Amino acid dipepetide frequency for Autographa californica nuclear polyhedrosis virus (AcMNPV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.81AlaAla: 3.81 ± 0.376
1.189AlaCys: 1.189 ± 0.204
3.058AlaAsp: 3.058 ± 0.272
2.888AlaGlu: 2.888 ± 0.332
2.427AlaPhe: 2.427 ± 0.25
1.65AlaGly: 1.65 ± 0.235
1.286AlaHis: 1.286 ± 0.234
3.495AlaIle: 3.495 ± 0.321
3.228AlaLys: 3.228 ± 0.294
4.781AlaLeu: 4.781 ± 0.356
1.044AlaMet: 1.044 ± 0.154
3.397AlaAsn: 3.397 ± 0.329
2.912AlaPro: 2.912 ± 0.333
2.257AlaGln: 2.257 ± 0.244
1.941AlaArg: 1.941 ± 0.209
3.349AlaSer: 3.349 ± 0.339
3.131AlaThr: 3.131 ± 0.299
3.325AlaVal: 3.325 ± 0.303
0.194AlaTrp: 0.194 ± 0.095
2.645AlaTyr: 2.645 ± 0.253
0.0AlaXaa: 0.0 ± 0.0
Cys
1.408CysAla: 1.408 ± 0.171
0.679CysCys: 0.679 ± 0.171
1.577CysAsp: 1.577 ± 0.175
0.922CysGlu: 0.922 ± 0.148
1.213CysPhe: 1.213 ± 0.194
0.922CysGly: 0.922 ± 0.166
0.631CysHis: 0.631 ± 0.122
1.99CysIle: 1.99 ± 0.21
1.99CysLys: 1.99 ± 0.234
2.16CysLeu: 2.16 ± 0.255
0.534CysMet: 0.534 ± 0.102
2.208CysAsn: 2.208 ± 0.258
1.213CysPro: 1.213 ± 0.206
0.631CysGln: 0.631 ± 0.111
1.48CysArg: 1.48 ± 0.2
1.213CysSer: 1.213 ± 0.159
1.165CysThr: 1.165 ± 0.155
2.087CysVal: 2.087 ± 0.243
0.243CysTrp: 0.243 ± 0.084
0.971CysTyr: 0.971 ± 0.151
0.0CysXaa: 0.0 ± 0.0
Asp
3.81AspAla: 3.81 ± 0.371
1.456AspCys: 1.456 ± 0.183
5.218AspAsp: 5.218 ± 0.457
3.907AspGlu: 3.907 ± 0.265
2.621AspPhe: 2.621 ± 0.234
2.645AspGly: 2.645 ± 0.309
1.068AspHis: 1.068 ± 0.159
3.033AspIle: 3.033 ± 0.285
4.126AspLys: 4.126 ± 0.346
5.266AspLeu: 5.266 ± 0.393
1.966AspMet: 1.966 ± 0.2
4.708AspAsn: 4.708 ± 0.396
1.796AspPro: 1.796 ± 0.213
1.456AspGln: 1.456 ± 0.185
2.524AspArg: 2.524 ± 0.294
3.519AspSer: 3.519 ± 0.292
3.373AspThr: 3.373 ± 0.328
3.859AspVal: 3.859 ± 0.295
0.558AspTrp: 0.558 ± 0.132
3.446AspTyr: 3.446 ± 0.25
0.0AspXaa: 0.0 ± 0.0
Glu
2.354GluAla: 2.354 ± 0.242
1.31GluCys: 1.31 ± 0.212
2.888GluAsp: 2.888 ± 0.293
2.815GluGlu: 2.815 ± 0.283
2.839GluPhe: 2.839 ± 0.274
1.505GluGly: 1.505 ± 0.254
1.432GluHis: 1.432 ± 0.213
3.859GluIle: 3.859 ± 0.282
3.422GluLys: 3.422 ± 0.289
5.315GluLeu: 5.315 ± 0.416
1.553GluMet: 1.553 ± 0.184
4.392GluAsn: 4.392 ± 0.363
1.772GluPro: 1.772 ± 0.284
2.281GluGln: 2.281 ± 0.242
2.742GluArg: 2.742 ± 0.289
3.834GluSer: 3.834 ± 0.3
3.592GluThr: 3.592 ± 0.267
1.796GluVal: 1.796 ± 0.217
0.558GluTrp: 0.558 ± 0.097
2.961GluTyr: 2.961 ± 0.265
0.0GluXaa: 0.0 ± 0.0
Phe
2.742PheAla: 2.742 ± 0.204
1.529PheCys: 1.529 ± 0.182
4.101PheAsp: 4.101 ± 0.349
3.64PheGlu: 3.64 ± 0.258
1.699PhePhe: 1.699 ± 0.202
1.65PheGly: 1.65 ± 0.199
0.777PheHis: 0.777 ± 0.128
3.252PheIle: 3.252 ± 0.286
3.98PheLys: 3.98 ± 0.289
4.053PheLeu: 4.053 ± 0.379
1.48PheMet: 1.48 ± 0.171
4.659PheAsn: 4.659 ± 0.352
1.48PhePro: 1.48 ± 0.138
1.31PheGln: 1.31 ± 0.194
1.626PheArg: 1.626 ± 0.17
2.645PheSer: 2.645 ± 0.24
2.233PheThr: 2.233 ± 0.218
4.126PheVal: 4.126 ± 0.342
0.194PheTrp: 0.194 ± 0.067
2.548PheTyr: 2.548 ± 0.219
0.0PheXaa: 0.0 ± 0.0
Gly
1.577GlyAla: 1.577 ± 0.207
0.679GlyCys: 0.679 ± 0.136
2.475GlyAsp: 2.475 ± 0.362
1.941GlyGlu: 1.941 ± 0.219
1.747GlyPhe: 1.747 ± 0.192
2.136GlyGly: 2.136 ± 0.37
0.849GlyHis: 0.849 ± 0.118
1.674GlyIle: 1.674 ± 0.211
2.16GlyLys: 2.16 ± 0.223
2.451GlyLeu: 2.451 ± 0.217
0.631GlyMet: 0.631 ± 0.111
1.893GlyAsn: 1.893 ± 0.218
0.922GlyPro: 0.922 ± 0.17
1.359GlyGln: 1.359 ± 0.211
1.626GlyArg: 1.626 ± 0.219
1.869GlySer: 1.869 ± 0.163
1.99GlyThr: 1.99 ± 0.236
2.742GlyVal: 2.742 ± 0.274
0.413GlyTrp: 0.413 ± 0.1
1.626GlyTyr: 1.626 ± 0.17
0.0GlyXaa: 0.0 ± 0.0
His
1.262HisAla: 1.262 ± 0.18
0.461HisCys: 0.461 ± 0.097
1.335HisAsp: 1.335 ± 0.174
1.116HisGlu: 1.116 ± 0.182
1.335HisPhe: 1.335 ± 0.154
0.655HisGly: 0.655 ± 0.13
0.631HisHis: 0.631 ± 0.12
1.505HisIle: 1.505 ± 0.157
1.553HisLys: 1.553 ± 0.2
2.087HisLeu: 2.087 ± 0.246
0.607HisMet: 0.607 ± 0.139
1.941HisAsn: 1.941 ± 0.232
0.971HisPro: 0.971 ± 0.149
0.534HisGln: 0.534 ± 0.112
0.922HisArg: 0.922 ± 0.168
1.335HisSer: 1.335 ± 0.173
1.238HisThr: 1.238 ± 0.173
1.529HisVal: 1.529 ± 0.231
0.291HisTrp: 0.291 ± 0.094
1.213HisTyr: 1.213 ± 0.175
0.0HisXaa: 0.0 ± 0.0
Ile
3.033IleAla: 3.033 ± 0.234
1.626IleCys: 1.626 ± 0.187
4.49IleAsp: 4.49 ± 0.31
3.931IleGlu: 3.931 ± 0.252
3.082IlePhe: 3.082 ± 0.268
1.626IleGly: 1.626 ± 0.242
1.092IleHis: 1.092 ± 0.175
5.193IleIle: 5.193 ± 0.398
6.479IleLys: 6.479 ± 0.436
5.315IleLeu: 5.315 ± 0.37
1.941IleMet: 1.941 ± 0.231
6.091IleAsn: 6.091 ± 0.358
2.014IlePro: 2.014 ± 0.249
2.087IleGln: 2.087 ± 0.209
2.427IleArg: 2.427 ± 0.226
3.349IleSer: 3.349 ± 0.338
3.519IleThr: 3.519 ± 0.26
5.485IleVal: 5.485 ± 0.329
0.243IleTrp: 0.243 ± 0.072
2.548IleTyr: 2.548 ± 0.236
0.0IleXaa: 0.0 ± 0.0
Lys
2.184LysAla: 2.184 ± 0.215
2.087LysCys: 2.087 ± 0.269
2.791LysAsp: 2.791 ± 0.337
3.179LysGlu: 3.179 ± 0.269
3.592LysPhe: 3.592 ± 0.339
1.602LysGly: 1.602 ± 0.221
2.451LysHis: 2.451 ± 0.296
6.018LysIle: 6.018 ± 0.46
4.878LysLys: 4.878 ± 0.48
7.766LysLeu: 7.766 ± 0.519
2.694LysMet: 2.694 ± 0.233
5.849LysAsn: 5.849 ± 0.407
2.451LysPro: 2.451 ± 0.282
3.179LysGln: 3.179 ± 0.291
4.295LysArg: 4.295 ± 0.339
5.072LysSer: 5.072 ± 0.348
4.004LysThr: 4.004 ± 0.326
3.252LysVal: 3.252 ± 0.295
0.534LysTrp: 0.534 ± 0.106
4.028LysTyr: 4.028 ± 0.342
0.0LysXaa: 0.0 ± 0.0
Leu
4.368LeuAla: 4.368 ± 0.355
2.305LeuCys: 2.305 ± 0.219
4.659LeuAsp: 4.659 ± 0.325
5.12LeuGlu: 5.12 ± 0.387
5.023LeuPhe: 5.023 ± 0.318
2.548LeuGly: 2.548 ± 0.274
1.844LeuHis: 1.844 ± 0.183
6.552LeuIle: 6.552 ± 0.41
7.426LeuLys: 7.426 ± 0.488
9.173LeuLeu: 9.173 ± 0.54
2.645LeuMet: 2.645 ± 0.275
7.984LeuAsn: 7.984 ± 0.493
3.373LeuPro: 3.373 ± 0.288
5.387LeuGln: 5.387 ± 0.41
3.689LeuArg: 3.689 ± 0.37
5.8LeuSer: 5.8 ± 0.298
4.635LeuThr: 4.635 ± 0.296
4.854LeuVal: 4.854 ± 0.379
0.631LeuTrp: 0.631 ± 0.116
4.805LeuTyr: 4.805 ± 0.364
0.0LeuXaa: 0.0 ± 0.0
Met
1.602MetAla: 1.602 ± 0.178
1.116MetCys: 1.116 ± 0.133
1.262MetAsp: 1.262 ± 0.146
1.092MetGlu: 1.092 ± 0.15
1.699MetPhe: 1.699 ± 0.21
0.777MetGly: 0.777 ± 0.127
0.728MetHis: 0.728 ± 0.106
1.529MetIle: 1.529 ± 0.174
1.505MetLys: 1.505 ± 0.202
3.131MetLeu: 3.131 ± 0.291
0.558MetMet: 0.558 ± 0.093
1.893MetAsn: 1.893 ± 0.208
1.044MetPro: 1.044 ± 0.141
1.359MetGln: 1.359 ± 0.21
1.48MetArg: 1.48 ± 0.19
2.16MetSer: 2.16 ± 0.205
1.359MetThr: 1.359 ± 0.16
1.262MetVal: 1.262 ± 0.147
0.388MetTrp: 0.388 ± 0.114
1.602MetTyr: 1.602 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
4.902AsnAla: 4.902 ± 0.387
1.99AsnCys: 1.99 ± 0.198
4.077AsnAsp: 4.077 ± 0.258
4.562AsnGlu: 4.562 ± 0.324
4.004AsnPhe: 4.004 ± 0.273
3.179AsnGly: 3.179 ± 0.34
1.383AsnHis: 1.383 ± 0.201
4.999AsnIle: 4.999 ± 0.364
6.14AsnLys: 6.14 ± 0.457
6.504AsnLeu: 6.504 ± 0.427
1.941AsnMet: 1.941 ± 0.174
6.455AsnAsn: 6.455 ± 0.484
2.014AsnPro: 2.014 ± 0.266
2.378AsnGln: 2.378 ± 0.248
3.3AsnArg: 3.3 ± 0.285
4.951AsnSer: 4.951 ± 0.361
4.514AsnThr: 4.514 ± 0.298
6.528AsnVal: 6.528 ± 0.294
0.534AsnTrp: 0.534 ± 0.12
4.587AsnTyr: 4.587 ± 0.348
0.0AsnXaa: 0.0 ± 0.0
Pro
2.572ProAla: 2.572 ± 0.365
0.655ProCys: 0.655 ± 0.12
2.475ProAsp: 2.475 ± 0.248
1.723ProGlu: 1.723 ± 0.267
1.844ProPhe: 1.844 ± 0.183
1.31ProGly: 1.31 ± 0.227
0.971ProHis: 0.971 ± 0.169
2.136ProIle: 2.136 ± 0.285
2.087ProLys: 2.087 ± 0.246
3.592ProLeu: 3.592 ± 0.299
0.558ProMet: 0.558 ± 0.121
2.669ProAsn: 2.669 ± 0.262
4.053ProPro: 4.053 ± 0.981
1.165ProGln: 1.165 ± 0.18
1.796ProArg: 1.796 ± 0.232
2.621ProSer: 2.621 ± 0.412
3.009ProThr: 3.009 ± 0.543
2.33ProVal: 2.33 ± 0.276
0.291ProTrp: 0.291 ± 0.101
1.602ProTyr: 1.602 ± 0.19
0.0ProXaa: 0.0 ± 0.0
Gln
1.553GlnAla: 1.553 ± 0.18
1.019GlnCys: 1.019 ± 0.165
1.553GlnAsp: 1.553 ± 0.172
2.184GlnGlu: 2.184 ± 0.265
2.208GlnPhe: 2.208 ± 0.189
0.704GlnGly: 0.704 ± 0.141
0.898GlnHis: 0.898 ± 0.145
2.669GlnIle: 2.669 ± 0.246
2.621GlnLys: 2.621 ± 0.275
4.101GlnLeu: 4.101 ± 0.337
1.116GlnMet: 1.116 ± 0.172
2.694GlnAsn: 2.694 ± 0.236
1.553GlnPro: 1.553 ± 0.202
2.427GlnGln: 2.427 ± 0.316
1.917GlnArg: 1.917 ± 0.205
2.742GlnSer: 2.742 ± 0.256
2.184GlnThr: 2.184 ± 0.222
1.82GlnVal: 1.82 ± 0.223
0.364GlnTrp: 0.364 ± 0.097
1.747GlnTyr: 1.747 ± 0.191
0.0GlnXaa: 0.0 ± 0.0
Arg
2.403ArgAla: 2.403 ± 0.253
1.238ArgCys: 1.238 ± 0.174
2.694ArgAsp: 2.694 ± 0.254
2.16ArgGlu: 2.16 ± 0.216
2.305ArgPhe: 2.305 ± 0.214
1.553ArgGly: 1.553 ± 0.201
1.432ArgHis: 1.432 ± 0.23
3.252ArgIle: 3.252 ± 0.32
2.888ArgLys: 2.888 ± 0.32
4.126ArgLeu: 4.126 ± 0.324
1.068ArgMet: 1.068 ± 0.137
3.131ArgAsn: 3.131 ± 0.269
2.087ArgPro: 2.087 ± 0.239
2.16ArgGln: 2.16 ± 0.248
3.373ArgArg: 3.373 ± 0.496
3.349ArgSer: 3.349 ± 0.491
2.038ArgThr: 2.038 ± 0.234
3.009ArgVal: 3.009 ± 0.265
0.461ArgTrp: 0.461 ± 0.112
1.699ArgTyr: 1.699 ± 0.199
0.0ArgXaa: 0.0 ± 0.0
Ser
3.203SerAla: 3.203 ± 0.308
1.48SerCys: 1.48 ± 0.188
4.562SerAsp: 4.562 ± 0.308
3.446SerGlu: 3.446 ± 0.384
3.058SerPhe: 3.058 ± 0.252
2.354SerGly: 2.354 ± 0.241
1.165SerHis: 1.165 ± 0.173
3.761SerIle: 3.761 ± 0.256
3.98SerLys: 3.98 ± 0.316
6.261SerLeu: 6.261 ± 0.394
1.626SerMet: 1.626 ± 0.184
4.611SerAsn: 4.611 ± 0.366
2.475SerPro: 2.475 ± 0.379
1.796SerGln: 1.796 ± 0.232
2.864SerArg: 2.864 ± 0.408
4.854SerSer: 4.854 ± 0.532
3.931SerThr: 3.931 ± 0.333
5.242SerVal: 5.242 ± 0.343
0.388SerTrp: 0.388 ± 0.099
2.111SerTyr: 2.111 ± 0.212
0.0SerXaa: 0.0 ± 0.0
Thr
3.106ThrAla: 3.106 ± 0.293
1.165ThrCys: 1.165 ± 0.162
3.397ThrAsp: 3.397 ± 0.363
2.694ThrGlu: 2.694 ± 0.293
2.985ThrPhe: 2.985 ± 0.273
2.208ThrGly: 2.208 ± 0.245
1.019ThrHis: 1.019 ± 0.143
3.689ThrIle: 3.689 ± 0.305
2.839ThrLys: 2.839 ± 0.231
5.387ThrLeu: 5.387 ± 0.38
1.553ThrMet: 1.553 ± 0.205
4.101ThrAsn: 4.101 ± 0.346
2.767ThrPro: 2.767 ± 0.514
1.893ThrGln: 1.893 ± 0.205
3.203ThrArg: 3.203 ± 0.302
3.689ThrSer: 3.689 ± 0.334
3.956ThrThr: 3.956 ± 0.39
4.077ThrVal: 4.077 ± 0.328
0.437ThrTrp: 0.437 ± 0.112
2.281ThrTyr: 2.281 ± 0.257
0.0ThrXaa: 0.0 ± 0.0
Val
3.446ValAla: 3.446 ± 0.29
1.941ValCys: 1.941 ± 0.242
4.538ValAsp: 4.538 ± 0.374
3.325ValGlu: 3.325 ± 0.316
3.3ValPhe: 3.3 ± 0.259
1.941ValGly: 1.941 ± 0.207
1.456ValHis: 1.456 ± 0.168
3.859ValIle: 3.859 ± 0.305
4.951ValLys: 4.951 ± 0.306
6.552ValLeu: 6.552 ± 0.422
1.99ValMet: 1.99 ± 0.209
5.169ValAsn: 5.169 ± 0.356
2.912ValPro: 2.912 ± 0.299
2.669ValGln: 2.669 ± 0.253
2.621ValArg: 2.621 ± 0.303
3.907ValSer: 3.907 ± 0.362
3.228ValThr: 3.228 ± 0.275
5.023ValVal: 5.023 ± 0.373
0.461ValTrp: 0.461 ± 0.122
3.567ValTyr: 3.567 ± 0.328
0.0ValXaa: 0.0 ± 0.0
Trp
0.17TrpAla: 0.17 ± 0.083
0.17TrpCys: 0.17 ± 0.06
0.34TrpAsp: 0.34 ± 0.092
0.388TrpGlu: 0.388 ± 0.101
0.315TrpPhe: 0.315 ± 0.073
0.243TrpGly: 0.243 ± 0.085
0.291TrpHis: 0.291 ± 0.088
0.364TrpIle: 0.364 ± 0.088
0.825TrpLys: 0.825 ± 0.18
0.679TrpLeu: 0.679 ± 0.126
0.194TrpMet: 0.194 ± 0.068
0.704TrpAsn: 0.704 ± 0.15
0.413TrpPro: 0.413 ± 0.096
0.34TrpGln: 0.34 ± 0.099
0.485TrpArg: 0.485 ± 0.107
0.461TrpSer: 0.461 ± 0.111
0.582TrpThr: 0.582 ± 0.109
0.388TrpVal: 0.388 ± 0.107
0.097TrpTrp: 0.097 ± 0.045
0.267TrpTyr: 0.267 ± 0.074
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.5TyrAla: 2.5 ± 0.238
1.141TyrCys: 1.141 ± 0.149
2.864TyrAsp: 2.864 ± 0.29
2.184TyrGlu: 2.184 ± 0.218
2.427TyrPhe: 2.427 ± 0.25
1.553TyrGly: 1.553 ± 0.204
1.116TyrHis: 1.116 ± 0.152
2.742TyrIle: 2.742 ± 0.233
4.829TyrLys: 4.829 ± 0.414
4.126TyrLeu: 4.126 ± 0.341
1.82TyrMet: 1.82 ± 0.206
4.392TyrAsn: 4.392 ± 0.269
1.238TyrPro: 1.238 ± 0.182
1.408TyrGln: 1.408 ± 0.189
2.111TyrArg: 2.111 ± 0.248
2.451TyrSer: 2.451 ± 0.215
2.791TyrThr: 2.791 ± 0.246
4.126TyrVal: 4.126 ± 0.32
0.437TyrTrp: 0.437 ± 0.109
2.985TyrTyr: 2.985 ± 0.268
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 155 proteins (41208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski