Amino acid dipepetide frequency for Shrew hepatitis B virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.537AlaAla: 4.537 ± 0.894
0.0AlaCys: 0.0 ± 0.0
3.24AlaAsp: 3.24 ± 1.424
2.592AlaGlu: 2.592 ± 0.97
3.889AlaPhe: 3.889 ± 1.764
1.296AlaGly: 1.296 ± 1.113
1.296AlaHis: 1.296 ± 1.273
3.24AlaIle: 3.24 ± 0.725
1.944AlaLys: 1.944 ± 0.697
5.833AlaLeu: 5.833 ± 2.688
1.944AlaMet: 1.944 ± 0.697
1.296AlaAsn: 1.296 ± 1.895
3.889AlaPro: 3.889 ± 2.461
2.592AlaGln: 2.592 ± 1.674
1.296AlaArg: 1.296 ± 1.273
7.777AlaSer: 7.777 ± 2.867
4.537AlaThr: 4.537 ± 1.721
2.592AlaVal: 2.592 ± 0.97
0.0AlaTrp: 0.0 ± 0.0
1.296AlaTyr: 1.296 ± 0.837
0.0AlaXaa: 0.0 ± 0.0
Cys
1.944CysAla: 1.944 ± 1.652
1.296CysCys: 1.296 ± 1.328
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.296CysPhe: 1.296 ± 0.826
1.296CysGly: 1.296 ± 0.826
1.296CysHis: 1.296 ± 0.837
0.648CysIle: 0.648 ± 0.413
0.648CysLys: 0.648 ± 0.664
3.889CysLeu: 3.889 ± 2.414
0.0CysMet: 0.0 ± 0.0
0.648CysAsn: 0.648 ± 0.413
3.24CysPro: 3.24 ± 1.654
0.0CysGln: 0.0 ± 0.0
3.889CysArg: 3.889 ± 3.764
3.24CysSer: 3.24 ± 1.377
1.944CysThr: 1.944 ± 1.741
1.296CysVal: 1.296 ± 0.541
0.648CysTrp: 0.648 ± 0.664
1.296CysTyr: 1.296 ± 1.273
0.0CysXaa: 0.0 ± 0.0
Asp
2.592AspAla: 2.592 ± 1.674
0.648AspCys: 0.648 ± 0.413
1.296AspAsp: 1.296 ± 0.837
0.648AspGlu: 0.648 ± 0.413
2.592AspPhe: 2.592 ± 0.649
0.0AspGly: 0.0 ± 0.0
0.648AspHis: 0.648 ± 0.664
0.648AspIle: 0.648 ± 0.98
1.296AspLys: 1.296 ± 0.837
5.185AspLeu: 5.185 ± 1.156
0.0AspMet: 0.0 ± 0.0
3.24AspAsn: 3.24 ± 1.671
0.648AspPro: 0.648 ± 1.433
1.296AspGln: 1.296 ± 0.826
1.296AspArg: 1.296 ± 0.826
2.592AspSer: 2.592 ± 1.515
1.296AspThr: 1.296 ± 1.328
1.296AspVal: 1.296 ± 0.826
1.944AspTrp: 1.944 ± 1.139
1.944AspTyr: 1.944 ± 0.697
0.0AspXaa: 0.0 ± 0.0
Glu
1.296GluAla: 1.296 ± 0.541
1.296GluCys: 1.296 ± 0.541
2.592GluAsp: 2.592 ± 1.01
1.296GluGlu: 1.296 ± 0.826
1.296GluPhe: 1.296 ± 0.837
0.648GluGly: 0.648 ± 0.664
1.296GluHis: 1.296 ± 0.826
2.592GluIle: 2.592 ± 2.107
1.296GluLys: 1.296 ± 0.541
3.889GluLeu: 3.889 ± 0.92
0.0GluMet: 0.0 ± 0.0
1.296GluAsn: 1.296 ± 0.541
2.592GluPro: 2.592 ± 0.97
3.24GluGln: 3.24 ± 1.424
0.648GluArg: 0.648 ± 0.413
1.296GluSer: 1.296 ± 0.826
3.24GluThr: 3.24 ± 1.403
1.944GluVal: 1.944 ± 0.812
0.0GluTrp: 0.0 ± 0.0
0.648GluTyr: 0.648 ± 0.98
0.0GluXaa: 0.0 ± 0.0
Phe
3.889PheAla: 3.889 ± 1.07
1.296PheCys: 1.296 ± 0.826
1.296PheAsp: 1.296 ± 1.273
0.0PheGlu: 0.0 ± 0.0
1.296PhePhe: 1.296 ± 0.837
4.537PheGly: 4.537 ± 3.971
0.648PheHis: 0.648 ± 0.98
2.592PheIle: 2.592 ± 1.401
1.944PheLys: 1.944 ± 1.239
5.833PheLeu: 5.833 ± 2.283
1.296PheMet: 1.296 ± 0.826
1.296PheAsn: 1.296 ± 1.328
3.24PhePro: 3.24 ± 0.972
3.889PheGln: 3.889 ± 1.764
1.296PheArg: 1.296 ± 0.826
5.833PheSer: 5.833 ± 2.968
3.889PheThr: 3.889 ± 1.818
1.296PheVal: 1.296 ± 0.826
1.296PheTrp: 1.296 ± 1.273
0.648PheTyr: 0.648 ± 0.413
0.0PheXaa: 0.0 ± 0.0
Gly
6.481GlyAla: 6.481 ± 1.759
1.944GlyCys: 1.944 ± 1.237
2.592GlyAsp: 2.592 ± 1.01
5.833GlyGlu: 5.833 ± 0.815
3.24GlyPhe: 3.24 ± 2.065
5.833GlyGly: 5.833 ± 0.815
0.648GlyHis: 0.648 ± 0.413
3.24GlyIle: 3.24 ± 1.377
3.24GlyLys: 3.24 ± 1.51
5.833GlyLeu: 5.833 ± 2.379
0.648GlyMet: 0.648 ± 1.207
3.24GlyAsn: 3.24 ± 1.859
3.889GlyPro: 3.889 ± 0.92
4.537GlyGln: 4.537 ± 1.97
2.592GlyArg: 2.592 ± 1.515
4.537GlySer: 4.537 ± 1.326
2.592GlyThr: 2.592 ± 1.225
4.537GlyVal: 4.537 ± 1.402
1.296GlyTrp: 1.296 ± 0.826
1.944GlyTyr: 1.944 ± 1.139
0.0GlyXaa: 0.0 ± 0.0
His
0.648HisAla: 0.648 ± 0.413
0.0HisCys: 0.0 ± 0.0
0.648HisAsp: 0.648 ± 0.413
0.648HisGlu: 0.648 ± 0.413
2.592HisPhe: 2.592 ± 1.01
1.296HisGly: 1.296 ± 0.826
6.481HisHis: 6.481 ± 2.413
2.592HisIle: 2.592 ± 0.649
3.24HisLys: 3.24 ± 1.54
9.073HisLeu: 9.073 ± 3.282
0.0HisMet: 0.0 ± 0.0
1.296HisAsn: 1.296 ± 1.273
1.944HisPro: 1.944 ± 1.239
1.944HisGln: 1.944 ± 1.239
1.944HisArg: 1.944 ± 1.239
2.592HisSer: 2.592 ± 0.649
2.592HisThr: 2.592 ± 1.674
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.296HisTyr: 1.296 ± 0.826
0.0HisXaa: 0.0 ± 0.0
Ile
0.648IleAla: 0.648 ± 0.413
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
0.648IleGlu: 0.648 ± 0.413
1.944IlePhe: 1.944 ± 0.697
1.944IleGly: 1.944 ± 0.697
1.296IleHis: 1.296 ± 0.826
1.944IleIle: 1.944 ± 0.697
2.592IleLys: 2.592 ± 1.01
5.185IleLeu: 5.185 ± 1.273
0.648IleMet: 0.648 ± 0.413
2.592IleAsn: 2.592 ± 0.649
2.592IlePro: 2.592 ± 1.082
1.944IleGln: 1.944 ± 0.697
1.296IleArg: 1.296 ± 1.96
1.944IleSer: 1.944 ± 1.162
0.648IleThr: 0.648 ± 0.664
0.0IleVal: 0.0 ± 0.0
2.592IleTrp: 2.592 ± 2.107
2.592IleTyr: 2.592 ± 1.097
0.0IleXaa: 0.0 ± 0.0
Lys
2.592LysAla: 2.592 ± 1.097
0.648LysCys: 0.648 ± 1.433
0.0LysAsp: 0.0 ± 0.0
1.944LysGlu: 1.944 ± 0.812
1.944LysPhe: 1.944 ± 0.697
0.648LysGly: 0.648 ± 0.413
0.648LysHis: 0.648 ± 0.413
2.592LysIle: 2.592 ± 1.652
1.944LysLys: 1.944 ± 1.239
5.185LysLeu: 5.185 ± 1.524
1.296LysMet: 1.296 ± 1.44
1.944LysAsn: 1.944 ± 1.162
2.592LysPro: 2.592 ± 1.784
1.296LysGln: 1.296 ± 0.826
3.24LysArg: 3.24 ± 0.972
4.537LysSer: 4.537 ± 1.685
3.24LysThr: 3.24 ± 1.377
1.296LysVal: 1.296 ± 0.541
0.648LysTrp: 0.648 ± 0.413
0.648LysTyr: 0.648 ± 0.413
0.0LysXaa: 0.0 ± 0.0
Leu
5.185LeuAla: 5.185 ± 2.02
4.537LeuCys: 4.537 ± 2.182
5.185LeuAsp: 5.185 ± 2.119
3.889LeuGlu: 3.889 ± 2.277
4.537LeuPhe: 4.537 ± 1.612
12.962LeuGly: 12.962 ± 2.674
5.833LeuHis: 5.833 ± 2.485
1.944LeuIle: 1.944 ± 1.239
5.185LeuLys: 5.185 ± 1.156
17.498LeuLeu: 17.498 ± 4.307
3.24LeuMet: 3.24 ± 1.207
2.592LeuAsn: 2.592 ± 1.097
10.369LeuPro: 10.369 ± 1.312
5.185LeuGln: 5.185 ± 0.539
6.481LeuArg: 6.481 ± 3.417
8.425LeuSer: 8.425 ± 2.023
6.481LeuThr: 6.481 ± 2.596
8.425LeuVal: 8.425 ± 2.298
3.889LeuTrp: 3.889 ± 1.552
3.889LeuTyr: 3.889 ± 2.479
0.0LeuXaa: 0.0 ± 0.0
Met
0.648MetAla: 0.648 ± 1.433
1.944MetCys: 1.944 ± 1.865
1.944MetAsp: 1.944 ± 0.812
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
2.592MetGly: 2.592 ± 1.01
0.648MetHis: 0.648 ± 0.413
0.648MetIle: 0.648 ± 0.664
0.0MetLys: 0.0 ± 0.0
1.944MetLeu: 1.944 ± 1.162
0.0MetMet: 0.0 ± 0.0
0.648MetAsn: 0.648 ± 1.433
1.944MetPro: 1.944 ± 1.239
1.296MetGln: 1.296 ± 0.826
0.0MetArg: 0.0 ± 0.0
0.648MetSer: 0.648 ± 0.664
0.648MetThr: 0.648 ± 0.664
0.648MetVal: 0.648 ± 0.413
0.0MetTrp: 0.0 ± 0.0
0.648MetTyr: 0.648 ± 0.413
0.0MetXaa: 0.0 ± 0.0
Asn
1.944AsnAla: 1.944 ± 1.865
1.944AsnCys: 1.944 ± 0.697
0.648AsnAsp: 0.648 ± 0.413
0.648AsnGlu: 0.648 ± 0.413
1.296AsnPhe: 1.296 ± 0.826
0.0AsnGly: 0.0 ± 0.0
0.648AsnHis: 0.648 ± 0.413
0.0AsnIle: 0.0 ± 0.0
0.648AsnLys: 0.648 ± 0.98
5.833AsnLeu: 5.833 ± 0.394
0.648AsnMet: 0.648 ± 0.413
1.296AsnAsn: 1.296 ± 1.273
4.537AsnPro: 4.537 ± 1.694
1.944AsnGln: 1.944 ± 0.884
1.296AsnArg: 1.296 ± 0.541
2.592AsnSer: 2.592 ± 1.401
1.944AsnThr: 1.944 ± 1.652
0.0AsnVal: 0.0 ± 0.0
1.296AsnTrp: 1.296 ± 1.273
1.944AsnTyr: 1.944 ± 0.697
0.0AsnXaa: 0.0 ± 0.0
Pro
4.537ProAla: 4.537 ± 2.872
1.944ProCys: 1.944 ± 1.237
1.944ProAsp: 1.944 ± 0.812
1.944ProGlu: 1.944 ± 0.884
4.537ProPhe: 4.537 ± 2.54
5.185ProGly: 5.185 ± 1.273
1.944ProHis: 1.944 ± 0.884
3.24ProIle: 3.24 ± 0.972
0.648ProLys: 0.648 ± 0.413
9.073ProLeu: 9.073 ± 3.786
1.944ProMet: 1.944 ± 1.243
1.944ProAsn: 1.944 ± 0.697
7.777ProPro: 7.777 ± 5.352
3.24ProGln: 3.24 ± 1.377
6.481ProArg: 6.481 ± 3.311
9.073ProSer: 9.073 ± 1.343
4.537ProThr: 4.537 ± 3.687
7.777ProVal: 7.777 ± 3.835
2.592ProTrp: 2.592 ± 1.01
1.296ProTyr: 1.296 ± 1.113
0.0ProXaa: 0.0 ± 0.0
Gln
3.889GlnAla: 3.889 ± 1.753
0.648GlnCys: 0.648 ± 0.664
1.944GlnAsp: 1.944 ± 0.697
2.592GlnGlu: 2.592 ± 0.649
1.944GlnPhe: 1.944 ± 1.239
3.889GlnGly: 3.889 ± 1.532
0.648GlnHis: 0.648 ± 0.413
1.296GlnIle: 1.296 ± 0.826
3.889GlnLys: 3.889 ± 1.07
4.537GlnLeu: 4.537 ± 1.95
0.0GlnMet: 0.0 ± 0.0
1.296GlnAsn: 1.296 ± 0.541
2.592GlnPro: 2.592 ± 1.082
1.944GlnGln: 1.944 ± 1.652
1.944GlnArg: 1.944 ± 1.239
6.481GlnSer: 6.481 ± 1.811
3.24GlnThr: 3.24 ± 2.346
1.944GlnVal: 1.944 ± 0.812
1.944GlnTrp: 1.944 ± 0.812
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
1.296ArgAla: 1.296 ± 0.826
0.0ArgCys: 0.0 ± 0.0
1.296ArgAsp: 1.296 ± 0.837
1.944ArgGlu: 1.944 ± 0.697
3.889ArgPhe: 3.889 ± 0.92
7.777ArgGly: 7.777 ± 4.306
4.537ArgHis: 4.537 ± 0.894
0.648ArgIle: 0.648 ± 0.664
1.296ArgLys: 1.296 ± 0.837
7.129ArgLeu: 7.129 ± 1.997
1.296ArgMet: 1.296 ± 1.273
1.296ArgAsn: 1.296 ± 0.826
4.537ArgPro: 4.537 ± 2.517
1.296ArgGln: 1.296 ± 1.273
8.425ArgArg: 8.425 ± 3.68
3.889ArgSer: 3.889 ± 3.304
3.24ArgThr: 3.24 ± 1.671
3.889ArgVal: 3.889 ± 1.764
0.0ArgTrp: 0.0 ± 0.0
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
5.185SerAla: 5.185 ± 1.156
4.537SerCys: 4.537 ± 2.517
1.296SerAsp: 1.296 ± 0.826
1.944SerGlu: 1.944 ± 1.239
4.537SerPhe: 4.537 ± 1.721
7.777SerGly: 7.777 ± 2.787
5.185SerHis: 5.185 ± 2.563
2.592SerIle: 2.592 ± 1.01
2.592SerLys: 2.592 ± 1.784
9.073SerLeu: 9.073 ± 2.794
0.648SerMet: 0.648 ± 0.664
1.296SerAsn: 1.296 ± 0.826
11.666SerPro: 11.666 ± 3.685
5.833SerGln: 5.833 ± 1.808
7.129SerArg: 7.129 ± 1.997
12.962SerSer: 12.962 ± 2.915
3.24SerThr: 3.24 ± 1.377
4.537SerVal: 4.537 ± 2.14
3.889SerTrp: 3.889 ± 0.92
3.24SerTyr: 3.24 ± 1.377
0.0SerXaa: 0.0 ± 0.0
Thr
3.889ThrAla: 3.889 ± 1.624
4.537ThrCys: 4.537 ± 1.347
1.296ThrAsp: 1.296 ± 1.96
1.944ThrGlu: 1.944 ± 1.162
2.592ThrPhe: 2.592 ± 2.977
3.24ThrGly: 3.24 ± 0.934
2.592ThrHis: 2.592 ± 2.546
0.648ThrIle: 0.648 ± 0.664
1.944ThrLys: 1.944 ± 0.697
5.833ThrLeu: 5.833 ± 1.305
0.648ThrMet: 0.648 ± 0.413
0.648ThrAsn: 0.648 ± 0.413
5.185ThrPro: 5.185 ± 3.031
1.944ThrGln: 1.944 ± 1.239
2.592ThrArg: 2.592 ± 1.082
10.369ThrSer: 10.369 ± 1.603
3.24ThrThr: 3.24 ± 1.207
1.944ThrVal: 1.944 ± 1.549
2.592ThrTrp: 2.592 ± 1.334
1.296ThrTyr: 1.296 ± 0.541
0.0ThrXaa: 0.0 ± 0.0
Val
2.592ValAla: 2.592 ± 1.674
1.296ValCys: 1.296 ± 0.541
3.24ValAsp: 3.24 ± 0.725
1.296ValGlu: 1.296 ± 0.541
0.648ValPhe: 0.648 ± 0.664
1.944ValGly: 1.944 ± 1.239
2.592ValHis: 2.592 ± 1.652
0.0ValIle: 0.0 ± 0.0
0.648ValLys: 0.648 ± 0.413
6.481ValLeu: 6.481 ± 1.502
0.0ValMet: 0.0 ± 0.0
1.944ValAsn: 1.944 ± 0.697
5.185ValPro: 5.185 ± 2.788
1.944ValGln: 1.944 ± 1.139
3.24ValArg: 3.24 ± 1.54
7.129ValSer: 7.129 ± 1.679
3.24ValThr: 3.24 ± 1.11
3.24ValVal: 3.24 ± 1.51
0.648ValTrp: 0.648 ± 0.98
1.944ValTyr: 1.944 ± 1.239
0.0ValXaa: 0.0 ± 0.0
Trp
0.648TrpAla: 0.648 ± 0.664
0.0TrpCys: 0.0 ± 0.0
0.648TrpAsp: 0.648 ± 0.664
2.592TrpGlu: 2.592 ± 1.01
0.648TrpPhe: 0.648 ± 0.98
3.889TrpGly: 3.889 ± 1.764
0.0TrpHis: 0.0 ± 0.0
1.296TrpIle: 1.296 ± 0.837
0.648TrpLys: 0.648 ± 0.413
4.537TrpLeu: 4.537 ± 1.612
1.296TrpMet: 1.296 ± 1.328
0.0TrpAsn: 0.0 ± 0.0
0.648TrpPro: 0.648 ± 0.413
0.0TrpGln: 0.0 ± 0.0
1.944TrpArg: 1.944 ± 1.237
0.648TrpSer: 0.648 ± 0.413
3.889TrpThr: 3.889 ± 2.324
0.648TrpVal: 0.648 ± 0.664
1.944TrpTrp: 1.944 ± 1.139
1.944TrpTyr: 1.944 ± 1.741
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.648TyrAla: 0.648 ± 0.98
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
2.592TyrPhe: 2.592 ± 1.334
2.592TyrGly: 2.592 ± 1.401
1.944TyrHis: 1.944 ± 1.239
0.648TyrIle: 0.648 ± 0.664
3.24TyrLys: 3.24 ± 1.403
3.889TyrLeu: 3.889 ± 0.985
0.648TyrMet: 0.648 ± 0.413
1.296TyrAsn: 1.296 ± 0.826
2.592TyrPro: 2.592 ± 1.01
1.296TyrGln: 1.296 ± 0.541
0.648TyrArg: 0.648 ± 0.98
2.592TyrSer: 2.592 ± 1.082
1.296TyrThr: 1.296 ± 0.826
1.944TyrVal: 1.944 ± 1.239
0.648TyrTrp: 0.648 ± 0.664
0.648TyrTyr: 0.648 ± 0.664
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski