Amino acid dipepetide frequency for Wenxinia saemankumensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.967AlaAla: 21.967 ± 0.264	1.088AlaCys: 1.088 ± 0.033	7.504AlaAsp: 7.504 ± 0.097	9.64AlaGlu: 9.64 ± 0.133	4.363AlaPhe: 4.363 ± 0.075	13.478AlaGly: 13.478 ± 0.137	2.379AlaHis: 2.379 ± 0.055	5.962AlaIle: 5.962 ± 0.081	2.384AlaLys: 2.384 ± 0.062	15.889AlaLeu: 15.889 ± 0.15	3.95AlaMet: 3.95 ± 0.067	2.183AlaAsn: 2.183 ± 0.052	7.875AlaPro: 7.875 ± 0.134	3.905AlaGln: 3.905 ± 0.065	11.828AlaArg: 11.828 ± 0.131	5.272AlaSer: 5.272 ± 0.075	6.244AlaThr: 6.244 ± 0.078	8.768AlaVal: 8.768 ± 0.103	1.857AlaTrp: 1.857 ± 0.045	2.386AlaTyr: 2.386 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.038	0.089CysCys: 0.089 ± 0.009	0.558CysAsp: 0.558 ± 0.021	0.44CysGlu: 0.44 ± 0.02	0.254CysPhe: 0.254 ± 0.015	0.928CysGly: 0.928 ± 0.034	0.246CysHis: 0.246 ± 0.015	0.33CysIle: 0.33 ± 0.019	0.117CysLys: 0.117 ± 0.01	0.822CysLeu: 0.822 ± 0.028	0.118CysMet: 0.118 ± 0.011	0.146CysAsn: 0.146 ± 0.013	0.494CysPro: 0.494 ± 0.025	0.168CysGln: 0.168 ± 0.014	0.586CysArg: 0.586 ± 0.021	0.316CysSer: 0.316 ± 0.017	0.376CysThr: 0.376 ± 0.019	0.524CysVal: 0.524 ± 0.023	0.116CysTrp: 0.116 ± 0.01	0.164CysTyr: 0.164 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.617AspAla: 7.617 ± 0.107	0.49AspCys: 0.49 ± 0.019	3.228AspAsp: 3.228 ± 0.078	4.01AspGlu: 4.01 ± 0.078	2.127AspPhe: 2.127 ± 0.049	6.426AspGly: 6.426 ± 0.097	1.268AspHis: 1.268 ± 0.035	2.644AspIle: 2.644 ± 0.057	1.025AspLys: 1.025 ± 0.036	6.881AspLeu: 6.881 ± 0.1	1.501AspMet: 1.501 ± 0.042	0.907AspAsn: 0.907 ± 0.03	4.653AspPro: 4.653 ± 0.079	1.445AspGln: 1.445 ± 0.038	5.599AspArg: 5.599 ± 0.086	1.976AspSer: 1.976 ± 0.042	2.693AspThr: 2.693 ± 0.064	4.031AspVal: 4.031 ± 0.068	1.439AspTrp: 1.439 ± 0.043	1.47AspTyr: 1.47 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	9.764GluAla: 9.764 ± 0.125	0.313GluCys: 0.313 ± 0.015	3.538GluAsp: 3.538 ± 0.063	4.091GluGlu: 4.091 ± 0.078	1.49GluPhe: 1.49 ± 0.041	6.343GluGly: 6.343 ± 0.08	0.972GluHis: 0.972 ± 0.028	3.566GluIle: 3.566 ± 0.061	1.449GluLys: 1.449 ± 0.048	4.831GluLeu: 4.831 ± 0.08	1.774GluMet: 1.774 ± 0.038	1.246GluAsn: 1.246 ± 0.04	2.68GluPro: 2.68 ± 0.063	1.501GluGln: 1.501 ± 0.037	4.955GluArg: 4.955 ± 0.073	2.424GluSer: 2.424 ± 0.054	3.914GluThr: 3.914 ± 0.064	4.689GluVal: 4.689 ± 0.071	0.752GluTrp: 0.752 ± 0.027	0.936GluTyr: 0.936 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.54PheAla: 4.54 ± 0.08	0.353PheCys: 0.353 ± 0.018	2.736PheAsp: 2.736 ± 0.049	2.019PheGlu: 2.019 ± 0.049	1.145PhePhe: 1.145 ± 0.043	3.521PheGly: 3.521 ± 0.061	0.68PheHis: 0.68 ± 0.025	1.143PheIle: 1.143 ± 0.038	0.489PheLys: 0.489 ± 0.022	3.281PheLeu: 3.281 ± 0.073	0.617PheMet: 0.617 ± 0.025	0.748PheAsn: 0.748 ± 0.03	1.534PhePro: 1.534 ± 0.033	0.781PheGln: 0.781 ± 0.03	2.362PheArg: 2.362 ± 0.049	1.581PheSer: 1.581 ± 0.036	1.801PheThr: 1.801 ± 0.038	2.708PheVal: 2.708 ± 0.053	0.575PheTrp: 0.575 ± 0.026	0.847PheTyr: 0.847 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	12.611GlyAla: 12.611 ± 0.129	0.852GlyCys: 0.852 ± 0.029	5.131GlyAsp: 5.131 ± 0.092	5.708GlyGlu: 5.708 ± 0.083	3.523GlyPhe: 3.523 ± 0.068	9.085GlyGly: 9.085 ± 0.14	1.913GlyHis: 1.913 ± 0.049	4.812GlyIle: 4.812 ± 0.062	2.088GlyLys: 2.088 ± 0.056	9.987GlyLeu: 9.987 ± 0.101	2.583GlyMet: 2.583 ± 0.056	1.799GlyAsn: 1.799 ± 0.057	5.406GlyPro: 5.406 ± 0.079	3.001GlyGln: 3.001 ± 0.061	8.209GlyArg: 8.209 ± 0.103	4.192GlySer: 4.192 ± 0.068	5.683GlyThr: 5.683 ± 0.081	6.048GlyVal: 6.048 ± 0.075	1.757GlyTrp: 1.757 ± 0.047	2.226GlyTyr: 2.226 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.419HisAla: 2.419 ± 0.047	0.177HisCys: 0.177 ± 0.016	1.27HisAsp: 1.27 ± 0.035	1.075HisGlu: 1.075 ± 0.038	0.708HisPhe: 0.708 ± 0.03	2.023HisGly: 2.023 ± 0.056	0.517HisHis: 0.517 ± 0.025	0.661HisIle: 0.661 ± 0.026	0.296HisLys: 0.296 ± 0.015	2.085HisLeu: 2.085 ± 0.053	0.471HisMet: 0.471 ± 0.023	0.326HisAsn: 0.326 ± 0.017	1.485HisPro: 1.485 ± 0.035	0.401HisGln: 0.401 ± 0.02	1.536HisArg: 1.536 ± 0.042	0.74HisSer: 0.74 ± 0.027	0.661HisThr: 0.661 ± 0.025	1.577HisVal: 1.577 ± 0.042	0.345HisTrp: 0.345 ± 0.02	0.506HisTyr: 0.506 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.119IleAla: 7.119 ± 0.075	0.5IleCys: 0.5 ± 0.021	3.373IleAsp: 3.373 ± 0.061	3.29IleGlu: 3.29 ± 0.059	1.434IlePhe: 1.434 ± 0.04	4.764IleGly: 4.764 ± 0.073	0.919IleHis: 0.919 ± 0.032	1.346IleIle: 1.346 ± 0.037	0.703IleLys: 0.703 ± 0.027	4.685IleLeu: 4.685 ± 0.079	0.801IleMet: 0.801 ± 0.028	0.882IleAsn: 0.882 ± 0.031	2.226IlePro: 2.226 ± 0.049	0.853IleGln: 0.853 ± 0.03	3.541IleArg: 3.541 ± 0.055	2.044IleSer: 2.044 ± 0.042	2.187IleThr: 2.187 ± 0.044	3.979IleVal: 3.979 ± 0.055	0.61IleTrp: 0.61 ± 0.022	0.89IleTyr: 0.89 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.609LysAla: 2.609 ± 0.059	0.103LysCys: 0.103 ± 0.011	1.247LysAsp: 1.247 ± 0.044	1.035LysGlu: 1.035 ± 0.033	0.527LysPhe: 0.527 ± 0.022	1.964LysGly: 1.964 ± 0.054	0.352LysHis: 0.352 ± 0.022	0.904LysIle: 0.904 ± 0.033	0.696LysLys: 0.696 ± 0.031	1.784LysLeu: 1.784 ± 0.052	0.501LysMet: 0.501 ± 0.022	0.377LysAsn: 0.377 ± 0.019	1.06LysPro: 1.06 ± 0.034	0.456LysGln: 0.456 ± 0.019	1.562LysArg: 1.562 ± 0.046	1.145LysSer: 1.145 ± 0.034	1.056LysThr: 1.056 ± 0.034	1.659LysVal: 1.659 ± 0.042	0.233LysTrp: 0.233 ± 0.015	0.36LysTyr: 0.36 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.098LeuAla: 15.098 ± 0.154	0.872LeuCys: 0.872 ± 0.03	6.621LeuAsp: 6.621 ± 0.102	4.944LeuGlu: 4.944 ± 0.078	3.339LeuPhe: 3.339 ± 0.066	8.938LeuGly: 8.938 ± 0.11	1.889LeuHis: 1.889 ± 0.045	4.529LeuIle: 4.529 ± 0.074	2.194LeuLys: 2.194 ± 0.059	9.078LeuLeu: 9.078 ± 0.138	2.343LeuMet: 2.343 ± 0.046	2.014LeuAsn: 2.014 ± 0.041	6.242LeuPro: 6.242 ± 0.08	2.477LeuGln: 2.477 ± 0.043	7.926LeuArg: 7.926 ± 0.094	6.175LeuSer: 6.175 ± 0.081	5.916LeuThr: 5.916 ± 0.077	7.558LeuVal: 7.558 ± 0.103	1.467LeuTrp: 1.467 ± 0.036	1.938LeuTyr: 1.938 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.463MetAla: 3.463 ± 0.055	0.146MetCys: 0.146 ± 0.012	1.406MetAsp: 1.406 ± 0.036	1.362MetGlu: 1.362 ± 0.037	0.651MetPhe: 0.651 ± 0.03	2.216MetGly: 2.216 ± 0.052	0.385MetHis: 0.385 ± 0.019	1.291MetIle: 1.291 ± 0.036	0.704MetLys: 0.704 ± 0.029	2.245MetLeu: 2.245 ± 0.051	0.626MetMet: 0.626 ± 0.026	0.652MetAsn: 0.652 ± 0.025	1.503MetPro: 1.503 ± 0.04	0.735MetGln: 0.735 ± 0.025	1.966MetArg: 1.966 ± 0.046	1.604MetSer: 1.604 ± 0.039	2.027MetThr: 2.027 ± 0.041	1.676MetVal: 1.676 ± 0.039	0.249MetTrp: 0.249 ± 0.015	0.279MetTyr: 0.279 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.492AsnAla: 2.492 ± 0.055	0.187AsnCys: 0.187 ± 0.014	1.092AsnAsp: 1.092 ± 0.037	0.885AsnGlu: 0.885 ± 0.029	0.727AsnPhe: 0.727 ± 0.028	1.829AsnGly: 1.829 ± 0.049	0.407AsnHis: 0.407 ± 0.021	0.898AsnIle: 0.898 ± 0.031	0.328AsnLys: 0.328 ± 0.02	2.02AsnLeu: 2.02 ± 0.041	0.508AsnMet: 0.508 ± 0.022	0.427AsnAsn: 0.427 ± 0.02	1.5AsnPro: 1.5 ± 0.042	0.486AsnGln: 0.486 ± 0.022	1.524AsnArg: 1.524 ± 0.038	0.833AsnSer: 0.833 ± 0.033	0.9AsnThr: 0.9 ± 0.032	1.619AsnVal: 1.619 ± 0.041	0.311AsnTrp: 0.311 ± 0.019	0.481AsnTyr: 0.481 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.14ProAla: 8.14 ± 0.136	0.363ProCys: 0.363 ± 0.019	4.639ProAsp: 4.639 ± 0.076	4.324ProGlu: 4.324 ± 0.074	1.999ProPhe: 1.999 ± 0.043	6.52ProGly: 6.52 ± 0.089	1.092ProHis: 1.092 ± 0.034	2.04ProIle: 2.04 ± 0.047	1.058ProLys: 1.058 ± 0.033	5.195ProLeu: 5.195 ± 0.072	1.315ProMet: 1.315 ± 0.04	1.06ProAsn: 1.06 ± 0.035	3.408ProPro: 3.408 ± 0.083	1.598ProGln: 1.598 ± 0.039	3.966ProArg: 3.966 ± 0.073	2.433ProSer: 2.433 ± 0.05	2.356ProThr: 2.356 ± 0.054	4.78ProVal: 4.78 ± 0.08	0.748ProTrp: 0.748 ± 0.029	1.1ProTyr: 1.1 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.551GlnAla: 3.551 ± 0.071	0.146GlnCys: 0.146 ± 0.011	1.593GlnAsp: 1.593 ± 0.039	1.445GlnGlu: 1.445 ± 0.041	0.821GlnPhe: 0.821 ± 0.03	2.413GlnGly: 2.413 ± 0.052	0.408GlnHis: 0.408 ± 0.019	1.512GlnIle: 1.512 ± 0.038	0.642GlnLys: 0.642 ± 0.025	2.332GlnLeu: 2.332 ± 0.051	0.796GlnMet: 0.796 ± 0.026	0.581GlnAsn: 0.581 ± 0.024	1.425GlnPro: 1.425 ± 0.045	0.856GlnGln: 0.856 ± 0.037	2.013GlnArg: 2.013 ± 0.051	1.335GlnSer: 1.335 ± 0.037	1.393GlnThr: 1.393 ± 0.037	2.205GlnVal: 2.205 ± 0.054	0.323GlnTrp: 0.323 ± 0.017	0.472GlnTyr: 0.472 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	11.032ArgAla: 11.032 ± 0.115	0.476ArgCys: 0.476 ± 0.021	4.952ArgAsp: 4.952 ± 0.07	4.409ArgGlu: 4.409 ± 0.073	2.713ArgPhe: 2.713 ± 0.053	6.103ArgGly: 6.103 ± 0.086	1.846ArgHis: 1.846 ± 0.043	4.532ArgIle: 4.532 ± 0.069	1.545ArgLys: 1.545 ± 0.04	8.983ArgLeu: 8.983 ± 0.114	2.31ArgMet: 2.31 ± 0.035	1.575ArgAsn: 1.575 ± 0.038	4.784ArgPro: 4.784 ± 0.084	2.339ArgGln: 2.339 ± 0.045	7.03ArgArg: 7.03 ± 0.11	3.348ArgSer: 3.348 ± 0.067	3.804ArgThr: 3.804 ± 0.056	5.359ArgVal: 5.359 ± 0.077	1.153ArgTrp: 1.153 ± 0.04	1.538ArgTyr: 1.538 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.566SerAla: 5.566 ± 0.081	0.386SerCys: 0.386 ± 0.018	2.829SerAsp: 2.829 ± 0.052	2.41SerGlu: 2.41 ± 0.045	1.865SerPhe: 1.865 ± 0.049	5.248SerGly: 5.248 ± 0.073	0.919SerHis: 0.919 ± 0.031	2.03SerIle: 2.03 ± 0.045	0.826SerLys: 0.826 ± 0.032	4.336SerLeu: 4.336 ± 0.06	1.056SerMet: 1.056 ± 0.031	0.972SerAsn: 0.972 ± 0.029	2.555SerPro: 2.555 ± 0.049	1.171SerGln: 1.171 ± 0.032	3.407SerArg: 3.407 ± 0.062	1.99SerSer: 1.99 ± 0.052	2.118SerThr: 2.118 ± 0.048	3.536SerVal: 3.536 ± 0.058	0.683SerTrp: 0.683 ± 0.025	1.145SerTyr: 1.145 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.14ThrAla: 6.14 ± 0.087	0.43ThrCys: 0.43 ± 0.023	3.289ThrAsp: 3.289 ± 0.054	3.022ThrGlu: 3.022 ± 0.052	1.992ThrPhe: 1.992 ± 0.043	6.088ThrGly: 6.088 ± 0.086	0.98ThrHis: 0.98 ± 0.033	2.706ThrIle: 2.706 ± 0.051	0.934ThrLys: 0.934 ± 0.029	5.912ThrLeu: 5.912 ± 0.084	1.233ThrMet: 1.233 ± 0.035	1.079ThrAsn: 1.079 ± 0.031	3.236ThrPro: 3.236 ± 0.058	1.133ThrGln: 1.133 ± 0.03	3.733ThrArg: 3.733 ± 0.064	2.267ThrSer: 2.267 ± 0.046	2.571ThrThr: 2.571 ± 0.055	3.823ThrVal: 3.823 ± 0.063	0.77ThrTrp: 0.77 ± 0.031	1.12ThrTyr: 1.12 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.575ValAla: 9.575 ± 0.118	0.552ValCys: 0.552 ± 0.022	4.065ValAsp: 4.065 ± 0.061	5.109ValGlu: 5.109 ± 0.074	2.507ValPhe: 2.507 ± 0.048	5.507ValGly: 5.507 ± 0.076	1.311ValHis: 1.311 ± 0.036	3.726ValIle: 3.726 ± 0.064	1.511ValLys: 1.511 ± 0.038	7.458ValLeu: 7.458 ± 0.101	1.857ValMet: 1.857 ± 0.047	1.629ValAsn: 1.629 ± 0.041	4.214ValPro: 4.214 ± 0.075	1.86ValGln: 1.86 ± 0.042	5.122ValArg: 5.122 ± 0.08	3.56ValSer: 3.56 ± 0.06	4.828ValThr: 4.828 ± 0.069	5.607ValVal: 5.607 ± 0.078	1.035ValTrp: 1.035 ± 0.029	1.405ValTyr: 1.405 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.637TrpAla: 1.637 ± 0.041	0.141TrpCys: 0.141 ± 0.012	0.855TrpAsp: 0.855 ± 0.031	0.761TrpGlu: 0.761 ± 0.027	0.545TrpPhe: 0.545 ± 0.021	1.191TrpGly: 1.191 ± 0.034	0.357TrpHis: 0.357 ± 0.019	0.799TrpIle: 0.799 ± 0.026	0.303TrpLys: 0.303 ± 0.019	1.723TrpLeu: 1.723 ± 0.051	0.408TrpMet: 0.408 ± 0.018	0.373TrpAsn: 0.373 ± 0.019	0.823TrpPro: 0.823 ± 0.028	0.586TrpGln: 0.586 ± 0.025	1.34TrpArg: 1.34 ± 0.042	0.855TrpSer: 0.855 ± 0.03	0.933TrpThr: 0.933 ± 0.03	0.888TrpVal: 0.888 ± 0.03	0.288TrpTrp: 0.288 ± 0.018	0.249TrpTyr: 0.249 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.049	0.202TyrCys: 0.202 ± 0.014	1.505TyrAsp: 1.505 ± 0.036	1.247TyrGlu: 1.247 ± 0.039	0.731TyrPhe: 0.731 ± 0.029	2.03TyrGly: 2.03 ± 0.052	0.437TyrHis: 0.437 ± 0.02	0.714TyrIle: 0.714 ± 0.026	0.34TyrLys: 0.34 ± 0.018	2.031TyrLeu: 2.031 ± 0.044	0.415TyrMet: 0.415 ± 0.021	0.476TyrAsn: 0.476 ± 0.021	1.035TyrPro: 1.035 ± 0.029	0.511TyrGln: 0.511 ± 0.025	1.63TyrArg: 1.63 ± 0.039	0.957TyrSer: 0.957 ± 0.032	0.995TyrThr: 0.995 ± 0.037	1.4TyrVal: 1.4 ± 0.038	0.345TyrTrp: 0.345 ± 0.018	0.489TyrTyr: 0.489 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3386 proteins (1058228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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