Amino acid dipepetide frequency for Streptococcus infantis SK1302

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.518AlaAla: 5.518 ± 0.154
0.539AlaCys: 0.539 ± 0.03
4.113AlaAsp: 4.113 ± 0.113
5.155AlaGlu: 5.155 ± 0.114
3.431AlaPhe: 3.431 ± 0.091
5.347AlaGly: 5.347 ± 0.128
1.263AlaHis: 1.263 ± 0.05
5.616AlaIle: 5.616 ± 0.108
5.18AlaLys: 5.18 ± 0.113
7.356AlaLeu: 7.356 ± 0.137
1.904AlaMet: 1.904 ± 0.071
2.949AlaAsn: 2.949 ± 0.079
2.239AlaPro: 2.239 ± 0.071
2.981AlaGln: 2.981 ± 0.081
2.875AlaArg: 2.875 ± 0.079
4.697AlaSer: 4.697 ± 0.112
4.352AlaThr: 4.352 ± 0.147
5.163AlaVal: 5.163 ± 0.111
0.615AlaTrp: 0.615 ± 0.04
2.696AlaTyr: 2.696 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.359CysAla: 0.359 ± 0.03
0.065CysCys: 0.065 ± 0.012
0.351CysAsp: 0.351 ± 0.03
0.277CysGlu: 0.277 ± 0.025
0.292CysPhe: 0.292 ± 0.023
0.503CysGly: 0.503 ± 0.036
0.186CysHis: 0.186 ± 0.02
0.338CysIle: 0.338 ± 0.028
0.3CysLys: 0.3 ± 0.026
0.687CysLeu: 0.687 ± 0.04
0.209CysMet: 0.209 ± 0.02
0.228CysAsn: 0.228 ± 0.022
0.264CysPro: 0.264 ± 0.025
0.397CysGln: 0.397 ± 0.034
0.298CysArg: 0.298 ± 0.025
0.439CysSer: 0.439 ± 0.03
0.254CysThr: 0.254 ± 0.025
0.349CysVal: 0.349 ± 0.027
0.07CysTrp: 0.07 ± 0.012
0.254CysTyr: 0.254 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.691AspAla: 3.691 ± 0.093
0.332AspCys: 0.332 ± 0.031
2.749AspAsp: 2.749 ± 0.08
4.124AspGlu: 4.124 ± 0.11
3.355AspPhe: 3.355 ± 0.089
3.826AspGly: 3.826 ± 0.111
1.023AspHis: 1.023 ± 0.049
4.063AspIle: 4.063 ± 0.1
4.348AspLys: 4.348 ± 0.113
5.935AspLeu: 5.935 ± 0.117
1.462AspMet: 1.462 ± 0.048
2.305AspAsn: 2.305 ± 0.079
1.749AspPro: 1.749 ± 0.077
2.36AspGln: 2.36 ± 0.08
2.18AspArg: 2.18 ± 0.071
2.928AspSer: 2.928 ± 0.09
2.647AspThr: 2.647 ± 0.072
3.68AspVal: 3.68 ± 0.099
0.63AspTrp: 0.63 ± 0.037
2.835AspTyr: 2.835 ± 0.097
0.0AspXaa: 0.0 ± 0.0
Glu
5.637GluAla: 5.637 ± 0.131
0.319GluCys: 0.319 ± 0.028
3.98GluAsp: 3.98 ± 0.097
6.64GluGlu: 6.64 ± 0.144
2.932GluPhe: 2.932 ± 0.074
4.029GluGly: 4.029 ± 0.097
1.28GluHis: 1.28 ± 0.051
5.742GluIle: 5.742 ± 0.116
6.372GluLys: 6.372 ± 0.114
7.17GluLeu: 7.17 ± 0.145
1.832GluMet: 1.832 ± 0.062
4.092GluAsn: 4.092 ± 0.101
1.701GluPro: 1.701 ± 0.069
2.858GluGln: 2.858 ± 0.081
3.235GluArg: 3.235 ± 0.094
3.771GluSer: 3.771 ± 0.099
3.927GluThr: 3.927 ± 0.106
5.225GluVal: 5.225 ± 0.105
0.657GluTrp: 0.657 ± 0.038
