Amino acid dipepetide frequency for Aspergillus turcosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.052AlaAla: 9.052 ± 0.064	1.056AlaCys: 1.056 ± 0.017	4.38AlaAsp: 4.38 ± 0.031	5.364AlaGlu: 5.364 ± 0.046	3.145AlaPhe: 3.145 ± 0.027	5.85AlaGly: 5.85 ± 0.04	1.788AlaHis: 1.788 ± 0.017	4.287AlaIle: 4.287 ± 0.032	3.937AlaLys: 3.937 ± 0.036	7.921AlaLeu: 7.921 ± 0.05	1.981AlaMet: 1.981 ± 0.02	2.953AlaAsn: 2.953 ± 0.026	4.63AlaPro: 4.63 ± 0.044	3.475AlaGln: 3.475 ± 0.028	5.097AlaArg: 5.097 ± 0.033	7.302AlaSer: 7.302 ± 0.046	5.233AlaThr: 5.233 ± 0.033	5.637AlaVal: 5.637 ± 0.036	1.188AlaTrp: 1.188 ± 0.02	2.205AlaTyr: 2.205 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.955CysAla: 0.955 ± 0.015	0.239CysCys: 0.239 ± 0.008	0.688CysAsp: 0.688 ± 0.011	0.602CysGlu: 0.602 ± 0.012	0.529CysPhe: 0.529 ± 0.011	0.92CysGly: 0.92 ± 0.017	0.328CysHis: 0.328 ± 0.009	0.681CysIle: 0.681 ± 0.012	0.466CysLys: 0.466 ± 0.01	1.322CysLeu: 1.322 ± 0.017	0.269CysMet: 0.269 ± 0.008	0.42CysAsn: 0.42 ± 0.01	0.67CysPro: 0.67 ± 0.015	0.452CysGln: 0.452 ± 0.011	0.772CysArg: 0.772 ± 0.012	0.92CysSer: 0.92 ± 0.017	0.681CysThr: 0.681 ± 0.015	0.805CysVal: 0.805 ± 0.013	0.2CysTrp: 0.2 ± 0.006	0.37CysTyr: 0.37 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.707AspAla: 4.707 ± 0.033	0.627AspCys: 0.627 ± 0.012	3.917AspAsp: 3.917 ± 0.04	4.465AspGlu: 4.465 ± 0.039	2.187AspPhe: 2.187 ± 0.021	3.935AspGly: 3.935 ± 0.036	1.275AspHis: 1.275 ± 0.019	3.049AspIle: 3.049 ± 0.028	2.217AspLys: 2.217 ± 0.025	5.267AspLeu: 5.267 ± 0.042	1.233AspMet: 1.233 ± 0.017	1.831AspAsn: 1.831 ± 0.021	3.466AspPro: 3.466 ± 0.031	1.933AspGln: 1.933 ± 0.02	3.178AspArg: 3.178 ± 0.032	4.139AspSer: 4.139 ± 0.035	2.896AspThr: 2.896 ± 0.026	3.728AspVal: 3.728 ± 0.029	0.875AspTrp: 0.875 ± 0.015	1.685AspTyr: 1.685 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.403GluAla: 5.403 ± 0.042	0.631GluCys: 0.631 ± 0.014	4.183GluAsp: 4.183 ± 0.04	5.615GluGlu: 5.615 ± 0.069	1.994GluPhe: 1.994 ± 0.023	3.662GluGly: 3.662 ± 0.03	1.432GluHis: 1.432 ± 0.015	3.157GluIle: 3.157 ± 0.03	3.635GluLys: 3.635 ± 0.035	5.323GluLeu: 5.323 ± 0.041	1.478GluMet: 1.478 ± 0.018	2.335GluAsn: 2.335 ± 0.023	2.796GluPro: 2.796 ± 0.043	2.61GluGln: 2.61 ± 0.025	4.104GluArg: 4.104 ± 0.034	4.439GluSer: 4.439 ± 0.037	3.601GluThr: 3.601 ± 0.03	3.558GluVal: 3.558 ± 0.029	0.885GluTrp: 0.885 ± 0.015	1.746GluTyr: 1.746 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.064PheAla: 3.064 ± 0.029	0.57PheCys: 0.57 ± 0.01	2.289PheAsp: 2.289 ± 0.024	2.138PheGlu: 2.138 ± 0.024	1.648PhePhe: 1.648 ± 0.023	2.773PheGly: 2.773 ± 0.034	0.927PheHis: 0.927 ± 0.013	1.795PheIle: 1.795 ± 0.022	1.438PheLys: 1.438 ± 0.019	3.622PheLeu: 3.622 ± 0.032	0.787PheMet: 0.787 ± 0.014	1.403PheAsn: 1.403 ± 0.019	2.016PhePro: 2.016 ± 0.021	1.425PheGln: 1.425 ± 0.02	2.052PheArg: 2.052 ± 0.024	3.003PheSer: 3.003 ± 0.026	2.105PheThr: 2.105 ± 0.024	2.465PheVal: 2.465 ± 0.025	0.652PheTrp: 0.652 ± 0.013	1.167PheTyr: 1.167 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.289GlyAla: 5.289 ± 0.041	0.87GlyCys: 0.87 ± 0.016	3.597GlyAsp: 3.597 ± 0.026	3.58GlyGlu: 3.58 ± 0.034	2.758GlyPhe: 2.758 ± 0.025	5.159GlyGly: 5.159 ± 0.051	1.643GlyHis: 1.643 ± 0.019	3.506GlyIle: 3.506 ± 0.031	3.262GlyLys: 3.262 ± 0.026	6.068GlyLeu: 6.068 ± 0.042	1.51GlyMet: 1.51 ± 0.019	2.432GlyAsn: 2.432 ± 0.026	3.348GlyPro: 3.348 ± 0.034	2.641GlyGln: 2.641 ± 0.029	4.078GlyArg: 4.078 ± 0.031	5.614GlySer: 5.614 ± 0.042	3.93GlyThr: 3.93 ± 0.032	4.397GlyVal: 4.397 ± 0.033	1.174GlyTrp: 1.174 ± 0.015	2.155GlyTyr: 2.155 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.868HisAla: 1.868 ± 0.021	0.329HisCys: 0.329 ± 0.009	1.291HisAsp: 1.291 ± 0.017	1.324HisGlu: 1.324 ± 0.016	0.927HisPhe: 0.927 ± 0.015	1.734HisGly: 1.734 ± 0.021	0.819HisHis: 0.819 ± 0.016	1.202HisIle: 1.202 ± 0.018	0.854HisLys: 0.854 ± 0.015	2.324HisLeu: 2.324 ± 0.025	0.471HisMet: 0.471 ± 0.011	0.824HisAsn: 0.824 ± 0.013	1.704HisPro: 1.704 ± 0.02	0.969HisGln: 0.969 ± 0.017	1.597HisArg: 1.597 ± 0.019	1.851HisSer: 1.851 ± 0.022	1.26HisThr: 1.26 ± 0.016	1.426HisVal: 1.426 ± 0.018	0.352HisTrp: 0.352 ± 0.01	0.71HisTyr: 0.71 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.247IleAla: 4.247 ± 0.029	0.776IleCys: 0.776 ± 0.013	2.82IleAsp: 2.82 ± 0.026	2.89IleGlu: 2.89 ± 0.024	1.994IlePhe: 1.994 ± 0.023	3.131IleGly: 3.131 ± 0.028	1.223IleHis: 1.223 ± 0.016	2.475IleIle: 2.475 ± 0.026	2.072IleLys: 2.072 ± 0.021	4.726IleLeu: 4.726 ± 0.038	0.978IleMet: 0.978 ± 0.015	1.772IleAsn: 1.772 ± 0.019	3.161IlePro: 3.161 ± 0.031	1.935IleGln: 1.935 ± 0.021	2.915IleArg: 2.915 ± 0.024	3.805IleSer: 3.805 ± 0.034	2.755IleThr: 2.755 ± 0.025	3.244IleVal: 3.244 ± 0.033	0.723IleTrp: 0.723 ± 0.013	1.473IleTyr: 1.473 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.07LysAla: 4.07 ± 0.029	0.474LysCys: 0.474 ± 0.01	2.693LysAsp: 2.693 ± 0.025	3.335LysGlu: 3.335 ± 0.035	1.388LysPhe: 1.388 ± 0.017	2.838LysGly: 2.838 ± 0.022	1.08LysHis: 1.08 ± 0.017	2.173LysIle: 2.173 ± 0.024	2.99LysLys: 2.99 ± 0.044	3.959LysLeu: 3.959 ± 0.034	0.95LysMet: 0.95 ± 0.015	1.66LysAsn: 1.66 ± 0.02	2.603LysPro: 2.603 ± 0.029	1.827LysGln: 1.827 ± 0.021	3.358LysArg: 3.358 ± 0.035	3.262LysSer: 3.262 ± 0.03	2.624LysThr: 2.624 ± 0.023	2.727LysVal: 2.727 ± 0.026	0.644LysTrp: 0.644 ± 0.012	1.371LysTyr: 1.371 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	8.06LeuAla: 8.06 ± 0.042	1.264LeuCys: 1.264 ± 0.017	5.287LeuAsp: 5.287 ± 0.037	5.671LeuGlu: 5.671 ± 0.044	3.395LeuPhe: 3.395 ± 0.028	5.981LeuGly: 5.981 ± 0.041	2.308LeuHis: 2.308 ± 0.025	4.053LeuIle: 4.053 ± 0.037	4.114LeuLys: 4.114 ± 0.034	8.787LeuLeu: 8.787 ± 0.07	1.811LeuMet: 1.811 ± 0.021	3.225LeuAsn: 3.225 ± 0.025	5.578LeuPro: 5.578 ± 0.042	3.996LeuGln: 3.996 ± 0.035	6.072LeuArg: 6.072 ± 0.044	7.598LeuSer: 7.598 ± 0.047	4.952LeuThr: 4.952 ± 0.032	5.564LeuVal: 5.564 ± 0.038	1.219LeuTrp: 1.219 ± 0.019	2.472LeuTyr: 2.472 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.155MetAla: 2.155 ± 0.023	0.239MetCys: 0.239 ± 0.007	1.232MetAsp: 1.232 ± 0.017	1.297MetGlu: 1.297 ± 0.017	0.744MetPhe: 0.744 ± 0.015	1.418MetGly: 1.418 ± 0.019	0.458MetHis: 0.458 ± 0.009	1.016MetIle: 1.016 ± 0.016	0.973MetLys: 0.973 ± 0.014	1.854MetLeu: 1.854 ± 0.021	0.557MetMet: 0.557 ± 0.012	0.791MetAsn: 0.791 ± 0.014	1.181MetPro: 1.181 ± 0.016	0.862MetGln: 0.862 ± 0.014	1.259MetArg: 1.259 ± 0.018	1.784MetSer: 1.784 ± 0.02	1.314MetThr: 1.314 ± 0.016	1.349MetVal: 1.349 ± 0.017	0.258MetTrp: 0.258 ± 0.007	0.525MetTyr: 0.525 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.134AsnAla: 3.134 ± 0.028	0.468AsnCys: 0.468 ± 0.012	1.886AsnAsp: 1.886 ± 0.019	2.057AsnGlu: 2.057 ± 0.019	1.331AsnPhe: 1.331 ± 0.018	2.95AsnGly: 2.95 ± 0.032	0.826AsnHis: 0.826 ± 0.013	2.006AsnIle: 2.006 ± 0.021	1.422AsnLys: 1.422 ± 0.018	3.255AsnLeu: 3.255 ± 0.027	0.808AsnMet: 0.808 ± 0.014	1.403AsnAsn: 1.403 ± 0.02	2.498AsnPro: 2.498 ± 0.026	1.354AsnGln: 1.354 ± 0.018	2.004AsnArg: 2.004 ± 0.02	2.609AsnSer: 2.609 ± 0.025	2.078AsnThr: 2.078 ± 0.023	2.313AsnVal: 2.313 ± 0.023	0.565AsnTrp: 0.565 ± 0.011	1.067AsnTyr: 1.067 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.248ProAla: 5.248 ± 0.046	0.544ProCys: 0.544 ± 0.012	3.278ProAsp: 3.278 ± 0.03	3.932ProGlu: 3.932 ± 0.04	2.105ProPhe: 2.105 ± 0.022	3.931ProGly: 3.931 ± 0.032	1.329ProHis: 1.329 ± 0.019	2.437ProIle: 2.437 ± 0.02	2.502ProLys: 2.502 ± 0.03	4.805ProLeu: 4.805 ± 0.032	1.038ProMet: 1.038 ± 0.015	2.131ProAsn: 2.131 ± 0.024	4.781ProPro: 4.781 ± 0.059	2.457ProGln: 2.457 ± 0.029	3.465ProArg: 3.465 ± 0.028	6.22ProSer: 6.22 ± 0.051	3.765ProThr: 3.765 ± 0.03	3.74ProVal: 3.74 ± 0.035	0.772ProTrp: 0.772 ± 0.014	1.559ProTyr: 1.559 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.496GlnAla: 3.496 ± 0.032	0.46GlnCys: 0.46 ± 0.01	2.045GlnAsp: 2.045 ± 0.023	2.515GlnGlu: 2.515 ± 0.026	1.347GlnPhe: 1.347 ± 0.017	2.418GlnGly: 2.418 ± 0.028	1.05GlnHis: 1.05 ± 0.015	1.963GlnIle: 1.963 ± 0.019	1.999GlnLys: 1.999 ± 0.024	3.631GlnLeu: 3.631 ± 0.028	0.913GlnMet: 0.913 ± 0.015	1.542GlnAsn: 1.542 ± 0.019	2.531GlnPro: 2.531 ± 0.03	2.323GlnGln: 2.323 ± 0.04	2.732GlnArg: 2.732 ± 0.027	3.285GlnSer: 3.285 ± 0.03	2.388GlnThr: 2.388 ± 0.025	2.224GlnVal: 2.224 ± 0.022	0.611GlnTrp: 0.611 ± 0.011	1.168GlnTyr: 1.168 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.856ArgAla: 4.856 ± 0.034	0.712ArgCys: 0.712 ± 0.012	3.428ArgAsp: 3.428 ± 0.033	3.996ArgGlu: 3.996 ± 0.039	2.288ArgPhe: 2.288 ± 0.023	3.649ArgGly: 3.649 ± 0.028	1.588ArgHis: 1.588 ± 0.019	3.006ArgIle: 3.006 ± 0.027	3.466ArgLys: 3.466 ± 0.032	5.83ArgLeu: 5.83 ± 0.039	1.312ArgMet: 1.312 ± 0.017	2.296ArgAsn: 2.296 ± 0.023	3.552ArgPro: 3.552 ± 0.034	2.701ArgGln: 2.701 ± 0.024	5.282ArgArg: 5.282 ± 0.05	4.862ArgSer: 4.862 ± 0.038	3.36ArgThr: 3.36 ± 0.028	3.586ArgVal: 3.586 ± 0.029	0.953ArgTrp: 0.953 ± 0.014	1.744ArgTyr: 1.744 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.849SerAla: 6.849 ± 0.045	0.851SerCys: 0.851 ± 0.015	4.285SerAsp: 4.285 ± 0.032	4.301SerGlu: 4.301 ± 0.038	3.024SerPhe: 3.024 ± 0.025	5.483SerGly: 5.483 ± 0.039	1.962SerHis: 1.962 ± 0.022	3.975SerIle: 3.975 ± 0.034	3.587SerLys: 3.587 ± 0.037	7.453SerLeu: 7.453 ± 0.044	1.679SerMet: 1.679 ± 0.02	2.948SerAsn: 2.948 ± 0.028	5.444SerPro: 5.444 ± 0.046	3.389SerGln: 3.389 ± 0.031	5.118SerArg: 5.118 ± 0.039	8.797SerSer: 8.797 ± 0.071	5.53SerThr: 5.53 ± 0.043	4.775SerVal: 4.775 ± 0.035	1.115SerTrp: 1.115 ± 0.016	2.062SerTyr: 2.062 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.316ThrAla: 5.316 ± 0.042	0.719ThrCys: 0.719 ± 0.012	2.914ThrAsp: 2.914 ± 0.026	3.126ThrGlu: 3.126 ± 0.027	2.233ThrPhe: 2.233 ± 0.023	4.224ThrGly: 4.224 ± 0.036	1.238ThrHis: 1.238 ± 0.015	3.016ThrIle: 3.016 ± 0.025	2.432ThrLys: 2.432 ± 0.025	5.282ThrLeu: 5.282 ± 0.034	1.176ThrMet: 1.176 ± 0.015	2.013ThrAsn: 2.013 ± 0.02	4.183ThrPro: 4.183 ± 0.04	2.073ThrGln: 2.073 ± 0.022	3.1ThrArg: 3.1 ± 0.027	5.179ThrSer: 5.179 ± 0.039	4.089ThrThr: 4.089 ± 0.044	3.941ThrVal: 3.941 ± 0.031	0.854ThrTrp: 0.854 ± 0.013	1.633ThrTyr: 1.633 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.321ValAla: 5.321 ± 0.036	0.846ValCys: 0.846 ± 0.014	3.834ValAsp: 3.834 ± 0.031	3.924ValGlu: 3.924 ± 0.035	2.52ValPhe: 2.52 ± 0.025	3.936ValGly: 3.936 ± 0.036	1.445ValHis: 1.445 ± 0.016	3.08ValIle: 3.08 ± 0.025	2.818ValLys: 2.818 ± 0.026	5.764ValLeu: 5.764 ± 0.036	1.322ValMet: 1.322 ± 0.018	2.267ValAsn: 2.267 ± 0.023	3.704ValPro: 3.704 ± 0.029	2.491ValGln: 2.491 ± 0.025	3.598ValArg: 3.598 ± 0.03	4.845ValSer: 4.845 ± 0.036	3.603ValThr: 3.603 ± 0.034	4.331ValVal: 4.331 ± 0.033	0.897ValTrp: 0.897 ± 0.014	1.853ValTyr: 1.853 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.13TrpAla: 1.13 ± 0.018	0.191TrpCys: 0.191 ± 0.006	0.904TrpAsp: 0.904 ± 0.016	0.863TrpGlu: 0.863 ± 0.014	0.548TrpPhe: 0.548 ± 0.013	0.919TrpGly: 0.919 ± 0.014	0.36TrpHis: 0.36 ± 0.009	0.763TrpIle: 0.763 ± 0.013	0.781TrpLys: 0.781 ± 0.013	1.402TrpLeu: 1.402 ± 0.019	0.372TrpMet: 0.372 ± 0.01	0.641TrpAsn: 0.641 ± 0.013	0.61TrpPro: 0.61 ± 0.013	0.59TrpGln: 0.59 ± 0.014	0.99TrpArg: 0.99 ± 0.015	1.04TrpSer: 1.04 ± 0.017	0.941TrpThr: 0.941 ± 0.016	0.898TrpVal: 0.898 ± 0.013	0.277TrpTrp: 0.277 ± 0.009	0.453TrpTyr: 0.453 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.26TyrAla: 2.26 ± 0.025	0.422TyrCys: 0.422 ± 0.01	1.659TyrAsp: 1.659 ± 0.019	1.595TyrGlu: 1.595 ± 0.019	1.233TyrPhe: 1.233 ± 0.018	2.103TyrGly: 2.103 ± 0.025	0.761TyrHis: 0.761 ± 0.013	1.474TyrIle: 1.474 ± 0.017	1.063TyrLys: 1.063 ± 0.016	2.811TyrLeu: 2.811 ± 0.026	0.618TyrMet: 0.618 ± 0.012	1.144TyrAsn: 1.144 ± 0.016	1.584TyrPro: 1.584 ± 0.022	1.136TyrGln: 1.136 ± 0.016	1.695TyrArg: 1.695 ± 0.018	2.073TyrSer: 2.073 ± 0.02	1.636TyrThr: 1.636 ± 0.019	1.692TyrVal: 1.692 ± 0.019	0.461TyrTrp: 0.461 ± 0.011	0.993TyrTyr: 0.993 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9174 proteins (4845878 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---