644 ± 0.549
1.809ProLys: 1.809 ± 0.437
3.757ProLeu: 3.757 ± 0.619
1.252ProMet: 1.252 ± 0.352
1.739ProAsn: 1.739 ± 0.36
2.853ProPro: 2.853 ± 0.668
1.252ProGln: 1.252 ± 0.294
2.505ProArg: 2.505 ± 0.505
2.992ProSer: 2.992 ± 0.546
2.505ProThr: 2.505 ± 0.386
4.036ProVal: 4.036 ± 0.625
0.905ProTrp: 0.905 ± 0.233
0.835ProTyr: 0.835 ± 0.234
0.0ProXaa: 0.0 ± 0.0
Gln
5.497GlnAla: 5.497 ± 1.231
0.696GlnCys: 0.696 ± 0.226
1.879GlnAsp: 1.879 ± 0.378
1.879GlnGlu: 1.879 ± 0.382
1.67GlnPhe: 1.67 ± 0.41
2.992GlnGly: 2.992 ± 0.402
0.696GlnHis: 0.696 ± 0.175
2.574GlnIle: 2.574 ± 0.437
1.739GlnLys: 1.739 ± 0.3
3.27GlnLeu: 3.27 ± 0.431
0.974GlnMet: 0.974 ± 0.299
1.113GlnAsn: 1.113 ± 0.264
2.157GlnPro: 2.157 ± 0.336
1.948GlnGln: 1.948 ± 0.402
3.062GlnArg: 3.062 ± 0.455
2.435GlnSer: 2.435 ± 0.387
1.252GlnThr: 1.252 ± 0.333
2.157GlnVal: 2.157 ± 0.471
0.557GlnTrp: 0.557 ± 0.173
1.113GlnTyr: 1.113 ± 0.321
0.0GlnXaa: 0.0 ± 0.0
Arg
10.924ArgAla: 10.924 ± 0.9
0.905ArgCys: 0.905 ± 0.25
3.827ArgAsp: 3.827 ± 0.549
5.149ArgGlu: 5.149 ± 0.81
3.34ArgPhe: 3.34 ± 0.402
4.801ArgGly: 4.801 ± 0.68
1.6ArgHis: 1.6 ± 0.367
4.105ArgIle: 4.105 ± 0.503
2.853ArgLys: 2.853 ± 0.388
6.193ArgLeu: 6.193 ± 0.573
2.157ArgMet: 2.157 ± 0.424
1.809ArgAsn: 1.809 ± 0.335
2.783ArgPro: 2.783 ± 0.501
3.479ArgGln: 3.479 ± 0.416
5.775ArgArg: 5.775 ± 0.745
4.662ArgSer: 4.662 ± 0.566
3.34ArgThr: 3.34 ± 0.511
5.497ArgVal: 5.497 ± 0.663
0.905ArgTrp: 0.905 ± 0.289
2.157ArgTyr: 2.157 ± 0.384
0.0ArgXaa: 0.0 ± 0.0
Ser
7.375SerAla: 7.375 ± 0.905
0.835SerCys: 0.835 ± 0.229
4.105SerAsp: 4.105 ± 0.569
3.618SerGlu: 3.618 ± 0.531
1.531SerPhe: 1.531 ± 0.257
5.358SerGly: 5.358 ± 0.684
1.113SerHis: 1.113 ± 0.267
3.549SerIle: 3.549 ± 0.413
2.922SerLys: 2.922 ± 0.442
4.523SerLeu: 4.523 ± 0.577
2.018SerMet: 2.018 ± 0.361
2.435SerAsn: 2.435 ± 0.437
3.062SerPro: 3.062 ± 0.733
1.809SerGln: 1.809 ± 0.408
3.27SerArg: 3.27 ± 0.599
4.523SerSer: 4.523 ± 0.632
3.479SerThr: 3.479 ± 0.515
4.94SerVal: 4.94 ± 0.64
0.557SerTrp: 0.557 ± 0.193
2.018SerTyr: 2.018 ± 0.565
0.0SerXaa: 0.0 ± 0.0
Thr
6.123ThrAla: 6.123 ± 1.156
0.209ThrCys: 0.209 ± 0.112
2.853ThrAsp: 2.853 ± 0.441
2.157ThrGlu: 2.157 ± 0.303
2.714ThrPhe: 2.714 ± 0.489
3.549ThrGly: 3.549 ± 0.468
