Amino acid dipepetide frequency for Lachnospiraceae bacterium 1_4_56FAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.546AlaAla: 7.546 ± 0.123	1.152AlaCys: 1.152 ± 0.039	4.509AlaAsp: 4.509 ± 0.068	6.289AlaGlu: 6.289 ± 0.104	3.062AlaPhe: 3.062 ± 0.065	6.205AlaGly: 6.205 ± 0.095	1.162AlaHis: 1.162 ± 0.036	4.62AlaIle: 4.62 ± 0.079	4.99AlaLys: 4.99 ± 0.083	6.797AlaLeu: 6.797 ± 0.094	2.418AlaMet: 2.418 ± 0.056	2.477AlaAsn: 2.477 ± 0.05	1.98AlaPro: 1.98 ± 0.056	2.351AlaGln: 2.351 ± 0.05	2.942AlaArg: 2.942 ± 0.061	3.748AlaSer: 3.748 ± 0.064	2.941AlaThr: 2.941 ± 0.055	6.626AlaVal: 6.626 ± 0.095	0.733AlaTrp: 0.733 ± 0.032	2.843AlaTyr: 2.843 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.094CysAla: 1.094 ± 0.034	0.27CysCys: 0.27 ± 0.017	0.828CysAsp: 0.828 ± 0.027	1.088CysGlu: 1.088 ± 0.034	0.645CysPhe: 0.645 ± 0.024	1.507CysGly: 1.507 ± 0.037	0.289CysHis: 0.289 ± 0.018	1.081CysIle: 1.081 ± 0.035	0.776CysLys: 0.776 ± 0.033	1.085CysLeu: 1.085 ± 0.036	0.487CysMet: 0.487 ± 0.019	0.518CysAsn: 0.518 ± 0.022	0.626CysPro: 0.626 ± 0.029	0.39CysGln: 0.39 ± 0.022	0.785CysArg: 0.785 ± 0.027	0.874CysSer: 0.874 ± 0.028	0.796CysThr: 0.796 ± 0.03	1.039CysVal: 1.039 ± 0.029	0.123CysTrp: 0.123 ± 0.011	0.583CysTyr: 0.583 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.363AspAla: 4.363 ± 0.072	0.771AspCys: 0.771 ± 0.029	2.551AspAsp: 2.551 ± 0.077	4.497AspGlu: 4.497 ± 0.076	2.437AspPhe: 2.437 ± 0.051	4.619AspGly: 4.619 ± 0.086	1.073AspHis: 1.073 ± 0.038	3.706AspIle: 3.706 ± 0.071	2.873AspLys: 2.873 ± 0.058	4.813AspLeu: 4.813 ± 0.077	1.722AspMet: 1.722 ± 0.043	1.719AspAsn: 1.719 ± 0.049	2.147AspPro: 2.147 ± 0.046	1.491AspGln: 1.491 ± 0.04	2.548AspArg: 2.548 ± 0.053	2.678AspSer: 2.678 ± 0.056	2.888AspThr: 2.888 ± 0.056	4.0AspVal: 4.0 ± 0.073	0.611AspTrp: 0.611 ± 0.024	2.54AspTyr: 2.54 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	5.874GluAla: 5.874 ± 0.092	0.932GluCys: 0.932 ± 0.03	4.374GluAsp: 4.374 ± 0.086	8.729GluGlu: 8.729 ± 0.151	2.648GluPhe: 2.648 ± 0.046	4.236GluGly: 4.236 ± 0.072	1.523GluHis: 1.523 ± 0.041	6.226GluIle: 6.226 ± 0.088	7.437GluLys: 7.437 ± 0.097	7.152GluLeu: 7.152 ± 0.116	2.951GluMet: 2.951 ± 0.062	4.235GluAsn: 4.235 ± 0.073	1.988GluPro: 1.988 ± 0.054	3.676GluGln: 3.676 ± 0.076	4.084GluArg: 4.084 ± 0.077	3.593GluSer: 3.593 ± 0.062	4.412GluThr: 4.412 ± 0.071	4.89GluVal: 4.89 ± 0.079	0.784GluTrp: 0.784 ± 0.031	3.203GluTyr: 3.203 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.029PheAla: 3.029 ± 0.06	0.741PheCys: 0.741 ± 0.028	2.45PheAsp: 2.45 ± 0.058	2.744PheGlu: 2.744 ± 0.057	1.787PhePhe: 1.787 ± 0.057	3.307PheGly: 3.307 ± 0.071	0.885PheHis: 0.885 ± 0.031	2.417PheIle: 2.417 ± 0.054	1.732PheLys: 1.732 ± 0.045	3.974PheLeu: 3.974 ± 0.084	1.22PheMet: 1.22 ± 0.039	1.257PheAsn: 1.257 ± 0.038	1.443PhePro: 1.443 ± 0.038	1.403PheGln: 1.403 ± 0.038	1.95PheArg: 1.95 ± 0.053	2.701PheSer: 2.701 ± 0.06	2.193PheThr: 2.193 ± 0.051	2.849PheVal: 2.849 ± 0.052	0.45PheTrp: 0.45 ± 0.024	1.685PheTyr: 1.685 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.239GlyAla: 5.239 ± 0.078	1.264GlyCys: 1.264 ± 0.04	3.431GlyAsp: 3.431 ± 0.056	5.345GlyGlu: 5.345 ± 0.079	3.186GlyPhe: 3.186 ± 0.07	5.218GlyGly: 5.218 ± 0.103	1.197GlyHis: 1.197 ± 0.038	6.402GlyIle: 6.402 ± 0.089	5.806GlyLys: 5.806 ± 0.094	5.69GlyLeu: 5.69 ± 0.079	2.723GlyMet: 2.723 ± 0.054	3.3GlyAsn: 3.3 ± 0.069	1.232GlyPro: 1.232 ± 0.04	2.142GlyGln: 2.142 ± 0.041	3.073GlyArg: 3.073 ± 0.059	4.121GlySer: 4.121 ± 0.068	4.381GlyThr: 4.381 ± 0.069	5.138GlyVal: 5.138 ± 0.077	0.803GlyTrp: 0.803 ± 0.039	3.287GlyTyr: 3.287 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.279HisAla: 1.279 ± 0.038	0.318HisCys: 0.318 ± 0.019	0.864HisAsp: 0.864 ± 0.031	1.154HisGlu: 1.154 ± 0.038	0.858HisPhe: 0.858 ± 0.032	1.351HisGly: 1.351 ± 0.037	0.426HisHis: 0.426 ± 0.031	1.407HisIle: 1.407 ± 0.044	0.919HisLys: 0.919 ± 0.035	1.641HisLeu: 1.641 ± 0.04	0.565HisMet: 0.565 ± 0.024	0.639HisAsn: 0.639 ± 0.028	0.993HisPro: 0.993 ± 0.035	0.565HisGln: 0.565 ± 0.025	0.832HisArg: 0.832 ± 0.031	0.953HisSer: 0.953 ± 0.033	1.052HisThr: 1.052 ± 0.033	1.212HisVal: 1.212 ± 0.035	0.192HisTrp: 0.192 ± 0.014	0.793HisTyr: 0.793 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.531IleAla: 5.531 ± 0.084	1.356IleCys: 1.356 ± 0.039	3.824IleAsp: 3.824 ± 0.065	5.014IleGlu: 5.014 ± 0.078	2.874IlePhe: 2.874 ± 0.071	5.448IleGly: 5.448 ± 0.086	1.377IleHis: 1.377 ± 0.036	4.114IleIle: 4.114 ± 0.087	3.482IleLys: 3.482 ± 0.063	7.097IleLeu: 7.097 ± 0.113	1.883IleMet: 1.883 ± 0.052	2.425IleAsn: 2.425 ± 0.05	3.22IlePro: 3.22 ± 0.068	2.317IleGln: 2.317 ± 0.053	4.17IleArg: 4.17 ± 0.08	4.481IleSer: 4.481 ± 0.072	3.828IleThr: 3.828 ± 0.069	4.997IleVal: 4.997 ± 0.074	0.688IleTrp: 0.688 ± 0.03	2.586IleTyr: 2.586 