Amino acid dipepetide frequency for Enteractinococcus helveticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.283AlaAla: 14.283 ± 0.166	0.588AlaCys: 0.588 ± 0.026	6.85AlaAsp: 6.85 ± 0.096	7.398AlaGlu: 7.398 ± 0.097	3.429AlaPhe: 3.429 ± 0.06	9.565AlaGly: 9.565 ± 0.109	2.464AlaHis: 2.464 ± 0.054	6.118AlaIle: 6.118 ± 0.08	3.369AlaLys: 3.369 ± 0.06	10.989AlaLeu: 10.989 ± 0.13	2.906AlaMet: 2.906 ± 0.055	2.978AlaAsn: 2.978 ± 0.06	4.579AlaPro: 4.579 ± 0.082	5.149AlaGln: 5.149 ± 0.088	6.236AlaArg: 6.236 ± 0.094	6.083AlaSer: 6.083 ± 0.07	7.219AlaThr: 7.219 ± 0.092	8.971AlaVal: 8.971 ± 0.108	1.601AlaTrp: 1.601 ± 0.044	2.373AlaTyr: 2.373 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.529CysAla: 0.529 ± 0.022	0.042CysCys: 0.042 ± 0.007	0.284CysAsp: 0.284 ± 0.017	0.252CysGlu: 0.252 ± 0.016	0.2CysPhe: 0.2 ± 0.013	0.531CysGly: 0.531 ± 0.025	0.161CysHis: 0.161 ± 0.013	0.267CysIle: 0.267 ± 0.017	0.104CysLys: 0.104 ± 0.011	0.44CysLeu: 0.44 ± 0.022	0.111CysMet: 0.111 ± 0.011	0.144CysAsn: 0.144 ± 0.011	0.306CysPro: 0.306 ± 0.02	0.191CysGln: 0.191 ± 0.012	0.288CysArg: 0.288 ± 0.016	0.327CysSer: 0.327 ± 0.018	0.336CysThr: 0.336 ± 0.019	0.371CysVal: 0.371 ± 0.02	0.075CysTrp: 0.075 ± 0.008	0.125CysTyr: 0.125 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.06AspAla: 7.06 ± 0.099	0.243AspCys: 0.243 ± 0.017	4.578AspAsp: 4.578 ± 0.105	4.523AspGlu: 4.523 ± 0.077	2.032AspPhe: 2.032 ± 0.048	4.754AspGly: 4.754 ± 0.085	1.639AspHis: 1.639 ± 0.045	3.157AspIle: 3.157 ± 0.068	1.433AspLys: 1.433 ± 0.042	5.622AspLeu: 5.622 ± 0.075	1.311AspMet: 1.311 ± 0.034	1.657AspAsn: 1.657 ± 0.042	3.784AspPro: 3.784 ± 0.071	2.587AspGln: 2.587 ± 0.059	3.438AspArg: 3.438 ± 0.058	2.883AspSer: 2.883 ± 0.062	3.704AspThr: 3.704 ± 0.065	4.83AspVal: 4.83 ± 0.074	0.894AspTrp: 0.894 ± 0.03	1.562AspTyr: 1.562 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.811GluAla: 6.811 ± 0.089	0.256GluCys: 0.256 ± 0.016	3.627GluAsp: 3.627 ± 0.071	3.937GluGlu: 3.937 ± 0.082	2.085GluPhe: 2.085 ± 0.05	3.641GluGly: 3.641 ± 0.064	2.069GluHis: 2.069 ± 0.046	3.46GluIle: 3.46 ± 0.058	1.701GluLys: 1.701 ± 0.051	6.81GluLeu: 6.81 ± 0.091	1.289GluMet: 1.289 ± 0.034	1.873GluAsn: 1.873 ± 0.056	3.032GluPro: 3.032 ± 0.064	3.098GluGln: 3.098 ± 0.054	3.728GluArg: 3.728 ± 0.066	3.138GluSer: 3.138 ± 0.055	3.878GluThr: 3.878 ± 0.068	4.615GluVal: 4.615 ± 0.07	0.732GluTrp: 0.732 ± 0.032	