Amino acid dipepetide frequency for Providencia sneebia DSM 19967

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.017AlaAla: 7.017 ± 0.131	0.927AlaCys: 0.927 ± 0.032	4.155AlaAsp: 4.155 ± 0.075	4.964AlaGlu: 4.964 ± 0.092	3.191AlaPhe: 3.191 ± 0.063	5.769AlaGly: 5.769 ± 0.089	1.473AlaHis: 1.473 ± 0.044	6.565AlaIle: 6.565 ± 0.095	4.744AlaLys: 4.744 ± 0.095	9.123AlaLeu: 9.123 ± 0.114	2.372AlaMet: 2.372 ± 0.049	3.43AlaAsn: 3.43 ± 0.061	2.799AlaPro: 2.799 ± 0.057	3.757AlaGln: 3.757 ± 0.081	3.626AlaArg: 3.626 ± 0.07	4.508AlaSer: 4.508 ± 0.073	4.102AlaThr: 4.102 ± 0.072	5.275AlaVal: 5.275 ± 0.087	0.966AlaTrp: 0.966 ± 0.035	2.342AlaTyr: 2.342 ± 0.051	0.002AlaXaa: 0.002 ± 0.001
Cys	0.794CysAla: 0.794 ± 0.029	0.154CysCys: 0.154 ± 0.013	0.611CysAsp: 0.611 ± 0.028	0.625CysGlu: 0.625 ± 0.024	0.461CysPhe: 0.461 ± 0.022	0.932CysGly: 0.932 ± 0.034	0.371CysHis: 0.371 ± 0.021	0.704CysIle: 0.704 ± 0.033	0.413CysLys: 0.413 ± 0.019	1.008CysLeu: 1.008 ± 0.036	0.214CysMet: 0.214 ± 0.016	0.407CysAsn: 0.407 ± 0.02	0.452CysPro: 0.452 ± 0.024	0.503CysGln: 0.503 ± 0.023	0.503CysArg: 0.503 ± 0.024	0.699CysSer: 0.699 ± 0.028	0.484CysThr: 0.484 ± 0.021	0.715CysVal: 0.715 ± 0.028	0.163CysTrp: 0.163 ± 0.013	0.428CysTyr: 0.428 ± 0.02	0.001CysXaa: 0.001 ± 0.001
Asp	4.073AspAla: 4.073 ± 0.07	0.54AspCys: 0.54 ± 0.023	2.825AspAsp: 2.825 ± 0.06	3.814AspGlu: 3.814 ± 0.071	2.304AspPhe: 2.304 ± 0.047	3.432AspGly: 3.432 ± 0.067	0.966AspHis: 0.966 ± 0.034	4.375AspIle: 4.375 ± 0.074	3.409AspLys: 3.409 ± 0.064	4.899AspLeu: 4.899 ± 0.077	1.327AspMet: 1.327 ± 0.036	2.828AspAsn: 2.828 ± 0.061	2.071AspPro: 2.071 ± 0.053	1.63AspGln: 1.63 ± 0.046	2.108AspArg: 2.108 ± 0.055	2.97AspSer: 2.97 ± 0.067	2.352AspThr: 2.352 ± 0.055	3.522AspVal: 3.522 ± 0.059	0.747AspTrp: 0.747 ± 0.028	1.995AspTyr: 1.995 ± 0.049	0.002AspXaa: 0.002 ± 0.001
Glu	4.536GluAla: 4.536 ± 0.096	0.512GluCys: 0.512 ± 0.024	2.622GluAsp: 2.622 ± 0.063	3.623GluGlu: 3.623 ± 0.076	2.175GluPhe: 2.175 ± 0.047	3.488GluGly: 3.488 ± 0.076	1.446GluHis: 1.446 ± 0.041	4.331GluIle: 4.331 ± 0.074	4.381GluLys: 4.381 ± 0.077	6.636GluLeu: 6.636 ± 0.085	1.694GluMet: 1.694 ± 0.041	3.191GluAsn: 3.191 ± 0.053	1.983GluPro: 1.983 ± 0.053	3.753GluGln: 3.753 ± 0.086	3.24GluArg: 3.24 ± 0.06	3.412GluSer: 3.412 ± 0.054	3.021GluThr: 3.021 ± 0.063	3.695GluVal: 3.695 ± 0.072	0.777GluTrp: 0.777 ± 0.03	1.845GluTyr: 1.845 ± 0.055	0.007GluXaa: 0.007 ± 0.004
Phe	3.223PheAla: 3.223 ± 0.067	0.552PheCys: 0.552 ± 0.024	2.496PheAsp: 2.496 ± 0.05	2.071PheGlu: 2.071 ± 0.047	1.823PhePhe: 1.823 ± 0.056	3.003PheGly: 3.003 ± 0.067	0.79PheHis: 0.79 ± 0.028	3.401PheIle: 3.401 ± 0.079	1.807PheLys: 1.807 ± 0.045	3.676PheLeu: 3.676 ± 0.078	1.11PheMet: 1.11 ± 0.034	2.219PheAsn: 2.219 ± 0.049	1.495PhePro: 1.495 ± 0.043	1.211PheGln: 1.211 ± 0.038	1.636PheArg: 1.636 ± 0.049	3.513PheSer: 3.513 ± 0.063	2.393PheThr: 2.393 ± 0.056	2.575PheVal: 2.575 ± 0.058	0.562PheTrp: 0.562 ± 0.031	1.48PheTyr: 1.48 ± 0.045	0.006PheXaa: 0.006 ± 0.002
Gly	5.164GlyAla: 5.164 ± 0.093	0.943GlyCys: 0.943 ± 0.03	3.395GlyAsp: 3.395 ± 0.066	3.948GlyGlu: 3.948 ± 0.07	3.22GlyPhe: 3.22 ± 0.057	4.635GlyGly: 4.635 ± 0.093	1.502GlyHis: 1.502 ± 0.042	5.447GlyIle: 5.447 ± 0.086	4.075GlyLys: 4.075 ± 0.074	6.764GlyLeu: 6.764 ± 0.103	1.984GlyMet: 1.984 ± 0.054	2.771GlyAsn: 2.771 ± 0.053	1.649GlyPro: 1.649 ± 0.044	2.686GlyGln: 2.686 ± 0.056	3.099GlyArg: 3.099 ± 0.069	3.989GlySer: 3.989 ± 0.069	3.447GlyThr: 3.447 ± 0.066	4.898GlyVal: 4.898 ± 0.088	0.984GlyTrp: 0.984 ± 0.038	2.564GlyTyr: 2.564 ± 0.056	0.007GlyXaa: 0.007 ± 0.003
His	1.482HisAla: 1.482 ± 0.041	0.305HisCys: 0.305 ± 0.018	1.066HisAsp: 1.066 ± 0.037	1.185HisGlu: 1.185 ± 0.037	1.069HisPhe: 1.069 ± 0.03	1.443HisGly: 1.443 ± 0.043	0.681HisHis: 0.681 ± 0.029	1.491HisIle: 1.491 ± 0.044	0.999HisLys: 0.999 ± 0.037	2.125HisLeu: 2.125 ± 0.048	0.494HisMet: 0.494 ± 0.02	0.972HisAsn: 0.972 ± 0.032	1.174HisPro: 1.174 ± 0.035	1.223HisGln: 1.223 ± 0.04	0.993HisArg: 0.993 ± 0.031	1.378HisSer: 1.378 ± 0.038	0.997HisThr: 0.997 ± 0.035	1.2HisVal: 1.2 ± 0.032	0.366HisTrp: 0.366 ± 0.022	0.98HisTyr: 0.98 ± 0.037	0.003HisXaa: 0.003 ± 0.002
Ile	6.851IleAla: 6.851 ± 0.102	0.869IleCys: 0.869 ± 0.033	4.513IleAsp: 4.513 ± 0.069	4.831IleGlu: 4.831 ± 0.073	2.824IlePhe: 2.824 ± 0.069	5.263IleGly: 5.263 ± 0.09	1.432IleHis: 1.432 ± 0.04	5.513IleIle: 5.513 ± 0.095	3.833IleLys: 3.833 ± 0.074	6.626IleLeu: 6.626 ± 0.11	1.666IleMet: 1.666 ± 0.043	3.932IleAsn: 3.932 ± 0.076	3.36IlePro: 3.36 ± 0.07	2.595IleGln: 2.595 ± 0.062	3.155IleArg: 3.155 ± 0.056	5.214IleSer: 5.214 ± 0.08	4.248IleThr: 4.248 ± 0.081	4.449IleVal: 4.449 ± 0.064	0.741IleTrp: 0.741 ± 0.026	2.213IleTyr: 2.213 ± 0.048	0.004IleXaa: 0.004 ± 0.002
Lys	4.429LysAla: 4.429 ± 0.087	0.336LysCys: 0.336 ± 0.022	2.826LysAsp: 2.826 ± 0.052	3.553LysGlu: 3.553 ± 0.08	1.594LysPhe: 1.594 ± 0.044	3.394LysGly: 3.394 ± 0.068	1.136LysHis: 1.136 ± 0.037	3.791LysIle: 3.791 ± 0.063	3.531LysLys: 3.531 ± 0.079	5.603LysLeu: 5.603 ± 0.083	1.711LysMet: 1.711 ± 0.043	3.054LysAsn: 3.054 ± 0.063	2.363LysPro: 2.363 ± 0.051	3.02LysGln: 3.02 ± 0.08	2.677LysArg: 2.677 ± 0.053	3.373LysSer: 3.373 ± 0.066	3.115LysThr: 3.115 ± 0.058	3.597LysVal: 3.597 ± 0.063	0.573LysTrp: 0.573 ± 0.025	1.629LysTyr: 1.629 ± 0.046	0.007LysXaa: 0.007 ± 0.003
Leu	9.427LeuAla: 9.427 ± 0.115	1.143LeuCys: 1.143 ± 0.032	5.311LeuAsp: 5.311 ± 0.079	5.643LeuGlu: 5.643 ± 0.079	4.471LeuPhe: 4.471 ± 0.082	6.801LeuGly: 6.801 ± 0.098	1.987LeuHis: 1.987 ± 0.043	7.291LeuIle: 7.291 ± 0.108	5.615LeuLys: 5.615 ± 0.079	11.01LeuLeu: 11.01 ± 0.167	2.721LeuMet: 2.721 ± 0.055	5.026LeuAsn: 5.026 ± 0.086	5.212LeuPro: 5.212 ± 0.085	3.978LeuGln: 3.978 ± 0.087	4.69LeuArg: 4.69 ± 0.083	7.831LeuSer: 7.831 ± 0.105	6.071LeuThr: 6.071 ± 0.081	6.392LeuVal: 6.392 ± 0.08	1.166LeuTrp: 1.166 ± 0.043	2.854LeuTyr: 2.854 ± 0.054	0.007LeuXaa: 0.007 ± 0.003
Met	2.45MetAla: 2.45 ± 0.051	0.201MetCys: 0.201 ± 0.013	1.147MetAsp: 1.147 ± 0.035	1.314MetGlu: 1.314 ± 0.036	0.868MetPhe: 0.868 ± 0.036	1.767MetGly: 1.767 ± 0.043	0.446MetHis: 0.446 ± 0.022	1.714MetIle: 1.714 ± 0.043	1.661MetLys: 1.661 ± 0.038	2.881MetLeu: 2.881 ± 0.057	0.826MetMet: 0.826 ± 0.035	1.333MetAsn: 1.333 ± 0.04	1.25MetPro: 1.25 ± 0.04	1.15MetGln: 1.15 ± 0.032	1.169MetArg: 1.169 ± 0.038	1.971MetSer: 1.971 ± 0.041	1.629MetThr: 1.629 ± 0.043	1.769MetVal: 1.769 ± 0.047	0.241MetTrp: 0.241 ± 0.018	0.577MetTyr: 0.577 ± 0.024	0.003MetXaa: 0.003 ± 0.002
Asn	3.507AsnAla: 3.507 ± 0.067	0.455AsnCys: 0.455 ± 0.024	2.453AsnAsp: 2.453 ± 0.056	2.911AsnGlu: 2.911 ± 0.054	1.701AsnPhe: 1.701 ± 0.048	3.183AsnGly: 3.183 ± 0.062	1.09AsnHis: 1.09 ± 0.038	3.776AsnIle: 3.776 ± 0.08	2.908AsnLys: 2.908 ± 0.061	4.352AsnLeu: 4.352 ± 0.082	1.243AsnMet: 1.243 ± 0.041	2.715AsnAsn: 2.715 ± 0.067	2.227AsnPro: 2.227 ± 0.048	2.312AsnGln: 2.312 ± 0.055	2.03AsnArg: 2.03 ± 0.044	2.964AsnSer: 2.964 ± 0.065	2.492AsnThr: 2.492 ± 0.063	2.68AsnVal: 2.68 ± 0.05	0.585AsnTrp: 0.585 ± 0.028	1.639AsnTyr: 1.639 ± 0.05	0.007AsnXaa: 0.007 ± 0.003
Pro	3.285ProAla: 3.285 ± 0.066	0.369ProCys: 0.369 ± 0.021	2.376ProAsp: 2.376 ± 0.049	3.492ProGlu: 3.492 ± 0.054	1.843ProPhe: 1.843 ± 0.041	2.287ProGly: 2.287 ± 0.055	0.89ProHis: 0.89 ± 0.031	3.064ProIle: 3.064 ± 0.057	2.115ProLys: 2.115 ± 0.046	4.444ProLeu: 4.444 ± 0.064	1.025ProMet: 1.025 ± 0.032	1.858ProAsn: 1.858 ± 0.044	1.313ProPro: 1.313 ± 0.04	1.761ProGln: 1.761 ± 0.042	1.416ProArg: 1.416 ± 0.038	2.366ProSer: 2.366 ± 0.053	2.218ProThr: 2.218 ± 0.046	2.999ProVal: 2.999 ± 0.066	0.502ProTrp: 0.502 ± 0.027	1.375ProTyr: 1.375 ± 0.038	0.003ProXaa: 0.003 ± 0.002
Gln	3.897GlnAla: 3.897 ± 0.077	0.383GlnCys: 0.383 ± 0.021	1.983GlnAsp: 1.983 ± 0.048	2.585GlnGlu: 2.585 ± 0.062	1.822GlnPhe: 1.822 ± 0.041	2.882GlnGly: 2.882 ± 0.058	1.191GlnHis: 1.191 ± 0.046	2.964GlnIle: 2.964 ± 0.055	2.626GlnLys: 2.626 ± 0.066	5.238GlnLeu: 5.238 ± 0.097	1.09GlnMet: 1.09 ± 0.036	1.96GlnAsn: 1.96 ± 0.059	1.851GlnPro: 1.851 ± 0.052	3.251GlnGln: 3.251 ± 0.124	2.305GlnArg: 2.305 ± 0.055	2.657GlnSer: 2.657 ± 0.073	2.177GlnThr: 2.177 ± 0.057	2.858GlnVal: 2.858 ± 0.056	0.623GlnTrp: 0.623 ± 0.027	1.465GlnTyr: 1.465 ± 0.048	0.003GlnXaa: 0.003 ± 0.002
Arg	3.154ArgAla: 3.154 ± 0.071	0.46ArgCys: 0.46 ± 0.022	2.474ArgAsp: 2.474 ± 0.052	3.059ArgGlu: 3.059 ± 0.069	2.211ArgPhe: 2.211 ± 0.056	2.546ArgGly: 2.546 ± 0.052	1.169ArgHis: 1.169 ± 0.037	3.387ArgIle: 3.387 ± 0.063	2.415ArgLys: 2.415 ± 0.051	5.061ArgLeu: 5.061 ± 0.09	1.23ArgMet: 1.23 ± 0.031	1.967ArgAsn: 1.967 ± 0.05	1.768ArgPro: 1.768 ± 0.05	2.392ArgGln: 2.392 ± 0.058	2.463ArgArg: 2.463 ± 0.059	2.416ArgSer: 2.416 ± 0.056	2.053ArgThr: 2.053 ± 0.045	2.866ArgVal: 2.866 ± 0.064	0.659ArgTrp: 0.659 ± 0.028	1.958ArgTyr: 1.958 ± 0.045	0.002ArgXaa: 0.002 ± 0.001
Ser	5.077SerAla: 5.077 ± 0.074	0.65SerCys: 0.65 ± 0.025	3.24SerAsp: 3.24 ± 0.056	3.674SerGlu: 3.674 ± 0.06	2.723SerPhe: 2.723 ± 0.068	4.931SerGly: 4.931 ± 0.078	1.569SerHis: 1.569 ± 0.037	4.543SerIle: 4.543 ± 0.082	2.985SerLys: 2.985 ± 0.059	7.076SerLeu: 7.076 ± 0.098	1.616SerMet: 1.616 ± 0.04	2.571SerAsn: 2.571 ± 0.055	2.681SerPro: 2.681 ± 0.057	3.144SerGln: 3.144 ± 0.069	2.969SerArg: 2.969 ± 0.062	4.31SerSer: 4.31 ± 0.084	3.215SerThr: 3.215 ± 0.059	4.18SerVal: 4.18 ± 0.064	0.883SerTrp: 0.883 ± 0.033	2.04SerTyr: 2.04 ± 0.048	0.007SerXaa: 0.007 ± 0.003
Thr	4.23ThrAla: 4.23 ± 0.074	0.519ThrCys: 0.519 ± 0.023	2.748ThrAsp: 2.748 ± 0.059	3.013ThrGlu: 3.013 ± 0.059	2.146ThrPhe: 2.146 ± 0.055	4.005ThrGly: 4.005 ± 0.077	1.157ThrHis: 1.157 ± 0.034	3.695ThrIle: 3.695 ± 0.072	2.413ThrLys: 2.413 ± 0.058	6.305ThrLeu: 6.305 ± 0.087	1.063ThrMet: 1.063 ± 0.032	2.13ThrAsn: 2.13 ± 0.053	2.872ThrPro: 2.872 ± 0.059	2.388ThrGln: 2.388 ± 0.056	2.255ThrArg: 2.255 ± 0.056	3.227ThrSer: 3.227 ± 0.057	2.702ThrThr: 2.702 ± 0.055	3.52ThrVal: 3.52 ± 0.063	0.618ThrTrp: 0.618 ± 0.026	1.486ThrTyr: 1.486 ± 0.042	0.006ThrXaa: 0.006 ± 0.003
Val	5.379ValAla: 5.379 ± 0.084	0.727ValCys: 0.727 ± 0.027	3.564ValAsp: 3.564 ± 0.063	3.888ValGlu: 3.888 ± 0.075	2.479ValPhe: 2.479 ± 0.056	4.425ValGly: 4.425 ± 0.082	1.109ValHis: 1.109 ± 0.033	5.26ValIle: 5.26 ± 0.081	3.416ValLys: 3.416 ± 0.06	6.394ValLeu: 6.394 ± 0.085	1.95ValMet: 1.95 ± 0.046	2.991ValAsn: 2.991 ± 0.061	2.546ValPro: 2.546 ± 0.054	2.038ValGln: 2.038 ± 0.052	2.819ValArg: 2.819 ± 0.059	4.403ValSer: 4.403 ± 0.07	3.771ValThr: 3.771 ± 0.059	4.448ValVal: 4.448 ± 0.08	0.752ValTrp: 0.752 ± 0.028	1.807ValTyr: 1.807 ± 0.045	0.005ValXaa: 0.005 ± 0.002
Trp	0.792TrpAla: 0.792 ± 0.032	0.162TrpCys: 0.162 ± 0.013	0.631TrpAsp: 0.631 ± 0.026	0.62TrpGlu: 0.62 ± 0.027	0.598TrpPhe: 0.598 ± 0.028	0.771TrpGly: 0.771 ± 0.029	0.352TrpHis: 0.352 ± 0.021	0.762TrpIle: 0.762 ± 0.029	0.576TrpLys: 0.576 ± 0.024	1.879TrpLeu: 1.879 ± 0.053	0.337TrpMet: 0.337 ± 0.019	0.469TrpAsn: 0.469 ± 0.025	0.464TrpPro: 0.464 ± 0.022	0.959TrpGln: 0.959 ± 0.032	0.698TrpArg: 0.698 ± 0.031	0.756TrpSer: 0.756 ± 0.028	0.392TrpThr: 0.392 ± 0.021	0.83TrpVal: 0.83 ± 0.036	0.18TrpTrp: 0.18 ± 0.014	0.363TrpTyr: 0.363 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.33TyrAla: 2.33 ± 0.051	0.437TyrCys: 0.437 ± 0.021	1.748TyrAsp: 1.748 ± 0.052	1.546TyrGlu: 1.546 ± 0.046	1.516TyrPhe: 1.516 ± 0.042	2.206TyrGly: 2.206 ± 0.058	0.867TyrHis: 0.867 ± 0.032	2.056TyrIle: 2.056 ± 0.057	1.381TyrLys: 1.381 ± 0.039	3.536TyrLeu: 3.536 ± 0.063	0.689TyrMet: 0.689 ± 0.026	1.402TyrAsn: 1.402 ± 0.046	1.468TyrPro: 1.468 ± 0.042	2.057TyrGln: 2.057 ± 0.053	1.857TyrArg: 1.857 ± 0.043	2.126TyrSer: 2.126 ± 0.052	1.618TyrThr: 1.618 ± 0.053	1.7TyrVal: 1.7 ± 0.043	0.503TyrTrp: 0.503 ± 0.022	1.158TyrTyr: 1.158 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.007XaaAla: 0.007 ± 0.003	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.009XaaGlu: 0.009 ± 0.003	0.003XaaPhe: 0.003 ± 0.002	0.009XaaGly: 0.009 ± 0.003	0.002XaaHis: 0.002 ± 0.001	0.004XaaIle: 0.004 ± 0.002	0.009XaaLys: 0.009 ± 0.003	0.009XaaLeu: 0.009 ± 0.004	0.002XaaMet: 0.002 ± 0.002	0.003XaaAsn: 0.003 ± 0.002	0.003XaaPro: 0.003 ± 0.002	0.003XaaGln: 0.003 ± 0.002	0.004XaaArg: 0.004 ± 0.002	0.003XaaSer: 0.003 ± 0.002	0.003XaaThr: 0.003 ± 0.002	0.004XaaVal: 0.004 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.008XaaXaa: 0.008 ± 0.004

Statistics based on 3113 proteins (951914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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