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.836LysAla: 4.836 ± 0.079	0.731LysCys: 0.731 ± 0.027	3.58LysAsp: 3.58 ± 0.078	7.25LysGlu: 7.25 ± 0.102	1.805LysPhe: 1.805 ± 0.042	4.026LysGly: 4.026 ± 0.068	1.066LysHis: 1.066 ± 0.034	4.786LysIle: 4.786 ± 0.077	6.298LysLys: 6.298 ± 0.095	5.125LysLeu: 5.125 ± 0.069	2.376LysMet: 2.376 ± 0.048	3.486LysAsn: 3.486 ± 0.059	1.981LysPro: 1.981 ± 0.055	2.507LysGln: 2.507 ± 0.052	3.581LysArg: 3.581 ± 0.056	3.248LysSer: 3.248 ± 0.057	3.786LysThr: 3.786 ± 0.066	4.035LysVal: 4.035 ± 0.062	0.652LysTrp: 0.652 ± 0.027	2.766LysTyr: 2.766 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	6.587LeuAla: 6.587 ± 0.092	1.525LeuCys: 1.525 ± 0.039	4.957LeuAsp: 4.957 ± 0.076	6.789LeuGlu: 6.789 ± 0.104	3.796LeuPhe: 3.796 ± 0.085	6.155LeuGly: 6.155 ± 0.094	1.616LeuHis: 1.616 ± 0.045	6.0LeuIle: 6.0 ± 0.099	6.131LeuLys: 6.131 ± 0.08	8.476LeuLeu: 8.476 ± 0.126	2.605LeuMet: 2.605 ± 0.056	3.671LeuAsn: 3.671 ± 0.07	3.62LeuPro: 3.62 ± 0.068	2.803LeuGln: 2.803 ± 0.059	3.841LeuArg: 3.841 ± 0.069	5.761LeuSer: 5.761 ± 0.075	5.001LeuThr: 5.001 ± 0.084	5.365LeuVal: 5.365 ± 0.086	0.764LeuTrp: 0.764 ± 0.027	3.334LeuTyr: 3.334 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.43MetAla: 2.43 ± 0.056	0.349MetCys: 0.349 ± 0.019	1.887MetAsp: 1.887 ± 0.044	2.915MetGlu: 2.915 ± 0.067	1.068MetPhe: 1.068 ± 0.035	2.15MetGly: 2.15 ± 0.059	0.503MetHis: 0.503 ± 0.024	2.267MetIle: 2.267 ± 0.055	2.756MetLys: 2.756 ± 0.052	2.938MetLeu: 2.938 ± 0.052	1.024MetMet: 1.024 ± 0.039	1.534MetAsn: 1.534 ± 0.039	1.125MetPro: 1.125 ± 0.033	1.219MetGln: 1.219 ± 0.035	1.495MetArg: 1.495 ± 0.042	1.728MetSer: 1.728 ± 0.04	1.877MetThr: 1.877 ± 0.045	1.852MetVal: 1.852 ± 0.048	0.248MetTrp: 0.248 ± 0.017	1.069MetTyr: 1.069 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.054	0.611AsnCys: 0.611 ± 0.027	1.886AsnAsp: 1.886 ± 0.049	2.87AsnGlu: 2.87 ± 0.059	1.398AsnPhe: 1.398 ± 0.039	3.648AsnGly: 3.648 ± 0.061	0.796AsnHis: 0.796 ± 0.032	2.898AsnIle: 2.898 ± 0.054	2.111AsnLys: 2.111 ± 0.052	3.673AsnLeu: 3.673 ± 0.07	1.31AsnMet: 1.31 ± 0.039	1.418AsnAsn: 1.418 ± 0.042	1.871AsnPro: 1.871 ± 0.044	1.373AsnGln: 1.373 ± 0.037	2.163AsnArg: 2.163 ± 0.052	2.019AsnSer: 2.019 ± 0.055	2.234AsnThr: 2.234 ± 0.045	2.889AsnVal: 2.889 ± 0.056	0.445AsnTrp: 0.445 ± 0.022	1.695AsnTyr: 1.695 ± 0.051	0.001AsnXaa: 0.001 ± 0.001