0.487ThrHis: 0.487 ± 0.196
2.505ThrIle: 2.505 ± 0.395
2.296ThrLys: 2.296 ± 0.426
3.896ThrLeu: 3.896 ± 0.625
1.183ThrMet: 1.183 ± 0.228
1.739ThrAsn: 1.739 ± 0.403
3.062ThrPro: 3.062 ± 0.407
2.435ThrGln: 2.435 ± 0.407
2.505ThrArg: 2.505 ± 0.489
3.34ThrSer: 3.34 ± 0.602
2.574ThrThr: 2.574 ± 0.525
4.453ThrVal: 4.453 ± 0.493
0.417ThrTrp: 0.417 ± 0.162
1.183ThrTyr: 1.183 ± 0.256
0.0ThrXaa: 0.0 ± 0.0
Val
7.515ValAla: 7.515 ± 0.659
0.905ValCys: 0.905 ± 0.282
4.036ValAsp: 4.036 ± 0.692
4.871ValGlu: 4.871 ± 0.67
2.157ValPhe: 2.157 ± 0.326
7.167ValGly: 7.167 ± 0.588
1.113ValHis: 1.113 ± 0.327
4.314ValIle: 4.314 ± 0.597
3.34ValLys: 3.34 ± 0.511
5.218ValLeu: 5.218 ± 0.723
1.322ValMet: 1.322 ± 0.245
2.227ValAsn: 2.227 ± 0.48
3.409ValPro: 3.409 ± 0.613
2.714ValGln: 2.714 ± 0.554
5.706ValArg: 5.706 ± 0.624
5.149ValSer: 5.149 ± 0.596
3.34ValThr: 3.34 ± 0.468
5.358ValVal: 5.358 ± 0.768
0.974ValTrp: 0.974 ± 0.236
1.948ValTyr: 1.948 ± 0.407
0.0ValXaa: 0.0 ± 0.0
Trp
1.531TrpAla: 1.531 ± 0.315
0.348TrpCys: 0.348 ± 0.148
0.765TrpAsp: 0.765 ± 0.266
0.626TrpGlu: 0.626 ± 0.252
0.348TrpPhe: 0.348 ± 0.183
0.974TrpGly: 0.974 ± 0.22
0.417TrpHis: 0.417 ± 0.155
1.183TrpIle: 1.183 ± 0.203
0.626TrpLys: 0.626 ± 0.182
1.531TrpLeu: 1.531 ± 0.377
0.487TrpMet: 0.487 ± 0.171
0.278TrpAsn: 0.278 ± 0.125
0.557TrpPro: 0.557 ± 0.203
0.626TrpGln: 0.626 ± 0.19
1.531TrpArg: 1.531 ± 0.343
0.835TrpSer: 0.835 ± 0.274
0.974TrpThr: 0.974 ± 0.277
1.392TrpVal: 1.392 ± 0.398
0.278TrpTrp: 0.278 ± 0.142
0.209TrpTyr: 0.209 ± 0.121
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.992TyrAla: 2.992 ± 0.459
0.487TyrCys: 0.487 ± 0.161
1.461TyrAsp: 1.461 ± 0.283
1.252TyrGlu: 1.252 ± 0.264
1.183TyrPhe: 1.183 ± 0.211
2.018TyrGly: 2.018 ± 0.369
0.278TyrHis: 0.278 ± 0.124
0.696TyrIle: 0.696 ± 0.215
0.905TyrLys: 0.905 ± 0.21
2.574TyrLeu: 2.574 ± 0.45
0.417TyrMet: 0.417 ± 0.169
0.696TyrAsn: 0.696 ± 0.228
1.113TyrPro: 1.113 ± 0.316
1.113TyrGln: 1.113 ± 0.255
2.157TyrArg: 2.157 ± 0.356
1.531TyrSer: 1.531 ± 0.391
1.392TyrThr: 1.392 ± 0.284
2.018TyrVal: 2.018 ± 0.38
0.696TyrTrp: 0.696 ± 0.203
0.278TyrTyr: 0.278 ± 0.114
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (14373 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski