Amino acid dipepetide frequency for Terasakiispira papahanaumokuakeensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.21AlaAla: 10.21 ± 0.116	1.137AlaCys: 1.137 ± 0.029	5.503AlaAsp: 5.503 ± 0.07	6.287AlaGlu: 6.287 ± 0.082	3.44AlaPhe: 3.44 ± 0.057	7.41AlaGly: 7.41 ± 0.099	2.643AlaHis: 2.643 ± 0.057	5.261AlaIle: 5.261 ± 0.08	2.851AlaLys: 2.851 ± 0.063	13.408AlaLeu: 13.408 ± 0.144	3.077AlaMet: 3.077 ± 0.049	2.57AlaAsn: 2.57 ± 0.052	4.252AlaPro: 4.252 ± 0.07	6.102AlaGln: 6.102 ± 0.11	6.066AlaArg: 6.066 ± 0.082	5.802AlaSer: 5.802 ± 0.084	4.833AlaThr: 4.833 ± 0.07	6.527AlaVal: 6.527 ± 0.085	1.499AlaTrp: 1.499 ± 0.04	2.468AlaTyr: 2.468 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.833CysAla: 0.833 ± 0.03	0.151CysCys: 0.151 ± 0.013	0.577CysAsp: 0.577 ± 0.024	0.543CysGlu: 0.543 ± 0.021	0.403CysPhe: 0.403 ± 0.019	0.84CysGly: 0.84 ± 0.03	0.323CysHis: 0.323 ± 0.019	0.483CysIle: 0.483 ± 0.023	0.176CysLys: 0.176 ± 0.012	1.04CysLeu: 1.04 ± 0.031	0.214CysMet: 0.214 ± 0.014	0.21CysAsn: 0.21 ± 0.013	0.508CysPro: 0.508 ± 0.022	0.61CysGln: 0.61 ± 0.028	0.625CysArg: 0.625 ± 0.022	0.543CysSer: 0.543 ± 0.022	0.381CysThr: 0.381 ± 0.018	0.656CysVal: 0.656 ± 0.022	0.198CysTrp: 0.198 ± 0.013	0.292CysTyr: 0.292 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.21AspAla: 5.21 ± 0.072	0.462AspCys: 0.462 ± 0.024	3.705AspAsp: 3.705 ± 0.075	3.963AspGlu: 3.963 ± 0.069	2.062AspPhe: 2.062 ± 0.051	3.652AspGly: 3.652 ± 0.069	1.72AspHis: 1.72 ± 0.046	3.242AspIle: 3.242 ± 0.063	1.685AspLys: 1.685 ± 0.043	5.665AspLeu: 5.665 ± 0.077	1.388AspMet: 1.388 ± 0.039	1.637AspAsn: 1.637 ± 0.045	2.953AspPro: 2.953 ± 0.059	3.564AspGln: 3.564 ± 0.064	3.263AspArg: 3.263 ± 0.068	2.733AspSer: 2.733 ± 0.063	2.861AspThr: 2.861 ± 0.057	3.613AspVal: 3.613 ± 0.06	0.969AspTrp: 0.969 ± 0.03	1.863AspTyr: 1.863 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.357GluAla: 7.357 ± 0.094	0.432GluCys: 0.432 ± 0.022	2.955GluAsp: 2.955 ± 0.057	2.939GluGlu: 2.939 ± 0.067	1.664GluPhe: 1.664 ± 0.045	4.169GluGly: 4.169 ± 0.067	1.784GluHis: 1.784 ± 0.037	2.861GluIle: 2.861 ± 0.058	2.028GluLys: 2.028 ± 0.052	5.526GluLeu: 5.526 ± 0.089	1.484GluMet: 1.484 ± 0.034	1.513GluAsn: 1.513 ± 0.042	2.31GluPro: 2.31 ± 0.045	3.931GluGln: 3.931 ± 0.074	4.177GluArg: 4.177 ± 0.069	3.178GluSer: 3.178 ± 0.051	3.293GluThr: 3.293 ± 0.049	4.366GluVal: 4.366 ± 0.063	0.742GluTrp: 0.742 ± 0.028	1.271GluTyr: 1.271 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.124PheAla: 3.124 ± 0.06	0.421PheCys: 0.421 ± 0.021	2.395PheAsp: 2.395 ± 0.052	2.113PheGlu: 2.113 ± 0.047	1.374PhePhe: 1.374 ± 0.041	2.734PheGly: 2.734 ± 0.06	0.779PheHis: 0.779 ± 0.026	2.014PheIle: 2.014 ± 0.046	1.305PheLys: 1.305 ± 0.035	2.999PheLeu: 2.999 ± 0.059	1.023PheMet: 1.023 ± 0.031	1.381PheAsn: 1.381 ± 0.034	1.434PhePro: 1.434 ± 0.035	1.286PheGln: 1.286 ± 0.035	1.711PheArg: 1.711 ± 0.039	2.473PheSer: 2.473 ± 0.053	1.907PheThr: 1.907 ± 0.039	2.269PheVal: 2.269 ± 0.046	0.564PheTrp: 0.564 ± 0.024	1.066PheTyr: 1.066 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.454GlyAla: 6.454 ± 0.108	0.84GlyCys: 0.84 ± 0.031	3.987GlyAsp: 3.987 ± 0.071	4.241GlyGlu: 4.241 ± 0.068	3.087GlyPhe: 3.087 ± 0.054	5.375GlyGly: 5.375 ± 0.099	2.227GlyHis: 2.227 ± 0.048	4.327GlyIle: 4.327 ± 0.072	2.375GlyLys: 2.375 ± 0.056	8.856GlyLeu: 8.856 ± 0.099	2.135GlyMet: 2.135 ± 0.041	1.911GlyAsn: 1.911 ± 0.052	2.598GlyPro: 2.598 ± 0.051	4.345GlyGln: 4.345 ± 0.075	4.562GlyArg: 4.562 ± 0.061	3.811GlySer: 3.811 ± 0.068	3.465GlyThr: 3.465 ± 0.071	5.45GlyVal: 5.45 ± 0.079	1.314GlyTrp: 1.314 ± 0.037	2.336GlyTyr: 2.336 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.304HisAla: 2.304 ± 0.049	0.352HisCys: 0.352 ± 0.018	1.603HisAsp: 1.603 ± 0.042	1.448HisGlu: 1.448 ± 0.04	1.172HisPhe: 1.172 ± 0.032	1.831HisGly: 1.831 ± 0.04	1.119HisHis: 1.119 ± 0.033	1.389HisIle: 1.389 ± 0.039	0.678HisLys: 0.678 ± 0.024	3.174HisLeu: 3.174 ± 0.063	0.623HisMet: 0.623 ± 0.022	0.798HisAsn: 0.798 ± 0.026	1.687HisPro: 1.687 ± 0.042	1.908HisGln: 1.908 ± 0.049	1.579HisArg: 1.579 ± 0.037	1.379HisSer: 1.379 ± 0.037	1.258HisThr: 1.258 ± 0.032	1.415HisVal: 1.415 ± 0.035	0.687HisTrp: 0.687 ± 0.025	1.082HisTyr: 1.082 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.58IleAla: 5.58 ± 0.087	0.481IleCys: 0.481 ± 0.023	3.327IleAsp: 3.327 ± 0.054	3.868IleGlu: 3.868 ± 0.053	1.564IlePhe: 1.564 ± 0.041	4.31IleGly: 4.31 ± 0.071	1.18IleHis: 1.18 ± 0.036	2.536IleIle: 2.536 ± 0.059	1.835IleLys: 1.835 ± 0.049	4.535IleLeu: 4.535 ± 0.074	1.253IleMet: 1.253 ± 0.037	1.948IleAsn: 1.948 ± 0.048	2.495IlePro: 2.495 ± 0.049	2.452IleGln: 2.452 ± 0.05	3.061IleArg: 3.061 ± 0.053	3.21IleSer: 3.21 ± 0.053	3.044IleThr: 3.044 ± 0.067	3.256IleVal: 3.256 ± 0.067	0.603IleTrp: 0.603 ± 0.022	1.177IleTyr: 1.177 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.938LysAla: 3.938 ± 0.078	0.16LysCys: 0.16 ± 0.012	1.499LysAsp: 1.499 ± 0.044	1.501LysGlu: 1.501 ± 0.05	0.715LysPhe: 0.715 ± 0.028	2.46LysGly: 2.46 ± 0.049	0.738LysHis: 0.738 ± 0.027	1.53LysIle: 1.53 ± 0.041	1.162LysLys: 1.162 ± 0.041	3.154LysLeu: 3.154 ± 0.062	0.769LysMet: 0.769 ± 0.025	0.884LysAsn: 0.884 ± 0.031	1.697LysPro: 1.697 ± 0.046	1.736LysGln: 1.736 ± 0.043	2.265LysArg: 2.265 ± 0.047	1.906LysSer: 1.906 ± 0.045	1.994LysThr: 1.994 ± 0.045	2.302LysVal: 2.302 ± 0.053	0.34LysTrp: 0.34 ± 0.018	0.557LysTyr: 0.557 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.241LeuAla: 12.241 ± 0.114	1.177LeuCys: 1.177 ± 0.033	6.551LeuAsp: 6.551 ± 0.087	6.139LeuGlu: 6.139 ± 0.081	3.629LeuPhe: 3.629 ± 0.067	8.332LeuGly: 8.332 ± 0.106	2.465LeuHis: 2.465 ± 0.051	6.019LeuIle: 6.019 ± 0.08	4.64LeuLys: 4.64 ± 0.072	12.344LeuLeu: 12.344 ± 0.182	3.358LeuMet: 3.358 ± 0.059	4.177LeuAsn: 4.177 ± 0.06	5.918LeuPro: 5.918 ± 0.092	4.693LeuGln: 4.693 ± 0.082	5.892LeuArg: 5.892 ± 0.076	8.228LeuSer: 8.228 ± 0.1	6.664LeuThr: 6.664 ± 0.093	7.449LeuVal: 7.449 ± 0.097	1.607LeuTrp: 1.607 ± 0.044	2.617LeuTyr: 2.617 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.281MetAla: 3.281 ± 0.06	0.176MetCys: 0.176 ± 0.013	1.134MetAsp: 1.134 ± 0.034	1.077MetGlu: 1.077 ± 0.033	0.698MetPhe: 0.698 ± 0.028	2.09MetGly: 2.09 ± 0.046	0.54MetHis: 0.54 ± 0.021	1.458MetIle: 1.458 ± 0.037	0.991MetLys: 0.991 ± 0.028	2.943MetLeu: 2.943 ± 0.051	0.867MetMet: 0.867 ± 0.03	0.951MetAsn: 0.951 ± 0.031	1.591MetPro: 1.591 ± 0.038	1.287MetGln: 1.287 ± 0.032	1.596MetArg: 1.596 ± 0.035	1.984MetSer: 1.984 ± 0.046	1.941MetThr: 1.941 ± 0.04	1.743MetVal: 1.743 ± 0.042	0.218MetTrp: 0.218 ± 0.013	0.365MetTyr: 0.365 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.047AsnAla: 3.047 ± 0.057	0.225AsnCys: 0.225 ± 0.015	1.649AsnAsp: 1.649 ± 0.047	1.69AsnGlu: 1.69 ± 0.053	0.998AsnPhe: 0.998 ± 0.029	2.283AsnGly: 2.283 ± 0.057	0.723AsnHis: 0.723 ± 0.025	1.624AsnIle: 1.624 ± 0.046	0.896AsnLys: 0.896 ± 0.03	3.04AsnLeu: 3.04 ± 0.048	0.704AsnMet: 0.704 ± 0.028	0.954AsnAsn: 0.954 ± 0.037	1.883AsnPro: 1.883 ± 0.044	1.588AsnGln: 1.588 ± 0.045	1.835AsnArg: 1.835 ± 0.04	1.52AsnSer: 1.52 ± 0.042	1.699AsnThr: 1.699 ± 0.038	1.758AsnVal: 1.758 ± 0.043	0.415AsnTrp: 0.415 ± 0.02	0.708AsnTyr: 0.708 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.337ProAla: 4.337 ± 0.065	