2.339GluTyr: 2.339 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
3.404PheAla: 3.404 ± 0.097
0.357PheCys: 0.357 ± 0.03
2.985PheAsp: 2.985 ± 0.083
3.273PheGlu: 3.273 ± 0.08
2.28PhePhe: 2.28 ± 0.087
3.249PheGly: 3.249 ± 0.075
0.837PheHis: 0.837 ± 0.042
3.184PheIle: 3.184 ± 0.091
2.575PheLys: 2.575 ± 0.072
4.984PheLeu: 4.984 ± 0.13
1.246PheMet: 1.246 ± 0.06
1.823PheAsn: 1.823 ± 0.063
1.601PhePro: 1.601 ± 0.059
1.532PheGln: 1.532 ± 0.055
1.506PheArg: 1.506 ± 0.05
3.292PheSer: 3.292 ± 0.091
2.546PheThr: 2.546 ± 0.079
3.292PheVal: 3.292 ± 0.08
0.577PheTrp: 0.577 ± 0.039
1.999PheTyr: 1.999 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
4.747GlyAla: 4.747 ± 0.118
0.414GlyCys: 0.414 ± 0.03
3.38GlyAsp: 3.38 ± 0.092
3.982GlyGlu: 3.982 ± 0.094
3.169GlyPhe: 3.169 ± 0.095
4.151GlyGly: 4.151 ± 0.115
1.272GlyHis: 1.272 ± 0.054
5.303GlyIle: 5.303 ± 0.11
4.773GlyLys: 4.773 ± 0.107
6.585GlyLeu: 6.585 ± 0.116
1.794GlyMet: 1.794 ± 0.071
2.681GlyAsn: 2.681 ± 0.076
1.428GlyPro: 1.428 ± 0.054
2.954GlyGln: 2.954 ± 0.077
2.736GlyArg: 2.736 ± 0.073
3.714GlySer: 3.714 ± 0.084
3.794GlyThr: 3.794 ± 0.111
5.155GlyVal: 5.155 ± 0.112
0.704GlyTrp: 0.704 ± 0.047
2.654GlyTyr: 2.654 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
1.183HisAla: 1.183 ± 0.054
0.135HisCys: 0.135 ± 0.017
0.946HisAsp: 0.946 ± 0.047
1.208HisGlu: 1.208 ± 0.059
1.05HisPhe: 1.05 ± 0.047
1.291HisGly: 1.291 ± 0.055
0.505HisHis: 0.505 ± 0.034
1.232HisIle: 1.232 ± 0.05
1.023HisLys: 1.023 ± 0.045
2.1HisLeu: 2.1 ± 0.087
0.482HisMet: 0.482 ± 0.038
0.685HisAsn: 0.685 ± 0.042
0.883HisPro: 0.883 ± 0.048
0.875HisGln: 0.875 ± 0.046
0.815HisArg: 0.815 ± 0.047
1.048HisSer: 1.048 ± 0.046
0.883HisThr: 0.883 ± 0.041
1.126HisVal: 1.126 ± 0.045
0.15HisTrp: 0.15 ± 0.019
0.9HisTyr: 0.9 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.759IleAla: 5.759 ± 0.112
0.585IleCys: 0.585 ± 0.036
4.175IleAsp: 4.175 ± 0.096
5.182IleGlu: 5.182 ± 0.109
3.49IlePhe: 3.49 ± 0.092
4.779IleGly: 4.779 ± 0.109
1.346IleHis: 1.346 ± 0.061
4.844IleIle: 4.844 ± 0.11
4.253IleLys: 4.253 ± 0.09
7.445IleLeu: 7.445 ± 0.144
1.644IleMet: 1.644 ± 0.059
2.787IleAsn: 2.787 ± 0.077
2.774IlePro: 2.774 ± 0.072
2.854IleGln: 2.854 ± 0.079
2.954IleArg: 2.954 ± 0.084
4.819IleSer: 4.819 ± 0.109
3.693IleThr: 3.693 ± 0.087
4.827IleVal: 4.827 ± 0.099
0.655IleTrp: 0.655 ± 0.042
2.554IleTyr: 2.554 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.853LysAla: 4.853 ± 0.109
0.245LysCys: 0.245 ± 0.024
4.35LysAsp: 4.35 ± 0.105
6.581LysGlu: 6.581 ± 0.135
2.045LysPhe: 2.045 ± 0.073
3.951LysGly: 3.951 ± 0.1
1.17LysHis: 1.17 ± 0.048
4.677LysIle: 4.677 ± 0.106
5.59LysLys: 5.59 ± 0.124
5.956LysLeu: 5.956 ± 0.108
2.075LysMet: 2.075 ± 0.062
3.475LysAsn: 3.475 ± 0.085
2.22LysPro: 2.22 ± 0.078
2.753LysGln: 2.753 ± 0.074
3.112LysArg: 3.112 ± 0.087
3.835LysSer: 3.835 ± 0.092
3.93LysThr: 3.93 ± 0.093
4.599LysVal: 4.599 ± 0.092
0.71LysTrp: 0.71 ± 0.042
2.233LysTyr: 2.233 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
8.514LeuAla: 8.514 ± 0.161
0.592LeuCys: 0.592 ± 0.037
5.835LeuAsp: 5.835 ± 0.117
7.458LeuGlu: 7.458 ± 0.154
4.72LeuPhe: 4.72 ± 0.121
6.566LeuGly: 6.566 ± 0.134
1.682LeuHis: 1.682 ± 0.068
6.42LeuIle: 6.42 ± 0.152
6.463LeuLys: 6.463 ± 0.117
10.168LeuLeu: 10.168 ± 0.195
2.531LeuMet: 2.531 ± 0.081
4.217LeuAsn: 4.217 ± 0.095
4.097LeuPro: 4.097 ± 0.105
3.611LeuGln: 3.611 ± 0.086
3.801LeuArg: 3.801 ± 0.094
7.067LeuSer: 7.067 ± 0.157
6.082LeuThr: 6.082 ± 0.108
7.312LeuVal: 7.312 ± 0.141
0.731LeuTrp: 0.731 ± 0.036
3.131LeuTyr: 3.131 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
1.916MetAla: 1.916 ± 0.06
0.133MetCys: 0.133 ± 0.016
1.386MetAsp: 1.386 ± 0.052
1.606MetGlu: 1.606 ± 0.059
0.908MetPhe: 0.908 ± 0.044
1.747MetGly: 1.747 ± 0.072
0.365MetHis: 0.365 ± 0.03
2.092MetIle: 2.092 ± 0.073
2.098MetLys: 2.098 ± 0.068
2.398MetLeu: 2.398 ± 0.062
0.735MetMet: 0.735 ± 0.042
1.363MetAsn: 1.363 ± 0.055
0.849MetPro: 0.849 ± 0.039
0.908MetGln: 0.908 ± 0.043
1.004MetArg: 1.004 ± 0.041
1.639MetSer: 1.639 ± 0.068
1.83MetThr: 1.83 ± 0.062
1.777MetVal: 1.777 ± 0.066
0.186MetTrp: 0.186 ± 0.021
0.617MetTyr: 0.617 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.962AsnAla: 2.962 ± 0.079
0.302AsnCys: 0.302 ± 0.023
2.119AsnAsp: 2.119 ± 0.078
2.402AsnGlu: 2.402 ± 0.084
2.049AsnPhe: 2.049 ± 0.069
3.395AsnGly: 3.395 ± 0.092
1.02AsnHis: 1.02 ± 0.053
3.129AsnIle: 3.129 ± 0.084
2.723AsnLys: 2.723 ± 0.085
4.536AsnLeu: 4.536 ± 0.106
1.221AsnMet: 1.221 ± 0.046
1.756AsnAsn: 1.756 ± 0.071
2.286AsnPro: 2.286 ± 0.069
2.17AsnGln: 2.17 ± 0.079
2.058AsnArg: 2.058 ± 0.063
2.43AsnSer: 2.43 ± 0.07
2.17AsnThr: 2.17 ± 0.073
2.609AsnVal: 2.609 ± 0.081
0.526AsnTrp: 0.526 ± 0.035
1.859AsnTyr: 1.859 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
2.533ProAla: 2.533 ± 0.091
0.203ProCys: 0.203 ± 0.019
2.136ProAsp: 2.136 ± 0.083
3.171ProGlu: 3.171 ± 0.094
1.756ProPhe: 1.756 ± 0.067
1.889ProGly: 1.889 ± 0.071
0.687ProHis: 0.687 ± 0.039
2.373ProIle: 2.373 ± 0.071
2.018ProLys: 2.018 ± 0.069
2.856ProLeu: 2.856 ± 0.077
0.729ProMet: 0.729 ± 0.039
1.566ProAsn: 1.566 ± 0.062
0.556ProPro: 0.556 ± 0.035
1.285ProGln: 1.285 ± 0.057
1.141ProArg: 1.141 ± 0.06
2.187ProSer: 2.187 ± 0.068
2.098ProThr: 2.098 ± 0.095
2.778ProVal: 2.778 ± 0.086
0.294ProTrp: 0.294 ± 0.025
1.304ProTyr: 1.304 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.627GlnAla: 3.627 ± 0.112
0.104GlnCys: 0.104 ± 0.016
2.22GlnAsp: 2.22 ± 0.066
3.554GlnGlu: 3.554 ± 0.099
1.648GlnPhe: 1.648 ± 0.053
2.518GlnGly: 2.518 ± 0.077
0.651GlnHis: 0.651 ± 0.042
2.782GlnIle: 2.782 ± 0.067
2.977GlnLys: 2.977 ± 0.091
4.141GlnLeu: 4.141 ± 0.103
0.995GlnMet: 0.995 ± 0.052
1.756GlnAsn: 1.756 ± 0.056
1.175GlnPro: 1.175 ± 0.047
1.384GlnGln: 1.384 ± 0.06
1.411GlnArg: 1.411 ± 0.054
2.296GlnSer: 2.296 ± 0.077
2.398GlnThr: 2.398 ± 0.077
3.226GlnVal: 3.226 ± 0.094
0.33GlnTrp: 0.33 ± 0.027
1.234GlnTyr: 1.234 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.472ArgAla: 2.472 ± 0.071
0.249ArgCys: 0.249 ± 0.026
2.275ArgAsp: 2.275 ± 0.069
3.27ArgGlu: 3.27 ± 0.101
2.134ArgPhe: 2.134 ± 0.068
2.263ArgGly: 2.263 ± 0.058
0.79ArgHis: 0.79 ± 0.037
3.0ArgIle: 3.0 ± 0.076
3.011ArgLys: 3.011 ± 0.086
4.073ArgLeu: 4.073 ± 0.095
1.175ArgMet: 1.175 ± 0.052
1.912ArgAsn: 1.912 ± 0.056
1.306ArgPro: 1.306 ± 0.053
1.718ArgGln: 1.718 ± 0.06
2.024ArgArg: 2.024 ± 0.07
2.214ArgSer: 2.214 ± 0.073
1.844ArgThr: 1.844 ± 0.068
2.848ArgVal: 2.848 ± 0.071
0.296ArgTrp: 0.296 ± 0.022
1.724ArgTyr: 1.724 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
3.932SerAla: 3.932 ± 0.094
0.41SerCys: 0.41 ± 0.03
3.368SerAsp: 3.368 ± 0.091
3.843SerGlu: 3.843 ± 0.1
3.051SerPhe: 3.051 ± 0.08
4.189SerGly: 4.189 ± 0.097
1.232SerHis: 1.232 ± 0.057
4.489SerIle: 4.489 ± 0.108
4.101SerLys: 4.101 ± 0.092
6.761SerLeu: 6.761 ± 0.145
1.593SerMet: 1.593 ± 0.066
2.569SerAsn: 2.569 ± 0.071
1.935SerPro: 1.935 ± 0.058
2.945SerGln: 2.945 ± 0.089
2.504SerArg: 2.504 ± 0.078
4.498SerSer: 4.498 ± 0.16
3.182SerThr: 3.182 ± 0.089
4.052SerVal: 4.052 ± 0.09
0.657SerTrp: 0.657 ± 0.044
2.611SerTyr: 2.611 ± 0.083
0.0SerXaa: 0.0 ± 0.0
Thr
4.213ThrAla: 4.213 ± 0.124
0.374ThrCys: 0.374 ± 0.029