Pro	2.428ProAla: 2.428 ± 0.051	0.436ProCys: 0.436 ± 0.022	2.255ProAsp: 2.255 ± 0.054	3.597ProGlu: 3.597 ± 0.073	1.499ProPhe: 1.499 ± 0.041	2.425ProGly: 2.425 ± 0.062	0.66ProHis: 0.66 ± 0.029	2.148ProIle: 2.148 ± 0.047	2.15ProLys: 2.15 ± 0.049	2.713ProLeu: 2.713 ± 0.06	0.946ProMet: 0.946 ± 0.035	1.232ProAsn: 1.232 ± 0.035	0.756ProPro: 0.756 ± 0.031	1.024ProGln: 1.024 ± 0.035	1.018ProArg: 1.018 ± 0.033	1.691ProSer: 1.691 ± 0.042	1.622ProThr: 1.622 ± 0.045	2.817ProVal: 2.817 ± 0.047	0.334ProTrp: 0.334 ± 0.02	1.465ProTyr: 1.465 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.48GlnAla: 2.48 ± 0.057	0.383GlnCys: 0.383 ± 0.018	1.594GlnAsp: 1.594 ± 0.043	2.909GlnGlu: 2.909 ± 0.068	1.286GlnPhe: 1.286 ± 0.031	1.931GlnGly: 1.931 ± 0.045	0.48GlnHis: 0.48 ± 0.022	2.959GlnIle: 2.959 ± 0.057	2.823GlnLys: 2.823 ± 0.06	2.774GlnLeu: 2.774 ± 0.066	1.33GlnMet: 1.33 ± 0.035	1.66GlnAsn: 1.66 ± 0.046	0.879GlnPro: 0.879 ± 0.037	1.199GlnGln: 1.199 ± 0.042	1.473GlnArg: 1.473 ± 0.045	1.583GlnSer: 1.583 ± 0.049	1.88GlnThr: 1.88 ± 0.048	2.072GlnVal: 2.072 ± 0.048	0.378GlnTrp: 0.378 ± 0.021	1.405GlnTyr: 1.405 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.059ArgAla: 3.059 ± 0.059	0.61ArgCys: 0.61 ± 0.028	2.226ArgAsp: 2.226 ± 0.049	4.422ArgGlu: 4.422 ± 0.08	1.968ArgPhe: 1.968 ± 0.047	2.743ArgGly: 2.743 ± 0.048	0.806ArgHis: 0.806 ± 0.028	3.586ArgIle: 3.586 ± 0.078	3.839ArgLys: 3.839 ± 0.063	4.011ArgLeu: 4.011 ± 0.071	1.859ArgMet: 1.859 ± 0.048	2.093ArgAsn: 2.093 ± 0.05	1.364ArgPro: 1.364 ± 0.036	1.89ArgGln: 1.89 ± 0.048	2.571ArgArg: 2.571 ± 0.062	2.323ArgSer: 2.323 ± 0.053	2.354ArgThr: 2.354 ± 0.054	2.798ArgVal: 2.798 ± 0.055	0.446ArgTrp: 0.446 ± 0.022	1.997ArgTyr: 1.997 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.254SerAla: 4.254 ± 0.077	0.813SerCys: 0.813 ± 0.031	2.967SerAsp: 2.967 ± 0.062	4.157SerGlu: 4.157 ± 0.068	2.402SerPhe: 2.402 ± 0.054	5.13SerGly: 5.13 ± 0.078	1.006SerHis: 1.006 ± 0.034	3.652SerIle: 3.652 ± 0.064	3.06SerLys: 3.06 ± 0.053	4.546SerLeu: 4.546 ± 0.069	1.833SerMet: 1.833 ± 0.046	1.856SerAsn: 1.856 ± 0.045	1.705SerPro: 1.705 ± 0.047	1.551SerGln: 1.551 ± 0.042	2.686SerArg: 2.686 ± 0.048	2.97SerSer: 2.97 ± 0.067	2.538SerThr: 2.538 ± 0.06	4.199SerVal: 4.199 ± 0.069	0.557SerTrp: 0.557 ± 0.027	2.395SerTyr: 2.395 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.452ThrAla: 4.452 ± 0.081	0.642ThrCys: 0.642 ± 0.022	3.187ThrAsp: 3.187 ± 0.06	4.184ThrGlu: 4.184 ± 0.071	2.248ThrPhe: 2.248 ± 0.056	4.574ThrGly: 4.574 ± 0.077	0.91ThrHis: 0.91 ± 0.035	3.761ThrIle: 3.761 ± 0.064	3.193ThrLys: 3.193 ± 0.059	4.814ThrLeu: 4.814 ± 0.079	1.532ThrMet: 1.532 ± 0.043	1.903ThrAsn: 1.903 ± 0.044	2.075ThrPro: 2.075 ± 0.05	1.433ThrGln: 1.433 ± 0.038	1.925ThrArg: 1.925 ± 0.043	2.718ThrSer: 2.718 ± 0.048	2.773ThrThr: 2.773 ± 0.06	4.373ThrVal: 4.373 ± 0.07	0.578ThrTrp: 0.578 ± 0.028	2.114ThrTyr: 2.114 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.468ValAla: 4.468 ± 0.078	1.22ValCys: 1.22 ± 0.036	3.673ValAsp: 3.673 ± 0.059	4.928ValGlu: 4.928 ± 0.077	3.064ValPhe: 3.064 ± 0.07	4.536ValGly: 4.536 ± 0.07	1.159ValHis: 1.159 ± 0.035	5.13ValIle: 5.13 ± 0.088	4.527ValLys: 4.527 ± 0.063	6.85ValLeu: 6.85 ± 0.097	2.125ValMet: 2.125 ± 0.055	2.727ValAsn: 2.727 ± 0.055	2.526ValPro: 2.526 ± 0.055	2.233ValGln: 2.233 ± 0.05	3.249ValArg: 3.249 ± 0.058	4.402ValSer: 4.402 ± 0.07	4.079ValThr: 4.079 ± 0.07	4.715ValVal: 4.715 ± 0.082	0.744ValTrp: 0.744 ± 0.031	2.699ValTyr: 2.699 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.563TrpAla: 0.563 ± 0.027	0.161TrpCys: 0.161 ± 0.012	0.579TrpAsp: 0.579 ± 0.028	0.769TrpGlu: 0.769 ± 0.028	0.445TrpPhe: 0.445 ± 0.023	0.728TrpGly: 0.728 ± 0.03	0.185TrpHis: 0.185 ± 0.014	0.869TrpIle: 0.869 ± 0.03	0.906TrpLys: 0.906 ± 0.032	0.827TrpLeu: 0.827 ± 0.031	0.394TrpMet: 0.394 ± 0.022	0.581TrpAsn: 0.581 ± 0.026	0.193TrpPro: 0.193 ± 0.016	0.372TrpGln: 0.372 ± 0.021	0.383TrpArg: 0.383 ± 0.02	0.504TrpSer: 0.504 ± 0.023	0.456TrpThr: 0.456 ± 0.021	0.559TrpVal: 0.559 ± 0.025	0.149TrpTrp: 0.149 ± 0.015	0.472TrpTyr: 0.472 ± 0.036	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.822TyrAla: 2.822 ± 0.056	0.599TyrCys: 0.599 ± 0.022	2.426TyrAsp: 2.426 ± 0.059	3.299TyrGlu: 3.299 ± 0.059	1.745TyrPhe: 1.745 ± 0.045	3.043TyrGly: 3.043 ± 0.06	0.895TyrHis: 0.895 ± 0.031	2.681TyrIle: 2.681 ± 0.063	2.112TyrLys: 2.112 ± 0.052	3.803TyrLeu: 3.803 ± 0.078	1.128TyrMet: 1.128 ± 0.035	1.63TyrAsn: 1.63 ± 0.044	1.493TyrPro: 1.493 ± 0.04	1.537TyrGln: 1.537 ± 0.043	2.194TyrArg: 2.194 ± 0.051	2.182TyrSer: 2.182 ± 0.051	2.299TyrThr: 2.299 ± 0.051	2.629TyrVal: 2.629 ± 0.051	0.416TyrTrp: 0.416 ± 0.021	1.895TyrTyr: 1.895 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3188 proteins (960594 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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