1.525GluTyr: 1.525 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.707PheAla: 3.707 ± 0.07	0.187PheCys: 0.187 ± 0.013	2.289PheAsp: 2.289 ± 0.05	2.081PheGlu: 2.081 ± 0.047	1.229PhePhe: 1.229 ± 0.038	3.383PheGly: 3.383 ± 0.068	0.68PheHis: 0.68 ± 0.025	1.801PheIle: 1.801 ± 0.053	0.715PheLys: 0.715 ± 0.029	2.831PheLeu: 2.831 ± 0.056	0.747PheMet: 0.747 ± 0.027	1.001PheAsn: 1.001 ± 0.032	1.408PhePro: 1.408 ± 0.038	1.077PheGln: 1.077 ± 0.027	1.732PheArg: 1.732 ± 0.046	2.174PheSer: 2.174 ± 0.046	2.325PheThr: 2.325 ± 0.052	2.587PheVal: 2.587 ± 0.053	0.484PheTrp: 0.484 ± 0.025	0.753PheTyr: 0.753 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.929GlyAla: 7.929 ± 0.094	0.498GlyCys: 0.498 ± 0.025	4.043GlyAsp: 4.043 ± 0.071	4.101GlyGlu: 4.101 ± 0.077	3.116GlyPhe: 3.116 ± 0.055	5.958GlyGly: 5.958 ± 0.103	1.897GlyHis: 1.897 ± 0.044	4.914GlyIle: 4.914 ± 0.076	2.634GlyLys: 2.634 ± 0.062	8.025GlyLeu: 8.025 ± 0.097	2.132GlyMet: 2.132 ± 0.055	2.099GlyAsn: 2.099 ± 0.053	3.365GlyPro: 3.365 ± 0.06	3.269GlyGln: 3.269 ± 0.056	4.416GlyArg: 4.416 ± 0.082	4.697GlySer: 4.697 ± 0.071	5.222GlyThr: 5.222 ± 0.076	6.37GlyVal: 6.37 ± 0.085	1.466GlyTrp: 1.466 ± 0.039	2.387GlyTyr: 2.387 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.41HisAla: 2.41 ± 0.051	0.142HisCys: 0.142 ± 0.01	1.699HisAsp: 1.699 ± 0.046	1.435HisGlu: 1.435 ± 0.042	0.778HisPhe: 0.778 ± 0.029	2.019HisGly: 2.019 ± 0.049	0.834HisHis: 0.834 ± 0.029	1.201HisIle: 1.201 ± 0.037	0.555HisLys: 0.555 ± 0.025	2.298HisLeu: 2.298 ± 0.051	0.506HisMet: 0.506 ± 0.023	0.686HisAsn: 0.686 ± 0.025	1.534HisPro: 1.534 ± 0.044	1.076HisGln: 1.076 ± 0.034	1.733HisArg: 1.733 ± 0.044	1.322HisSer: 1.322 ± 0.037	1.498HisThr: 1.498 ± 0.043	1.659HisVal: 1.659 ± 0.037	0.408HisTrp: 0.408 ± 0.018	0.655HisTyr: 0.655 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.847IleAla: 6.847 ± 0.096	0.273IleCys: 0.273 ± 0.016	3.83IleAsp: 3.83 ± 0.06	3.442IleGlu: 3.442 ± 0.057	1.8IlePhe: 1.8 ± 0.048	4.891IleGly: 4.891 ± 0.078	1.087IleHis: 1.087 ± 0.033	2.96IleIle: 2.96 ± 0.067	1.253IleLys: 1.253 ± 0.038	4.622IleLeu: 4.622 ± 0.076	1.126IleMet: 1.126 ± 0.034	1.707IleAsn: 1.707 ± 0.038	2.738IlePro: 2.738 ± 0.055	1.733IleGln: 1.733 ± 0.039	3.028IleArg: 3.028 ± 0.056	3.244IleSer: 3.244 ± 0.057	3.762IleThr: 3.762 ± 0.057	4.322IleVal: 4.322 ± 0.068	0.694IleTrp: 0.694 ± 0.027	1.171IleTyr: 1.171 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.061LysAla: 3.061 ± 0.066	0.104LysCys: 0.104 ± 0.011	1.522LysAsp: 1.522 ± 0.044	1.391LysGlu: 1.391 ± 0.046	0.838LysPhe: 0.838 ± 0.03	1.533LysGly: 1.533 ± 0.038	0.748LysHis: 0.748 ± 0.028	1.643LysIle: 1.643 ± 0.041	1.054LysLys: 1.054 ± 0.04	2.687LysLeu: 2.687 ± 0.065	0.698LysMet: 0.698 ± 0.024	0.899LysAsn: 0.899 ± 0.031	1.679LysPro: 1.679 ± 0.051	1.097LysGln: 1.097 ± 0.036	1.817LysArg: 1.817 ± 0.041	1.506LysSer: 1.506 ± 0.042	1.999LysThr: 1.999 ± 0.051	2.156LysVal: 2.156 ± 0.05	0.316LysTrp: 0.316 ± 0.018	0.723LysTyr: 0.723 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.066LeuAla: 12.066 ± 0.145	0.489LeuCys: 0.489 ± 0.023	6.234LeuAsp: 6.234 ± 0.085	5.745LeuGlu: 5.745 ± 0.084	2.967LeuPhe: 2.967 ± 0.066	7.824LeuGly: 7.824 ± 0.108	2.23LeuHis: 2.23 ± 0.049	5.268LeuIle: 5.268 ± 0.096	2.453LeuLys: 2.453 ± 0.057	9.196LeuLeu: 9.196 ± 0.128	2.25LeuMet: 2.25 ± 0.051	2.814LeuAsn: 2.814 ± 0.06	4.981LeuPro: 4.981 ± 0.072	3.274LeuGln: 3.274 ± 0.06	5.811LeuArg: 5.811 ± 0.094	5.799LeuSer: 5.799 ± 0.07	6.731LeuThr: 6.731 ± 0.078	7.966LeuVal: 7.966 ± 0.119	1.187LeuTrp: 1.187 ± 0.034	1.845LeuTyr: 1.845 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.614MetAla: 2.614 ± 0.049	0.115MetCys: 0.115 ± 0.01	1.171MetAsp: 1.171 ± 0.033	1.095MetGlu: 1.095 ± 0.028	0.727MetPhe: 0.727 ± 0.027	1.671MetGly: 1.671 ± 0.046	0.55MetHis: 0.55 ± 0.022	1.32MetIle: 1.32 ± 0.04	0.666MetLys: 0.666 ± 0.025	2.492MetLeu: 2.492 ± 0.05	0.588MetMet: 0.588 ± 0.023	0.732MetAsn: 0.732 ± 0.03	1.204MetPro: 1.204 ± 0.036	0.9MetGln: 0.9 ± 0.028	1.405MetArg: 1.405 ± 0.039	1.726MetSer: 1.726 ± 0.04	2.037MetThr: 2.037 ± 0.042	1.835MetVal: 1.835 ± 0.049	0.298MetTrp: 0.298 ± 0.02	0.45MetTyr: 0.45 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.058AsnAla: 3.058 ± 0.064	0.163AsnCys: 0.163 ± 0.013	1.689AsnAsp: 1.689 ± 0.041	1.503AsnGlu: 1.503 ± 0.045	0.983AsnPhe: 0.983 ± 0.03	2.289AsnGly: 2.289 ± 0.055	0.7AsnHis: 0.7 ± 0.028	1.695AsnIle: 1.695 ± 0.045	0.774AsnLys: 0.774 ± 0.032	2.64AsnLeu: 2.64 ± 0.053	0.698AsnMet: 0.698 ± 0.027	0.835AsnAsn: 0.835 ± 0.031	1.999AsnPro: 1.999 ± 0.045	1.062AsnGln: 1.062 ± 0.035	1.72AsnArg: 1.72 ± 0.047	1.478AsnSer: 1.478 ± 0.043	1.918AsnThr: 1.918 ± 0.053	2.193AsnVal: 2.193 ± 0.049	0.457AsnTrp: 0.457 ± 0.025	0.74AsnTyr: 0.74 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.551ProAla: 5.551 ± 0.074	0.185ProCys: 0.185 ± 0.015	3.42ProAsp: 3.42 ± 0.067	4.252ProGlu: 4.252 ± 0.065	1.534ProPhe: 1.534 ± 0.043	4.121ProGly: 4.121 ± 0.078	1.211ProHis: 1.211 ± 0.037	2.332ProIle: 2.332 ± 0.051	1.512ProLys: 1.512 ± 0.052	4.26ProLeu: 4.26 ± 0.063	1.088ProMet: 1.088 ± 0.03	1.505ProAsn: 1.505 ± 0.041	1.922ProPro: 1.922 ± 0.056	2.075ProGln: 2.075 ± 0.052	2.435ProArg: 2.435 ± 0.047	2.861ProSer: 2.861 ± 0.055	3.293ProThr: 3.293 ± 0.064	4.313ProVal: 4.313 ± 0.068	0.699ProTrp: 0.699 ± 0.027	1.211ProTyr: 1.211 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.746GlnAla: 4.746 ± 0.08	0.185GlnCys: 0.185 ± 0.013	2.252GlnAsp: 2.252 ± 0.048	2.273GlnGlu: 2.273 ± 0.051	1.16GlnPhe: 1.16 ± 0.031	2.47GlnGly: 2.47 ± 0.045	1.257GlnHis: 1.257 ± 0.032	1.975GlnIle: 1.975 ± 0.039	0.965GlnLys: 0.965 ± 0.031	4.794GlnLeu: 4.794 ± 0.069	0.878GlnMet: 0.878 ± 0.03	0.981GlnAsn: 0.981 ± 0.032	2.217GlnPro: 2.217 ± 0.056	2.472GlnGln: 2.472 ± 0.073	3.396GlnArg: 3.396 ± 0.058	1.943GlnSer: 1.943 ± 0.04	2.309GlnThr: 2.309 ± 0.044	2.956GlnVal: 2.956 ± 0.053	0.676GlnTrp: 0.676 ± 0.03	1.046GlnTyr: 1.046 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.874ArgAla: 5.874 ± 0.077	0.311ArgCys: 0.311 ± 0.017	3.369ArgAsp: 3.369 ± 0.071	3.436ArgGlu: 3.436 ± 0.064	2.11ArgPhe: 2.11 ± 0.045	3.825ArgGly: 3.825 ± 0.059	1.497ArgHis: 1.497 ± 0.043	3.435ArgIle: 3.435 ± 0.051	2.007ArgLys: 2.007 ± 0.047	5.898ArgLeu: 5.898 ± 0.083	1.527ArgMet: 1.527 ± 0.037	1.83ArgAsn: 1.83 ± 0.039	2.774ArgPro: 2.774 ± 0.052	2.659ArgGln: 2.659 ± 0.059	4.539ArgArg: 4.539 ± 0.079	3.46ArgSer: 3.46 ± 0.061	3.56ArgThr: 3.56 ± 0.06	4.215ArgVal: 4.215 ± 0.067	1.023ArgTrp: 1.023 ± 0.033	1.636ArgTyr: 1.636 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.15SerAla: 6.15 ± 0.092	0.26SerCys: 0.26 ± 0.018	3.26SerAsp: 3.26 ± 0.065	3.228SerGlu: 3.228 ± 0.058	1.97SerPhe: 1.97 ± 0.047	5.203SerGly: 5.203 ± 0.067	1.285SerHis: 1.285 ± 0.04	2.949SerIle: 2.949 ± 0.053	1.706SerLys: 1.706 ± 0.047	5.205SerLeu: 5.205 ± 0.074	1.61SerMet: 1.61 ± 0.038	1.649SerAsn: 1.649 ± 0.045	2.832SerPro: 2.832 ± 0.051	2.291SerGln: 2.291 ± 0.049	3.206SerArg: 3.206 ± 0.067	3.678SerSer: 3.678 ± 0.087	3.783SerThr: 3.783 ± 0.065	4.405SerVal: 4.405 ± 0.072	0.957SerTrp: 0.957 ± 0.033	1.436SerTyr: 1.436 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.512ThrAla: 7.512 ± 0.095	0.287ThrCys: 0.287 ± 0.018	4.083ThrAsp: 4.083 ± 0.08	3.782ThrGlu: 3.782 ± 0.063	2.01ThrPhe: 2.01 ± 0.043	5.909ThrGly: 5.909 ± 0.078	1.425ThrHis: 1.425 ± 0.038	3.534ThrIle: 3.534 ± 0.066	1.786ThrLys: 1.786 ± 0.046	5.984ThrLeu: 5.984 ± 0.075	1.443ThrMet: 1.443 ± 0.042	1.815ThrAsn: 1.815 ± 0.045	3.767ThrPro: 3.767 ± 0.061	2.62ThrGln: 2.62 ± 0.053	3.413ThrArg: 3.413 ± 0.065	3.826ThrSer: 3.826 ± 0.065	4.8ThrThr: 4.8 ± 0.081	5.788ThrVal: 5.788 ± 0.092	0.975ThrTrp: 0.975 ± 0.04	1.554ThrTyr: 1.554 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	9.122ValAla: 9.122 ± 0.103	0.484ValCys: 0.484 ± 0.023	5.014ValAsp: 5.014 ± 0.078	5.243ValGlu: 5.243 ± 0.087	2.717ValPhe: 2.717 ± 0.059	5.879ValGly: 5.879 ± 0.08	1.775ValHis: 1.775 ± 0.043	4.689ValIle: 4.689 ± 0.076	1.898ValLys: 1.898 ± 0.051	8.22ValLeu: 8.22 ± 0.111	1.825ValMet: 1.825 ± 0.036	2.24ValAsn: 2.24 ± 0.057	3.779ValPro: 3.779 ± 0.059	2.63ValGln: 2.63 ± 0.052	3.985ValArg: 3.985 ± 0.071	4.689ValSer: 4.689 ± 0.079	5.664ValThr: 5.664 ± 0.075	7.268ValVal: 7.268 ± 0.108	1.02ValTrp: 1.02 ± 0.032	1.594ValTyr: 1.594 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.435TrpAla: 1.435 ± 0.044	0.113TrpCys: 0.113 ± 0.011	0.88TrpAsp: 0.88 ± 0.03	0.725TrpGlu: 0.725 ± 0.025	0.593TrpPhe: 0.593 ± 0.023	0.981TrpGly: 0.981 ± 0.034	0.38TrpHis: 0.38 ± 0.022	0.831TrpIle: 0.831 ± 0.028	0.36TrpLys: 0.36 ± 0.02	1.725TrpLeu: 1.725 ± 0.048	0.417TrpMet: 0.417 ± 0.022	0.489TrpAsn: 0.489 ± 0.022	0.619TrpPro: 0.619 ± 0.025	0.687TrpGln: 0.687 ± 0.027	0.937TrpArg: 0.937 ± 0.031	0.86TrpSer: 0.86 ± 0.029	0.829TrpThr: 0.829 ± 0.032	1.162TrpVal: 1.162 ± 0.033	0.34TrpTrp: 0.34 ± 0.018	0.347TrpTyr: 0.347 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.381TyrAla: 2.381 ± 0.054	0.157TyrCys: 0.157 ± 0.014	1.6TyrAsp: 1.6 ± 0.051	1.463TyrGlu: 1.463 ± 0.038	0.913TyrPhe: 0.913 ± 0.029	2.09TyrGly: 2.09 ± 0.046	0.562TyrHis: 0.562 ± 0.026	0.981TyrIle: 0.981 ± 0.031	0.527TyrLys: 0.527 ± 0.025	2.394TyrLeu: 2.394 ± 0.061	0.448TyrMet: 0.448 ± 0.021	0.658TyrAsn: 0.658 ± 0.025	1.26TyrPro: 1.26 ± 0.038	1.001TyrGln: 1.001 ± 0.031	1.724TyrArg: 1.724 ± 0.036	1.37TyrSer: 1.37 ± 0.041	1.444TyrThr: 1.444 ± 0.039	1.752TyrVal: 1.752 ± 0.04	0.406TyrTrp: 0.406 ± 0.019	0.602TyrTyr: 0.602 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3201 proteins (1011829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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