Amino acid dipepetide frequency for Aspergillus rambellii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.815AlaAla: 8.815 ± 0.081	1.001AlaCys: 1.001 ± 0.018	4.059AlaAsp: 4.059 ± 0.034	5.048AlaGlu: 5.048 ± 0.046	3.084AlaPhe: 3.084 ± 0.032	5.592AlaGly: 5.592 ± 0.046	1.785AlaHis: 1.785 ± 0.022	4.077AlaIle: 4.077 ± 0.031	3.791AlaLys: 3.791 ± 0.037	7.755AlaLeu: 7.755 ± 0.054	1.858AlaMet: 1.858 ± 0.019	2.832AlaAsn: 2.832 ± 0.028	4.72AlaPro: 4.72 ± 0.046	3.409AlaGln: 3.409 ± 0.032	4.932AlaArg: 4.932 ± 0.035	7.248AlaSer: 7.248 ± 0.053	5.166AlaThr: 5.166 ± 0.045	5.34AlaVal: 5.34 ± 0.043	1.062AlaTrp: 1.062 ± 0.017	2.083AlaTyr: 2.083 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.91CysAla: 0.91 ± 0.015	0.227CysCys: 0.227 ± 0.008	0.646CysAsp: 0.646 ± 0.014	0.592CysGlu: 0.592 ± 0.012	0.537CysPhe: 0.537 ± 0.011	0.888CysGly: 0.888 ± 0.019	0.325CysHis: 0.325 ± 0.009	0.687CysIle: 0.687 ± 0.016	0.458CysLys: 0.458 ± 0.011	1.246CysLeu: 1.246 ± 0.019	0.267CysMet: 0.267 ± 0.007	0.411CysAsn: 0.411 ± 0.011	0.646CysPro: 0.646 ± 0.014	0.424CysGln: 0.424 ± 0.01	0.74CysArg: 0.74 ± 0.015	0.925CysSer: 0.925 ± 0.018	0.661CysThr: 0.661 ± 0.014	0.755CysVal: 0.755 ± 0.015	0.185CysTrp: 0.185 ± 0.007	0.343CysTyr: 0.343 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.469AspAla: 4.469 ± 0.034	0.609AspCys: 0.609 ± 0.014	4.244AspAsp: 4.244 ± 0.053	4.364AspGlu: 4.364 ± 0.043	2.168AspPhe: 2.168 ± 0.022	3.888AspGly: 3.888 ± 0.032	1.251AspHis: 1.251 ± 0.019	3.147AspIle: 3.147 ± 0.031	2.147AspLys: 2.147 ± 0.025	5.261AspLeu: 5.261 ± 0.038	1.209AspMet: 1.209 ± 0.017	1.86AspAsn: 1.86 ± 0.021	3.485AspPro: 3.485 ± 0.032	1.967AspGln: 1.967 ± 0.023	3.157AspArg: 3.157 ± 0.04	4.283AspSer: 4.283 ± 0.036	2.877AspThr: 2.877 ± 0.029	3.444AspVal: 3.444 ± 0.03	0.825AspTrp: 0.825 ± 0.016	1.594AspTyr: 1.594 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.15GluAla: 5.15 ± 0.046	0.613GluCys: 0.613 ± 0.014	4.148GluAsp: 4.148 ± 0.042	5.848GluGlu: 5.848 ± 0.079	2.044GluPhe: 2.044 ± 0.023	3.586GluGly: 3.586 ± 0.038	1.354GluHis: 1.354 ± 0.02	3.247GluIle: 3.247 ± 0.028	3.642GluLys: 3.642 ± 0.036	5.237GluLeu: 5.237 ± 0.048	1.468GluMet: 1.468 ± 0.021	2.441GluAsn: 2.441 ± 0.023	2.87GluPro: 2.87 ± 0.042	2.574GluGln: 2.574 ± 0.03	3.932GluArg: 3.932 ± 0.037	4.589GluSer: 4.589 ± 0.04	3.625GluThr: 3.625 ± 0.035	3.475GluVal: 3.475 ± 0.032	0.861GluTrp: 0.861 ± 0.014	1.728GluTyr: 1.728 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	2.965PheAla: 2.965 ± 0.03	0.559PheCys: 0.559 ± 0.012	2.248PheAsp: 2.248 ± 0.026	2.094PheGlu: 2.094 ± 0.024	1.633PhePhe: 1.633 ± 0.026	2.771PheGly: 2.771 ± 0.034	0.946PheHis: 0.946 ± 0.013	1.811PheIle: 1.811 ± 0.022	1.426PheLys: 1.426 ± 0.021	3.664PheLeu: 3.664 ± 0.034	0.782PheMet: 0.782 ± 0.014	1.406PheAsn: 1.406 ± 0.02	2.089PhePro: 2.089 ± 0.025	1.483PheGln: 1.483 ± 0.02	2.043PheArg: 2.043 ± 0.024	3.175PheSer: 3.175 ± 0.027	2.164PheThr: 2.164 ± 0.025	2.351PheVal: 2.351 ± 0.029	0.614PheTrp: 0.614 ± 0.015	1.124PheTyr: 1.124 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.137GlyAla: 5.137 ± 0.044	0.825GlyCys: 0.825 ± 0.016	3.56GlyAsp: 3.56 ± 0.032	3.67GlyGlu: 3.67 ± 0.035	2.782GlyPhe: 2.782 ± 0.027	5.413GlyGly: 5.413 ± 0.06	1.629GlyHis: 1.629 ± 0.025	3.526GlyIle: 3.526 ± 0.035	3.26GlyLys: 3.26 ± 0.034	6.042GlyLeu: 6.042 ± 0.04	1.507GlyMet: 1.507 ± 0.022	2.472GlyAsn: 2.472 ± 0.025	3.359GlyPro: 3.359 ± 0.033	2.511GlyGln: 2.511 ± 0.027	3.957GlyArg: 3.957 ± 0.039	5.771GlySer: 5.771 ± 0.049	3.785GlyThr: 3.785 ± 0.035	4.336GlyVal: 4.336 ± 0.039	1.07GlyTrp: 1.07 ± 0.017	2.08GlyTyr: 2.08 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.838HisAla: 1.838 ± 0.021	0.306HisCys: 0.306 ± 0.009	1.329HisAsp: 1.329 ± 0.02	1.329HisGlu: 1.329 ± 0.02	0.927HisPhe: 0.927 ± 0.015	1.658HisGly: 1.658 ± 0.023	0.935HisHis: 0.935 ± 0.021	1.235HisIle: 1.235 ± 0.019	0.856HisLys: 0.856 ± 0.014	2.327HisLeu: 2.327 ± 0.023	0.466HisMet: 0.466 ± 0.01	0.844HisAsn: 0.844 ± 0.015	1.813HisPro: 1.813 ± 0.024	1.027HisGln: 1.027 ± 0.017	1.622HisArg: 1.622 ± 0.022	1.981HisSer: 1.981 ± 0.024	1.285HisThr: 1.285 ± 0.017	1.367HisVal: 1.367 ± 0.02	0.333HisTrp: 0.333 ± 0.01	0.697HisTyr: 0.697 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.074IleAla: 4.074 ± 0.033	0.754IleCys: 0.754 ± 0.014	2.85IleAsp: 2.85 ± 0.031	2.877IleGlu: 2.877 ± 0.032	1.999IlePhe: 1.999 ± 0.026	3.093IleGly: 3.093 ± 0.029	1.264IleHis: 1.264 ± 0.018	2.524IleIle: 2.524 ± 0.03	2.072IleLys: 2.072 ± 0.022	4.793IleLeu: 4.793 ± 0.043	1.003IleMet: 1.003 ± 0.016	1.764IleAsn: 1.764 ± 0.023	3.308IlePro: 3.308 ± 0.031	2.09IleGln: 2.09 ± 0.025	2.927IleArg: 2.927 ± 0.025	4.061IleSer: 4.061 ± 0.032	2.84IleThr: 2.84 ± 0.026	3.11IleVal: 3.11 ± 0.031	0.688IleTrp: 0.688 ± 0.012	1.457IleTyr: 1.457 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.93LysAla: 3.93 ± 0.033	0.466LysCys: 0.466 ± 0.013	2.614LysAsp: 2.614 ± 0.03	3.31LysGlu: 3.31 ± 0.036	1.428LysPhe: 1.428 ± 0.017	2.79LysGly: 2.79 ± 0.028	1.051LysHis: 1.051 ± 0.018	2.233LysIle: 2.233 ± 0.026	3.147LysLys: 3.147 ± 0.054	3.998LysLeu: 3.998 ± 0.038	0.954LysMet: 0.954 ± 0.014	1.712LysAsn: 1.712 ± 0.018	2.651LysPro: 2.651 ± 0.028	1.837LysGln: 1.837 ± 0.02	3.392LysArg: 3.392 ± 0.039	3.443LysSer: 3.443 ± 0.033	2.669LysThr: 2.669 ± 0.026	2.655LysVal: 2.655 ± 0.029	0.606LysTrp: 0.606 ± 0.014	1.362LysTyr: 1.362 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.824LeuAla: 7.824 ± 0.048	1.188LeuCys: 1.188 ± 0.02	5.334LeuAsp: 5.334 ± 0.04	5.701LeuGlu: 5.701 ± 0.043	3.425LeuPhe: 3.425 ± 0.032	5.96LeuGly: 5.96 ± 0.041	2.296LeuHis: 2.296 ± 0.023	4.04LeuIle: 4.04 ± 0.029	4.159LeuLys: 4.159 ± 0.033	8.637LeuLeu: 8.637 ± 0.071	1.762LeuMet: 1.762 ± 0.02	3.253LeuAsn: 3.253 ± 0.029	5.625LeuPro: 5.625 ± 0.042	4.003LeuGln: 4.003 ± 0.035	6.032LeuArg: 6.032 ± 0.048	7.797LeuSer: 7.797 ± 0.053	4.861LeuThr: 4.861 ± 0.04	5.577LeuVal: 5.577 ± 0.039	1.161LeuTrp: 1.161 ± 0.02	2.428LeuTyr: 2.428 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.084MetAla: 2.084 ± 0.024	0.221MetCys: 0.221 ± 0.008	1.257MetAsp: 1.257 ± 0.019	1.317MetGlu: 1.317 ± 0.02	0.722MetPhe: 0.722 ± 0.013	1.412MetGly: 1.412 ± 0.019	0.444MetHis: 0.444 ± 0.01	1.02MetIle: 1.02 ± 0.015	0.983MetLys: 0.983 ± 0.014	1.789MetLeu: 1.789 ± 0.021	0.54MetMet: 0.54 ± 0.012	0.805MetAsn: 0.805 ± 0.014	1.163MetPro: 1.163 ± 0.019	0.856MetGln: 0.856 ± 0.016	1.215MetArg: 1.215 ± 0.015	1.806MetSer: 1.806 ± 0.022	1.201MetThr: 1.201 ± 0.018	1.309MetVal: 1.309 ± 0.018	0.232MetTrp: 0.232 ± 0.007	0.504MetTyr: 0.504 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.044AsnAla: 3.044 ± 0.03	0.431AsnCys: 0.431 ± 0.011	1.903AsnAsp: 1.903 ± 0.024	2.042AsnGlu: 2.042 ± 0.025	1.33AsnPhe: 1.33 ± 0.018	2.793AsnGly: 2.793 ± 0.03	0.902AsnHis: 0.902 ± 0.017	2.036AsnIle: 2.036 ± 0.024	1.464AsnLys: 1.464 ± 0.021	3.295AsnLeu: 3.295 ± 0.035	0.815AsnMet: 0.815 ± 0.014	1.471AsnAsn: 1.471 ± 0.027	2.708AsnPro: 2.708 ± 0.024	1.401AsnGln: 1.401 ± 0.019	1.999AsnArg: 1.999 ± 0.021	2.841AsnSer: 2.841 ± 0.03	2.16AsnThr: 2.16 ± 0.026	2.214AsnVal: 2.214 ± 0.024	0.528AsnTrp: 0.528 ± 0.013	1.051AsnTyr: 1.051 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.234ProAla: 5.234 ± 0.047	0.53ProCys: 0.53 ± 0.012	3.281ProAsp: 3.281 ± 0.029	3.991ProGlu: 3.991 ± 0.04	2.137ProPhe: 2.137 ± 0.024	4.087ProGly: 4.087 ± 0.046	1.427ProHis: 1.427 ± 0.021	2.579ProIle: 2.579 ± 0.027	2.562ProLys: 2.562 ± 0.025	4.953ProLeu: 4.953 ± 0.041	1.053ProMet: 1.053 ± 0.019	2.233ProAsn: 2.233 ± 0.024	5.513ProPro: 5.513 ± 0.076	2.606ProGln: 2.606 ± 0.035	3.628ProArg: 3.628 ± 0.033	6.552ProSer: 6.552 ± 0.062	4.008ProThr: 4.008 ± 0.041	3.712ProVal: 3.712 ± 0.032	0.736ProTrp: 0.736 ± 0.014	1.558ProTyr: 1.558 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.388GlnAla: 3.388 ± 0.037	0.433GlnCys: 0.433 ± 0.012	2.109GlnAsp: 2.109 ± 0.023	2.577GlnGlu: 2.577 ± 0.026	1.348GlnPhe: 1.348 ± 0.019	2.427GlnGly: 2.427 ± 0.025	1.078GlnHis: 1.078 ± 0.018	1.989GlnIle: 1.989 ± 0.023	2.021GlnLys: 2.021 ± 0.024	3.623GlnLeu: 3.623 ± 0.036	0.894GlnMet: 0.894 ± 0.016	1.638GlnAsn: 1.638 ± 0.026	2.696GlnPro: 2.696 ± 0.035	2.523GlnGln: 2.523 ± 0.061	2.736GlnArg: 2.736 ± 0.031	3.359GlnSer: 3.359 ± 0.038	2.369GlnThr: 2.369 ± 0.026	2.26GlnVal: 2.26 ± 0.026	0.544GlnTrp: 0.544 ± 0.011	1.189GlnTyr: 1.189 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.723ArgAla: 4.723 ± 0.039	0.717ArgCys: 0.717 ± 0.015	3.401ArgAsp: 3.401 ± 0.037	4.008ArgGlu: 4.008 ± 0.042	2.222ArgPhe: 2.222 ± 0.024	3.731ArgGly: 3.731 ± 0.035	1.599ArgHis: 1.599 ± 0.019	3.006ArgIle: 3.006 ± 0.025	3.53ArgLys: 3.53 ± 0.036	5.662ArgLeu: 5.662 ± 0.034	1.295ArgMet: 1.295 ± 0.017	2.326ArgAsn: 2.326 ± 0.026	3.623ArgPro: 3.623 ± 0.039	2.705ArgGln: 2.705 ± 0.027	5.263ArgArg: 5.263 ± 0.048	5.083ArgSer: 5.083 ± 0.048	3.327ArgThr: 3.327 ± 0.029	3.491ArgVal: 3.491 ± 0.029	0.903ArgTrp: 0.903 ± 0.017	1.683ArgTyr: 1.683 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.69SerAla: 6.69 ± 0.044	0.889SerCys: 0.889 ± 0.015	4.311SerAsp: 4.311 ± 0.041	4.341SerGlu: 4.341 ± 0.038	3.184SerPhe: 3.184 ± 0.03	5.638SerGly: 5.638 ± 0.043	2.072SerHis: 2.072 ± 0.024	4.135SerIle: 4.135 ± 0.03	3.721SerLys: 3.721 ± 0.039	7.815SerLeu: 7.815 ± 0.053	1.664SerMet: 1.664 ± 0.02	3.032SerAsn: 3.032 ± 0.025	5.958SerPro: 5.958 ± 0.062	3.556SerGln: 3.556 ± 0.037	5.443SerArg: 5.443 ± 0.049	9.847SerSer: 9.847 ± 0.092	5.844SerThr: 5.844 ± 0.049	4.743SerVal: 4.743 ± 0.035	1.154SerTrp: 1.154 ± 0.017	2.122SerTyr: 2.122 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.186ThrAla: 5.186 ± 0.042	0.714ThrCys: 0.714 ± 0.016	2.801ThrAsp: 2.801 ± 0.026	3.098ThrGlu: 3.098 ± 0.03	2.185ThrPhe: 2.185 ± 0.024	4.167ThrGly: 4.167 ± 0.033	1.336ThrHis: 1.336 ± 0.019	3.028ThrIle: 3.028 ± 0.031	2.471ThrLys: 2.471 ± 0.028	5.329ThrLeu: 5.329 ± 0.043	1.129ThrMet: 1.129 ± 0.015	2.028ThrAsn: 2.028 ± 0.026	4.436ThrPro: 4.436 ± 0.041	2.166ThrGln: 2.166 ± 0.023	3.21ThrArg: 3.21 ± 0.03	5.374ThrSer: 5.374 ± 0.047	4.553ThrThr: 4.553 ± 0.067	3.757ThrVal: 3.757 ± 0.032	0.806ThrTrp: 0.806 ± 0.015	1.557ThrTyr: 1.557 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.015ValAla: 5.015 ± 0.042	0.819ValCys: 0.819 ± 0.015	3.697ValAsp: 3.697 ± 0.027	3.838ValGlu: 3.838 ± 0.031	2.488ValPhe: 2.488 ± 0.026	3.898ValGly: 3.898 ± 0.038	1.402ValHis: 1.402 ± 0.018	3.019ValIle: 3.019 ± 0.029	2.721ValLys: 2.721 ± 0.026	5.621ValLeu: 5.621 ± 0.048	1.254ValMet: 1.254 ± 0.018	2.185ValAsn: 2.185 ± 0.025	3.599ValPro: 3.599 ± 0.034	2.404ValGln: 2.404 ± 0.024	3.478ValArg: 3.478 ± 0.03	4.878ValSer: 4.878 ± 0.033	3.468ValThr: 3.468 ± 0.036	4.219ValVal: 4.219 ± 0.04	0.828ValTrp: 0.828 ± 0.015	1.732ValTyr: 1.732 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.065TrpAla: 1.065 ± 0.014	0.179TrpCys: 0.179 ± 0.008	0.857TrpAsp: 0.857 ± 0.018	0.844TrpGlu: 0.844 ± 0.014	0.496TrpPhe: 0.496 ± 0.011	0.884TrpGly: 0.884 ± 0.016	0.327TrpHis: 0.327 ± 0.009	0.756TrpIle: 0.756 ± 0.015	0.768TrpLys: 0.768 ± 0.015	1.277TrpLeu: 1.277 ± 0.019	0.368TrpMet: 0.368 ± 0.009	0.62TrpAsn: 0.62 ± 0.013	0.556TrpPro: 0.556 ± 0.013	0.516TrpGln: 0.516 ± 0.011	0.914TrpArg: 0.914 ± 0.016	1.013TrpSer: 1.013 ± 0.016	0.849TrpThr: 0.849 ± 0.017	0.835TrpVal: 0.835 ± 0.015	0.261TrpTrp: 0.261 ± 0.009	0.41TrpTyr: 0.41 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.116TyrAla: 2.116 ± 0.026	0.391TyrCys: 0.391 ± 0.011	1.603TyrAsp: 1.603 ± 0.022	1.544TyrGlu: 1.544 ± 0.022	1.209TyrPhe: 1.209 ± 0.02	2.014TyrGly: 2.014 ± 0.026	0.75TyrHis: 0.75 ± 0.014	1.451TyrIle: 1.451 ± 0.018	1.048TyrLys: 1.048 ± 0.016	2.74TyrLeu: 2.74 ± 0.027	0.592TyrMet: 0.592 ± 0.012	1.095TyrAsn: 1.095 ± 0.015	1.559TyrPro: 1.559 ± 0.025	1.143TyrGln: 1.143 ± 0.017	1.676TyrArg: 1.676 ± 0.025	2.131TyrSer: 2.131 ± 0.021	1.619TyrThr: 1.619 ± 0.02	1.615TyrVal: 1.615 ± 0.02	0.403TyrTrp: 0.403 ± 0.01	0.973TyrTyr: 0.973 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7761 proteins (4081960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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