Amino acid dipepetide frequency for Testudinid alphaherpesvirus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.292AlaAla: 4.292 ± 0.371
1.675AlaCys: 1.675 ± 0.235
3.278AlaAsp: 3.278 ± 0.22
3.16AlaGlu: 3.16 ± 0.35
2.665AlaPhe: 2.665 ± 0.235
2.264AlaGly: 2.264 ± 0.247
1.84AlaHis: 1.84 ± 0.19
4.151AlaIle: 4.151 ± 0.456
2.995AlaLys: 2.995 ± 0.268
6.085AlaLeu: 6.085 ± 0.432
1.958AlaMet: 1.958 ± 0.183
2.453AlaAsn: 2.453 ± 0.255
2.925AlaPro: 2.925 ± 0.453
1.863AlaGln: 1.863 ± 0.246
3.396AlaArg: 3.396 ± 0.244
3.656AlaSer: 3.656 ± 0.3
3.868AlaThr: 3.868 ± 0.311
4.245AlaVal: 4.245 ± 0.301
0.755AlaTrp: 0.755 ± 0.125
2.689AlaTyr: 2.689 ± 0.227
0.0AlaXaa: 0.0 ± 0.0
Cys
1.25CysAla: 1.25 ± 0.159
0.66CysCys: 0.66 ± 0.133
1.368CysAsp: 1.368 ± 0.184
1.108CysGlu: 1.108 ± 0.146
0.967CysPhe: 0.967 ± 0.14
1.486CysGly: 1.486 ± 0.257
0.684CysHis: 0.684 ± 0.11
1.557CysIle: 1.557 ± 0.216
0.967CysLys: 0.967 ± 0.164
2.618CysLeu: 2.618 ± 0.233
0.283CysMet: 0.283 ± 0.066
0.849CysAsn: 0.849 ± 0.164
1.061CysPro: 1.061 ± 0.175
0.66CysGln: 0.66 ± 0.134
1.675CysArg: 1.675 ± 0.22
1.557CysSer: 1.557 ± 0.184
1.179CysThr: 1.179 ± 0.161
2.217CysVal: 2.217 ± 0.262
0.165CysTrp: 0.165 ± 0.053
0.92CysTyr: 0.92 ± 0.151
0.0CysXaa: 0.0 ± 0.0
Asp
2.995AspAla: 2.995 ± 0.303
1.132AspCys: 1.132 ± 0.184
3.231AspAsp: 3.231 ± 0.277
3.514AspGlu: 3.514 ± 0.308
2.453AspPhe: 2.453 ± 0.231
2.877AspGly: 2.877 ± 0.249
1.344AspHis: 1.344 ± 0.172
3.396AspIle: 3.396 ± 0.313
2.311AspLys: 2.311 ± 0.235
4.717AspLeu: 4.717 ± 0.29
1.462AspMet: 1.462 ± 0.259
2.406AspAsn: 2.406 ± 0.281
3.278AspPro: 3.278 ± 0.503
1.486AspGln: 1.486 ± 0.164
4.104AspArg: 4.104 ± 0.475
4.127AspSer: 4.127 ± 0.309
3.208AspThr: 3.208 ± 0.272
3.42AspVal: 3.42 ± 0.244
0.731AspTrp: 0.731 ± 0.137
2.406AspTyr: 2.406 ± 0.263
0.0AspXaa: 0.0 ± 0.0
Glu
4.08GluAla: 4.08 ± 0.4
1.274GluCys: 1.274 ± 0.175
2.948GluAsp: 2.948 ± 0.268
3.679GluGlu: 3.679 ± 0.379
2.547GluPhe: 2.547 ± 0.227
2.358GluGly: 2.358 ± 0.223
1.509GluHis: 1.509 ± 0.18
3.208GluIle: 3.208 ± 0.263
2.146GluLys: 2.146 ± 0.235
5.896GluLeu: 5.896 ± 0.351
1.651GluMet: 1.651 ± 0.207
2.783GluAsn: 2.783 ± 0.278
2.877GluPro: 2.877 ± 0.279
1.863GluGln: 1.863 ± 0.203
3.325GluArg: 3.325 ± 0.321
4.009GluSer: 4.009 ± 0.36
4.434GluThr: 4.434 ± 0.282
2.642GluVal: 2.642 ± 0.258
0.637GluTrp: 0.637 ± 0.119
2.17GluTyr: 2.17 ± 0.195
0.0GluXaa: 0.0 ± 0.0
Phe
2.075PheAla: 2.075 ± 0.26
0.873PheCys: 0.873 ± 0.159
2.476PheAsp: 2.476 ± 0.236
2.5PheGlu: 2.5 ± 0.177
1.958PhePhe: 1.958 ± 0.219
2.193PheGly: 2.193 ± 0.227
1.061PheHis: 1.061 ± 0.163
3.396PheIle: 3.396 ± 0.315
2.311PheLys: 2.311 ± 0.241
3.797PheLeu: 3.797 ± 0.312
1.203PheMet: 1.203 ± 0.162
2.382PheAsn: 2.382 ± 0.214
2.288PhePro: 2.288 ± 0.183
1.415PheGln: 1.415 ± 0.27
1.84PheArg: 1.84 ± 0.192
3.443PheSer: 3.443 ± 0.287
2.712PheThr: 2.712 ± 0.276
2.547PheVal: 2.547 ± 0.238
0.566PheTrp: 0.566 ± 0.141
2.241PheTyr: 2.241 ± 0.264
0.0PheXaa: 0.0 ± 0.0
Gly
2.689GlyAla: 2.689 ± 0.233
1.108GlyCys: 1.108 ± 0.186
2.5GlyAsp: 2.5 ± 0.262
2.689GlyGlu: 2.689 ± 0.248
2.665GlyPhe: 2.665 ± 0.22
3.113GlyGly: 3.113 ± 0.499
1.439GlyHis: 1.439 ± 0.172
2.429GlyIle: 2.429 ± 0.234
2.689GlyLys: 2.689 ± 0.248
5.967GlyLeu: 5.967 ± 0.316
1.156GlyMet: 1.156 ± 0.162
2.288GlyAsn: 2.288 ± 0.212
3.16GlyPro: 3.16 ± 0.553
1.934GlyGln: 1.934 ± 0.221
3.42GlyArg: 3.42 ± 0.3
3.892GlySer: 3.892 ± 0.459
3.137GlyThr: 3.137 ± 0.319
3.656GlyVal: 3.656 ± 0.277
0.66GlyTrp: 0.66 ± 0.12
1.84GlyTyr: 1.84 ± 0.193
0.0GlyXaa: 0.0 ± 0.0
His
1.226HisAla: 1.226 ± 0.173
0.566HisCys: 0.566 ± 0.128
1.061HisAsp: 1.061 ± 0.161
1.179HisGlu: 1.179 ± 0.164
0.943HisPhe: 0.943 ± 0.158
1.415HisGly: 1.415 ± 0.202
0.991HisHis: 0.991 ± 0.137
1.698HisIle: 1.698 ± 0.225
1.132HisLys: 1.132 ± 0.171
2.689HisLeu: 2.689 ± 0.302
0.637HisMet: 0.637 ± 0.113
1.179HisAsn: 1.179 ± 0.159
1.792HisPro: 1.792 ± 0.211
0.849HisGln: 0.849 ± 0.138
2.052HisArg: 2.052 ± 0.23
1.604HisSer: 1.604 ± 0.176
1.981HisThr: 1.981 ± 0.206
1.392HisVal: 1.392 ± 0.181
0.354HisTrp: 0.354 ± 0.087
0.613HisTyr: 0.613 ± 0.109
0.0HisXaa: 0.0 ± 0.0
Ile
3.325IleAla: 3.325 ± 0.326
1.297IleCys: 1.297 ± 0.195
3.137IleAsp: 3.137 ± 0.336
3.231IleGlu: 3.231 ± 0.287
1.958IlePhe: 1.958 ± 0.261
3.184IleGly: 3.184 ± 0.282
1.533IleHis: 1.533 ± 0.173
3.986IleIle: 3.986 ± 0.38
3.656IleLys: 3.656 ± 0.347
5.212IleLeu: 5.212 ± 0.332
1.415IleMet: 1.415 ± 0.186
3.585IleAsn: 3.585 ± 0.346
3.892IlePro: 3.892 ± 0.343
2.123IleGln: 2.123 ± 0.259
3.821IleArg: 3.821 ± 0.33
5.165IleSer: 5.165 ± 0.38
4.811IleThr: 4.811 ± 0.374
3.066IleVal: 3.066 ± 0.273
0.448IleTrp: 0.448 ± 0.13
2.571IleTyr: 2.571 ± 0.297
0.0IleXaa: 0.0 ± 0.0
Lys
2.689LysAla: 2.689 ± 0.284
1.038LysCys: 1.038 ± 0.163
2.241LysAsp: 2.241 ± 0.274
2.241LysGlu: 2.241 ± 0.267
1.863LysPhe: 1.863 ± 0.176
1.604LysGly: 1.604 ± 0.176
1.344LysHis: 1.344 ± 0.205
2.877LysIle: 2.877 ± 0.285
2.382LysLys: 2.382 ± 0.315
4.458LysLeu: 4.458 ± 0.403
1.226LysMet: 1.226 ± 0.161
2.5LysAsn: 2.5 ± 0.285
1.934LysPro: 1.934 ± 0.204
2.123LysGln: 2.123 ± 0.219
3.208LysArg: 3.208 ± 0.256
3.538LysSer: 3.538 ± 0.281
3.821LysThr: 3.821 ± 0.288
2.099LysVal: 2.099 ± 0.242
0.613LysTrp: 0.613 ± 0.11
2.476LysTyr: 2.476 ± 0.219
0.0LysXaa: 0.0 ± 0.0
Leu
6.014LeuAla: 6.014 ± 0.337
1.816LeuCys: 1.816 ± 0.203
5.613LeuAsp: 5.613 ± 0.531
5.991LeuGlu: 5.991 ± 0.352
4.127LeuPhe: 4.127 ± 0.306
5.212LeuGly: 5.212 ± 0.356
1.816LeuHis: 1.816 ± 0.189
5.283LeuIle: 5.283 ± 0.363
4.835LeuLys: 4.835 ± 0.365
10.094LeuLeu: 10.094 ± 0.634
2.476LeuMet: 2.476 ± 0.184
4.434LeuAsn: 4.434 ± 0.311
4.528LeuPro: 4.528 ± 0.28
3.066LeuGln: 3.066 ± 0.314
4.858LeuArg: 4.858 ± 0.283
7.406LeuSer: 7.406 ± 0.372
6.863LeuThr: 6.863 ± 0.439
6.651LeuVal: 6.651 ± 0.442
1.038LeuTrp: 1.038 ± 0.145
4.858LeuTyr: 4.858 ± 0.298
0.0LeuXaa: 0.0 ± 0.0
Met
2.5MetAla: 2.5 ± 0.232
0.778MetCys: 0.778 ± 0.148
1.344MetAsp: 1.344 ± 0.179
1.745MetGlu: 1.745 ± 0.181
1.25MetPhe: 1.25 ± 0.208
1.203MetGly: 1.203 ± 0.177
0.33MetHis: 0.33 ± 0.079
1.651MetIle: 1.651 ± 0.202
0.896MetLys: 0.896 ± 0.17
2.547MetLeu: 2.547 ± 0.255
0.943MetMet: 0.943 ± 0.141
0.967MetAsn: 0.967 ± 0.132
1.061MetPro: 1.061 ± 0.173
0.66MetGln: 0.66 ± 0.112
1.108MetArg: 1.108 ± 0.145
2.028MetSer: 2.028 ± 0.207
1.486MetThr: 1.486 ± 0.184
1.934MetVal: 1.934 ± 0.257
0.189MetTrp: 0.189 ± 0.068
1.085MetTyr: 1.085 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
2.453AsnAla: 2.453 ± 0.254
1.203AsnCys: 1.203 ± 0.167
2.358AsnAsp: 2.358 ± 0.207
2.547AsnGlu: 2.547 ± 0.272
2.382AsnPhe: 2.382 ± 0.303
2.429AsnGly: 2.429 ± 0.285
1.038AsnHis: 1.038 ± 0.199
3.491AsnIle: 3.491 ± 0.348
2.358AsnLys: 2.358 ± 0.264
3.585AsnLeu: 3.585 ± 0.272
1.179AsnMet: 1.179 ± 0.15
2.712AsnAsn: 2.712 ± 0.24
2.335AsnPro: 2.335 ± 0.245
1.816AsnGln: 1.816 ± 0.221
3.208AsnArg: 3.208 ± 0.231
3.208AsnSer: 3.208 ± 0.418
3.373AsnThr: 3.373 ± 0.244
3.255AsnVal: 3.255 ± 0.332
0.448AsnTrp: 0.448 ± 0.12
2.571AsnTyr: 2.571 ± 0.27
0.0AsnXaa: 0.0 ± 0.0
Pro
2.83ProAla: 2.83 ± 0.299
1.462ProCys: 1.462 ± 0.192
3.042ProAsp: 3.042 ± 0.496
3.208ProGlu: 3.208 ± 0.316
1.91ProPhe: 1.91 ± 0.202
3.231ProGly: 3.231 ± 0.59
1.274ProHis: 1.274 ± 0.196
3.184ProIle: 3.184 ± 0.364
2.17ProLys: 2.17 ± 0.222
4.458ProLeu: 4.458 ± 0.49
1.321ProMet: 1.321 ± 0.154
2.193ProAsn: 2.193 ± 0.203
4.104ProPro: 4.104 ± 0.545
1.958ProGln: 1.958 ± 0.233
2.665ProArg: 2.665 ± 0.301
4.599ProSer: 4.599 ± 0.456
3.679ProThr: 3.679 ± 0.268
3.915ProVal: 3.915 ± 0.307
0.613ProTrp: 0.613 ± 0.148
1.722ProTyr: 1.722 ± 0.153
0.0ProXaa: 0.0 ± 0.0
Gln
1.745GlnAla: 1.745 ± 0.223
0.708GlnCys: 0.708 ± 0.114
1.462GlnAsp: 1.462 ± 0.18
1.816GlnGlu: 1.816 ± 0.158
1.557GlnPhe: 1.557 ± 0.229
1.792GlnGly: 1.792 ± 0.297
0.825GlnHis: 0.825 ± 0.123
1.462GlnIle: 1.462 ± 0.187
1.557GlnLys: 1.557 ± 0.188
4.175GlnLeu: 4.175 ± 0.322
0.708GlnMet: 0.708 ± 0.153
1.58GlnAsn: 1.58 ± 0.188
1.887GlnPro: 1.887 ± 0.272
1.533GlnGln: 1.533 ± 0.246
1.863GlnArg: 1.863 ± 0.233
2.429GlnSer: 2.429 ± 0.226
2.052GlnThr: 2.052 ± 0.232
1.651GlnVal: 1.651 ± 0.262
0.354GlnTrp: 0.354 ± 0.088
1.509GlnTyr: 1.509 ± 0.193
0.0GlnXaa: 0.0 ± 0.0
Arg
4.127ArgAla: 4.127 ± 0.445
1.321ArgCys: 1.321 ± 0.172
2.854ArgAsp: 2.854 ± 0.206
3.255ArgGlu: 3.255 ± 0.256
2.358ArgPhe: 2.358 ± 0.269
3.396ArgGly: 3.396 ± 0.286
1.792ArgHis: 1.792 ± 0.212
3.208ArgIle: 3.208 ± 0.285
2.712ArgLys: 2.712 ± 0.289
6.344ArgLeu: 6.344 ± 0.344
1.368ArgMet: 1.368 ± 0.196
2.5ArgAsn: 2.5 ± 0.225
2.925ArgPro: 2.925 ± 0.325
1.58ArgGln: 1.58 ± 0.155
4.057ArgArg: 4.057 ± 0.375
4.599ArgSer: 4.599 ± 0.391
3.113ArgThr: 3.113 ± 0.267
3.868ArgVal: 3.868 ± 0.353
0.731ArgTrp: 0.731 ± 0.137
2.759ArgTyr: 2.759 ± 0.271
0.0ArgXaa: 0.0 ± 0.0
Ser
4.245SerAla: 4.245 ± 0.367
1.58SerCys: 1.58 ± 0.209
4.646SerAsp: 4.646 ± 0.39
4.929SerGlu: 4.929 ± 0.339
3.349SerPhe: 3.349 ± 0.304
4.646SerGly: 4.646 ± 0.384
1.934SerHis: 1.934 ± 0.222
4.363SerIle: 4.363 ± 0.375
2.83SerLys: 2.83 ± 0.274
6.604SerLeu: 6.604 ± 0.372
1.722SerMet: 1.722 ± 0.148
3.538SerAsn: 3.538 ± 0.447
4.623SerPro: 4.623 ± 0.515
2.288SerGln: 2.288 ± 0.243
3.774SerArg: 3.774 ± 0.305
5.943SerSer: 5.943 ± 0.407
4.929SerThr: 4.929 ± 0.322
5.495SerVal: 5.495 ± 0.325
0.755SerTrp: 0.755 ± 0.123
2.712SerTyr: 2.712 ± 0.249
0.0SerXaa: 0.0 ± 0.0
Thr
4.151ThrAla: 4.151 ± 0.311
1.722ThrCys: 1.722 ± 0.181
4.245ThrAsp: 4.245 ± 0.342
4.151ThrGlu: 4.151 ± 0.346
2.524ThrPhe: 2.524 ± 0.254
3.514ThrGly: 3.514 ± 0.249
1.627ThrHis: 1.627 ± 0.159
4.387ThrIle: 4.387 ± 0.43
3.42ThrLys: 3.42 ± 0.304
6.297ThrLeu: 6.297 ± 0.391
1.769ThrMet: 1.769 ± 0.181
3.349ThrAsn: 3.349 ± 0.26
3.467ThrPro: 3.467 ± 0.434
2.028ThrGln: 2.028 ± 0.225
3.726ThrArg: 3.726 ± 0.379
4.34ThrSer: 4.34 ± 0.338
4.693ThrThr: 4.693 ± 0.378
4.528ThrVal: 4.528 ± 0.387
0.967ThrTrp: 0.967 ± 0.162
2.712ThrTyr: 2.712 ± 0.212
0.0ThrXaa: 0.0 ± 0.0
Val
4.481ValAla: 4.481 ± 0.339
1.557ValCys: 1.557 ± 0.179
3.42ValAsp: 3.42 ± 0.267
2.618ValGlu: 2.618 ± 0.258
2.948ValPhe: 2.948 ± 0.279
3.208ValGly: 3.208 ± 0.267
1.439ValHis: 1.439 ± 0.183
4.623ValIle: 4.623 ± 0.405
2.901ValLys: 2.901 ± 0.212
5.943ValLeu: 5.943 ± 0.421
1.792ValMet: 1.792 ± 0.162
2.901ValAsn: 2.901 ± 0.249
3.019ValPro: 3.019 ± 0.261
1.745ValGln: 1.745 ± 0.245
3.797ValArg: 3.797 ± 0.302
5.33ValSer: 5.33 ± 0.368
4.623ValThr: 4.623 ± 0.418
4.245ValVal: 4.245 ± 0.31
0.448ValTrp: 0.448 ± 0.116
3.113ValTyr: 3.113 ± 0.297
0.0ValXaa: 0.0 ± 0.0
Trp
0.802TrpAla: 0.802 ± 0.15
0.377TrpCys: 0.377 ± 0.095
0.472TrpAsp: 0.472 ± 0.086
0.613TrpGlu: 0.613 ± 0.111
0.613TrpPhe: 0.613 ± 0.14
0.637TrpGly: 0.637 ± 0.119
0.259TrpHis: 0.259 ± 0.098
0.566TrpIle: 0.566 ± 0.121
0.472TrpLys: 0.472 ± 0.085
1.368TrpLeu: 1.368 ± 0.178
0.189TrpMet: 0.189 ± 0.085
0.731TrpAsn: 0.731 ± 0.168
0.354TrpPro: 0.354 ± 0.118
0.472TrpGln: 0.472 ± 0.111
0.519TrpArg: 0.519 ± 0.125
0.92TrpSer: 0.92 ± 0.174
0.708TrpThr: 0.708 ± 0.126
0.542TrpVal: 0.542 ± 0.114
0.377TrpTrp: 0.377 ± 0.108
0.495TrpTyr: 0.495 ± 0.092
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.241TyrAla: 2.241 ± 0.269
1.085TyrCys: 1.085 ± 0.141
2.901TyrAsp: 2.901 ± 0.229
1.863TyrGlu: 1.863 ± 0.2
2.241TyrPhe: 2.241 ± 0.235
2.665TyrGly: 2.665 ± 0.205
1.274TyrHis: 1.274 ± 0.166
2.5TyrIle: 2.5 ± 0.229
1.533TyrLys: 1.533 ± 0.198
4.127TyrLeu: 4.127 ± 0.306
1.226TyrMet: 1.226 ± 0.204
2.618TyrAsn: 2.618 ± 0.277
2.028TyrPro: 2.028 ± 0.208
1.203TyrGln: 1.203 ± 0.137
2.453TyrArg: 2.453 ± 0.235
3.137TyrSer: 3.137 ± 0.302
2.948TyrThr: 2.948 ± 0.295
2.783TyrVal: 2.783 ± 0.251
0.637TyrTrp: 0.637 ± 0.149
1.84TyrTyr: 1.84 ± 0.209
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 100 proteins (42401 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski