Amino acid dipepetide frequency for Paenisporosarcina antarctica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.282AlaAla: 5.282 ± 0.096	0.608AlaCys: 0.608 ± 0.024	3.301AlaAsp: 3.301 ± 0.063	4.28AlaGlu: 4.28 ± 0.07	3.372AlaPhe: 3.372 ± 0.07	5.043AlaGly: 5.043 ± 0.089	1.339AlaHis: 1.339 ± 0.035	6.348AlaIle: 6.348 ± 0.1	4.53AlaLys: 4.53 ± 0.064	7.027AlaLeu: 7.027 ± 0.085	2.062AlaMet: 2.062 ± 0.046	2.748AlaAsn: 2.748 ± 0.055	2.031AlaPro: 2.031 ± 0.048	2.364AlaGln: 2.364 ± 0.053	2.608AlaArg: 2.608 ± 0.054	4.151AlaSer: 4.151 ± 0.064	3.821AlaThr: 3.821 ± 0.064	5.183AlaVal: 5.183 ± 0.076	0.634AlaTrp: 0.634 ± 0.028	2.281AlaTyr: 2.281 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.422CysAla: 0.422 ± 0.021	0.088CysCys: 0.088 ± 0.01	0.385CysAsp: 0.385 ± 0.021	0.441CysGlu: 0.441 ± 0.022	0.28CysPhe: 0.28 ± 0.017	0.633CysGly: 0.633 ± 0.024	0.193CysHis: 0.193 ± 0.016	0.502CysIle: 0.502 ± 0.023	0.332CysLys: 0.332 ± 0.022	0.607CysLeu: 0.607 ± 0.026	0.187CysMet: 0.187 ± 0.012	0.244CysAsn: 0.244 ± 0.017	0.358CysPro: 0.358 ± 0.022	0.218CysGln: 0.218 ± 0.017	0.272CysArg: 0.272 ± 0.021	0.463CysSer: 0.463 ± 0.02	0.371CysThr: 0.371 ± 0.019	0.408CysVal: 0.408 ± 0.019	0.06CysTrp: 0.06 ± 0.007	0.242CysTyr: 0.242 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.449AspAla: 3.449 ± 0.062	0.337AspCys: 0.337 ± 0.018	2.597AspAsp: 2.597 ± 0.056	4.341AspGlu: 4.341 ± 0.064	2.548AspPhe: 2.548 ± 0.049	3.288AspGly: 3.288 ± 0.069	1.112AspHis: 1.112 ± 0.035	4.142AspIle: 4.142 ± 0.07	2.945AspLys: 2.945 ± 0.063	5.138AspLeu: 5.138 ± 0.061	1.393AspMet: 1.393 ± 0.038	1.928AspAsn: 1.928 ± 0.046	1.822AspPro: 1.822 ± 0.042	1.972AspGln: 1.972 ± 0.047	2.134AspArg: 2.134 ± 0.052	2.797AspSer: 2.797 ± 0.052	2.436AspThr: 2.436 ± 0.051	4.037AspVal: 4.037 ± 0.076	0.602AspTrp: 0.602 ± 0.025	1.963AspTyr: 1.963 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.015GluAla: 5.015 ± 0.077	0.369GluCys: 0.369 ± 0.018	3.814GluAsp: 3.814 ± 0.062	6.232GluGlu: 6.232 ± 0.099	2.785GluPhe: 2.785 ± 0.05	4.058GluGly: 4.058 ± 0.065	1.49GluHis: 1.49 ± 0.043	5.566GluIle: 5.566 ± 0.084	5.806GluLys: 5.806 ± 0.086	7.222GluLeu: 7.222 ± 0.102	2.274GluMet: 2.274 ± 0.049	3.438GluAsn: 3.438 ± 0.052	1.887GluPro: 1.887 ± 0.046	3.255GluGln: 3.255 ± 0.06	3.285GluArg: 3.285 ± 0.064	3.899GluSer: 3.899 ± 0.071	3.85GluThr: 3.85 ± 0.072	5.202GluVal: 5.202 ± 0.078	0.867GluTrp: 0.867 ± 0.034	1.923GluTyr: 1.923 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.165PheAla: 3.165 ± 0.064	0.297PheCys: 0.297 ± 0.016	2.53PheAsp: 2.53 ± 0.045	3.104PheGlu: 3.104 ± 0.057	2.328PhePhe: 2.328 ± 0.055	3.483PheGly: 3.483 ± 0.073	0.997PheHis: 0.997 ± 0.029	4.055PheIle: 4.055 ± 0.08	2.44PheLys: 2.44 ± 0.044	4.459PheLeu: 4.459 ± 0.081	1.244PheMet: 1.244 ± 0.03	1.998PheAsn: 1.998 ± 0.044	1.732PhePro: 1.732 ± 0.04	1.575PheGln: 1.575 ± 0.04	1.518PheArg: 1.518 ± 0.037	3.325PheSer: 3.325 ± 0.063	2.76PheThr: 2.76 ± 0.062	3.325PheVal: 3.325 ± 0.063	0.462PheTrp: 0.462 ± 0.023	1.684PheTyr: 1.684 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.715GlyAla: 4.715 ± 0.078	0.575GlyCys: 0.575 ± 0.026	3.248GlyAsp: 3.248 ± 0.064	4.236GlyGlu: 4.236 ± 0.07	3.44GlyPhe: 3.44 ± 0.071	4.672GlyGly: 4.672 ± 0.087	1.434GlyHis: 1.434 ± 0.042	6.076GlyIle: 6.076 ± 0.094	4.782GlyLys: 4.782 ± 0.081	6.638GlyLeu: 6.638 ± 0.1	2.149GlyMet: 2.149 ± 0.047	2.565GlyAsn: 2.565 ± 0.052	1.721GlyPro: 1.721 ± 0.05	2.269GlyGln: 2.269 ± 0.046	2.652GlyArg: 2.652 ± 0.056	4.168GlySer: 4.168 ± 0.073	3.971GlyThr: 3.971 ± 0.068	4.945GlyVal: 4.945 ± 0.076	0.735GlyTrp: 0.735 ± 0.029	2.712GlyTyr: 2.712 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.487HisAla: 1.487 ± 0.034	0.185HisCys: 0.185 ± 0.013	1.053HisAsp: 1.053 ± 0.031	1.451HisGlu: 1.451 ± 0.037	1.012HisPhe: 1.012 ± 0.032	1.406HisGly: 1.406 ± 0.041	0.635HisHis: 0.635 ± 0.025	1.641HisIle: 1.641 ± 0.044	1.098HisLys: 1.098 ± 0.033	2.105HisLeu: 2.105 ± 0.045	0.6HisMet: 0.6 ± 0.024	0.751HisAsn: 0.751 ± 0.029	1.155HisPro: 1.155 ± 0.036	0.867HisGln: 0.867 ± 0.028	0.852HisArg: 0.852 ± 0.031	1.231HisSer: 1.231 ± 0.033	1.111HisThr: 1.111 ± 0.032	1.581HisVal: 1.581 ± 0.038	0.182HisTrp: 0.182 ± 0.012	0.795HisTyr: 0.795 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.198IleAla: 6.198 ± 0.089	0.596IleCys: 0.596 ± 0.024	4.506IleAsp: 4.506 ± 0.069	6.161IleGlu: 6.161 ± 0.092	3.542IlePhe: 3.542 ± 0.07	6.273IleGly: 6.273 ± 0.094	1.802IleHis: 1.802 ± 0.042	6.311IleIle: 6.311 ± 0.1	4.436IleLys: 4.436 ± 0.066	7.604IleLeu: 7.604 ± 0.105	1.894IleMet: 1.894 ± 0.044	3.315IleAsn: 3.315 ± 0.064	3.371IlePro: 3.371 ± 0.065	3.083IleGln: 3.083 ± 0.057	3.273IleArg: 3.273 ± 0.062	5.573IleSer: 5.573 ± 0.083	4.497IleThr: 4.497 ± 0.074	6.123IleVal: 6.123 ± 0.082	0.712IleTrp: 0.712 ± 0.031	2.377IleTyr: 2.377 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.186LysAla: 4.186 ± 0.064	0.306LysCys: 0.306 ± 0.019	3.565LysAsp: 3.565 ± 0.06	5.968LysGlu: 5.968 ± 0.079	2.123LysPhe: 2.123 ± 0.05	4.187LysGly: 4.187 ± 0.067	1.306LysHis: 1.306 ± 0.035	4.723LysIle: 4.723 ± 0.076	5.519LysLys: 5.519 ± 0.086	5.705LysLeu: 5.705 ± 0.072	2.257LysMet: 2.257 ± 0.048	3.187LysAsn: 3.187 ± 0.068	2.16LysPro: 2.16 ± 0.046	2.894LysGln: 2.894 ± 0.055	3.077LysArg: 3.077 ± 0.058	3.727LysSer: 3.727 ± 0.061	3.691LysThr: 3.691 ± 0.058	4.499LysVal: 4.499 ± 0.073	0.874LysTrp: 0.874 ± 0.03	2.016LysTyr: 2.016 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.426LeuAla: 7.426 ± 0.095	0.597LeuCys: 0.597 ± 0.027	4.671LeuAsp: 4.671 ± 0.065	6.49LeuGlu: 6.49 ± 0.085	4.917LeuPhe: 4.917 ± 0.088	6.294LeuGly: 6.294 ± 0.093	2.014LeuHis: 2.014 ± 0.052	7.791LeuIle: 7.791 ± 0.109	6.297LeuLys: 6.297 ± 0.085	10.422LeuLeu: 10.422 ± 0.152	2.665LeuMet: 2.665 ± 0.06	4.194LeuAsn: 4.194 ± 0.071	3.885LeuPro: 3.885 ± 0.066	3.738LeuGln: 3.738 ± 0.07	3.626LeuArg: 3.626 ± 0.057	6.923LeuSer: 6.923 ± 0.091	5.974LeuThr: 5.974 ± 0.069	6.722LeuVal: 6.722 ± 0.082	0.889LeuTrp: 0.889 ± 0.036	2.996LeuTyr: 2.996 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.984MetAla: 1.984 ± 0.045	0.141MetCys: 0.141 ± 0.012	1.525MetAsp: 1.525 ± 0.038	1.86MetGlu: 1.86 ± 0.047	1.147MetPhe: 1.147 ± 0.035	1.901MetGly: 1.901 ± 0.045	0.504MetHis: 0.504 ± 0.021	2.308MetIle: 2.308 ± 0.051	2.585MetLys: 2.585 ± 0.047	2.574MetLeu: 2.574 ± 0.051	0.964MetMet: 0.964 ± 0.035	1.669MetAsn: 1.669 ± 0.043	1.039MetPro: 1.039 ± 0.031	0.945MetGln: 0.945 ± 0.03	1.13MetArg: 1.13 ± 0.034	1.782MetSer: 1.782 ± 0.043	1.988MetThr: 1.988 ± 0.044	1.812MetVal: 1.812 ± 0.04	0.221MetTrp: 0.221 ± 0.015	0.81MetTyr: 0.81 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.693AsnAla: 2.693 ± 0.052	0.332AsnCys: 0.332 ± 0.018	2.224AsnAsp: 2.224 ± 0.05	3.548AsnGlu: 3.548 ± 0.069	1.765AsnPhe: 1.765 ± 0.038	3.157AsnGly: 3.157 ± 0.051	1.04AsnHis: 1.04 ± 0.034	3.269AsnIle: 3.269 ± 0.056	2.764AsnLys: 2.764 ± 0.059	3.866AsnLeu: 3.866 ± 0.062	1.293AsnMet: 1.293 ± 0.034	1.895AsnAsn: 1.895 ± 0.047	2.109AsnPro: 2.109 ± 0.044	1.909AsnGln: 1.909 ± 0.047	1.997AsnArg: 1.997 ± 0.035	2.523AsnSer: 2.523 ± 0.058	2.057AsnThr: 2.057 ± 0.045	2.979AsnVal: 2.979 ± 0.053	0.508AsnTrp: 0.508 ± 0.023	1.367AsnTyr: 1.367 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.137ProAla: 2.137 ± 0.045	0.219ProCys: 0.219 ± 0.015	1.814ProAsp: 1.814 ± 0.049	2.73ProGlu: 2.73 ± 0.053	2.0ProPhe: 2.0 ± 0.042	2.187ProGly: 2.187 ± 0.047	0.814ProHis: 0.814 ± 0.03	3.089ProIle: 3.089 ± 0.061	2.166ProLys: 2.166 ± 0.047	3.453ProLeu: 3.453 ± 0.062	0.865ProMet: 0.865 ± 0.029	1.651ProAsn: 1.651 ± 0.044	0.963ProPro: 0.963 ± 0.037	1.191ProGln: 1.191 ± 0.04	1.051ProArg: 1.051 ± 0.034	2.406ProSer: 2.406 ± 0.048	2.132ProThr: 2.132 ± 0.044	2.881ProVal: 2.881 ± 0.055	0.36ProTrp: 0.36 ± 0.02	1.327ProTyr: 1.327 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.753GlnAla: 2.753 ± 0.052	0.19GlnCys: 0.19 ± 0.015	1.794GlnAsp: 1.794 ± 0.039	2.704GlnGlu: 2.704 ± 0.053	1.676GlnPhe: 1.676 ± 0.037	2.275GlnGly: 2.275 ± 0.057	0.873GlnHis: 0.873 ± 0.027	2.7GlnIle: 2.7 ± 0.049	2.517GlnLys: 2.517 ± 0.05	4.137GlnLeu: 4.137 ± 0.077	1.242GlnMet: 1.242 ± 0.039	1.624GlnAsn: 1.624 ± 0.04	1.226GlnPro: 1.226 ± 0.038	2.058GlnGln: 2.058 ± 0.056	1.41GlnArg: 1.41 ± 0.039	2.352GlnSer: 2.352 ± 0.057	2.167GlnThr: 2.167 ± 0.051	2.558GlnVal: 2.558 ± 0.043	0.431GlnTrp: 0.431 ± 0.023	1.234GlnTyr: 1.234 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.578ArgAla: 2.578 ± 0.055	0.232ArgCys: 0.232 ± 0.017	2.054ArgAsp: 2.054 ± 0.046	2.967ArgGlu: 2.967 ± 0.059	1.869ArgPhe: 1.869 ± 0.045	2.347ArgGly: 2.347 ± 0.051	0.825ArgHis: 0.825 ± 0.026	3.316ArgIle: 3.316 ± 0.062	2.942ArgLys: 2.942 ± 0.052	4.021ArgLeu: 4.021 ± 0.067	1.226ArgMet: 1.226 ± 0.033	1.813ArgAsn: 1.813 ± 0.044	1.311ArgPro: 1.311 ± 0.036	1.525ArgGln: 1.525 ± 0.039	1.621ArgArg: 1.621 ± 0.04	2.205ArgSer: 2.205 ± 0.043	2.031ArgThr: 2.031 ± 0.05	2.745ArgVal: 2.745 ± 0.06	0.38ArgTrp: 0.38 ± 0.019	1.409ArgTyr: 1.409 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	3.667SerAla: 3.667 ± 0.064	0.428SerCys: 0.428 ± 0.021	3.005SerAsp: 3.005 ± 0.05	4.062SerGlu: 4.062 ± 0.062	3.342SerPhe: 3.342 ± 0.06	4.643SerGly: 4.643 ± 0.07	1.359SerHis: 1.359 ± 0.038	5.61SerIle: 5.61 ± 0.08	3.97SerLys: 3.97 ± 0.068	6.151SerLeu: 6.151 ± 0.088	1.883SerMet: 1.883 ± 0.043	2.712SerAsn: 2.712 ± 0.057	2.169SerPro: 2.169 ± 0.044	2.165SerGln: 2.165 ± 0.054	2.45SerArg: 2.45 ± 0.045	4.236SerSer: 4.236 ± 0.075	3.541SerThr: 3.541 ± 0.06	4.531SerVal: 4.531 ± 0.068	0.609SerTrp: 0.609 ± 0.026	2.279SerTyr: 2.279 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	3.966ThrAla: 3.966 ± 0.066	0.362ThrCys: 0.362 ± 0.019	2.819ThrAsp: 2.819 ± 0.052	3.516ThrGlu: 3.516 ± 0.056	2.815ThrPhe: 2.815 ± 0.049	4.231ThrGly: 4.231 ± 0.071	1.149ThrHis: 1.149 ± 0.033	4.927ThrIle: 4.927 ± 0.074	3.568ThrLys: 3.568 ± 0.06	5.628ThrLeu: 5.628 ± 0.079	1.431ThrMet: 1.431 ± 0.037	2.563ThrAsn: 2.563 ± 0.05	2.276ThrPro: 2.276 ± 0.051	1.7ThrGln: 1.7 ± 0.04	1.856ThrArg: 1.856 ± 0.038	3.555ThrSer: 3.555 ± 0.063	3.359ThrThr: 3.359 ± 0.067	4.122ThrVal: 4.122 ± 0.069	0.516ThrTrp: 0.516 ± 0.023	2.071ThrTyr: 2.071 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.088ValAla: 5.088 ± 0.079	0.514ValCys: 0.514 ± 0.025	3.691ValAsp: 3.691 ± 0.069	5.058ValGlu: 5.058 ± 0.091	3.258ValPhe: 3.258 ± 0.051	4.68ValGly: 4.68 ± 0.078	1.428ValHis: 1.428 ± 0.039	5.996ValIle: 5.996 ± 0.082	4.648ValLys: 4.648 ± 0.067	7.184ValLeu: 7.184 ± 0.095	2.036ValMet: 2.036 ± 0.051	3.148ValAsn: 3.148 ± 0.063	2.643ValPro: 2.643 ± 0.053	2.397ValGln: 2.397 ± 0.051	2.757ValArg: 2.757 ± 0.062	4.797ValSer: 4.797 ± 0.07	4.236ValThr: 4.236 ± 0.07	5.354ValVal: 5.354 ± 0.083	0.645ValTrp: 0.645 ± 0.024	2.261ValTyr: 2.261 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.59TrpAla: 0.59 ± 0.026	0.066TrpCys: 0.066 ± 0.007	0.479TrpAsp: 0.479 ± 0.022	0.624TrpGlu: 0.624 ± 0.023	0.529TrpPhe: 0.529 ± 0.025	0.639TrpGly: 0.639 ± 0.027	0.191TrpHis: 0.191 ± 0.014	0.91TrpIle: 0.91 ± 0.034	0.7TrpLys: 0.7 ± 0.025	1.176TrpLeu: 1.176 ± 0.031	0.38TrpMet: 0.38 ± 0.018	0.496TrpAsn: 0.496 ± 0.02	0.284TrpPro: 0.284 ± 0.019	0.392TrpGln: 0.392 ± 0.022	0.432TrpArg: 0.432 ± 0.019	0.663TrpSer: 0.663 ± 0.029	0.607TrpThr: 0.607 ± 0.023	0.62TrpVal: 0.62 ± 0.027	0.144TrpTrp: 0.144 ± 0.013	0.293TrpTyr: 0.293 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.214TyrAla: 2.214 ± 0.048	0.264TyrCys: 0.264 ± 0.016	1.908TyrAsp: 1.908 ± 0.048	2.468TyrGlu: 2.468 ± 0.045	1.733TyrPhe: 1.733 ± 0.043	2.308TyrGly: 2.308 ± 0.047	0.692TyrHis: 0.692 ± 0.027	2.366TyrIle: 2.366 ± 0.049	1.925TyrLys: 1.925 ± 0.042	3.415TyrLeu: 3.415 ± 0.054	0.845TyrMet: 0.845 ± 0.027	1.353TyrAsn: 1.353 ± 0.039	1.295TyrPro: 1.295 ± 0.035	1.404TyrGln: 1.404 ± 0.036	1.411TyrArg: 1.411 ± 0.042	2.036TyrSer: 2.036 ± 0.047	1.831TyrThr: 1.831 ± 0.045	2.191TyrVal: 2.191 ± 0.046	0.381TyrTrp: 0.381 ± 0.023	1.262TyrTyr: 1.262 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3570 proteins (1051335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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