0.384ProCys: 0.384 ± 0.019	3.316ProAsp: 3.316 ± 0.058	4.099ProGlu: 4.099 ± 0.075	1.718ProPhe: 1.718 ± 0.036	3.503ProGly: 3.503 ± 0.057	1.289ProHis: 1.289 ± 0.035	2.268ProIle: 2.268 ± 0.049	1.498ProLys: 1.498 ± 0.04	5.446ProLeu: 5.446 ± 0.087	1.36ProMet: 1.36 ± 0.035	1.449ProAsn: 1.449 ± 0.037	1.92ProPro: 1.92 ± 0.05	2.548ProGln: 2.548 ± 0.053	2.253ProArg: 2.253 ± 0.048	2.775ProSer: 2.775 ± 0.053	2.45ProThr: 2.45 ± 0.046	3.62ProVal: 3.62 ± 0.055	0.845ProTrp: 0.845 ± 0.028	1.187ProTyr: 1.187 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	6.883GlnAla: 6.883 ± 0.122	0.474GlnCys: 0.474 ± 0.022	2.467GlnAsp: 2.467 ± 0.054	2.308GlnGlu: 2.308 ± 0.055	1.495GlnPhe: 1.495 ± 0.039	4.094GlnGly: 4.094 ± 0.068	1.926GlnHis: 1.926 ± 0.044	2.172GlnIle: 2.172 ± 0.05	1.526GlnLys: 1.526 ± 0.044	6.842GlnLeu: 6.842 ± 0.119	1.353GlnMet: 1.353 ± 0.036	1.225GlnAsn: 1.225 ± 0.037	2.682GlnPro: 2.682 ± 0.062	4.421GlnGln: 4.421 ± 0.108	3.963GlnArg: 3.963 ± 0.074	3.148GlnSer: 3.148 ± 0.059	2.726GlnThr: 2.726 ± 0.058	4.125GlnVal: 4.125 ± 0.076	1.276GlnTrp: 1.276 ± 0.043	1.325GlnTyr: 1.325 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	4.948ArgAla: 4.948 ± 0.069	0.6ArgCys: 0.6 ± 0.027	3.289ArgAsp: 3.289 ± 0.061	3.678ArgGlu: 3.678 ± 0.067	2.61ArgPhe: 2.61 ± 0.045	3.343ArgGly: 3.343 ± 0.061	2.198ArgHis: 2.198 ± 0.044	3.177ArgIle: 3.177 ± 0.059	1.729ArgLys: 1.729 ± 0.041	8.003ArgLeu: 8.003 ± 0.097	1.556ArgMet: 1.556 ± 0.037	1.635ArgAsn: 1.635 ± 0.035	2.599ArgPro: 2.599 ± 0.055	4.299ArgGln: 4.299 ± 0.079	4.003ArgArg: 4.003 ± 0.072	3.016ArgSer: 3.016 ± 0.055	2.434ArgThr: 2.434 ± 0.044	3.72ArgVal: 3.72 ± 0.064	1.188ArgTrp: 1.188 ± 0.037	2.209ArgTyr: 2.209 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.74SerAla: 5.74 ± 0.074	0.477SerCys: 0.477 ± 0.021	3.236SerAsp: 3.236 ± 0.059	3.418SerGlu: 3.418 ± 0.062	2.102SerPhe: 2.102 ± 0.043	5.118SerGly: 5.118 ± 0.083	1.584SerHis: 1.584 ± 0.035	3.082SerIle: 3.082 ± 0.05	1.593SerLys: 1.593 ± 0.043	6.904SerLeu: 6.904 ± 0.086	1.564SerMet: 1.564 ± 0.04	1.582SerAsn: 1.582 ± 0.045	2.92SerPro: 2.92 ± 0.051	3.059SerGln: 3.059 ± 0.056	3.575SerArg: 3.575 ± 0.067	3.832SerSer: 3.832 ± 0.073	3.28SerThr: 3.28 ± 0.058	3.976SerVal: 3.976 ± 0.063	0.862SerTrp: 0.862 ± 0.025	1.353SerTyr: 1.353 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.188ThrAla: 5.188 ± 0.079	0.483ThrCys: 0.483 ± 0.02	2.82ThrAsp: 2.82 ± 0.061	2.739ThrGlu: 2.739 ± 0.051	1.788ThrPhe: 1.788 ± 0.052	4.289ThrGly: 4.289 ± 0.082	1.534ThrHis: 1.534 ± 0.042	2.335ThrIle: 2.335 ± 0.05	0.982ThrLys: 0.982 ± 0.028	7.586ThrLeu: 7.586 ± 0.097	1.053ThrMet: 1.053 ± 0.029	1.156ThrAsn: 1.156 ± 0.04	3.598ThrPro: 3.598 ± 0.069	2.996ThrGln: 2.996 ± 0.049	3.059ThrArg: 3.059 ± 0.058	3.068ThrSer: 3.068 ± 0.063	2.766ThrThr: 2.766 ± 0.058	3.482ThrVal: 3.482 ± 0.06	0.703ThrTrp: 0.703 ± 0.028	1.268ThrTyr: 1.268 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.96ValAla: 6.96 ± 0.09	0.673ValCys: 0.673 ± 0.025	4.004ValAsp: 4.004 ± 0.055	4.058ValGlu: 4.058 ± 0.07	2.317ValPhe: 2.317 ± 0.053	4.878ValGly: 4.878 ± 0.075	1.449ValHis: 1.449 ± 0.032	4.044ValIle: 4.044 ± 0.066	2.299ValLys: 2.299 ± 0.054	7.323ValLeu: 7.323 ± 0.092	2.235ValMet: 2.235 ± 0.046	2.222ValAsn: 2.222 ± 0.049	3.008ValPro: 3.008 ± 0.048	2.639ValGln: 2.639 ± 0.052	3.619ValArg: 3.619 ± 0.065	4.328ValSer: 4.328 ± 0.064	3.957ValThr: 3.957 ± 0.066	5.09ValVal: 5.09 ± 0.077	0.832ValTrp: 0.832 ± 0.028	1.526ValTyr: 1.526 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.368TrpAla: 1.368 ± 0.038	0.202TrpCys: 0.202 ± 0.014	0.638TrpAsp: 0.638 ± 0.026	0.528TrpGlu: 0.528 ± 0.025	0.539TrpPhe: 0.539 ± 0.019	0.967TrpGly: 0.967 ± 0.032	0.558TrpHis: 0.558 ± 0.023	0.744TrpIle: 0.744 ± 0.025	0.382TrpLys: 0.382 ± 0.018	2.402TrpLeu: 2.402 ± 0.056	0.379TrpMet: 0.379 ± 0.017	0.326TrpAsn: 0.326 ± 0.017	0.87TrpPro: 0.87 ± 0.03	1.267TrpGln: 1.267 ± 0.045	1.166TrpArg: 1.166 ± 0.035	0.909TrpSer: 0.909 ± 0.026	0.623TrpThr: 0.623 ± 0.023	1.133TrpVal: 1.133 ± 0.033	0.313TrpTrp: 0.313 ± 0.018	0.353TrpTyr: 0.353 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.346TyrAla: 2.346 ± 0.048	0.298TyrCys: 0.298 ± 0.015	1.554TyrAsp: 1.554 ± 0.052	1.343TyrGlu: 1.343 ± 0.035	0.999TyrPhe: 0.999 ± 0.03	2.017TyrGly: 2.017 ± 0.044	0.709TyrHis: 0.709 ± 0.024	1.151TyrIle: 1.151 ± 0.032	0.674TyrLys: 0.674 ± 0.026	2.948TyrLeu: 2.948 ± 0.047	0.534TyrMet: 0.534 ± 0.025	0.712TyrAsn: 0.712 ± 0.027	1.343TyrPro: 1.343 ± 0.04	1.7TyrGln: 1.7 ± 0.04	1.963TyrArg: 1.963 ± 0.04	1.411TyrSer: 1.411 ± 0.037	1.319TyrThr: 1.319 ± 0.035	1.512TyrVal: 1.512 ± 0.039	0.489TyrTrp: 0.489 ± 0.021	0.745TyrTyr: 0.745 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3403 proteins (1145210 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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