3.129ThrAsp: 3.129 ± 0.093
3.577ThrGlu: 3.577 ± 0.096
2.609ThrPhe: 2.609 ± 0.08
4.192ThrGly: 4.192 ± 0.111
0.955ThrHis: 0.955 ± 0.051
4.236ThrIle: 4.236 ± 0.106
3.308ThrLys: 3.308 ± 0.087
5.282ThrLeu: 5.282 ± 0.107
1.189ThrMet: 1.189 ± 0.05
2.446ThrAsn: 2.446 ± 0.062
2.394ThrPro: 2.394 ± 0.115
1.751ThrGln: 1.751 ± 0.066
2.045ThrArg: 2.045 ± 0.073
3.767ThrSer: 3.767 ± 0.097
3.104ThrThr: 3.104 ± 0.119
4.382ThrVal: 4.382 ± 0.116
0.562ThrTrp: 0.562 ± 0.035
2.155ThrTyr: 2.155 ± 0.074
0.0ThrXaa: 0.0 ± 0.0
Val
5.683ValAla: 5.683 ± 0.117
0.473ValCys: 0.473 ± 0.032
3.993ValAsp: 3.993 ± 0.086
5.487ValGlu: 5.487 ± 0.111
3.188ValPhe: 3.188 ± 0.081
4.485ValGly: 4.485 ± 0.109
1.2ValHis: 1.2 ± 0.053
4.84ValIle: 4.84 ± 0.103
4.462ValLys: 4.462 ± 0.098
7.046ValLeu: 7.046 ± 0.112
1.614ValMet: 1.614 ± 0.057
3.078ValAsn: 3.078 ± 0.09
2.476ValPro: 2.476 ± 0.091
2.427ValGln: 2.427 ± 0.074
2.768ValArg: 2.768 ± 0.092
4.464ValSer: 4.464 ± 0.096
4.475ValThr: 4.475 ± 0.107
5.066ValVal: 5.066 ± 0.117
0.545ValTrp: 0.545 ± 0.039
2.394ValTyr: 2.394 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
0.537TrpAla: 0.537 ± 0.035
0.051TrpCys: 0.051 ± 0.01
0.535TrpAsp: 0.535 ± 0.033
0.573TrpGlu: 0.573 ± 0.037
0.473TrpPhe: 0.473 ± 0.033
0.604TrpGly: 0.604 ± 0.038
0.19TrpHis: 0.19 ± 0.022
0.693TrpIle: 0.693 ± 0.042
0.657TrpLys: 0.657 ± 0.041
1.025TrpLeu: 1.025 ± 0.049
0.302TrpMet: 0.302 ± 0.026
0.52TrpAsn: 0.52 ± 0.036
0.186TrpPro: 0.186 ± 0.021
0.442TrpGln: 0.442 ± 0.034
0.361TrpArg: 0.361 ± 0.026
0.613TrpSer: 0.613 ± 0.034
0.503TrpThr: 0.503 ± 0.031
0.492TrpVal: 0.492 ± 0.033
0.123TrpTrp: 0.123 ± 0.017
0.473TrpTyr: 0.473 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.453TyrAla: 2.453 ± 0.067
0.237TyrCys: 0.237 ± 0.023
2.195TyrAsp: 2.195 ± 0.067
2.377TyrGlu: 2.377 ± 0.074
1.961TyrPhe: 1.961 ± 0.063
2.415TyrGly: 2.415 ± 0.08
0.866TyrHis: 0.866 ± 0.046
2.366TyrIle: 2.366 ± 0.076
2.13TyrLys: 2.13 ± 0.063
4.494TyrLeu: 4.494 ± 0.102
0.824TyrMet: 0.824 ± 0.04
1.515TyrAsn: 1.515 ± 0.054
1.437TyrPro: 1.437 ± 0.06
2.223TyrGln: 2.223 ± 0.087
1.77TyrArg: 1.77 ± 0.059
2.204TyrSer: 2.204 ± 0.069
1.958TyrThr: 1.958 ± 0.089
2.206TyrVal: 2.206 ± 0.057
0.336TyrTrp: 0.336 ± 0.027
1.775TyrTyr: 1.775 ± 0.088
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2102 proteins (473331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski